dbPTM

SI1L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SI1L3_HUMAN
UniProt AC	O60292
Protein Name	Signal-induced proliferation-associated 1-like protein 3
Gene Name	SIPA1L3
Organism	Homo sapiens (Human).
Sequence Length	1781
Subcellular Localization	Apical cell membrane . Detected in tricellular junctions. Colocalizes with apical F-actin.
Protein Description	Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. [PubMed: 26231217]
Protein Sequence	MTTYRAIPSDGVDLAASCGARVGDVLPGPHTGDYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREALREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQDGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQGMPEQSFFDILNEFRSEQPDARGCQALTELLRADPGPHLMGGGGGAKGDSHNGQPAKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIFCREKKEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	DGVDLAASCGARVGD CCCHHHHHCCCCCCC	13.89	24719451
34	Phosphorylation	PGPHTGDYAPLGFWA CCCCCCCCCCCCEEE	16.09	-
64	Phosphorylation	ATATATATTRPSPTT EEEEEEEECCCCCCC	20.98	28348404
65	Phosphorylation	TATATATTRPSPTTP EEEEEEECCCCCCCC	37.81	28348404
68	Phosphorylation	ATATTRPSPTTPAMP EEEECCCCCCCCCCC	31.43	28348404
97	Phosphorylation	REALREHSNPSPSQD HHHHHHCCCCCCCCC	45.76	29255136
100	Phosphorylation	LREHSNPSPSQDTDG HHHCCCCCCCCCCCC	41.24	29255136
102	Phosphorylation	EHSNPSPSQDTDGTK HCCCCCCCCCCCCCH	45.05	29255136
105	Phosphorylation	NPSPSQDTDGTKATK CCCCCCCCCCCHHHH	28.79	29255136
108	Phosphorylation	PSQDTDGTKATKMAH CCCCCCCCHHHHHHH	21.95	29255136
119	Phosphorylation	KMAHSMRSIQNGQPP HHHHHHHHHHCCCCC	21.64	24719451
127	Phosphorylation	IQNGQPPTSTPASSG HHCCCCCCCCCCCHH	52.49	22199227
128	Phosphorylation	QNGQPPTSTPASSGS HCCCCCCCCCCCHHH	37.86	22199227
129	Phosphorylation	NGQPPTSTPASSGSK CCCCCCCCCCCHHHH	25.92	22199227
132	Phosphorylation	PPTSTPASSGSKAFH CCCCCCCCHHHHHHH	36.11	22199227
133	Phosphorylation	PTSTPASSGSKAFHR CCCCCCCHHHHHHHH	49.55	22199227
135	Phosphorylation	STPASSGSKAFHRLS CCCCCHHHHHHHHHH	23.82	22199227
142	Phosphorylation	SKAFHRLSRRRSKDV HHHHHHHHHCCCCCC	24.57	30266825
146	Phosphorylation	HRLSRRRSKDVEFQD HHHHHCCCCCCCCCC	31.25	30266825
158	Phosphorylation	FQDGWPRSPGRAFLP CCCCCCCCCCEEEEE	27.85	28355574
170	Phosphorylation	FLPLRHRSSSEITLS EEEECCCCCCCEEEE	31.90	23401153
171	Phosphorylation	LPLRHRSSSEITLSE EEECCCCCCCEEEEE	31.76	30278072
172	Phosphorylation	PLRHRSSSEITLSEC EECCCCCCCEEEEEC	33.97	27273156
175	Phosphorylation	HRSSSEITLSECDAE CCCCCCEEEEECCHH	21.85	23927012
177	Phosphorylation	SSSEITLSECDAEDA CCCCEEEEECCHHHC	27.77	26657352
193	Phosphorylation	EPRGARHTGALPLFR CCCCCCCCCCCHHHH	20.71	28555341
202	Phosphorylation	ALPLFREYGSTSSID CCHHHHHHCCCCCEE	16.48	22496350
204	Phosphorylation	PLFREYGSTSSIDVQ HHHHHHCCCCCEECC	24.98	26657352
205	Phosphorylation	LFREYGSTSSIDVQG HHHHHCCCCCEECCC	23.33	26657352
206	Phosphorylation	FREYGSTSSIDVQGM HHHHCCCCCEECCCC	27.30	26657352
207	Phosphorylation	REYGSTSSIDVQGMP HHHCCCCCEECCCCC	23.93	28464451
217	Phosphorylation	VQGMPEQSFFDILNE CCCCCHHHHHHHHHH	26.64	27732954
296	Phosphorylation	RGLGGGDTVDSSIFR CCCCCCCCCCHHHHH	29.50	29255136
299	Phosphorylation	GGGDTVDSSIFRKLR CCCCCCCHHHHHHHH	22.46	28857561
300	Phosphorylation	GGDTVDSSIFRKLRS CCCCCCHHHHHHHHC	22.68	29255136
307	Phosphorylation	SIFRKLRSSKPEGEA HHHHHHHCCCCCCCC	53.82	28176443
308	Phosphorylation	IFRKLRSSKPEGEAG HHHHHHCCCCCCCCC	45.88	28176443
317	Phosphorylation	PEGEAGRSPGEADEG CCCCCCCCCCCCCCC	36.02	28985074
326	Phosphorylation	GEADEGRSPPEASRP CCCCCCCCCCCCCCC	56.51	28348404
368	Phosphorylation	SVSQRRNTTTGASAA CHHHHCCCCCCHHHH	24.75	27762562
369	Phosphorylation	VSQRRNTTTGASAAS HHHHCCCCCCHHHHH	27.12	28348404
370	Phosphorylation	SQRRNTTTGASAASA HHHCCCCCCHHHHHH	28.81	28348404
383	Phosphorylation	SAASAMASLTASRAH HHHHHHHHHHHHHHH	17.11	-
385	Phosphorylation	ASAMASLTASRAHSL HHHHHHHHHHHHHHC	21.79	-
391	Phosphorylation	LTASRAHSLGGLDPA HHHHHHHHCCCCCCC	27.94	26657352
400	Phosphorylation	GGLDPAFTSTEDLNC CCCCCCCCCHHHCCC	36.52	29255136
401	Phosphorylation	GLDPAFTSTEDLNCK CCCCCCCCHHHCCCH	24.28	29255136
402	Phosphorylation	LDPAFTSTEDLNCKE CCCCCCCHHHCCCHH	30.38	29255136
448	Phosphorylation	NVSFSRASVGSPSSG CEEECCCCCCCCCCC	26.38	23312004
451	Phosphorylation	FSRASVGSPSSGEGH ECCCCCCCCCCCCCC	21.32	22199227
453	Phosphorylation	RASVGSPSSGEGHLA CCCCCCCCCCCCCCC	53.31	22199227
454	Phosphorylation	ASVGSPSSGEGHLAE CCCCCCCCCCCCCCH	44.22	22199227
469	Phosphorylation	PALSAYRTNASISVL HHHHHHHCCCEEEEE	23.59	22817900
487	Phosphorylation	KEQQRTQSRPRQYSI HHHHCCCCCCCEEEE	43.57	22817900
492	Phosphorylation	TQSRPRQYSIEHVDL CCCCCCEEEEEEEEC	16.94	23312004
493	Phosphorylation	QSRPRQYSIEHVDLG CCCCCEEEEEEEECC	17.11	23312004
504	Phosphorylation	VDLGARYYQDYFVGK EECCCHHHHHEECCH	6.86	27642862
669	Phosphorylation	CLKGFTKYAAQLDVK HHHCHHHEEEECCCC	12.24	23403867
677	Phosphorylation	AAQLDVKTDSTGTHS EEECCCCCCCCCCCC	34.72	30576142
699	Phosphorylation	YEIMFHVSTLLPYTP CEEEEEHHHHCCCCC	12.55	30576142
782	Phosphorylation	PFGPPIPSGTTFRKS CCCCCCCCCCCCCCC	49.87	-
785	Phosphorylation	PPIPSGTTFRKSDVF CCCCCCCCCCCCHHH	25.60	-
799	Ubiquitination	FRDFLLAKVINAENA HHHHHHHHHHCHHHH	43.55	21906983
812	Ubiquitination	NAAHKSDKFHTMATR HHHHHCCHHHHHHHH	46.25	-
824	Phosphorylation	ATRTRQEYLKDLAEN HHHHHHHHHHHHHHH	15.66	-
848	Phosphorylation	TGKFNLISLTSKKKE CCCEEEEEECCCCHH	28.85	28857561
850	Phosphorylation	KFNLISLTSKKKEKT CEEEEEECCCCHHHH	31.54	24173317
904	Phosphorylation	VVLLDLRTKEVVFNC EEEEECCCCEEEEEE	38.56	30631047
925	Phosphorylation	GWTPDSSTLKIFYGR CCCCCCCCEEEEECC	35.70	30631047
960	Phosphorylation	QRLKVMTSGWETVDM HHHHHHHCCCEEEEE	24.66	-
1017	Phosphorylation	ICKVAVVTLTHDQMI HCEEEEEEECHHHHH	21.24	-
1019	Phosphorylation	KVAVVTLTHDQMIDL EEEEEEECHHHHHHH	17.65	-
1054	Phosphorylation	RRGWPETYDMNTSEP CCCCCCCCCCCCCCC	16.13	22210691
1058	Phosphorylation	PETYDMNTSEPKTEQ CCCCCCCCCCCCCCC	28.03	22210691
1059	Phosphorylation	ETYDMNTSEPKTEQE CCCCCCCCCCCCCCC	47.07	22210691
1063	Phosphorylation	MNTSEPKTEQESITP CCCCCCCCCCCCCCC	54.33	23403867
1067	Phosphorylation	EPKTEQESITPGGRP CCCCCCCCCCCCCCC	31.30	23403867
1069	Phosphorylation	KTEQESITPGGRPPY CCCCCCCCCCCCCCC	25.76	23403867
1076	Phosphorylation	TPGGRPPYRSNAPWQ CCCCCCCCCCCCCCC	29.38	21214269
1100	Phosphorylation	LPASKWATPTTPGHA CCHHHCCCCCCCCCH	21.76	22199227
1102	Phosphorylation	ASKWATPTTPGHAQS HHHCCCCCCCCCHHH	41.07	27251275
1103	Phosphorylation	SKWATPTTPGHAQSL HHCCCCCCCCCHHHC	28.60	24719451
1109	Phosphorylation	TTPGHAQSLSRPLKQ CCCCCHHHCCCCCCC	29.15	29514088
1111	Phosphorylation	PGHAQSLSRPLKQTP CCCHHHCCCCCCCCC	36.78	29514088
1117	Phosphorylation	LSRPLKQTPIVPFRE CCCCCCCCCCCCCCC	17.25	23312004
1125	Phosphorylation	PIVPFRESQPLHSKR CCCCCCCCCCCCCCC	32.61	-
1130	Phosphorylation	RESQPLHSKRPVSFP CCCCCCCCCCCCCCC	37.73	-
1135	Phosphorylation	LHSKRPVSFPETPYT CCCCCCCCCCCCCCE	37.45	19276368
1139	Phosphorylation	RPVSFPETPYTVSPA CCCCCCCCCCEECCC	23.10	27050516
1141	Phosphorylation	VSFPETPYTVSPAGA CCCCCCCCEECCCCC	27.48	28387310
1142	Phosphorylation	SFPETPYTVSPAGAD CCCCCCCEECCCCCC	18.73	25850435
1144	Phosphorylation	PETPYTVSPAGADRV CCCCCEECCCCCCCC	10.96	25850435
1158	Phosphorylation	VPPYRQPSGSFSTPG CCCCCCCCCCCCCCC	38.44	25106551
1160	Phosphorylation	PYRQPSGSFSTPGSA CCCCCCCCCCCCCCC	21.99	27050516
1162	Phosphorylation	RQPSGSFSTPGSATY CCCCCCCCCCCCCEE	35.08	23312004
1163	Phosphorylation	QPSGSFSTPGSATYV CCCCCCCCCCCCEEE	29.65	23312004
1166	Phosphorylation	GSFSTPGSATYVRYK CCCCCCCCCEEEEEC	20.74	28152594
1168	Phosphorylation	FSTPGSATYVRYKPS CCCCCCCEEEEECCC	25.01	28152594
1169	Phosphorylation	STPGSATYVRYKPSP CCCCCCEEEEECCCH	5.22	28152594
1175	Phosphorylation	TYVRYKPSPERYTAA EEEEECCCHHHCCCC	34.93	24719451
1233	Phosphorylation	VPAQARLSAIAGSSG CCCHHHHHHHHCCCC	16.45	28985074
1238	Phosphorylation	RLSAIAGSSGNKHPS HHHHHHCCCCCCCCC	26.50	22199227
1239	Phosphorylation	LSAIAGSSGNKHPSR HHHHHCCCCCCCCCH	45.53	20886841
1254	Phosphorylation	QDAAGKDSPNRHSKG HCCCCCCCCCCCCCC	27.79	28985074
1265	Phosphorylation	HSKGEPQYSSHSSSN CCCCCCCCCCCCCCC	23.90	22817900
1269	Phosphorylation	EPQYSSHSSSNTLSS CCCCCCCCCCCCCCC	37.09	-
1270	Phosphorylation	PQYSSHSSSNTLSSN CCCCCCCCCCCCCCC	23.37	-
1273	Phosphorylation	SSHSSSNTLSSNASS CCCCCCCCCCCCCCC	29.93	-
1281	Phosphorylation	LSSNASSSHSDDRWF CCCCCCCCCCCCCCC	25.23	-
1283	Phosphorylation	SNASSSHSDDRWFDP CCCCCCCCCCCCCCC	43.06	-
1306	Phosphorylation	DPLSKGGSSDSGIDT CCCCCCCCCCCCCCC	39.37	23090842
1307	Phosphorylation	PLSKGGSSDSGIDTT CCCCCCCCCCCCCCE	38.79	23090842
1309	Phosphorylation	SKGGSSDSGIDTTLY CCCCCCCCCCCCEEE	39.33	27251275
1313	Phosphorylation	SSDSGIDTTLYTSSP CCCCCCCCEEECCCH	19.44	23090842
1314	Phosphorylation	SDSGIDTTLYTSSPS CCCCCCCEEECCCHH	17.64	23090842
1316	Phosphorylation	SGIDTTLYTSSPSCM CCCCCEEECCCHHHH	11.50	27259358
1317	Phosphorylation	GIDTTLYTSSPSCMS CCCCEEECCCHHHHH	26.33	22199227
1318	Phosphorylation	IDTTLYTSSPSCMSL CCCEEECCCHHHHHH	27.05	24719451
1319	Phosphorylation	DTTLYTSSPSCMSLA CCEEECCCHHHHHHH	17.03	22199227
1321	Phosphorylation	TLYTSSPSCMSLAKA EEECCCHHHHHHHCC	25.13	22199227
1364	Phosphorylation	ADRRREVSPAPAVAG HHCCCCCCCCCCCCC	15.59	23401153
1373	Phosphorylation	APAVAGQSKGYRPKL CCCCCCCCCCCCCCE	27.42	23403867
1376	Phosphorylation	VAGQSKGYRPKLYSS CCCCCCCCCCCEECC	27.72	-
1381	Phosphorylation	KGYRPKLYSSGSSTP CCCCCCEECCCCCCC	13.60	22817900
1382	Phosphorylation	GYRPKLYSSGSSTPT CCCCCEECCCCCCCC	38.36	29116813
1383	Phosphorylation	YRPKLYSSGSSTPTG CCCCEECCCCCCCCC	29.19	28857561
1385	Phosphorylation	PKLYSSGSSTPTGLA CCEECCCCCCCCCCC	32.74	28857561
1386	Phosphorylation	KLYSSGSSTPTGLAG CEECCCCCCCCCCCC	41.76	28387310
1387	Phosphorylation	LYSSGSSTPTGLAGG EECCCCCCCCCCCCC	26.94	21815630
1389	Phosphorylation	SSGSSTPTGLAGGSR CCCCCCCCCCCCCCC	44.94	28985074
1407	Phosphorylation	RQPSDMGSRVGYPAQ CCCCCCCCCCCCCEE	19.70	26657352
1411	Phosphorylation	DMGSRVGYPAQVYKT CCCCCCCCCEEEEEC	7.79	26657352
1416	Phosphorylation	VGYPAQVYKTASAET CCCCEEEEECCCCCC	7.19	-
1418	Phosphorylation	YPAQVYKTASAETPR CCEEEEECCCCCCCC	14.25	22199227
1420	Phosphorylation	AQVYKTASAETPRPS EEEEECCCCCCCCHH	31.69	22199227
1423	Phosphorylation	YKTASAETPRPSQLA EECCCCCCCCHHHCC	25.06	22199227
1427	Phosphorylation	SAETPRPSQLAQPSP CCCCCCHHHCCCCCC	38.82	29978859
1433	Phosphorylation	PSQLAQPSPFQLSAS HHHCCCCCCCCCCCC	26.68	22199227
1438	Phosphorylation	QPSPFQLSASVPKSF CCCCCCCCCCCCHHH	14.02	22199227
1440	Phosphorylation	SPFQLSASVPKSFFS CCCCCCCCCCHHHCC	35.26	22199227
1448	Acetylation	VPKSFFSKQPVRNKH CCHHHCCCCCCCCCC	54.16	19608861
1448	Methylation	VPKSFFSKQPVRNKH CCHHHCCCCCCCCCC	54.16	19608861
1473	Phosphorylation	PPRPLPFSDPKKQVD CCCCCCCCCCCCCCC	51.57	21712546
1476	Acetylation	PLPFSDPKKQVDTNT CCCCCCCCCCCCCCC	61.91	7833869
1495	Phosphorylation	GQPRLRASLRDLRSP CCHHHHHHHHHHCCC	19.94	26074081
1501	Phosphorylation	ASLRDLRSPRKNYKS HHHHHHCCCCCCCCC	36.03	17081983
1507	Methylation	RSPRKNYKSTIEDDL CCCCCCCCCCHHHHH	50.98	115981181
1531	Phosphorylation	GPEQERDTGQSPQKG CHHHHCCCCCCCCHH	43.26	25159151
1534	Phosphorylation	QERDTGQSPQKGLQR HHCCCCCCCCHHHHH	30.55	25159151
1537	Ubiquitination	DTGQSPQKGLQRTLS CCCCCCCHHHHHHCC	66.04	-
1542	Phosphorylation	PQKGLQRTLSDESLC CCHHHHHHCCCCCCC	20.04	30266825
1544	Phosphorylation	KGLQRTLSDESLCSG HHHHHHCCCCCCCCC	38.42	19664994
1547	Phosphorylation	QRTLSDESLCSGRRE HHHCCCCCCCCCCCC	39.40	30266825
1550	Phosphorylation	LSDESLCSGRREPSF CCCCCCCCCCCCCCC	40.40	30266825
1556	Phosphorylation	CSGRREPSFASPAGL CCCCCCCCCCCCCCC	28.79	24732914
1559	Phosphorylation	RREPSFASPAGLEPG CCCCCCCCCCCCCCC	17.17	24732914
1581	Phosphorylation	TSTCAFPSSTLPARR ECCCCCCCCCCCCHH	29.51	-
1582	Phosphorylation	STCAFPSSTLPARRQ CCCCCCCCCCCCHHC	33.91	-
1583	Phosphorylation	TCAFPSSTLPARRQH CCCCCCCCCCCHHCC	40.89	-
1602	Phosphorylation	PPVGPGATPAAGSGF CCCCCCCCCCCCCCC	21.26	28555341
1614	Phosphorylation	SGFPEKKSTISASEL CCCCCCCCCCCHHHH	41.88	29255136
1615	Phosphorylation	GFPEKKSTISASELS CCCCCCCCCCHHHHH	28.03	29255136
1617	Phosphorylation	PEKKSTISASELSLA CCCCCCCCHHHHHHC	26.32	29255136
1619	Phosphorylation	KKSTISASELSLADG CCCCCCHHHHHHCCC	32.07	29255136
1622	Phosphorylation	TISASELSLADGRDR CCCHHHHHHCCCCCC	19.91	29255136
1651	Phosphorylation	TAAGLEWSSLVNAAK CCCCCCHHHHHHHHH	12.38	21130716
1667	Phosphorylation	YEVQRAVSLFSLNDP HHHHHHHHHHCCCCC	23.78	23312004
1670	Phosphorylation	QRAVSLFSLNDPALS HHHHHHHCCCCCCCC	31.40	23312004
1677	Phosphorylation	SLNDPALSPDIPPAH CCCCCCCCCCCCCCC	23.72	26055452
1685	Phosphorylation	PDIPPAHSPVHSHLS CCCCCCCCCCCCCCC	30.62	25849741
1689	Phosphorylation	PAHSPVHSHLSLERG CCCCCCCCCCCCCCC	26.76	29255136
1692	Phosphorylation	SPVHSHLSLERGPPT CCCCCCCCCCCCCCC	23.82	29255136
1699	Phosphorylation	SLERGPPTPRTTPTM CCCCCCCCCCCCCCC	28.65	22617229
1702	Phosphorylation	RGPPTPRTTPTMSEE CCCCCCCCCCCCCCC	38.03	23927012
1703	Phosphorylation	GPPTPRTTPTMSEEP CCCCCCCCCCCCCCC	20.31	23927012
1705	Phosphorylation	PTPRTTPTMSEEPPL CCCCCCCCCCCCCCC	31.10	23927012
1707	Phosphorylation	PRTTPTMSEEPPLDL CCCCCCCCCCCCCCC	41.09	23403867
1719	Phosphorylation	LDLTGKVYQLEVMLK CCCCCCEEHHHHHHH	15.74	27642862
1730	Phosphorylation	VMLKQLHTDLQKEKQ HHHHHHCHHHHHHHH	47.17	24905233
1739	Ubiquitination	LQKEKQDKVVLQSEV HHHHHHHHHHHHHHH	31.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SI1L3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SI1L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SI1L3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SI1L3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SI1L3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1448, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1544, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1544, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1364, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135 AND SER-1364, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1699, AND MASSSPECTROMETRY.	19690332 [Abstract]
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