ZN668_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN668_HUMAN
• UniProt AC: Q96K58
• Protein Name: Zinc finger protein 668
• Gene Name: ZNF668
• Organism: Homo sapiens (Human).
• Sequence Length: 619
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEVEAAEARSPAPGYKRSGRRYKCVSCTKTFPNAPRAARHAATHGPADCSEEVAEVKPKPETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVREAPGPLEGAGEAGGEEADEKPPQFVCRECKETFSTMTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGTPTPLEPLVALLGMPEEGPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVEAAEA -------CCCCHHHH	13.53	22814378
2 (in isoform 2)	Phosphorylation	-	49.41	28302921
10	Phosphorylation	VEAAEARSPAPGYKR CCHHHHCCCCCCCCC	32.25	23401153
15	Phosphorylation	ARSPAPGYKRSGRRY HCCCCCCCCCCCCEE	11.36	22199227
33	Phosphorylation	SCTKTFPNAPRAARH EECCCCCCCCHHHHH	59.39	-
38	Phosphorylation	FPNAPRAARHAATHG CCCCCHHHHHHHHHC	12.69	-
57	Sumoylation	SEEVAEVKPKPETEA CHHHHHCCCCCHHHH	38.54	28112733
59	Sumoylation	EVAEVKPKPETEAKA HHHHCCCCCHHHHHH	50.17	28112733
65	Sumoylation	PKPETEAKAEEASGE CCCHHHHHHHHHCCC	50.53	28112733
80	Sumoylation	KVSGSAAKPRPYACP CCCCCCCCCCCCCCC	41.08	28112733
80	Acetylation	KVSGSAAKPRPYACP CCCCCCCCCCCCCCC	41.08	26051181
84	Phosphorylation	SAAKPRPYACPLCPK CCCCCCCCCCCCCCH	23.32	-
93	Phosphorylation	CPLCPKAYKTAPELR CCCCCHHHHCCHHHH	18.26	-
94	Sumoylation	PLCPKAYKTAPELRS CCCCHHHHCCHHHHH	42.97	-
105	Phosphorylation	ELRSHGRSHTGEKPF HHHHCCCCCCCCCCC	29.96	28348404
107	Phosphorylation	RSHGRSHTGEKPFPC HHCCCCCCCCCCCCC	48.56	29214152
110	Acetylation	GRSHTGEKPFPCPEC CCCCCCCCCCCCCHH	53.99	26051181
117	Sumoylation	KPFPCPECGRRFMQP CCCCCCHHCCCCCCH	2.87	-
130	Phosphorylation	QPVCLRVHLASHAGE CHHHHHHHHHHHCCC	14.83	-
154	Sumoylation	KAYGALSKLKIHQRG HHHCHHHCCEECCCC	55.43	28112733
154	Sumoylation	KAYGALSKLKIHQRG HHHCHHHCCEECCCC	55.43	-
163	Phosphorylation	KIHQRGHTGERPYAC EECCCCCCCCCCEEE	43.49	25159151
176	Phosphorylation	ACADCGKSFADPSVF EECCCCCCCCCHHHH	15.79	25159151
177	Ubiquitination	CADCGKSFADPSVFR ECCCCCCCCCHHHHH	11.57	-
177	Sumoylation	CADCGKSFADPSVFR ECCCCCCCCCHHHHH	11.57	-
186	Phosphorylation	DPSVFRKHRRTHAGL CHHHHHHHCCCCCCC	21.87	27251275
197	Phosphorylation	HAGLRPYSCERCGKA CCCCCCCCHHHCCHH	16.51	24719451
199	Phosphorylation	GLRPYSCERCGKAYA CCCCCCHHHCCHHHH	45.10	-
217	Phosphorylation	DLRNHERSHTGERPF HHHCCCCCCCCCCCE	23.55	24719451
219	Phosphorylation	RNHERSHTGERPFLC HCCCCCCCCCCCEEE	41.82	25159151
220	Phosphorylation	NHERSHTGERPFLCS CCCCCCCCCCCEEEC	24.40	-
234	Phosphorylation	SECGKSFSRSSSLTC CCCCCCCCCCCCCCH	38.04	17081983
237	Phosphorylation	GKSFSRSSSLTCHQR CCCCCCCCCCCHHHH	28.40	28348404
238	Phosphorylation	KSFSRSSSLTCHQRI CCCCCCCCCCHHHHH	29.01	28348404
242	Phosphorylation	RSSSLTCHQRIHAAQ CCCCCCHHHHHHHCC	18.08	-
250	Acetylation	QRIHAAQKPYRCPAC HHHHHCCCCCCCCCC	39.01	25953088
273	Phosphorylation	SYQSHERTHSGEKPF HCCCCCCCCCCCCCE	19.87	28348404
275	Phosphorylation	QSHERTHSGEKPFLC CCCCCCCCCCCCEEC	48.29	22817900
290	Phosphorylation	PRCGRMFSDPSSFRR CCCCCCCCCHHHHHH	38.99	20860994
293	Phosphorylation	GRMFSDPSSFRRHQR CCCCCCHHHHHHHHH	47.28	-
294	Phosphorylation	RMFSDPSSFRRHQRA CCCCCHHHHHHHHHH	28.32	28787133
298	Phosphorylation	DPSSFRRHQRAHEGV CHHHHHHHHHHHCCC	19.74	-
331	Phosphorylation	AMHRRVHTGDRPFKC HHHCCCCCCCCCEEE	37.61	20068231
352	Sumoylation	FVASWDLKRHALVHS EEEEEECHHCCEECC	39.40	-
354	Phosphorylation	ASWDLKRHALVHSGQ EEEECHHCCEECCCC	23.10	20068231
359	Phosphorylation	KRHALVHSGQRPFRC HHCCEECCCCCCCCH	29.19	29214152
375	Sumoylation	ECGRAFAERASLTKH HHHHHHHHHHCCCCC	42.18	-
387	Phosphorylation	TKHSRVHSGERPFHC CCCCCCCCCCCCEEC	39.22	28348404
400	Phosphorylation	HCNACGKSFVVSSSL ECCCCCCEEEEEHHH	14.46	28555341
404	Phosphorylation	CGKSFVVSSSLRKHE CCCEEEEEHHHHHCC	14.65	29214152
405	Phosphorylation	GKSFVVSSSLRKHER CCEEEEEHHHHHCCC	23.06	28555341
406	Phosphorylation	KSFVVSSSLRKHERT CEEEEEHHHHHCCCC	25.37	29214152
410	Phosphorylation	VSSSLRKHERTHRSS EEHHHHHCCCCCCHH	24.28	20068231
512	Sumoylation	GGEEADEKPPQFVCR CCCCCCCCCCCEECH	63.65	28112733
524	Phosphorylation	VCRECKETFSTMTLL ECHHHHHHHHHHHHH	14.37	23403867
526	Phosphorylation	RECKETFSTMTLLRR HHHHHHHHHHHHHHH	25.37	23403867
527	Phosphorylation	ECKETFSTMTLLRRH HHHHHHHHHHHHHHH	15.24	23403867
529	Phosphorylation	KETFSTMTLLRRHER HHHHHHHHHHHHHHH	23.80	23403867
554	Phosphorylation	TQCGKSFSDRAGLRK CCCCCCHHHHHCCHH	33.02	-
563	Phosphorylation	RAGLRKHSRTHSSVR HHCCHHCCCCCCCCC	41.74	-
567	Phosphorylation	RKHSRTHSSVRPYTC HHCCCCCCCCCCCCC	29.89	29214152
568	Phosphorylation	KHSRTHSSVRPYTCP HCCCCCCCCCCCCCC	17.97	25627689
572	Phosphorylation	THSSVRPYTCPHCPK CCCCCCCCCCCCCCC	15.48	-
583	Phosphorylation	HCPKAFLSASDLRKH CCCCEECCHHHHHHC	21.19	23403867
585	Phosphorylation	PKAFLSASDLRKHER CCEECCHHHHHHCCC	33.53	21815630
590	Phosphorylation	SASDLRKHERTHPVP CHHHHHHCCCCCCCC	24.28	-
593	Phosphorylation	DLRKHERTHPVPMGT HHHHCCCCCCCCCCC	27.78	28450419
600	Phosphorylation	THPVPMGTPTPLEPL CCCCCCCCCCCCHHH	20.10	24719451
602	Phosphorylation	PVPMGTPTPLEPLVA CCCCCCCCCCHHHHH	40.10	28450419
608	Phosphorylation	PTPLEPLVALLGMPE CCCCHHHHHHHCCCC	5.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN668_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN668_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN668_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPM_HUMAN	NPM1	physical	21852383
P53_HUMAN	TP53	physical	21852383
MDM2_HUMAN	MDM2	physical	21852383

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.