| UniProt ID | CP135_HUMAN | |
|---|---|---|
| UniProt AC | Q66GS9 | |
| Protein Name | Centrosomal protein of 135 kDa | |
| Gene Name | CEP135 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1140 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. | |
| Protein Description | Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.. | |
| Protein Sequence | MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRNV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MTTAVERKYI -----CCCHHHHHHH | 40.33 | 28634120 | |
| 25 | Ubiquitination | QLGYRQTLTVECLPL HCCCCCCEEHHHHHH | 3.70 | 22817900 | |
| 51 | Acetylation | TESLRQSKLSAVKAE HHHHHHHHHHHHHHH | 37.82 | 24847261 | |
| 86 | Phosphorylation | SRENNELYLELMKLR CCCCCHHHHHHHHHH | 7.61 | - | |
| 127 | Acetylation | LNNQYAHKLKLLEKE HHHHHHHHHHHHHHH | 38.86 | 25953088 | |
| 129 | Ubiquitination | NQYAHKLKLLEKESK HHHHHHHHHHHHHHH | 56.69 | 25015289 | |
| 133 | Ubiquitination | HKLKLLEKESKAKNE HHHHHHHHHHHHHHH | 68.22 | 25015289 | |
| 135 | Phosphorylation | LKLLEKESKAKNERI HHHHHHHHHHHHHHH | 49.32 | 23909892 | |
| 136 | Ubiquitination | KLLEKESKAKNERIQ HHHHHHHHHHHHHHH | 65.55 | 25015289 | |
| 148 | Ubiquitination | RIQQLQEKNLHAVVQ HHHHHHHCCCCEEEE | 52.42 | 29967540 | |
| 156 | Phosphorylation | NLHAVVQTPGGKKRS CCCEEEECCCCCCCH | 16.58 | 30266825 | |
| 160 | Ubiquitination | VVQTPGGKKRSIAFR EEECCCCCCCHHHHH | 51.43 | 32015554 | |
| 178 | Ubiquitination | MQIDEPVPPSEVSSY CCCCCCCCCHHHCCC | 37.10 | 22817900 | |
| 184 | Phosphorylation | VPPSEVSSYPVPQPD CCCHHHCCCCCCCCC | 38.34 | - | |
| 225 | Phosphorylation | EKLAMMESGVRDYSK HHHHHHHHCCCCHHH | 25.37 | 23403867 | |
| 245 | Phosphorylation | EREIERLSVALDGGR HHHHHHHHHHHCCCC | 16.15 | 27251275 | |
| 253 | Phosphorylation | VALDGGRSPDVLSLE HHHCCCCCCCCCCCC | 28.82 | 30266825 | |
| 258 | Phosphorylation | GRSPDVLSLESRNKT CCCCCCCCCCCCCCC | 29.91 | 30266825 | |
| 261 | O-linked_Glycosylation | PDVLSLESRNKTNEK CCCCCCCCCCCCCHH | 46.58 | 30379171 | |
| 261 | Phosphorylation | PDVLSLESRNKTNEK CCCCCCCCCCCCCHH | 46.58 | 30108239 | |
| 298 | Ubiquitination | IRELMETKETVTSEV HHHHHHCHHHHHHHH | 37.77 | 32015554 | |
| 300 | Phosphorylation | ELMETKETVTSEVVN HHHHCHHHHHHHHHH | 30.55 | 30622161 | |
| 302 | Phosphorylation | METKETVTSEVVNLS HHCHHHHHHHHHHCC | 26.96 | 22468782 | |
| 303 | Phosphorylation | ETKETVTSEVVNLSN HCHHHHHHHHHHCCC | 24.86 | 22468782 | |
| 311 | Ubiquitination | EVVNLSNKNEKLCQE HHHHCCCCCHHHHHH | 64.21 | 32015554 | |
| 314 | Ubiquitination | NLSNKNEKLCQELTE HCCCCCHHHHHHHHH | 65.05 | 32015554 | |
| 333 | Ubiquitination | AQQLERHKEEVLETA HHHHHHHHHHHHHHH | 62.89 | 33845483 | |
| 354 | Acetylation | AKKEIKRKLSEMQDL HHHHHHHHHHHCCHH | 51.90 | 19821531 | |
| 356 | Phosphorylation | KEIKRKLSEMQDLEE HHHHHHHHHCCHHHH | 33.77 | 30266825 | |
| 364 | Phosphorylation | EMQDLEETMAKLQLE HCCHHHHHHHHHHHH | 17.04 | 29978859 | |
| 383 | Phosphorylation | QKEKERLSDELLVKS HHHHHHCCHHHHHHH | 34.95 | 28450419 | |
| 389 | Ubiquitination | LSDELLVKSDLETVV CCHHHHHHHHHHHHH | 37.92 | 29967540 | |
| 403 | Ubiquitination | VHQLEQEKQRLSKKV HHHHHHHHHHHHHHH | 40.17 | 29967540 | |
| 409 | Ubiquitination | EKQRLSKKVESFAVT HHHHHHHHHHHHHHC | 48.10 | 29967540 | |
| 439 | Phosphorylation | GIKRRDRSPSRLDTF CCCCCCCCHHHHHHH | 31.36 | 25159151 | |
| 441 | Phosphorylation | KRRDRSPSRLDTFLK CCCCCCHHHHHHHHH | 46.88 | 30266825 | |
| 445 | Phosphorylation | RSPSRLDTFLKGIEE CCHHHHHHHHHHHHH | 35.14 | 30266825 | |
| 448 | Ubiquitination | SRLDTFLKGIEEERD HHHHHHHHHHHHHHH | 54.36 | 29967540 | |
| 472 | Phosphorylation | QHIIQRRSCSTSYSA HHHHHHCCCCCCCCH | 18.01 | 22468782 | |
| 474 | Phosphorylation | IIQRRSCSTSYSARE HHHHCCCCCCCCHHH | 22.95 | 22468782 | |
| 475 | Phosphorylation | IQRRSCSTSYSAREK HHHCCCCCCCCHHHH | 35.69 | 22468782 | |
| 482 | Ubiquitination | TSYSAREKSSIFRTP CCCCHHHHCCCCCCC | 43.90 | 29967540 | |
| 483 | Phosphorylation | SYSAREKSSIFRTPE CCCHHHHCCCCCCCC | 24.74 | 30108239 | |
| 484 | Phosphorylation | YSAREKSSIFRTPEK CCHHHHCCCCCCCCC | 36.49 | 30108239 | |
| 488 | Phosphorylation | EKSSIFRTPEKGDYN HHCCCCCCCCCCCCC | 25.67 | 30266825 | |
| 491 | Ubiquitination | SIFRTPEKGDYNSEI CCCCCCCCCCCCHHH | 59.28 | 29967540 | |
| 494 | Phosphorylation | RTPEKGDYNSEIHQI CCCCCCCCCHHHHHH | 29.29 | 30266825 | |
| 496 | Phosphorylation | PEKGDYNSEIHQITR CCCCCCCHHHHHHHH | 31.53 | 30266825 | |
| 502 | Phosphorylation | NSEIHQITRERDELQ CHHHHHHHHHHHHHH | 21.65 | - | |
| 517 | Ubiquitination | RMLERFEKYMEDIQS HHHHHHHHHHHHHHH | 47.38 | - | |
| 518 | Phosphorylation | MLERFEKYMEDIQSN HHHHHHHHHHHHHHH | 9.87 | 19664994 | |
| 524 | Ubiquitination | KYMEDIQSNVKLLTA HHHHHHHHHCHHHHH | 43.88 | 22817900 | |
| 527 | Ubiquitination | EDIQSNVKLLTAERD HHHHHHCHHHHHHHH | 41.87 | 32015554 | |
| 535 | Ubiquitination | LLTAERDKLSVLYNE HHHHHHHHHHHHHHH | 49.21 | 22817900 | |
| 535 (in isoform 1) | Ubiquitination | - | 49.21 | 21906983 | |
| 537 | Phosphorylation | TAERDKLSVLYNEAQ HHHHHHHHHHHHHHH | 18.80 | 20873877 | |
| 540 | Phosphorylation | RDKLSVLYNEAQEEL HHHHHHHHHHHHHHH | 14.59 | 20873877 | |
| 548 | Phosphorylation | NEAQEELSALRKEST HHHHHHHHHHHHHHC | 28.65 | - | |
| 552 | Ubiquitination | EELSALRKESTQTTA HHHHHHHHHHCCCCC | 57.79 | 29967540 | |
| 554 | Phosphorylation | LSALRKESTQTTAPH HHHHHHHHCCCCCCH | 28.93 | 20860994 | |
| 555 | Phosphorylation | SALRKESTQTTAPHN HHHHHHHCCCCCCHH | 30.90 | 21712546 | |
| 557 | Phosphorylation | LRKESTQTTAPHNIV HHHHHCCCCCCHHHH | 25.64 | 21712546 | |
| 558 | Phosphorylation | RKESTQTTAPHNIVS HHHHCCCCCCHHHHH | 28.51 | 28555341 | |
| 565 | Phosphorylation | TAPHNIVSLMEKEKE CCCHHHHHHHHHHHH | 20.43 | 23879269 | |
| 569 | Ubiquitination | NIVSLMEKEKELALS HHHHHHHHHHHHHHH | 61.18 | 32015554 | |
| 571 | Ubiquitination | VSLMEKEKELALSDL HHHHHHHHHHHHHHH | 69.92 | 29967540 | |
| 576 | Phosphorylation | KEKELALSDLRRIMA HHHHHHHHHHHHHHH | 29.05 | 24719451 | |
| 585 | Ubiquitination | LRRIMAEKEALREKL HHHHHHHHHHHHHHH | 38.46 | 29967540 | |
| 591 | Ubiquitination | EKEALREKLEHIEEV HHHHHHHHHHHHHHH | 53.38 | 33845483 | |
| 599 | Phosphorylation | LEHIEEVSLFGKSEL HHHHHHHHHCCHHHH | 22.66 | 21815630 | |
| 603 | Ubiquitination | EEVSLFGKSELEKTI HHHHHCCHHHHHHHH | 33.16 | 29967540 | |
| 608 | Ubiquitination | FGKSELEKTIEHLTC CCHHHHHHHHHHHHH | 68.38 | 29967540 | |
| 630 | Ubiquitination | EKYELKSKVLIMKET CCCCHHHHEEEEHHH | 39.20 | - | |
| 635 | Ubiquitination | KSKVLIMKETIESLE HHHEEEEHHHHHHHH | 44.72 | 29967540 | |
| 644 | Ubiquitination | TIESLENKLKVQAQK HHHHHHHHHHHHHHH | 40.07 | 29967540 | |
| 651 | Ubiquitination | KLKVQAQKFSHVAGD HHHHHHHHHHHCCCC | 52.42 | 29967540 | |
| 663 | Ubiquitination | AGDSSHQKTEVNSLR CCCCCCCCHHHHHHH | 41.03 | 29967540 | |
| 688 | Phosphorylation | DDYQHRLSIKRGELE HHHHHHHHHHHCCHH | 26.48 | 30108239 | |
| 702 | Ubiquitination | ESAQAQIKILEEKID HHHHHHHHHHHHHHH | 29.20 | 29967540 | |
| 727 | Acetylation | EEAHVMKKTIGVIDK HHHHHHHHHHEEECH | 27.55 | 30587623 | |
| 727 | Ubiquitination | EEAHVMKKTIGVIDK HHHHHHHHHHEEECH | 27.55 | 29967540 | |
| 728 | Phosphorylation | EAHVMKKTIGVIDKE HHHHHHHHHEEECHH | 19.90 | - | |
| 734 | Ubiquitination | KTIGVIDKEKDFLQE HHHEEECHHHHHHHH | 56.38 | 29967540 | |
| 742 | Phosphorylation | EKDFLQETVDEKTEK HHHHHHHHHCHHHHH | 21.94 | 23403867 | |
| 749 | Ubiquitination | TVDEKTEKIANLQEN HHCHHHHHHHHHHHH | 52.96 | 29967540 | |
| 784 | Phosphorylation | SVNQLKETLVNRDRE HHHHHHHHHHHHHHH | 34.12 | - | |
| 794 | Phosphorylation | NRDREINSLRRQLDA HHHHHHHHHHHHHHH | 28.99 | 24247654 | |
| 804 | Ubiquitination | RQLDAAHKELDEVGR HHHHHHHHHHHHHHH | 56.07 | 29967540 | |
| 818 | Methylation | RSREIAFKENRRLQD HHHHHHHHHCHHHHH | 45.09 | - | |
| 818 | Ubiquitination | RSREIAFKENRRLQD HHHHHHHHHCHHHHH | 45.09 | 29967540 | |
| 857 | Ubiquitination | EMKSRVHKYITEVSR HHHHHHHHHHHHHHH | 35.18 | 29967540 | |
| 858 | Phosphorylation | MKSRVHKYITEVSRW HHHHHHHHHHHHHHH | 9.74 | 26074081 | |
| 860 | Phosphorylation | SRVHKYITEVSRWES HHHHHHHHHHHHHHH | 27.52 | 26074081 | |
| 863 | Phosphorylation | HKYITEVSRWESLMA HHHHHHHHHHHHHHH | 25.99 | 26074081 | |
| 867 | Phosphorylation | TEVSRWESLMAAKEK HHHHHHHHHHHHHHH | 19.24 | 26074081 | |
| 874 | Ubiquitination | SLMAAKEKENQDLLD HHHHHHHHHCHHHHH | 62.35 | 29967540 | |
| 951 | Ubiquitination | SQISSMAKAMSRLEE HHHHHHHHHHHHHHH | 35.66 | 29967540 | |
| 967 | Ubiquitination | LRHQEDEKATVLNDL HHCCHHHHHHHHHCH | 62.77 | 29967540 | |
| 975 | Phosphorylation | ATVLNDLSSLRELCI HHHHHCHHHHHHHHH | 30.14 | 30108239 | |
| 976 | Phosphorylation | TVLNDLSSLRELCIK HHHHCHHHHHHHHHH | 38.45 | 30108239 | |
| 983 | Ubiquitination | SLRELCIKLDSGKDI HHHHHHHHHCCCCCH | 45.29 | 29967540 | |
| 988 | Ubiquitination | CIKLDSGKDIMTQQL HHHHCCCCCHHHHHH | 48.29 | - | |
| 1014 | Phosphorylation | VELENVKSESDLLKK EEHHHCCCHHHHHHH | 37.74 | 28857561 | |
| 1016 | Phosphorylation | LENVKSESDLLKKQL HHHCCCHHHHHHHHH | 40.42 | 30622161 | |
| 1024 | Phosphorylation | DLLKKQLSNERHTVK HHHHHHHCCCHHHHH | 33.86 | 30622161 | |
| 1031 | Ubiquitination | SNERHTVKNLESLLA CCCHHHHHCHHHHHH | 57.90 | 29967540 | |
| 1035 | Phosphorylation | HTVKNLESLLATNRD HHHHCHHHHHHHCCC | 31.67 | 25693802 | |
| 1039 | Phosphorylation | NLESLLATNRDKEFH CHHHHHHHCCCHHHH | 30.65 | 25693802 | |
| 1043 | Ubiquitination | LLATNRDKEFHSHLT HHHHCCCHHHHHHHH | 60.07 | 29967540 | |
| 1085 | Ubiquitination | ENTMLRAKVAQLQTD HHHHHHHHHHHHHHC | 31.50 | 29967540 | |
| 1097 | Ubiquitination | QTDYDALKRQISTER HHCHHHHHHHHCHHH | 43.93 | 29967540 | |
| 1121 | Phosphorylation | MRRHGLATPPLSSTL HHHCCCCCCCCCCCC | 30.40 | 30266825 | |
| 1125 | Phosphorylation | GLATPPLSSTLRSPS CCCCCCCCCCCCCCC | 27.35 | 30266825 | |
| 1126 | Phosphorylation | LATPPLSSTLRSPSH CCCCCCCCCCCCCCC | 38.86 | 23927012 | |
| 1127 | Phosphorylation | ATPPLSSTLRSPSHS CCCCCCCCCCCCCCC | 23.86 | 23927012 | |
| 1130 | Phosphorylation | PLSSTLRSPSHSPEH CCCCCCCCCCCCCCC | 33.59 | 23927012 | |
| 1132 | Phosphorylation | SSTLRSPSHSPEHRN CCCCCCCCCCCCCCC | 37.53 | 23927012 | |
| 1134 | Phosphorylation | TLRSPSHSPEHRNV- CCCCCCCCCCCCCC- | 36.00 | 23927012 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CP135_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP135_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP135_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614673 | Microcephaly 8, primary, autosomal recessive (MCPH8) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY. | |
