dbPTM

GPTC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPTC1_HUMAN
UniProt AC	Q9BRR8
Protein Name	G patch domain-containing protein 1
Gene Name	GPATCH1
Organism	Homo sapiens (Human).
Sequence Length	931
Subcellular Localization
Protein Description
Protein Sequence	MAARDSDSEEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTKDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRRPRRQKPDPGVKIYGCALPPGSSEGSEGEDDDYLPDNVTFAPKDVTPVDFTPKDNVHGLAYKGLDPHQALFGTSGEHFNLFSGGSERAGDLGEIGLNKGRKLGISGQAFGVGALEEEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPRQYKNQKESEKDLRYVGKILDGFSLASKPLSSKKIYPPPELPRDYRPVHYFRPMVAATSENSHLLQVLSESAGKATPDPGTHSKHQLNASKRAELLGETPIQGSATSVLEFLSQKDKERIKEMKQATDLKAAQLKARSLAQNAQSSRAQLSPAAAAGHCSWNMALGGGTATLKASNFKPFAKDPEKQKRYDEFLVHMKQGQKDALERCLDPSMTEWERGRERDEFARAALLYASSHSTLSSRFTHAKEEDDSDQVEVPRDQENDVGDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTLPETASLPTTQASSEKVSQHRGPDKSRKPSRWDTSKHEKKEDSISEFLSLARSKAEPPKQQSSPLVNKEEEHAPELSANQTVNKDVDAQAEGEGSRPSMDLFRAIFASSSDEKSSSSEDEQGDSEDDQAGSGEANFQSSQDTDLGETSSVAHALVPAPQEPPPSFPIQKMQIDEREEFGPRLPPVFCPNARQTLEVPQKEKHKKNKDKHKAKKEHRRKKEKKKKHRKHKHKGKQKNKKPEKSSSSESSDSSDSQSDEETADVSPQELLRRLKSLPLRRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAARDSDSE ------CCCCCCCCH	15.94	21406692
6	Phosphorylation	--MAARDSDSEEDLV --CCCCCCCCHHHHH	37.17	25159151
8	Phosphorylation	MAARDSDSEEDLVSY CCCCCCCCHHHHHHC	47.00	25159151
14	Phosphorylation	DSEEDLVSYGTGLEP CCHHHHHHCCCCCCC	25.74	29116813
15	Phosphorylation	SEEDLVSYGTGLEPL CHHHHHHCCCCCCCC	15.95	26552605
17	Phosphorylation	EDLVSYGTGLEPLEE HHHHHCCCCCCCCCC	30.29	26552605
72	Phosphorylation	VGSKEGWTPSTFVSS CCCCCCCCHHHHHHH	20.44	28555341
87	Phosphorylation	RQNRADKSVLGPEDF CCCCCCCCCCCHHHC	24.11	21712546
112	Phosphorylation	IAPKAIVTTDDFASK CCCCEEEECHHHHHH	20.56	25002506
113	Phosphorylation	APKAIVTTDDFASKT CCCEEEECHHHHHHH	23.76	25002506
118	Phosphorylation	VTTDDFASKTKDRIR EECHHHHHHHHHHHH	40.63	25002506
119	Acetylation	TTDDFASKTKDRIRE ECHHHHHHHHHHHHH	57.05	25953088
120	Phosphorylation	TDDFASKTKDRIREK CHHHHHHHHHHHHHH	35.36	25002506
135	Phosphorylation	ARQLAAATAPIPGAT HHHHHHHCCCCCCCC	28.39	20068231
142	Phosphorylation	TAPIPGATLLDDLIT CCCCCCCCHHHHHCC	33.49	20068231
149	Phosphorylation	TLLDDLITPAKLSVG CHHHHHCCHHHHHHH	25.21	20068231
154	Phosphorylation	LITPAKLSVGFELLR HCCHHHHHHHHHHHH	21.35	20068231
191	Phosphorylation	PDPGVKIYGCALPPG CCCCCEEEEEECCCC	10.63	20873877
199	Phosphorylation	GCALPPGSSEGSEGE EEECCCCCCCCCCCC	30.87	20873877
200	Phosphorylation	CALPPGSSEGSEGED EECCCCCCCCCCCCC	52.47	25159151
203	Phosphorylation	PPGSSEGSEGEDDDY CCCCCCCCCCCCCCC	38.07	20873877
210	Phosphorylation	SEGEDDDYLPDNVTF CCCCCCCCCCCCCEE	27.42	20873877
216	Phosphorylation	DYLPDNVTFAPKDVT CCCCCCCEECCCCCC	21.97	20873877
223	Phosphorylation	TFAPKDVTPVDFTPK EECCCCCCCCCCCCC	27.94	21406692
228	Phosphorylation	DVTPVDFTPKDNVHG CCCCCCCCCCCCCCC	25.60	21406692
299	Phosphorylation	EEEDDDIYATETLSK CCCCCCEEEEECHHH	17.92	27642862
312	Sumoylation	SKYDTVLKDEEPGDG HHCCEEECCCCCCCC	59.77	28112733
321	Phosphorylation	EEPGDGLYGWTAPRQ CCCCCCCCCCCCCCC	19.02	25884760
324	Phosphorylation	GDGLYGWTAPRQYKN CCCCCCCCCCCCCCC	23.56	28796482
330	Acetylation	WTAPRQYKNQKESEK CCCCCCCCCHHHCHH	44.56	20167786
333	Ubiquitination	PRQYKNQKESEKDLR CCCCCCHHHCHHHHH	73.02	24816145
333	Acetylation	PRQYKNQKESEKDLR CCCCCCHHHCHHHHH	73.02	20167786
337	Acetylation	KNQKESEKDLRYVGK CCHHHCHHHHHHHHH	71.93	20167786
350	Phosphorylation	GKILDGFSLASKPLS HHHHCCCCCCCCCCC	28.67	23186163
353	Phosphorylation	LDGFSLASKPLSSKK HCCCCCCCCCCCCCC	39.85	23312004
357	Phosphorylation	SLASKPLSSKKIYPP CCCCCCCCCCCCCCC	48.95	25159151
358	Phosphorylation	LASKPLSSKKIYPPP CCCCCCCCCCCCCCC	45.72	23186163
407	Phosphorylation	KATPDPGTHSKHQLN CCCCCCCCCCHHHCC	28.50	26074081
409	Phosphorylation	TPDPGTHSKHQLNAS CCCCCCCCHHHCCHH	31.50	26074081
416	Phosphorylation	SKHQLNASKRAELLG CHHHCCHHHHHHHHC	22.92	26074081
456	Methylation	MKQATDLKAAQLKAR HHHHHHHHHHHHHHH	44.48	-
461	Methylation	DLKAAQLKARSLAQN HHHHHHHHHHHHHHH	29.67	-
464	Phosphorylation	AAQLKARSLAQNAQS HHHHHHHHHHHHHHH	32.68	20068231
471	Phosphorylation	SLAQNAQSSRAQLSP HHHHHHHHHHHCCCH	21.27	20068231
472	Phosphorylation	LAQNAQSSRAQLSPA HHHHHHHHHHCCCHH	21.39	20068231
477	Phosphorylation	QSSRAQLSPAAAAGH HHHHHCCCHHHHHCC	10.62	28450419
486	Phosphorylation	AAAAGHCSWNMALGG HHHHCCCCEEEECCC	18.79	23186163
561	Phosphorylation	AALLYASSHSTLSSR HHHHHHHCCCHHHHC	17.18	-
563	Phosphorylation	LLYASSHSTLSSRFT HHHHHCCCHHHHCCC	32.75	24505115
566	Phosphorylation	ASSHSTLSSRFTHAK HHCCCHHHHCCCCCC	21.40	22210691
567	Phosphorylation	SSHSTLSSRFTHAKE HCCCHHHHCCCCCCC	34.23	22210691
594	Ubiquitination	QENDVGDKQSAVKMK CCCCCCCHHHHHHHH	39.98	-
596	Phosphorylation	NDVGDKQSAVKMKMF CCCCCHHHHHHHHHH	40.55	25159151
601	Ubiquitination	KQSAVKMKMFGKLTR HHHHHHHHHHCCCCC	25.92	-
661	O-linked_Glycosylation	PETASLPTTQASSEK CCCCCCCCCHHHCHH	36.51	30379171
665	Phosphorylation	SLPTTQASSEKVSQH CCCCCHHHCHHHHHC	29.25	21712546
695	Phosphorylation	KHEKKEDSISEFLSL CCCCCCCHHHHHHHH	29.16	21712546
701	Phosphorylation	DSISEFLSLARSKAE CHHHHHHHHHHHCCC	25.88	26074081
705	Phosphorylation	EFLSLARSKAEPPKQ HHHHHHHHCCCCCCC	30.52	26074081
714	Phosphorylation	AEPPKQQSSPLVNKE CCCCCCCCCCCCCCH	31.28	26074081
715	Phosphorylation	EPPKQQSSPLVNKEE CCCCCCCCCCCCCHH	20.22	25159151
729	Phosphorylation	EEHAPELSANQTVNK HHCCCCCCCCCCCCC	24.42	27251275
750	Phosphorylation	EGEGSRPSMDLFRAI CCCCCCCCHHHHHHH	24.66	28555341
760	Phosphorylation	LFRAIFASSSDEKSS HHHHHHCCCCCCCCC	21.45	20873877
761	Phosphorylation	FRAIFASSSDEKSSS HHHHHCCCCCCCCCC	38.08	20873877
762	Phosphorylation	RAIFASSSDEKSSSS HHHHCCCCCCCCCCC	47.49	20873877
845	Phosphorylation	FCPNARQTLEVPQKE CCCCHHHEECCCHHH	21.23	24043423
925	Phosphorylation	ELLRRLKSLPLRRQ- HHHHHHHCCCCCCC-	39.55	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPTC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPTC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
714	Phosphorylation	724 (10)	H ⇒ R	rs10416265	Bone properties (heel)	24430505
715	Phosphorylation	724 (9)	H ⇒ R	rs10416265	Bone properties (heel)	24430505

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RBM39_HUMAN	RBM39	physical	22939629
RS8_HUMAN	RPS8	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPTC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND THR-17, AND MASSSPECTROMETRY.	17081983 [Abstract]