RTTN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTTN_HUMAN
• UniProt AC: Q86VV8
• Protein Name: Rotatin
• Gene Name: RTTN
• Organism: Homo sapiens (Human).
• Sequence Length: 2226
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body . Colocalizes with the basal bodies at the primary cilium.
• Protein Description: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2..
• Protein Sequence: MVLAGLIRKLGHQLAEIRERALKSILCKIEHNLICYADLIQERQLFLHLLEWFNFPSVPMKEEVLNLLSRLVKYPPAVQHLVDVGAVEFLSKLRSNVEPNLQAEIDGILDGLFLLPSEVPALSSASYQTNQTELSKNPEILTGYFPQDKSNFQQMEVPPRPVVNQTVKCLKFSTFPWLPLTTTDRHVLSSNESSLRSSNHTLIWNTCELLKDVIMQDFPAEIFLQRPKIVQSLLSLLKLAFGDGKHRLALQSVSCLQQLCMYLRNRLNFHRDPGFFSNKHDTVSQNSSLSYCHEARGTHHSQNPSPGSSSPRPSVVGRTGQRPRGDGQDWDAASSSGSSSHAHVNSRISVHSPLDMGHIDLPELETEDTLELQFQQLSLPQFCVSILESAVPLLRTGSRQVIIRVLELLTEDMTLIGEAISTDIWDDSSLFGIDMKEKLLLVLGALGETMCYHKSSISLEQPEVMLVHHRMAFISISLFAVRLLQTLLPVEKASEFLSEPMSTALFLLSLDMPISLEYPNIHEAVVAYLEQLNSENYSIYKRTAEAVYSIECTCNFLSDIGKEGEKNLLELVELADQALRSFSYHQHFPLIKEIISICSKIWKSAQASPLLQGESQKVLLHMLSHPLPRVKAETYHCCLEITKECLGVHNVTKPVSSLCNGIHFLLHPKVLYEISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILLLSKASSDTEEMLPCTTRLKSMLRLLLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAEQLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLLSAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVIQDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRKAGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTASLQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSDVILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKANLIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNCLYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLLCVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPLENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALPKGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESENQNAQRIGAAALWALIYNYQKAKTALKSPSVKRRVDEAYSLAKKTFPNSEANPLNAYYLKCLENLVQLLNSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	LLEWFNFPSVPMKEE HHHHCCCCCCCCCHH	35.21	27667366
65	Ubiquitination	VPMKEEVLNLLSRLV CCCCHHHHHHHHHHC	4.18	21963094
133	Ubiquitination	SYQTNQTELSKNPEI CCCCCCCHHHCCHHH	41.08	29967540
142	Ubiquitination	SKNPEILTGYFPQDK HCCHHHHCCCCCCCC	35.18	29967540
144	Phosphorylation	NPEILTGYFPQDKSN CHHHHCCCCCCCCCC	13.57	27642862
149	Ubiquitination	TGYFPQDKSNFQQME CCCCCCCCCCCCCCC	41.89	29967540
171	Ubiquitination	NQTVKCLKFSTFPWL CCCEEEEECCCCCCC	46.90	-
211	Acetylation	WNTCELLKDVIMQDF HHHHHHHHHHHHCCC	63.67	25953088
235	Phosphorylation	KIVQSLLSLLKLAFG HHHHHHHHHHHHHHC	36.63	24719451
259	Ubiquitination	SVSCLQQLCMYLRNR HHHHHHHHHHHHHHH	0.86	27667366
268	Ubiquitination	MYLRNRLNFHRDPGF HHHHHHCCCCCCCCC	27.69	27667366
279	Ubiquitination	DPGFFSNKHDTVSQN CCCCCCCCCCCCCCC	41.48	21963094
282	Phosphorylation	FFSNKHDTVSQNSSL CCCCCCCCCCCCCCC	23.06	28555341
284	Phosphorylation	SNKHDTVSQNSSLSY CCCCCCCCCCCCCHH	26.24	28555341
287	Phosphorylation	HDTVSQNSSLSYCHE CCCCCCCCCCHHHHH	25.64	28555341
288	Phosphorylation	DTVSQNSSLSYCHEA CCCCCCCCCHHHHHC	28.96	28555341
298	Phosphorylation	YCHEARGTHHSQNPS HHHHCCCCCCCCCCC	15.74	20873877
301	Phosphorylation	EARGTHHSQNPSPGS HCCCCCCCCCCCCCC	24.85	20873877
305	Phosphorylation	THHSQNPSPGSSSPR CCCCCCCCCCCCCCC	49.82	26055452
308	Phosphorylation	SQNPSPGSSSPRPSV CCCCCCCCCCCCCCC	30.90	27794612
309	Phosphorylation	QNPSPGSSSPRPSVV CCCCCCCCCCCCCCC	50.72	30576142
310	Phosphorylation	NPSPGSSSPRPSVVG CCCCCCCCCCCCCCC	26.99	26055452
314	Phosphorylation	GSSSPRPSVVGRTGQ CCCCCCCCCCCCCCC	30.62	27794612
334	Phosphorylation	GQDWDAASSSGSSSH CCCCCCCCCCCCCCC	27.10	-
336	Phosphorylation	DWDAASSSGSSSHAH CCCCCCCCCCCCCCC	39.95	-
404	Ubiquitination	GSRQVIIRVLELLTE CCHHHHHHHHHHHHC	18.82	27667366
413	Ubiquitination	LELLTEDMTLIGEAI HHHHHCCCCHHHHHH	2.40	27667366
545	Ubiquitination	SIYKRTAEAVYSIEC EEHHHHCHHHHEEEE	37.75	27667366
554	Ubiquitination	VYSIECTCNFLSDIG HHEEEEHHHHHHHCC	5.25	27667366
566	Ubiquitination	DIGKEGEKNLLELVE HCCHHHHHCHHHHHH	64.85	29967540
599 (in isoform 2)	Phosphorylation	-	26.04	25690035
603	Ubiquitination	SICSKIWKSAQASPL HHHHHHHHHHCCCHH	39.11	29967540
616	Ubiquitination	PLLQGESQKVLLHML HHHCCCHHHHHHHHH	35.26	22817900
617	Ubiquitination	LLQGESQKVLLHMLS HHCCCHHHHHHHHHC	44.09	29967540
705	Phosphorylation	LQGRLMMTALTWNKF HHHCHHHHHHHHHHH	12.44	22210691
708	Phosphorylation	RLMMTALTWNKFIES CHHHHHHHHHHHHHH	25.24	22210691
715	Phosphorylation	TWNKFIESLCPVIPI HHHHHHHHHCCHHHH	30.38	22210691
745	Phosphorylation	LLLSKASSDTEEMLP EEEECCCCCCHHCCH	54.11	22210691
747	Phosphorylation	LSKASSDTEEMLPCT EECCCCCCHHCCHHH	35.47	22210691
754	Phosphorylation	TEEMLPCTTRLKSML CHHCCHHHHHHHHHH	17.01	-
755	Phosphorylation	EEMLPCTTRLKSMLR HHCCHHHHHHHHHHH	40.50	-
758	Ubiquitination	LPCTTRLKSMLRLLL CHHHHHHHHHHHHHH	30.45	27667366
759	Phosphorylation	PCTTRLKSMLRLLLV HHHHHHHHHHHHHHC	27.86	-
759	Ubiquitination	PCTTRLKSMLRLLLV HHHHHHHHHHHHHHC	27.86	27667366
767	Ubiquitination	MLRLLLVKKPSVRSL HHHHHHCCCHHHHHH	59.96	27667366
768	Ubiquitination	LRLLLVKKPSVRSLA HHHHHCCCHHHHHHH	34.74	27667366
770	Phosphorylation	LLLVKKPSVRSLALK HHHCCCHHHHHHHHH	38.76	29496907
773	Phosphorylation	VKKPSVRSLALKLLA CCCHHHHHHHHHHHH	18.81	29496907
792	Ubiquitination	SEEGADTKRPLIDAR CCCCCCCCCCCCCHH	53.19	-
802	Phosphorylation	LIDARVLSRVTDLFI CCCHHHHHHHHHHHC	23.11	22496350
811	Acetylation	VTDLFIGKKPIELRL HHHHHCCCCCEEEEC	51.03	19608861
811	Ubiquitination	VTDLFIGKKPIELRL HHHHHCCCCCEEEEC	51.03	-
812	Acetylation	TDLFIGKKPIELRLD HHHHCCCCCEEEECC	46.12	26051181
812	Ubiquitination	TDLFIGKKPIELRLD HHHHCCCCCEEEECC	46.12	-
826	Ubiquitination	DDRRELVIKLETVEK CCCCCEEEEEHHHHH	7.05	22817900
827	Ubiquitination	DRRELVIKLETVEKV CCCCEEEEEHHHHHH	32.56	29967540
830	Phosphorylation	ELVIKLETVEKVYEI CEEEEEHHHHHHHHH	44.39	-
849	Ubiquitination	DVDLVLRKSAAEQLA CHHHHHCCCHHHHHH	40.04	29967540
901	Phosphorylation	CLVQPCLTLLRKVLC HHHHHHHHHHHHHHH	30.39	24260401
901	Ubiquitination	CLVQPCLTLLRKVLC HHHHHHHHHHHHHHH	30.39	29967540
903	Ubiquitination	VQPCLTLLRKVLCGD HHHHHHHHHHHHHCC	4.14	29967540
924	Ubiquitination	LSQQSSLLTVLFRVS HHHHHHHHHHHHHHH	3.17	29967540
940	Ubiquitination	IFHEDCSVVTEVGAL HHCCCCHHHHHHHHH	8.53	29967540
970	Ubiquitination	SVNPSNKPSLPSVFS CCCCCCCCCCCCCCC	45.40	29967540
982	Ubiquitination	VFSLPVSVFRRYHLP CCCCCHHHHHHCCCC	4.38	29967540
997	Ubiquitination	VHVIGHHAVSPYSIV EEEECCCCCCCCEEE	9.60	29967540
1029	Ubiquitination	RIAWNLSWYHGSDNL HHHHHHHHHCCCHHH	7.72	22817900
1033	Phosphorylation	NLSWYHGSDNLLKQM HHHHHCCCHHHHHHC	15.26	30576142
1045	Ubiquitination	KQMNSETKTQEILDA HHCCCCHHHHHHHHH	44.13	29967540
1054	Ubiquitination	QEILDALKLSTEDIL HHHHHHHCCCHHHHH	41.95	29967540
1057	Phosphorylation	LDALKLSTEDILTLK HHHHCCCHHHHHHHH	48.38	23403867
1096	Phosphorylation	RAAVTRMSFYLLNDR HHHHHHHHHHHHCCC	13.88	29083192
1098	Phosphorylation	AVTRMSFYLLNDRLS HHHHHHHHHHCCCCC	11.72	29083192
1107	Ubiquitination	LNDRLSLKGCPGPCG HCCCCCCCCCCCCCC	55.90	-
1137	Phosphorylation	LQVLPACTEDEKLLI HHHHHCCCCCHHHHH	48.88	29523821
1161	Phosphorylation	IKEQRKNSSLELLNW HHHHHHCCHHHHHHH	39.06	-
1162	Phosphorylation	KEQRKNSSLELLNWI HHHHHCCHHHHHHHH	34.94	-
1174	Ubiquitination	NWILELLLRHSANPL HHHHHHHHHCCCCHH	7.86	22817900
1269	Ubiquitination	SLERTLRGMANLTAF CHHHHHHHHHHCCCC	23.75	29967540
1285	Ubiquitination	GWSSHSPLTKPLDIC CCCCCCCCCCCHHHH	12.32	29967540
1286	Ubiquitination	WSSHSPLTKPLDICV CCCCCCCCCCHHHHH	33.72	29967540
1307	Phosphorylation	LEVITSFYVERGGNA HHHHHHHHHHCCCCC	10.94	-
1315	Ubiquitination	VERGGNAMSFMGKGV HHCCCCCHHHCCCCC	3.53	22817900
1386	Ubiquitination	DPEVRFTSLGLGSAL CCCCCCEECCCCHHH	20.09	22817900
1448	Ubiquitination	NLLVIPMPTEIIKDY CCCCCCCCHHHHCCC	22.86	22817900
1449	Ubiquitination	LLVIPMPTEIIKDYT CCCCCCCHHHHCCCC	33.30	22817900
1470	Phosphorylation	HDEDSGLSLIGKPAL CCCCCCCCCCCHHHH	22.82	23312004
1526	Phosphorylation	DLNGLDDSFKFWRAP CCCCCCCCCCCCCCC	29.97	21815630
1528	Ubiquitination	NGLDDSFKFWRAPSR CCCCCCCCCCCCCCC	48.22	22817900
1528 (in isoform 1)	Ubiquitination	-	48.22	21906983
1528 (in isoform 3)	Ubiquitination	-	48.22	21906983
1529	Ubiquitination	GLDDSFKFWRAPSRT CCCCCCCCCCCCCCC	5.13	22817900
1536	Phosphorylation	FWRAPSRTSQDRDPS CCCCCCCCCCCCCCC	34.77	-
1537	Phosphorylation	WRAPSRTSQDRDPSS CCCCCCCCCCCCCCC	29.04	-
1546	Phosphorylation	DRDPSSLSTSETTVA CCCCCCCCCCCCCCC	31.66	-
1813	Ubiquitination	AKGHLQAKSKTHLCC HHCCCCCCCCCEECC	39.25	29967540
1815	Ubiquitination	GHLQAKSKTHLCCSP CCCCCCCCCEECCCH	38.98	29967540
1836	Ubiquitination	DDSQENQKSLEQLSD CCCHHHHHHHHHHHH	69.46	29967540
1852	Ubiquitination	ILQCYEGKSSKDILK HHHHHCCCCHHHHHH	39.35	29967540
1855	Ubiquitination	CYEGKSSKDILKRVA HHCCCCHHHHHHHHH	56.74	-
1868	Phosphorylation	VAANALMSLLAVSRR HHHHHHHHHHHHHHH	22.53	23403867
1882	Ubiquitination	RAQKHALKANLIDNC HHHHHHHHHHHHHHH	35.69	29967540
1894	Ubiquitination	DNCMEQMKHINAQLN HHHHHHHHHHHHHCC	40.81	29967540
1909	Ubiquitination	LDSLRPGKAALKKKE HHHCCCCHHHHHCCC	32.92	29967540
1913	Acetylation	RPGKAALKKKEDGVI CCCHHHHHCCCCCHH	58.01	19823021
1913	Ubiquitination	RPGKAALKKKEDGVI CCCHHHHHCCCCCHH	58.01	-
1914	Acetylation	PGKAALKKKEDGVIK CCHHHHHCCCCCHHH	63.34	19823031
2178	Phosphorylation	YNYQKAKTALKSPSV HHHHHHHHHHCCHHH	41.92	23312004
2181	Ubiquitination	QKAKTALKSPSVKRR HHHHHHHCCHHHHHH	58.83	29967540
2182	Phosphorylation	KAKTALKSPSVKRRV HHHHHHCCHHHHHHH	24.21	28348404
2184	Phosphorylation	KTALKSPSVKRRVDE HHHHCCHHHHHHHHH	47.57	28348404
2193	Phosphorylation	KRRVDEAYSLAKKTF HHHHHHHHHHHHHHC	11.36	27642862
2197	Ubiquitination	DEAYSLAKKTFPNSE HHHHHHHHHHCCCCC	58.60	29967540
2198	Ubiquitination	EAYSLAKKTFPNSEA HHHHHHHHHCCCCCC	50.20	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTTN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTTN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTTN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RTTN_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614833: Polymicrogyria with seizures (PMGYS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-811, AND MASS SPECTROMETRY.
PubMed: 19608861