dbPTM

TXLNG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TXLNG_HUMAN
UniProt AC	Q9NUQ3
Protein Name	Gamma-taxilin
Gene Name	TXLNG
Organism	Homo sapiens (Human).
Sequence Length	528
Subcellular Localization	Nucleus membrane . Cytoplasm, cytosol .
Protein Description	May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression..
Protein Sequence	MATRVEEAARGRGGGAEEATEAGRGGRRRSPRQKFEIGTMEEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQRSAVQKPPSTGSAPAIESVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	TRVEEAARGRGGGAE CHHHHHHCCCCCCHH	42.25	115368707
12	Methylation	VEEAARGRGGGAEEA HHHHHCCCCCCHHHH	34.72	24129315
24	Methylation	EEATEAGRGGRRRSP HHHHHCCCCCCCCCH	51.98	24129315
27	Methylation	TEAGRGGRRRSPRQK HHCCCCCCCCCHHHC	33.39	30989833
30	Phosphorylation	GRGGRRRSPRQKFEI CCCCCCCCHHHCEEC	23.71	22817900
43	Ubiquitination	EIGTMEEAGICGLGV ECCCHHHHCCCCCCC	10.19	32015554
54	Sulfoxidation	GLGVKADMLCNSQSN CCCCCHHHHCCCCCC	5.70	21406390
58	Phosphorylation	KADMLCNSQSNDILQ CHHHHCCCCCCCHHH	33.71	23663014
60	Phosphorylation	DMLCNSQSNDILQHQ HHHCCCCCCCHHHHC	35.97	23663014
69	Phosphorylation	DILQHQGSNCGGTSN CHHHHCCCCCCCCCC	23.52	29978859
70	Ubiquitination	ILQHQGSNCGGTSNK HHHHCCCCCCCCCCC	34.96	21890473
72	Ubiquitination	QHQGSNCGGTSNKHS HHCCCCCCCCCCCCC	46.81	22817900
73	Ubiquitination	HQGSNCGGTSNKHSL HCCCCCCCCCCCCCC	28.33	22817900
74	Phosphorylation	QGSNCGGTSNKHSLE CCCCCCCCCCCCCCC	17.89	26714015
75	Ubiquitination	GSNCGGTSNKHSLEE CCCCCCCCCCCCCCC	47.35	32015554
75	Phosphorylation	GSNCGGTSNKHSLEE CCCCCCCCCCCCCCC	47.35	27251275
79	Phosphorylation	GGTSNKHSLEEDEGS CCCCCCCCCCCCCCC	38.80	30576142
86	Phosphorylation	SLEEDEGSDFITENR CCCCCCCCCCCCCCC	27.57	25159151
88	Ubiquitination	EEDEGSDFITENRNL CCCCCCCCCCCCCCC	8.79	24816145
90	Phosphorylation	DEGSDFITENRNLVS CCCCCCCCCCCCCCC	27.48	29978859
97	Phosphorylation	TENRNLVSPAYCTQE CCCCCCCCCCCCCHH	13.64	19664994
100	Phosphorylation	RNLVSPAYCTQESRE CCCCCCCCCCHHHHC	10.22	23927012
102	Phosphorylation	LVSPAYCTQESREEI CCCCCCCCHHHHCCC	23.77	22167270
105	Phosphorylation	PAYCTQESREEIPGG CCCCCHHHHCCCCCC	34.86	23927012
116	Phosphorylation	IPGGEARTDPPDGQQ CCCCCCCCCCCCCCC	60.96	26074081
126	Ubiquitination	PDGQQDSECNRNKEK CCCCCCCCCCHHHCH	44.06	24816145
134	Phosphorylation	CNRNKEKTLGKEVLL CCHHHCHHHHHHHHH	41.66	-
143	Ubiquitination	GKEVLLLMQALNTLS HHHHHHHHHHHHCCC	1.90	33845483
143	Ubiquitination	GKEVLLLMQALNTLS HHHHHHHHHHHHCCC	1.90	21890473
143	Neddylation	GKEVLLLMQALNTLS HHHHHHHHHHHHCCC	1.90	32015554
145	Ubiquitination	EVLLLMQALNTLSTP HHHHHHHHHHCCCCH	6.71	22817900
146	Ubiquitination	VLLLMQALNTLSTPE HHHHHHHHHCCCCHH	2.57	22817900
161	Ubiquitination	EKLAALCKKYADLLE HHHHHHHHHHHHHHH	50.06	32015554
162	Acetylation	KLAALCKKYADLLEE HHHHHHHHHHHHHHH	44.68	26051181
163	Phosphorylation	LAALCKKYADLLEES HHHHHHHHHHHHHHH	7.28	20068231
170	Phosphorylation	YADLLEESRSVQKQM HHHHHHHHHHHHHHH	22.08	20068231
172	Phosphorylation	DLLEESRSVQKQMKI HHHHHHHHHHHHHHH	37.87	28509920
175	Ubiquitination	EESRSVQKQMKILQK HHHHHHHHHHHHHHH	50.64	29967540
199	Ubiquitination	VHLQSEHSKAILARS HHCCCHHHHHHHHHH	21.52	24816145
207	Ubiquitination	KAILARSKLESLCRE HHHHHHHHHHHHHHH	51.20	32015554
210	Phosphorylation	LARSKLESLCRELQR HHHHHHHHHHHHHHH	43.11	24719451
220	Ubiquitination	RELQRHNKTLKEENM HHHHHHHHHHHHHHH	49.46	24816145
223	Acetylation	QRHNKTLKEENMQQA HHHHHHHHHHHHHHH	69.11	26051181
238	Ubiquitination	REEEERRKEATAHFQ HHHHHHHHHHHHHHH	58.90	32015554
275	Neddylation	ENIELGEKLKKLIEQ HHHHHHHHHHHHHHH	64.90	32015554
275	Ubiquitination	ENIELGEKLKKLIEQ HHHHHHHHHHHHHHH	64.90	22817900
277	Ubiquitination	IELGEKLKKLIEQYA HHHHHHHHHHHHHHH	57.51	22817900
278	Ubiquitination	ELGEKLKKLIEQYAL HHHHHHHHHHHHHHH	66.20	22817900
283	Phosphorylation	LKKLIEQYALREEHI HHHHHHHHHHHHHHH	8.53	20068231
292	Acetylation	LREEHIDKVFKHKEL HHHHHHHHHHCCHHH	49.30	26051181
292	Ubiquitination	LREEHIDKVFKHKEL HHHHHHHHHHCCHHH	49.30	-
301	Ubiquitination	FKHKELQQQLVDAKL HCCHHHHHHHHHHHH	51.72	24816145
307	Ubiquitination	QQQLVDAKLQQTTQL HHHHHHHHHHHHHHH	42.22	29967540
309	Ubiquitination	QLVDAKLQQTTQLIK HHHHHHHHHHHHHHH	37.56	24816145
319	Ubiquitination	TQLIKEADEKHQRER HHHHHHHHHHHHHHH	67.57	29967540
331	Ubiquitination	REREFLLKEATESRH HHHHHHHHHHHHHHH	47.66	24816145
370	Ubiquitination	EFQTTMAKSNELFTT HHHHHHHHHCHHHHH	42.88	32015554
371	Phosphorylation	FQTTMAKSNELFTTF HHHHHHHHCHHHHHH	26.46	20068231
374	Ubiquitination	TMAKSNELFTTFRQE HHHHHCHHHHHHHHH	5.59	24816145
376	Phosphorylation	AKSNELFTTFRQEME HHHCHHHHHHHHHHH	37.33	20068231
377	Phosphorylation	KSNELFTTFRQEMEK HHCHHHHHHHHHHHH	14.97	20068231
382	Ubiquitination	FTTFRQEMEKMTKKI HHHHHHHHHHHHHHH	4.55	24816145
386	Phosphorylation	RQEMEKMTKKIKKLE HHHHHHHHHHHHHHH	40.01	17081983
388	Acetylation	EMEKMTKKIKKLEKE HHHHHHHHHHHHHHH	51.06	12436935
402	Acetylation	ETIIWRTKWENNNKA HHHHEEECCCCCHHH	43.89	25953088
430	Acetylation	EYKALQIKLERLEKL HHHHHHHHHHHHHHH	31.19	26051181
451	Ubiquitination	ERNELNEKVEVLKEQ HHHHHHHHHHHHHHH	42.49	29967540
460	Phosphorylation	EVLKEQVSIKAAIKA HHHHHHHHHHHHHHH	20.33	21406692
474	Phosphorylation	AANRDLATPVMQPCT HHCCCCCCCCCCCCC	24.58	26462736
481	Phosphorylation	TPVMQPCTALDSHKE CCCCCCCCHHHHHCC	36.62	-
487	Acetylation	CTALDSHKELNTSSK CCHHHHHCCCCCHHH	68.78	26051181
491	Phosphorylation	DSHKELNTSSKRALG HHHCCCCCHHHHHHH	47.18	29214152
506	Ubiquitination	AHLEAEPKSQRSAVQ HHHCCCCHHHHHCCC	51.21	24816145
510	Phosphorylation	AEPKSQRSAVQKPPS CCCHHHHHCCCCCCC	25.75	29396449
514	Ubiquitination	SQRSAVQKPPSTGSA HHHHCCCCCCCCCCC	52.90	24816145
514	Acetylation	SQRSAVQKPPSTGSA HHHHCCCCCCCCCCC	52.90	30593163
517	Phosphorylation	SAVQKPPSTGSAPAI HCCCCCCCCCCCCCC	54.66	25159151
518	Phosphorylation	AVQKPPSTGSAPAIE CCCCCCCCCCCCCCC	40.71	25159151
520	Phosphorylation	QKPPSTGSAPAIESV CCCCCCCCCCCCCCC	31.03	25159151
526	Phosphorylation	GSAPAIESVD----- CCCCCCCCCC-----	26.02	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TXLNG_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TXLNG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TXLNG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBK1_HUMAN	TBK1	physical	21903422
TXLNA_HUMAN	TXLNA	physical	21903422
TXLNB_HUMAN	TXLNB	physical	21903422
WIPF2_HUMAN	WIPF2	physical	22939629
UBP3_HUMAN	USP3	physical	22939629
CHAP1_HUMAN	CHAMP1	physical	22939629
ZC11A_HUMAN	ZC3H11A	physical	22939629
UBA1_HUMAN	UBA1	physical	22939629
CDV3_HUMAN	CDV3	physical	26344197
DDX17_HUMAN	DDX17	physical	26344197
TXLNA_HUMAN	TXLNA	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TXLNG_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97 AND SER-517, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97 AND SER-105, AND MASSSPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-386, AND MASSSPECTROMETRY.	17081983 [Abstract]