HAUS3_HUMAN - dbPTM
HAUS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAUS3_HUMAN
UniProt AC Q68CZ6
Protein Name HAUS augmin-like complex subunit 3
Gene Name HAUS3
Organism Homo sapiens (Human).
Sequence Length 603
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein Description Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex..
Protein Sequence MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSCGNEFVE
------CCCCHHHHH		30.6319413330
10PhosphorylationCGNEFVETLKKIGYP
CCHHHHHHHHHHCCC		38.2829083192
12UbiquitinationNEFVETLKKIGYPKA
HHHHHHHHHHCCCCC		50.17-
12UbiquitinationNEFVETLKKIGYPKA
HHHHHHHHHHCCCCC		50.17-
18UbiquitinationLKKIGYPKADNLNGE
HHHHCCCCCCCCCCC		60.9529967540
38PhosphorylationFEGVEDESFLKWFCG
HCCCCCHHHHHHHHC		48.4724719451
66UbiquitinationEAFSILQKSGKPILE
HHHHHHHHHCCCCCC		58.70-
66UbiquitinationEAFSILQKSGKPILE
HHHHHHHHHCCCCCC		58.7032015554
69UbiquitinationSILQKSGKPILEGAA
HHHHHHCCCCCCHHH		35.6629967540
69UbiquitinationSILQKSGKPILEGAA
HHHHHHCCCCCCHHH		35.66-
82UbiquitinationAALDEALKTCKTSDL
HHHHHHHHHCCCCCC		59.9529967540
90UbiquitinationTCKTSDLKTPRLDDK
HCCCCCCCCCCCCHH		62.5729967540
91PhosphorylationCKTSDLKTPRLDDKE
CCCCCCCCCCCCHHH		22.42-
101UbiquitinationLDDKELEKLEDEVQT
CCHHHHHHHHHHHHH		70.5629967540
111UbiquitinationDEVQTLLKLKNLKIQ
HHHHHHHHHCCHHHH		61.60-
111UbiquitinationDEVQTLLKLKNLKIQ
HHHHHHHHHCCHHHH		61.6021906983
113UbiquitinationVQTLLKLKNLKIQRR
HHHHHHHCCHHHHCC		59.6622817900
116UbiquitinationLLKLKNLKIQRRNKC
HHHHCCHHHHCCCCC		46.3022817900
122UbiquitinationLKIQRRNKCQLMASV
HHHHCCCCCCHHHHH		22.8829967540
128PhosphorylationNKCQLMASVTSHKSL
CCCCHHHHHHCHHHH		16.38-
151PhosphorylationATKKLKQSQGILNAM
HHHHHHHHHHHHHHH		28.8723612710
160PhosphorylationGILNAMITKISNELQ
HHHHHHHHHHHHHHH		14.83-
219UbiquitinationAALTLYTKKQFFQGI
HHHHHHHHHHHHCHH		30.90-
219UbiquitinationAALTLYTKKQFFQGI
HHHHHHHHHHHHCHH		30.9021906983
220UbiquitinationALTLYTKKQFFQGIH
HHHHHHHHHHHCHHH		44.5322817900
287UbiquitinationKASNSSMKSSIKWAE
HCCCCHHHHHHHHHH		42.8929967540
291UbiquitinationSSMKSSIKWAEESLH
CHHHHHHHHHHHHHH		42.15-
291UbiquitinationSSMKSSIKWAEESLH
CHHHHHHHHHHHHHH		42.1529967540
299PhosphorylationWAEESLHSLTSKAVD
HHHHHHHHHHHHHCC		38.3429038488
301PhosphorylationEESLHSLTSKAVDKE
HHHHHHHHHHHCCHH		31.06-
302PhosphorylationESLHSLTSKAVDKEN
HHHHHHHHHHCCHHH		24.7429038488
303UbiquitinationSLHSLTSKAVDKENL
HHHHHHHHHCCHHHH		47.3921906983
303AcetylationSLHSLTSKAVDKENL
HHHHHHHHHCCHHHH		47.397826079
303UbiquitinationSLHSLTSKAVDKENL
HHHHHHHHHCCHHHH		47.39-
307AcetylationLTSKAVDKENLDAKI
HHHHHCCHHHHHHHH		41.737826089
307UbiquitinationLTSKAVDKENLDAKI
HHHHHCCHHHHHHHH		41.7322817900
313UbiquitinationDKENLDAKISSLTSE
CHHHHHHHHHHHHHH		42.67-
313UbiquitinationDKENLDAKISSLTSE
CHHHHHHHHHHHHHH		42.6721906983
316PhosphorylationNLDAKISSLTSEIMK
HHHHHHHHHHHHHHH		38.8626074081
318PhosphorylationDAKISSLTSEIMKLE
HHHHHHHHHHHHHHH		26.6826074081
319PhosphorylationAKISSLTSEIMKLEK
HHHHHHHHHHHHHHH		30.3426074081
323UbiquitinationSLTSEIMKLEKEVTQ
HHHHHHHHHHHHHHH		60.19-
323UbiquitinationSLTSEIMKLEKEVTQ
HHHHHHHHHHHHHHH		60.19-
326UbiquitinationSEIMKLEKEVTQIKD
HHHHHHHHHHHHHHC		68.8429967540
326UbiquitinationSEIMKLEKEVTQIKD
HHHHHHHHHHHHHHC		68.84-
332UbiquitinationEKEVTQIKDRSLPAV
HHHHHHHHCCCCCHH		36.9529967540
332UbiquitinationEKEVTQIKDRSLPAV
HHHHHHHHCCCCCHH		36.95-
362UbiquitinationDFDLQIAKQDYYTAR
CCCHHHHHCCHHHHH		45.38-
362UbiquitinationDFDLQIAKQDYYTAR
CCCHHHHHCCHHHHH		45.3821906983
379UbiquitinationLVLNQLIKQKASFEL
HHHHHHHHHHHHHHH		55.1021906983
379UbiquitinationLVLNQLIKQKASFEL
HHHHHHHHHHHHHHH		55.1021890473
379UbiquitinationLVLNQLIKQKASFEL
HHHHHHHHHHHHHHH		55.1021890473
381UbiquitinationLNQLIKQKASFELLQ
HHHHHHHHHHHHHHH		40.7822817900
391PhosphorylationFELLQLSYEIELRKH
HHHHHHHHHHHHHHH		29.53-
444UbiquitinationPRNTIDTKDYSTHRL
CCCCCCCCCCCHHHH		51.42-
444UbiquitinationPRNTIDTKDYSTHRL
CCCCCCCCCCCHHHH		51.4229967540
446PhosphorylationNTIDTKDYSTHRLYQ
CCCCCCCCCHHHHHH		19.6125839225
452PhosphorylationDYSTHRLYQVLEGEN
CCCHHHHHHHHCCCC		9.1327642862
460UbiquitinationQVLEGENKKKELFLT
HHHCCCCCCEEEEEC		62.0029967540
461UbiquitinationVLEGENKKKELFLTH
HHCCCCCCEEEEECC		64.1629967540
462UbiquitinationLEGENKKKELFLTHG
HCCCCCCEEEEECCC		62.35-
462UbiquitinationLEGENKKKELFLTHG
HCCCCCCEEEEECCC		62.3529967540
477UbiquitinationNLEEVAEKLKQNISL
CHHHHHHHHHHCHHH		51.7729967540
479UbiquitinationEEVAEKLKQNISLVQ
HHHHHHHHHCHHHHH		52.98-
502UbiquitinationEHSFFLSKRNKDVDM
HHHHHHCCCCCCHHH		63.2429967540
505UbiquitinationFFLSKRNKDVDMLCD
HHHCCCCCCHHHHHH		64.2629967540
541UbiquitinationKVESQLNKLNHLLTD
HHHHHHHHHHHHHHH		60.2929967540
554UbiquitinationTDILADVKTKRKTLA
HHHHHHHHHHHHHHH		49.2121906983
554AcetylationTDILADVKTKRKTLA
HHHHHHHHHHHHHHH		49.2125953088
556UbiquitinationILADVKTKRKTLANN
HHHHHHHHHHHHHCC		46.2922817900
558UbiquitinationADVKTKRKTLANNKL
HHHHHHHHHHHCCHH		49.8222817900
559PhosphorylationDVKTKRKTLANNKLH
HHHHHHHHHHCCHHH		34.8330622161
564UbiquitinationRKTLANNKLHQMERE
HHHHHCCHHHHHHHH		47.3421890473
564UbiquitinationRKTLANNKLHQMERE
HHHHHCCHHHHHHHH		47.3421890473
564UbiquitinationRKTLANNKLHQMERE
HHHHHCCHHHHHHHH		47.3421906983
582PhosphorylationYFLKDEDYLKDIVEN
EEECCHHHHHHHHHH		17.38-
584UbiquitinationLKDEDYLKDIVENLE
ECCHHHHHHHHHHHH		38.9021906983
592PhosphorylationDIVENLETQSKIKAV
HHHHHHHHHHCCEEE		41.1122210691
594PhosphorylationVENLETQSKIKAVSL
HHHHHHHHCCEEEEC		43.7120873877
595UbiquitinationENLETQSKIKAVSLE
HHHHHHHCCEEEECC		38.1122817900
597UbiquitinationLETQSKIKAVSLED-
HHHHHCCEEEECCC-		46.6122817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAUS3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAUS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAUS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HAUS6_HUMANHAUS6physical
19369198
KDM1A_HUMANKDM1Aphysical
23455924
TXLNB_HUMANTXLNBphysical
25416956
TXLNA_HUMANTXLNAphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAUS3_HUMAN

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Related Literatures of Post-Translational Modification

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