dbPTM

RS8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS8_HUMAN
UniProt AC	P62241
Protein Name	40S ribosomal protein S8
Gene Name	RPS8
Organism	Homo sapiens (Human).
Sequence Length	208
Subcellular Localization	Cytoplasm . Membrane Lipid-anchor . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein Description
Protein Sequence	MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGISRDNWH ------CCCCCCCHH	26.95	25255805
4	Phosphorylation	----MGISRDNWHKR ----CCCCCCCHHHC	28.05	25159151
23	Acetylation	GKRKPYHKKRKYELG CCCCCCHHHCCCCCC	48.72	30592065
24	Acetylation	KRKPYHKKRKYELGR CCCCCHHHCCCCCCC	40.59	129691
26	Sumoylation	KPYHKKRKYELGRPA CCCHHHCCCCCCCCC	52.54	-
26	Acetylation	KPYHKKRKYELGRPA CCCHHHCCCCCCCCC	52.54	26051181
26	Ubiquitination	KPYHKKRKYELGRPA CCCHHHCCCCCCCCC	52.54	-
26	Sumoylation	KPYHKKRKYELGRPA CCCHHHCCCCCCCCC	52.54	-
27	Phosphorylation	PYHKKRKYELGRPAA CCHHHCCCCCCCCCC	22.03	28152594
36	Phosphorylation	LGRPAANTKIGPRRI CCCCCCCCCCCCCEE	21.22	20068231
37	Acetylation	GRPAANTKIGPRRIH CCCCCCCCCCCCEEE	45.53	23236377
37	Ubiquitination	GRPAANTKIGPRRIH CCCCCCCCCCCCEEE	45.53	21906983
37	2-Hydroxyisobutyrylation	GRPAANTKIGPRRIH CCCCCCCCCCCCEEE	45.53	-
66	Phosphorylation	RLDVGNFSWGSECCT EEECCCCCCCHHHCC	34.23	21406692
69	Phosphorylation	VGNFSWGSECCTRKT CCCCCCCHHHCCCCC	22.62	30108239
73	Phosphorylation	SWGSECCTRKTRIID CCCHHHCCCCCEEEE	47.03	21406692
76	Phosphorylation	SECCTRKTRIIDVVY HHHCCCCCEEEEEEE	24.66	-
83	Nitration	TRIIDVVYNASNNEL CEEEEEEEECCCCCE	12.59	-
83	Phosphorylation	TRIIDVVYNASNNEL CEEEEEEEECCCCCE	12.59	28152594
86	Phosphorylation	IDVVYNASNNELVRT EEEEEECCCCCEECC	36.23	28152594
93	Phosphorylation	SNNELVRTKTLVKNC CCCCEECCHHHHCCE	22.39	-
98	Acetylation	VRTKTLVKNCIVLID ECCHHHHCCEEEEEC	49.57	25953088
98	Ubiquitination	VRTKTLVKNCIVLID ECCHHHHCCEEEEEC	49.57	-
100	Glutathionylation	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	22555962
100	S-nitrosylation	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	22178444
100	S-palmitoylation	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	29575903
100	S-nitrosocysteine	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	-
106	Phosphorylation	NCIVLIDSTPYRQWY CEEEEECCCCCHHHH	25.04	21712546
107	Phosphorylation	CIVLIDSTPYRQWYE EEEEECCCCCHHHHH	22.16	21815630
109	Phosphorylation	VLIDSTPYRQWYESH EEECCCCCHHHHHHC	18.61	-
110	Methylation	LIDSTPYRQWYESHY EECCCCCHHHHHHCC	23.04	115492783
113	Phosphorylation	STPYRQWYESHYALP CCCCHHHHHHCCCCC	10.14	28152594
115	Phosphorylation	PYRQWYESHYALPLG CCHHHHHHCCCCCCC	13.20	28152594
117	Phosphorylation	RQWYESHYALPLGRK HHHHHHCCCCCCCCC	21.07	28152594
125	Ubiquitination	ALPLGRKKGAKLTPE CCCCCCCCCCCCCHH	63.84	-
125	Acetylation	ALPLGRKKGAKLTPE CCCCCCCCCCCCCHH	63.84	23749302
128	Sumoylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	-
128	Sumoylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	-
128	2-Hydroxyisobutyrylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	-
128	Ubiquitination	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	20639865
128	Acetylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	23954790
128	Malonylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	26320211
130	Phosphorylation	RKKGAKLTPEEEEIL CCCCCCCCHHHHHHH	28.13	19664994
139	Ubiquitination	EEEEILNKKRSKKIQ HHHHHHCHHHHHHHH	46.23	-
139	Acetylation	EEEEILNKKRSKKIQ HHHHHHCHHHHHHHH	46.23	23236377
139	2-Hydroxyisobutyrylation	EEEEILNKKRSKKIQ HHHHHHCHHHHHHHH	46.23	-
140	Ubiquitination	EEEILNKKRSKKIQK HHHHHCHHHHHHHHH	61.91	-
142	Phosphorylation	EILNKKRSKKIQKKY HHHCHHHHHHHHHHH	47.37	-
157	Ubiquitination	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	21890473
157	Acetylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	23236377
157	Malonylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	26320211
157	Sumoylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	-
157	2-Hydroxyisobutyrylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	-
157	Sumoylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	-
159	Phosphorylation	RKKNAKISSLLEEQF HHHHHHHHHHHHHHH	17.77	30266825
160	Phosphorylation	KKNAKISSLLEEQFQ HHHHHHHHHHHHHHH	40.21	29255136
170	Sumoylation	EEQFQQGKLLACIAS HHHHHHCCEEHHHHC	35.67	28112733
170	Acetylation	EEQFQQGKLLACIAS HHHHHHCCEEHHHHC	35.67	25953088
170	Ubiquitination	EEQFQQGKLLACIAS HHHHHHCCEEHHHHC	35.67	21890473
174	S-palmitoylation	QQGKLLACIASRPGQ HHCCEEHHHHCCCCC	2.42	29575903
182	S-palmitoylation	IASRPGQCGRADGYV HHCCCCCCCCCCCEE	5.02	29575903
184	Methylation	SRPGQCGRADGYVLE CCCCCCCCCCCEEEC	36.81	115492775
188	Phosphorylation	QCGRADGYVLEGKEL CCCCCCCEEECCCCH	11.47	28152594
193	2-Hydroxyisobutyrylation	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	-
193	Sumoylation	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	28112733
193	Acetylation	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	26051181
193	Ubiquitination	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	21890473
198	Phosphorylation	EGKELEFYLRKIKAR CCCCHHHHHHHHHHH	9.02	28152594
200	Methylation	KELEFYLRKIKARKG CCHHHHHHHHHHHCC	27.55	115492767

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSSA_HUMAN	RPSA	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
UTP15_HUMAN	UTP15	physical	22939629
DCAF1_HUMAN	VPRBP	physical	22939629
ADRM1_HUMAN	ADRM1	physical	22863883
RSSA_HUMAN	RPSA	physical	22863883
LARP1_HUMAN	LARP1	physical	22863883
PRS4_HUMAN	PSMC1	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
PSD11_HUMAN	PSMD11	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
RS26_HUMAN	RPS26	physical	22863883
RS28_HUMAN	RPS28	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS6_HUMAN	RPS6	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
LARP7_HUMAN	LARP7	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
RL26_HUMAN	RPL26	physical	26186194
SR140_HUMAN	U2SURP	physical	26186194
SF3B1_HUMAN	SF3B1	physical	26186194
RM46_HUMAN	MRPL46	physical	26186194
RT26_HUMAN	MRPS26	physical	26186194
SF3B2_HUMAN	SF3B2	physical	26186194
ZN668_HUMAN	ZNF668	physical	26186194
PTCD3_HUMAN	PTCD3	physical	26186194
DKC1_HUMAN	DKC1	physical	26186194
IPO4_HUMAN	IPO4	physical	26186194
NAT10_HUMAN	NAT10	physical	26186194
ZSC25_HUMAN	ZSCAN25	physical	26186194
AATF_HUMAN	AATF	physical	26186194
HP1B3_HUMAN	HP1BP3	physical	26186194
DDX27_HUMAN	DDX27	physical	26186194
RM09_HUMAN	MRPL9	physical	26186194
RS3A_HUMAN	RPS3A	physical	26186194
RM32_HUMAN	MRPL32	physical	26186194
RM40_HUMAN	MRPL40	physical	26186194
RM03_HUMAN	MRPL3	physical	26186194
RT34_HUMAN	MRPS34	physical	26186194
RT29_HUMAN	DAP3	physical	26186194
RM01_HUMAN	MRPL1	physical	26186194
RBM19_HUMAN	RBM19	physical	26186194
SURF6_HUMAN	SURF6	physical	26186194
RM23_HUMAN	MRPL23	physical	26186194
NOL10_HUMAN	NOL10	physical	26186194
RM22_HUMAN	MRPL22	physical	26186194
RT05_HUMAN	MRPS5	physical	26186194
RT07_HUMAN	MRPS7	physical	26186194
RT22_HUMAN	MRPS22	physical	26186194
RM10_HUMAN	MRPL10	physical	26186194
RM24_HUMAN	MRPL24	physical	26186194
RM49_HUMAN	MRPL49	physical	26186194
LLPH_HUMAN	LLPH	physical	26186194
RT31_HUMAN	MRPS31	physical	26186194
RM44_HUMAN	MRPL44	physical	26186194
RT09_HUMAN	MRPS9	physical	26186194
RT25_HUMAN	MRPS25	physical	26186194
RM38_HUMAN	MRPL38	physical	26186194
KRR1_HUMAN	KRR1	physical	26186194
ZC3H8_HUMAN	ZC3H8	physical	26186194
RM20_HUMAN	MRPL20	physical	26186194
CHERP_HUMAN	CHERP	physical	26186194
NGDN_HUMAN	NGDN	physical	26186194
RT33_HUMAN	MRPS33	physical	26186194
RM27_HUMAN	MRPL27	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
RT11_HUMAN	MRPS11	physical	26186194
RM47_HUMAN	MRPL47	physical	26186194
RS13_HUMAN	RPS13	physical	26186194
RM16_HUMAN	MRPL16	physical	26186194
RT24_HUMAN	MRPS24	physical	26186194
GPT11_HUMAN	GPATCH11	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
RM19_HUMAN	MRPL19	physical	26186194
RT14_HUMAN	MRPS14	physical	26186194
ICT1_HUMAN	ICT1	physical	26186194
RM02_HUMAN	MRPL2	physical	26186194
RPF2_HUMAN	RPF2	physical	26186194
RM21_HUMAN	MRPL21	physical	26186194
RM13_HUMAN	MRPL13	physical	26186194
RM43_HUMAN	MRPL43	physical	26186194
RM17_HUMAN	MRPL17	physical	26186194
PURA_HUMAN	PURA	physical	26186194
RBMX2_HUMAN	RBMX2	physical	26186194
H2A2B_HUMAN	HIST2H2AB	physical	26186194
G45IP_HUMAN	GADD45GIP1	physical	26186194
RBM5_HUMAN	RBM5	physical	26186194
RM15_HUMAN	MRPL15	physical	26186194
RM30_HUMAN	MRPL30	physical	26186194
RT30_HUMAN	MRPS30	physical	26186194
RM18_HUMAN	MRPL18	physical	26186194
RM51_HUMAN	MRPL51	physical	26186194
RM34_HUMAN	MRPL34	physical	26186194
EF1A1_HUMAN	EEF1A1	physical	26344197
IMA6_HUMAN	KPNA5	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS3_HUMAN	RPS3	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RL40_HUMAN	UBA52	physical	26344197
RM47_HUMAN	MRPL47	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
IPO4_HUMAN	IPO4	physical	28514442
RT30_HUMAN	MRPS30	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RM24_HUMAN	MRPL24	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RM02_HUMAN	MRPL2	physical	28514442
CHERP_HUMAN	CHERP	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
ICT1_HUMAN	ICT1	physical	28514442
RM49_HUMAN	MRPL49	physical	28514442
RBM4_HUMAN	RBM4	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
LARP7_HUMAN	LARP7	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
RM18_HUMAN	MRPL18	physical	28514442
RT14_HUMAN	MRPS14	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
RM22_HUMAN	MRPL22	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
ZSC25_HUMAN	ZSCAN25	physical	28514442
RM15_HUMAN	MRPL15	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
NAT10_HUMAN	NAT10	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442
RM44_HUMAN	MRPL44	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
RL19_HUMAN	RPL19	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
ZBT24_HUMAN	ZBTB24	physical	28514442
RL26_HUMAN	RPL26	physical	28514442
RM19_HUMAN	MRPL19	physical	28514442
ZC3H8_HUMAN	ZC3H8	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
RM11_HUMAN	MRPL11	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RT63_HUMAN	MRPL57	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS8_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.	19007248 [Abstract]