WIPF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIPF2_HUMAN
• UniProt AC: Q8TF74
• Protein Name: WAS/WASL-interacting protein family member 2
• Gene Name: WIPF2
• Organism: Homo sapiens (Human).
• Sequence Length: 440
• Subcellular Localization: Cytoplasm, cytoskeleton . Localized to stress fibers and bundles of actin filaments.
• Protein Description: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system..
• Protein Sequence: MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPLPPILR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Methylation	SRDEQRGRGALLQDI CHHHHCCHHHHHHHH	29.42	16186317
37	Asymmetric dimethylarginine	SRDEQRGRGALLQDI CHHHHCCHHHHHHHH	29.42	-
66	Acetylation	RSAPILEKPKGSSGG CCCCCCCCCCCCCCC	48.89	20167786
68	Acetylation	APILEKPKGSSGGYG CCCCCCCCCCCCCCC	80.59	20167786
70	Phosphorylation	ILEKPKGSSGGYGSG CCCCCCCCCCCCCCC	31.75	21945579
71	Phosphorylation	LEKPKGSSGGYGSGG CCCCCCCCCCCCCCC	44.93	21945579
74	Phosphorylation	PKGSSGGYGSGGAAL CCCCCCCCCCCCCCC	16.19	21945579
76	Phosphorylation	GSSGGYGSGGAALQP CCCCCCCCCCCCCCC	26.10	21945579
110	Methylation	GSENLAGKPALQIPS CCCCCCCCCCCCCCC	22.85	115978515
117	O-linked_Glycosylation	KPALQIPSSRAAAPR CCCCCCCCCCCCCCC	33.80	30059200
118	O-linked_Glycosylation	PALQIPSSRAAAPRP CCCCCCCCCCCCCCC	22.15	30059200
119	Methylation	ALQIPSSRAAAPRPP CCCCCCCCCCCCCCC	32.36	81453783
128	O-linked_Glycosylation	AAPRPPVSAASGRPQ CCCCCCCCCCCCCCC	24.72	30059200
131	O-linked_Glycosylation	RPPVSAASGRPQDDT CCCCCCCCCCCCCCC	34.74	30059200
140	Phosphorylation	RPQDDTDSSRASLPE CCCCCCCCCCCCCCC	24.66	25690035
141	Phosphorylation	PQDDTDSSRASLPEL CCCCCCCCCCCCCCC	34.38	25690035
144	Phosphorylation	DTDSSRASLPELPRM CCCCCCCCCCCCCCC	43.26	28857561
155	Phosphorylation	LPRMQRPSLPDLSRP CCCCCCCCCCCCCCC	55.51	26657352
160	Phosphorylation	RPSLPDLSRPNTTSS CCCCCCCCCCCCCCC	53.74	23312004
164	Phosphorylation	PDLSRPNTTSSTGMK CCCCCCCCCCCCCCC	30.64	23312004
165	Phosphorylation	DLSRPNTTSSTGMKH CCCCCCCCCCCCCCC	27.59	23312004
166	Phosphorylation	LSRPNTTSSTGMKHS CCCCCCCCCCCCCCC	24.70	22210691
167	Phosphorylation	SRPNTTSSTGMKHSS CCCCCCCCCCCCCCC	27.21	23312004
168	Phosphorylation	RPNTTSSTGMKHSSS CCCCCCCCCCCCCCC	40.85	23312004
171	Methylation	TTSSTGMKHSSSAPP CCCCCCCCCCCCCCC	41.50	115978523
173	Phosphorylation	SSTGMKHSSSAPPPP CCCCCCCCCCCCCCC	22.07	24275569
174	Phosphorylation	STGMKHSSSAPPPPP CCCCCCCCCCCCCCC	30.18	25159151
175	Phosphorylation	TGMKHSSSAPPPPPP CCCCCCCCCCCCCCC	48.05	25159151
191	Phosphorylation	RRANAPPTPLPMHSS CCCCCCCCCCCCCCC	36.08	28857561
212	Phosphorylation	REKPLPPTPGQRLHP CCCCCCCCCCCCCCC	37.80	25159151
235	Phosphorylation	PPVKPPPSPVNIRTG CCCCCCCCCCCCCCC	47.45	29255136
241	Phosphorylation	PSPVNIRTGPSGQSL CCCCCCCCCCCCCCC	50.04	21945579
244	Phosphorylation	VNIRTGPSGQSLAPP CCCCCCCCCCCCCCC	51.30	21945579
247	Phosphorylation	RTGPSGQSLAPPPPP CCCCCCCCCCCCCCC	29.98	21945579
255	Phosphorylation	LAPPPPPYRQPPGVP CCCCCCCCCCCCCCC	27.88	21945579
266	Phosphorylation	PGVPNGPSSPTNESA CCCCCCCCCCCCCCC	50.80	21945579
267	Phosphorylation	GVPNGPSSPTNESAP CCCCCCCCCCCCCCC	38.59	21945579
269	Phosphorylation	PNGPSSPTNESAPEL CCCCCCCCCCCCCCH	54.27	21945579
272	Phosphorylation	PSSPTNESAPELPQR CCCCCCCCCCCHHHH	51.71	21945579
282	Phosphorylation	ELPQRHNSLHRKTPG CHHHHHHCCCCCCCC	21.30	27422710
300	Phosphorylation	GLAPPPPTSASPSLL CCCCCCCCCCCHHHH	42.57	27794612
301	O-linked_Glycosylation	LAPPPPTSASPSLLS CCCCCCCCCCHHHHH	32.30	30059200
301	Phosphorylation	LAPPPPTSASPSLLS CCCCCCCCCCHHHHH	32.30	27794612
303	Phosphorylation	PPPPTSASPSLLSNR CCCCCCCCHHHHHCC	18.13	25159151
305	Phosphorylation	PPTSASPSLLSNRPP CCCCCCHHHHHCCCC	39.17	24505115
308	Phosphorylation	SASPSLLSNRPPPPA CCCHHHHHCCCCCCC	35.77	28985074
310	Methylation	SPSLLSNRPPPPARD CHHHHHCCCCCCCCC	41.55	58860319
320	Phosphorylation	PPARDPPSRGAAPPP CCCCCCCCCCCCCCC	49.05	-
321	Methylation	PARDPPSRGAAPPPP CCCCCCCCCCCCCCC	44.54	58860303
337	Methylation	PVIRNGARDAPPPPP CCCCCCCCCCCCCCC	41.86	115390771
337	Dimethylation	PVIRNGARDAPPPPP CCCCCCCCCCCCCCC	41.86	-
346	Phosphorylation	APPPPPPYRMHGSEP CCCCCCCCCCCCCCC	26.75	21945579
356	Methylation	HGSEPPSRGKPPPPP CCCCCCCCCCCCCCC	64.03	54560595
358	Methylation	SEPPSRGKPPPPPSR CCCCCCCCCCCCCCC	53.92	115920065
364	Phosphorylation	GKPPPPPSRTPAGPP CCCCCCCCCCCCCCC	55.34	-
385	Phosphorylation	LRNGHRDSITTVRSF CCCCCCCCHHHHHHH	23.07	26055452
387	Phosphorylation	NGHRDSITTVRSFLD CCCCCCHHHHHHHHH	24.16	23403867
388	Phosphorylation	GHRDSITTVRSFLDD CCCCCHHHHHHHHHH	16.55	23403867
391	Phosphorylation	DSITTVRSFLDDFES CCHHHHHHHHHHHHH	26.31	26657352
400	Phosphorylation	LDDFESKYSFHPVED HHHHHHCCCCCCCCC	26.33	27642862
401	Phosphorylation	DDFESKYSFHPVEDF HHHHHCCCCCCCCCC	22.33	27642862
414	Phosphorylation	DFPAPEEYKHFQRIY CCCCHHHHHHHHHHC	14.22	27642862
430	Methylation	SKTNRAARGAPPLPP CCCCHHHCCCCCCCC	40.60	54560603

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIPF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIPF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIPF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCK2_HUMAN	NCK2	physical	12213210
ZFAN5_HUMAN	ZFAND5	physical	22939629
ZN830_HUMAN	ZNF830	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.