TXLNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXLNB_HUMAN
• UniProt AC: Q8N3L3
• Protein Name: Beta-taxilin
• Gene Name: TXLNB
• Organism: Homo sapiens (Human).
• Sequence Length: 684
• Protein Description: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic..
• Protein Sequence: MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAEELPVGASAGPQPRNVADTNLEGVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ANHSEQLSAERQSTP CCHHHHHCCCCCCCC	27.98	24719451
15	Phosphorylation	QLSAERQSTPPGDSS HHCCCCCCCCCCCCC	49.45	22673903
16	Phosphorylation	LSAERQSTPPGDSSS HCCCCCCCCCCCCCC	25.76	26437602
38	Phosphorylation	EKEDGQDSPTPVQPP CCCCCCCCCCCCCCC	23.84	26437602
40	Phosphorylation	EDGQDSPTPVQPPEK CCCCCCCCCCCCCCH	39.79	26437602
50	Phosphorylation	QPPEKEASVHPDISE CCCCHHCCCCCCHHH	23.27	26437602
69	Phosphorylation	QLEDIINTYGSAAST HHHHHHHHHHHHHHH	20.89	29978859
70	Phosphorylation	LEDIINTYGSAASTA HHHHHHHHHHHHHHC	12.47	29978859
72	Phosphorylation	DIINTYGSAASTAGK HHHHHHHHHHHHCCC	15.39	29978859
75	Phosphorylation	NTYGSAASTAGKEGS HHHHHHHHHCCCCCC	20.64	29978859
76	Phosphorylation	TYGSAASTAGKEGSA HHHHHHHHCCCCCCC	34.40	29978859
82	Phosphorylation	STAGKEGSARASEQP HHCCCCCCCCCCCCC	18.70	22817900
116	Phosphorylation	AGREPVASGEPPTVK HCCCCCCCCCCCCCC	43.87	15302935
169	Phosphorylation	FDFLFKKYAELLDEH HHHHHHHHHHHHHHH	13.09	-
213	Ubiquitination	RAILARSKLESLCRE HHHHHHHHHHHHHHH	51.20	-
216	Phosphorylation	LARSKLESLCRELQR HHHHHHHHHHHHHHH	43.11	24719451
364	Phosphorylation	QAQLTLYSGRFEEFQ HHHHHHHHCCHHHHH	26.97	21060948
402	Phosphorylation	MKKLEKDTATWKARF HHHHHHHHHHHHHHH	36.73	-
470	Phosphorylation	ISEKDDQSQHNSDEE HHCCCCCCCCCCCCC	40.16	22673903
474	Phosphorylation	DDQSQHNSDEEPESN CCCCCCCCCCCCCCC	44.25	22673903
480	Phosphorylation	NSDEEPESNVSVDQE CCCCCCCCCCCCCCC	53.93	22673903
483	Phosphorylation	EEPESNVSVDQEIDA CCCCCCCCCCCCCCH	24.99	-
549	Phosphorylation	EQPPLIPSRDSESPL CCCCCCCCCCCCCCC	41.55	22673903
552	Phosphorylation	PLIPSRDSESPLPPL CCCCCCCCCCCCCCC	38.57	19764811
554	Phosphorylation	IPSRDSESPLPPLTP CCCCCCCCCCCCCCH	35.37	26657352
603	Phosphorylation	GAQADQASWKPEAEA CCCCCCCCCCCCHHH	29.96	24719451
611	Phosphorylation	WKPEAEASGQAPQAP CCCCHHHCCCCCCCC	23.96	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXLNB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXLNB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXLNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX4_HUMAN	STX4	physical	15184072
STX1A_HUMAN	STX1A	physical	15184072
TXLNB_HUMAN	TXLNB	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
CAGE1_HUMAN	CAGE1	physical	25416956
LURA1_HUMAN	LURAP1	physical	25416956
TXLNG_HUMAN	TXLNG	physical	28514442
DTBP1_HUMAN	DTNBP1	physical	28514442
CP135_HUMAN	CEP135	physical	28514442
KI18B_HUMAN	KIF18B	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
CA122_HUMAN	C1orf122	physical	28514442
CEP63_HUMAN	CEP63	physical	28514442
MED4_HUMAN	MED4	physical	28514442
SPDLY_HUMAN	SPDL1	physical	28514442
CACO1_HUMAN	CALCOCO1	physical	28514442
LAMC1_HUMAN	LAMC1	physical	28514442
TBK1_HUMAN	TBK1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.