CAGE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAGE1_HUMAN
• UniProt AC: Q8TC20
• Protein Name: Cancer-associated gene 1 protein
• Gene Name: CAGE1
• Organism: Homo sapiens (Human).
• Sequence Length: 777
• Protein Sequence: MNKDYQKFWSSPSDPVHFEVDTSHEKVESMSESDTMNVSNLSQGVMLSHSPICMETTGTTCDLPQNEIKNFERENEYESTLCEDAYGTLDNLLNDNNIENYSTNALIQPVDTISISSLRQFETVCKFHWVEAFDDEMTEKPEFQSQVYNYAKDNNIKQDSFKEENPMETSVSANTDQLGNEYFRQPPPRSPPLIHCSGEMLKFTEKSLAKSIAKESALNPSQPPSFLCKTAVPSKEIQNYGEIPEMSVSYEKEVTAEGVERPEIVSTWSSAGISWRSEACRENCEMPDWEQSAESLQPVQEDMALNEVLQKLKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKENVEELIEDKYKIILEKNDTKKTLQNLEEVLANTQKHLQESRNDKEMLQLQFKKIKANYVCLQERYMTEMQQKNKSVSQYLEMDKTLSKKEEEVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLKSRLEKLLTQVRNLQFMSENERTKNIKLQQQINEVKNENAKLKQQVARSEEQNYVPKFETAQLKDQLEEVLKSDITKDTKTTHSNLLPDCSPCEERLNPADIKRASQLASKMHSLLALMVGLLTCQDIINSDAEHFKESEKVSDIMLQKLKSLHLKKKTLDKEVIDCDSDEAKSIRDVPTLLGAKLDKYHSLNEELDFLVTSYEEIIECADQRLAISHSQIAHLEERNKHLEDLIRKPREKARKPRSKSLENHPKSMTMMPALFKENRNDLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	PVDTISISSLRQFET CCCEEEHHHHHHHHH	19.27	24719451
117	Phosphorylation	VDTISISSLRQFETV CCEEEHHHHHHHHHH	26.38	25954137
138	Phosphorylation	EAFDDEMTEKPEFQS HCCCHHHHCCHHHHH	38.52	-
145	Phosphorylation	TEKPEFQSQVYNYAK HCCHHHHHHHHHHHH	27.25	-
160	Phosphorylation	DNNIKQDSFKEENPM HCCCCCCCCCCCCCC	35.41	-
169	Phosphorylation	KEENPMETSVSANTD CCCCCCCCCCCCCHH	28.33	22210691
170	Phosphorylation	EENPMETSVSANTDQ CCCCCCCCCCCCHHH	10.77	22210691
182	Phosphorylation	TDQLGNEYFRQPPPR HHHCCHHHHCCCCCC	14.20	22210691
240	Phosphorylation	PSKEIQNYGEIPEMS CCHHHCCCCCCCCCC	10.36	-
255	Phosphorylation	VSYEKEVTAEGVERP EEEEEEEECCCCCCC	21.78	22210691
267	Phosphorylation	ERPEIVSTWSSAGIS CCCCCEEEHHHCCCC	20.62	22210691
274	Phosphorylation	TWSSAGISWRSEACR EHHHCCCCCCHHHHH	18.60	22210691
345	Phosphorylation	KELQMKITKQQVFID HHHHHHHHHHHHHHH	19.79	29978859
434	Phosphorylation	EMQQKNKSVSQYLEM HHHHHCCCHHHHHHH	36.07	29759185
436	Phosphorylation	QQKNKSVSQYLEMDK HHHCCCHHHHHHHHH	21.87	29759185
438	Phosphorylation	KNKSVSQYLEMDKTL HCCCHHHHHHHHHCC	9.34	29759185
514	Phosphorylation	SRLEKLLTQVRNLQF HHHHHHHHHHHHHHH	35.14	26074081
523	Phosphorylation	VRNLQFMSENERTKN HHHHHHCCCCHHHHH	38.26	26074081
565 (in isoform 5)	Phosphorylation	-	23.88	24719451
565	Phosphorylation	NYVPKFETAQLKDQL CCCCHHHHHHHHHHH	23.88	24719451
578 (in isoform 5)	Phosphorylation	-	30.04	24719451
578	Phosphorylation	QLEEVLKSDITKDTK HHHHHHHCCCCCCCC	30.04	24719451
581 (in isoform 5)	Phosphorylation	-	28.05	24719451
581	Phosphorylation	EVLKSDITKDTKTTH HHHHCCCCCCCCCCC	28.05	24719451
656	Acetylation	DIMLQKLKSLHLKKK HHHHHHHHHCCCCCC	58.99	19819151
662	Acetylation	LKSLHLKKKTLDKEV HHHCCCCCCCCCCHH	58.30	19819159
685	Phosphorylation	KSIRDVPTLLGAKLD HHHHHHHHHHHHCHH	34.17	21712546
742	Acetylation	HLEDLIRKPREKARK HHHHHHHHHHHHHCC	41.24	30587377
754	Phosphorylation	ARKPRSKSLENHPKS HCCCCCHHHHCCCCH	42.01	18669648
761	Phosphorylation	SLENHPKSMTMMPAL HHHCCCCHHHHHHHH	24.76	25693802
763	Phosphorylation	ENHPKSMTMMPALFK HCCCCHHHHHHHHHH	19.87	18669648
768 (in isoform 5)	Phosphorylation	-	5.33	25693802
769 (in isoform 5)	Phosphorylation	-	11.51	25693802
770 (in isoform 5)	Phosphorylation	-	55.73	25693802
797 (in isoform 3)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAGE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAGE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAGE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIPA1_HUMAN	PPFIA1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.