dbPTM

MDM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDM2_HUMAN
UniProt AC	Q00987
Protein Name	E3 ubiquitin-protein ligase Mdm2
Gene Name	MDM2
Organism	Homo sapiens (Human).
Sequence Length	491
Subcellular Localization	Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may
Protein Description	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. [PubMed: 12821780]
Protein Sequence	MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	TDGAVTTSQIPASEQ CCCCEECCCCCHHHH	19.42	21191186
21 (in isoform 11)	Phosphorylation	-	27.59	22210691
23	Phosphorylation	TSQIPASEQETLVRP CCCCCHHHHCCCCCC	55.32	-
24 (in isoform 6)	Ubiquitination	-	46.62	21906983
36	Ubiquitination	RPKPLLLKLLKSVGA CCHHHHHHHHHHCCC	52.31	21890473
36 (in isoform 5)	Ubiquitination	-	52.31	21890473
39	Acetylation	PLLLKLLKSVGAQKD HHHHHHHHHCCCCCC	54.23	25953088
39	Ubiquitination	PLLLKLLKSVGAQKD HHHHHHHHHCCCCCC	54.23	-
40	Phosphorylation	LLLKLLKSVGAQKDT HHHHHHHHCCCCCCC	26.25	30576142
42	Ubiquitination	LKLLKSVGAQKDTYT HHHHHHCCCCCCCCC	29.40	-
42 (in isoform 10)	Ubiquitination	-	29.40	21890473
42 (in isoform 11)	Ubiquitination	-	29.40	21890473
42 (in isoform 7)	Ubiquitination	-	29.40	21890473
42 (in isoform 9)	Ubiquitination	-	29.40	21890473
45	Ubiquitination	LKSVGAQKDTYTMKE HHHCCCCCCCCCHHH	52.05	21890473
45 (in isoform 1)	Ubiquitination	-	52.05	21890473
45 (in isoform 5)	Ubiquitination	-	52.05	21890473
47	Phosphorylation	SVGAQKDTYTMKEVL HCCCCCCCCCHHHHH	28.11	29083192
48	Phosphorylation	VGAQKDTYTMKEVLF CCCCCCCCCHHHHHH	18.25	29083192
49	Phosphorylation	GAQKDTYTMKEVLFY CCCCCCCCHHHHHHH	24.70	29083192
51	Ubiquitination	QKDTYTMKEVLFYLG CCCCCCHHHHHHHHH	36.55	-
51 (in isoform 10)	Ubiquitination	-	36.55	21890473
51 (in isoform 11)	Ubiquitination	-	36.55	21890473
51 (in isoform 7)	Ubiquitination	-	36.55	21890473
51 (in isoform 8)	Ubiquitination	-	36.55	21906983
51 (in isoform 9)	Ubiquitination	-	36.55	21890473
56	Phosphorylation	TMKEVLFYLGQYIMT CHHHHHHHHHHHHHH	13.03	25072903
60	Phosphorylation	VLFYLGQYIMTKRLY HHHHHHHHHHHCCCC	7.29	25072903
61 (in isoform 4)	Ubiquitination	-	1.86	21906983
63	Phosphorylation	YLGQYIMTKRLYDEK HHHHHHHHCCCCCCC	11.94	25072903
63 (in isoform 4)	Ubiquitination	-	11.94	21906983
65 (in isoform 4)	Ubiquitination	-	29.34	21906983
70	Ubiquitination	TKRLYDEKQQHIVYC HCCCCCCCCCCEEEE	52.97	-
71 (in isoform 4)	Ubiquitination	-	37.73	21906983
77	S-nitrosocysteine	KQQHIVYCSNDLLGD CCCCEEEECCCHHHH	1.81	-
77	S-nitrosylation	KQQHIVYCSNDLLGD CCCCEEEECCCHHHH	1.81	22178444
91 (in isoform 4)	Ubiquitination	-	8.78	21906983
94	Ubiquitination	GVPSFSVKEHRKIYT CCCCCCHHHHHHHHE	46.75	-
98	Ubiquitination	FSVKEHRKIYTMIYR CCHHHHHHHHEEEEE	41.81	-
113 (in isoform 3)	Ubiquitination	-	47.54	21906983
115 (in isoform 3)	Ubiquitination	-	34.80	21906983
117 (in isoform 3)	Ubiquitination	-	61.44	21906983
118	Phosphorylation	NQQESSDSGTSVSEN CCCCCCCCCCCCCCC	46.01	20708156
121	Phosphorylation	ESSDSGTSVSENRCH CCCCCCCCCCCCCCC	27.46	20708156
123 (in isoform 3)	Ubiquitination	-	28.99	21906983
124	Phosphorylation	DSGTSVSENRCHLEG CCCCCCCCCCCCCCC	46.68	-
127	Phosphorylation	TSVSENRCHLEGGSD CCCCCCCCCCCCCCC	6.91	-
139 (in isoform 2)	Ubiquitination	-	6.27	21906983
141 (in isoform 2)	Ubiquitination	-	44.96	21906983
143 (in isoform 2)	Ubiquitination	-	56.93	21906983
143 (in isoform 3)	Ubiquitination	-	56.93	21906983
148	Phosphorylation	ELQEEKPSSSHLVSR HHHHHCCCCCCCCCC	56.38	-
149 (in isoform 2)	Ubiquitination	-	30.24	21906983
152	Ubiquitination	EKPSSSHLVSRPSTS HCCCCCCCCCCCCCH	3.96	-
157	Phosphorylation	SHLVSRPSTSSRRRA CCCCCCCCCHHHHHH	39.55	15688025
158	Phosphorylation	HLVSRPSTSSRRRAI CCCCCCCCHHHHHHH	33.14	-
160	Phosphorylation	VSRPSTSSRRRAISE CCCCCCHHHHHHHHC	29.87	15527798
163	Phosphorylation	PSTSSRRRAISETEE CCCHHHHHHHHCCHH	34.85	15688025
164	Phosphorylation	STSSRRRAISETEEN CCHHHHHHHHCCHHC	14.09	-
164 (in isoform 5)	Ubiquitination	-	14.09	21890473
166	Phosphorylation	SSRRRAISETEENSD HHHHHHHHCCHHCHH	37.16	22322096
166 (in isoform 5)	Ubiquitination	-	37.16	21890473
168	Phosphorylation	RRRAISETEENSDEL HHHHHHCCHHCHHHC	41.63	22322096
168 (in isoform 5)	Ubiquitination	-	41.63	21890473
169 (in isoform 2)	Ubiquitination	-	51.64	21906983
172	Phosphorylation	ISETEENSDELSGER HHCCHHCHHHCCHHH	35.42	23927012
172 (in isoform 11)	Phosphorylation	-	35.42	24719451
174	Phosphorylation	ETEENSDELSGERQR CCHHCHHHCCHHHHH	44.66	-
174 (in isoform 5)	Ubiquitination	-	44.66	21890473
176	Phosphorylation	EENSDELSGERQRKR HHCHHHCCHHHHHHH	36.24	23403867
178	Phosphorylation	NSDELSGERQRKRHK CHHHCCHHHHHHHHH	42.12	-
182	Acetylation	LSGERQRKRHKSDSI CCHHHHHHHHHCCCE	50.98	70960657
182	Phosphorylation	LSGERQRKRHKSDSI CCHHHHHHHHHCCCE	50.98	-
182	Sumoylation	LSGERQRKRHKSDSI CCHHHHHHHHHCCCE	50.98	12393906
185	Acetylation	ERQRKRHKSDSISLS HHHHHHHHCCCEEEE	61.05	126230425
185	Sumoylation	ERQRKRHKSDSISLS HHHHHHHHCCCEEEE	61.05	12393906
186	Phosphorylation	RQRKRHKSDSISLSF HHHHHHHCCCEEEEH	30.39	15001356
188	Acetylation	RKRHKSDSISLSFDE HHHHHCCCEEEEHHH	22.59	-
188	Phosphorylation	RKRHKSDSISLSFDE HHHHHCCCEEEEHHH	22.59	15527798
190	Phosphorylation	RHKSDSISLSFDESL HHHCCCEEEEHHHHH	23.16	20708156
191	Acetylation	HKSDSISLSFDESLA HHCCCEEEEHHHHHH	5.88	-
192	Phosphorylation	KSDSISLSFDESLAL HCCCEEEEHHHHHHH	24.70	11504915
194	Phosphorylation	DSISLSFDESLALCV CCEEEEHHHHHHHHH	40.99	15169778
194 (in isoform 5)	Ubiquitination	-	40.99	21890473
196	Phosphorylation	ISLSFDESLALCVIR EEEEHHHHHHHHHHH	22.31	-
198	Phosphorylation	LSFDESLALCVIREI EEHHHHHHHHHHHHH	14.27	-
218	Phosphorylation	SSSESTGTPSNPDLD CCCCCCCCCCCCCCC	24.51	-
220	Phosphorylation	SESTGTPSNPDLDAG CCCCCCCCCCCCCCC	61.91	20708156
224	Phosphorylation	GTPSNPDLDAGVSEH CCCCCCCCCCCCCCC	5.26	-
226	Phosphorylation	PSNPDLDAGVSEHSG CCCCCCCCCCCCCCC	27.81	-
229	Phosphorylation	PDLDAGVSEHSGDWL CCCCCCCCCCCCCCC	28.77	20708156
235	Phosphorylation	VSEHSGDWLDQDSVS CCCCCCCCCCCCCCC	12.83	-
240	Phosphorylation	GDWLDQDSVSDQFSV CCCCCCCCCCCCEEE	20.21	20708156
242	Phosphorylation	WLDQDSVSDQFSVEF CCCCCCCCCCEEEEE	29.64	20708156
246	Phosphorylation	DSVSDQFSVEFEVES CCCCCCEEEEEEEEE	18.33	12167711
248	Phosphorylation	VSDQFSVEFEVESLD CCCCEEEEEEEEECC	34.59	12167711
252	Phosphorylation	FSVEFEVESLDSEDY EEEEEEEEECCCCCC	38.08	12167711
253	Phosphorylation	SVEFEVESLDSEDYS EEEEEEEECCCCCCC	42.52	20708156
256	Phosphorylation	FEVESLDSEDYSLSE EEEEECCCCCCCCCC	37.35	20708156
259	Phosphorylation	ESLDSEDYSLSEEGQ EECCCCCCCCCCCCC	13.88	-
260	Phosphorylation	SLDSEDYSLSEEGQE ECCCCCCCCCCCCCC	37.43	20708156
262	Phosphorylation	DSEDYSLSEEGQELS CCCCCCCCCCCCCCC	27.88	20708156
266	Phosphorylation	YSLSEEGQELSDEDD CCCCCCCCCCCCCCC	52.30	12167711
268	Phosphorylation	LSEEGQELSDEDDEV CCCCCCCCCCCCCCE	6.34	12167711
269	Phosphorylation	SEEGQELSDEDDEVY CCCCCCCCCCCCCEE	37.90	20708156
275	Phosphorylation	LSDEDDEVYQVTVYQ CCCCCCCEEEEEEEE	5.36	15703839
276	Phosphorylation	SDEDDEVYQVTVYQA CCCCCCEEEEEEEEC	8.67	16702947
279	Phosphorylation	DDEVYQVTVYQAGES CCCEEEEEEEECCCC	9.66	20708156
281	Phosphorylation	EVYQVTVYQAGESDT CEEEEEEEECCCCCC	5.36	-
282	Phosphorylation	VYQVTVYQAGESDTD EEEEEEEECCCCCCC	38.26	-
285	Phosphorylation	VTVYQAGESDTDSFE EEEEECCCCCCCCCC	48.75	-
285 (in isoform 10)	Ubiquitination	-	48.75	21890473
286	Phosphorylation	TVYQAGESDTDSFEE EEEECCCCCCCCCCC	44.91	20708156
287	Phosphorylation	VYQAGESDTDSFEED EEECCCCCCCCCCCC	50.67	-
287 (in isoform 10)	Ubiquitination	-	50.67	21890473
288	Phosphorylation	YQAGESDTDSFEEDP EECCCCCCCCCCCCC	42.70	20708156
289 (in isoform 10)	Ubiquitination	-	57.21	21890473
290	Phosphorylation	AGESDTDSFEEDPEI CCCCCCCCCCCCCCC	36.33	20708156
292	Phosphorylation	ESDTDSFEEDPEISL CCCCCCCCCCCCCCH	66.50	-
294	Phosphorylation	DTDSFEEDPEISLAD CCCCCCCCCCCCHHH	38.65	-
295 (in isoform 10)	Ubiquitination	-	44.06	21890473
295 (in isoform 9)	Ubiquitination	-	44.06	21890473
296	Phosphorylation	DSFEEDPEISLADYW CCCCCCCCCCHHHHC	58.49	-
297 (in isoform 9)	Ubiquitination	-	5.07	21890473
299 (in isoform 9)	Ubiquitination	-	5.30	21890473
302	Phosphorylation	PEISLADYWKCTSCN CCCCHHHHCCCCCCC	10.93	-
305 (in isoform 9)	Ubiquitination	-	1.78	21890473
306	Phosphorylation	LADYWKCTSCNEMNP HHHHCCCCCCCCCCC	32.37	-
307	Phosphorylation	ADYWKCTSCNEMNPP HHHCCCCCCCCCCCC	25.15	-
308	Phosphorylation	DYWKCTSCNEMNPPL HHCCCCCCCCCCCCC	2.42	-
315 (in isoform 10)	Ubiquitination	-	7.78	21890473
325 (in isoform 9)	Ubiquitination	-	2.82	21890473
334	Ubiquitination	ENWLPEDKGKDKGEI HCCCCCCCCCCCCCC	67.22	21906983
334 (in isoform 1)	Ubiquitination	-	67.22	21890473
336	Ubiquitination	WLPEDKGKDKGEISE CCCCCCCCCCCCCCH	63.11	21906983
336 (in isoform 1)	Ubiquitination	-	63.11	21890473
338	Ubiquitination	PEDKGKDKGEISEKA CCCCCCCCCCCCHHH	63.03	21906983
338 (in isoform 1)	Ubiquitination	-	63.03	21890473
340	Ubiquitination	DKGKDKGEISEKAKL CCCCCCCCCCHHHCC	49.43	-
340 (in isoform 8)	Ubiquitination	-	49.43	21906983
342	Phosphorylation	GKDKGEISEKAKLEN CCCCCCCCHHHCCCC	28.83	20708156
342	Ubiquitination	GKDKGEISEKAKLEN CCCCCCCCHHHCCCC	28.83	-
342 (in isoform 8)	Ubiquitination	-	28.83	21906983
344	Ubiquitination	DKGEISEKAKLENST CCCCCCHHHCCCCCC	43.99	21906983
344 (in isoform 1)	Ubiquitination	-	43.99	21890473
344 (in isoform 8)	Ubiquitination	-	43.99	21906983
346	Ubiquitination	GEISEKAKLENSTQA CCCCHHHCCCCCCCC	68.36	-
348	Phosphorylation	ISEKAKLENSTQAEE CCHHHCCCCCCCCCC	48.72	-
350	Phosphorylation	EKAKLENSTQAEEGF HHHCCCCCCCCCCCC	16.72	30576142
350	Ubiquitination	EKAKLENSTQAEEGF HHHCCCCCCCCCCCC	16.72	-
350 (in isoform 8)	Ubiquitination	-	16.72	21906983
351	Phosphorylation	KAKLENSTQAEEGFD HHCCCCCCCCCCCCC	43.30	30576142
352	Ubiquitination	AKLENSTQAEEGFDV HCCCCCCCCCCCCCC	46.74	-
352 (in isoform 11)	Ubiquitination	-	46.74	-
356	Phosphorylation	NSTQAEEGFDVPDCK CCCCCCCCCCCCCHH	18.63	-
357	Phosphorylation	STQAEEGFDVPDCKK CCCCCCCCCCCCHHC	10.94	-
363	Ubiquitination	GFDVPDCKKTIVNDS CCCCCCHHCEEECCC	61.40	-
364	Ubiquitination	FDVPDCKKTIVNDSR CCCCCHHCEEECCCH	50.22	2190698
364 (in isoform 1)	Ubiquitination	-	50.22	21890473
365	Phosphorylation	DVPDCKKTIVNDSRE CCCCHHCEEECCCHH	18.69	20708156
369	Ubiquitination	CKKTIVNDSRESCVE HHCEEECCCHHHHHH	37.87	-
369 (in isoform 11)	Ubiquitination	-	37.87	-
370	Phosphorylation	KKTIVNDSRESCVEE HCEEECCCHHHHHHH	32.51	28985074
370	Ubiquitination	KKTIVNDSRESCVEE HCEEECCCHHHHHHH	32.51	-
370 (in isoform 11)	Ubiquitination	-	32.51	-
370 (in isoform 8)	Ubiquitination	-	32.51	21906983
371	Phosphorylation	KTIVNDSRESCVEEN CEEECCCHHHHHHHC	42.59	-
373	Phosphorylation	IVNDSRESCVEENDD EECCCHHHHHHHCCH	23.50	25159151
379	Phosphorylation	ESCVEENDDKITQAS HHHHHHCCHHHHHHH	62.96	-
386	Phosphorylation	DDKITQASQSQESED CHHHHHHHHHHCCCC	22.13	19816404
388	Phosphorylation	KITQASQSQESEDYS HHHHHHHHHCCCCCC	33.16	20708156
392	Phosphorylation	ASQSQESEDYSQPST HHHHHCCCCCCCCCC	61.28	19816404
394	Phosphorylation	QSQESEDYSQPSTSS HHHCCCCCCCCCCCC	12.73	14757045
395	Phosphorylation	SQESEDYSQPSTSSS HHCCCCCCCCCCCCC	48.19	19816404
400	Phosphorylation	DYSQPSTSSSIIYSS CCCCCCCCCCEEECC	26.82	14757045
401	Phosphorylation	YSQPSTSSSIIYSSQ CCCCCCCCCEEECCH	26.16	11331603
405	Phosphorylation	STSSSIIYSSQEDVK CCCCCEEECCHHHHH	10.70	16702947
406	Phosphorylation	TSSSIIYSSQEDVKE CCCCEEECCHHHHHH	18.35	20708156
407	Phosphorylation	SSSIIYSSQEDVKEF CCCEEECCHHHHHHH	22.18	19816404
411	Phosphorylation	IYSSQEDVKEFEREE EECCHHHHHHHHHHH	6.69	-
412	Phosphorylation	YSSQEDVKEFEREET ECCHHHHHHHHHHHH	69.84	-
413	Phosphorylation	SSQEDVKEFEREETQ CCHHHHHHHHHHHHC	53.22	19816404
419	Phosphorylation	KEFEREETQDKEESV HHHHHHHHCCHHHHH	37.00	19816404
425	Phosphorylation	ETQDKEESVESSLPL HHCCHHHHHHHCCCC	32.07	19816404
429	Phosphorylation	KEESVESSLPLNAIE HHHHHHHCCCCCCCC	22.09	16479015
431	Phosphorylation	ESVESSLPLNAIEPC HHHHHCCCCCCCCCE	26.05	19816404
435	Phosphorylation	SSLPLNAIEPCVICQ HCCCCCCCCCEEEEC	6.21	19816404
446	Sumoylation	VICQGRPKNGCIVHG EEECCCCCCCEEECC	65.69	-
446	Sumoylation	VICQGRPKNGCIVHG EEECCCCCCCEEECC	65.69	-
446	Ubiquitination	VICQGRPKNGCIVHG EEECCCCCCCEEECC	65.69	-
452	Sumoylation	PKNGCIVHGKTGHLM CCCCEEECCCCCCHH	16.48	-
454	Ubiquitination	NGCIVHGKTGHLMAC CCEEECCCCCCHHHH	36.13	-
455	Phosphorylation	GCIVHGKTGHLMACF CEEECCCCCCHHHHH	34.13	29523821
463	Phosphorylation	GHLMACFTCAKKLKK CCHHHHHHHHHHHHH	16.07	29523821
466	Acetylation	MACFTCAKKLKKRNK HHHHHHHHHHHHCCC	61.87	15013777
466	Ubiquitination	MACFTCAKKLKKRNK HHHHHHHHHHHHCCC	61.87	-
467	Acetylation	ACFTCAKKLKKRNKP HHHHHHHHHHHCCCC	47.19	15013777
467	Ubiquitination	ACFTCAKKLKKRNKP HHHHHHHHHHHCCCC	47.19	-
469	Acetylation	FTCAKKLKKRNKPCP HHHHHHHHHCCCCCC	59.57	15013777
470	Acetylation	TCAKKLKKRNKPCPV HHHHHHHHCCCCCCC	72.19	15013777
473	Ubiquitination	KKLKKRNKPCPVCRQ HHHHHCCCCCCCCCC	52.62	-
479	Ubiquitination	NKPCPVCRQPIQMIV CCCCCCCCCCCEEEE	45.61	-
479 (in isoform 11)	Ubiquitination	-	45.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
118	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
121	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
157	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
158	T	Phosphorylation	Kinase	PAK6	Q9NQU5	PSP
166	S	Phosphorylation	Kinase	PKM	P14618	PSP
166	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
166	S	Phosphorylation	Kinase	AKT1	P31749	PSP
166	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
166	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
166	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
166	S	Phosphorylation	Kinase	SGK1	O00141	Uniprot
166	S	Phosphorylation	Kinase	PIM1	P11309	PSP
166	S	Phosphorylation	Kinase	DAPK3	O43293	PSP
166	S	Phosphorylation	Kinase	MAPKAPK2	P49138	PSP
172	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
176	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
186	S	Phosphorylation	Kinase	PAK6	Q9NQU5	PSP
186	S	Phosphorylation	Kinase	DAPK3	O43293	PSP
186	S	Phosphorylation	Kinase	PIM1	P11309	PSP
186	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
186	S	Phosphorylation	Kinase	AKT1	P31749	PSP
186	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
188	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
188	S	Phosphorylation	Kinase	AKT1	P31749	PSP
188	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
220	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
229	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
240	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
242	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
246	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
253	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
260	S	Phosphorylation	Kinase	PLK1	P53350	PSP
260	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
260	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
262	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
269	S	Phosphorylation	Kinase	CSNK2B	-	GPS
269	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
269	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
276	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
279	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
281	Y	Phosphorylation	Kinase	SRC	P12931	PSP
290	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
302	Y	Phosphorylation	Kinase	SRC	P12931	PSP
342	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
350	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
351	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
351	T	Phosphorylation	Kinase	PKM	P14618	PSP
365	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
373	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
383	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
386	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
386	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
394	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
394	Y	Phosphorylation	Kinase	ABL1	P00519	PhosphoELM
395	S	Phosphorylation	Kinase	ATM	Q62388	PSP
395	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
405	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
407	S	Phosphorylation	Kinase	ATR	Q13535	PSP
407	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
419	T	Phosphorylation	Kinase	ATM	Q13315	Uniprot
419	T	Phosphorylation	Kinase	CSNK1D	P48730	GPS
425	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
429	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM13	O60858	PMID:21333377
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:24413081
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO31	Q5XUX0	PMID:26124108
-	K	Ubiquitination	E3 ubiquitin ligase	NAT10	Q9H0A0	PMID:26882543
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:26926424
-	K	Ubiquitination	E3 ubiquitin ligase	MDM4	O15151	PMID:10218570
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:10892746
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:20009572

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
166	S	Phosphorylation		19756449
Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	14671306
CTBP1_HUMAN	CTBP1	physical	12867035
P53_HUMAN	TP53	physical	11709713
P73_HUMAN	TP73	physical	10435614
RL11_HUMAN	RPL11	physical	14612427
RL5_HUMAN	RPL5	physical	14612427
CDN2A_HUMAN	CDKN2A	physical	14612427
ARF_HUMAN	CDKN2A	physical	14612427
P53_HUMAN	TP53	physical	14612427
PML_HUMAN	PML	physical	12915590
NUMB_HUMAN	NUMB	physical	12646252
HIF1A_HUMAN	HIF1A	physical	12606552
KAT5_HUMAN	KAT5	physical	11927554
HDAC1_HUMAN	HDAC1	physical	12426395
KAT2B_HUMAN	KAT2B	physical	12068014
EP300_HUMAN	EP300	physical	9809062
P53_HUMAN	TP53	physical	9809062
TBP_HUMAN	TBP	physical	9388200
TAF1_HUMAN	TAF1	physical	9388200
P53_HUMAN	TP53	physical	10722742
MDM2_HUMAN	MDM2	physical	10722742
ARRB2_HUMAN	ARRB2	physical	12488444
CDN2A_HUMAN	CDKN2A	physical	9529249
ARF_HUMAN	CDKN2A	physical	9529249
P53_HUMAN	TP53	physical	9529249
ABL1_HUMAN	ABL1	physical	12110584
CCNG1_HUMAN	CCNG1	physical	12556559
MDM4_HUMAN	MDM4	physical	10218570
RL5_HUMAN	RPL5	physical	7935455
ARRB1_HUMAN	ARRB1	physical	12538596
ARRB2_HUMAN	ARRB2	physical	12538596
P53_HUMAN	TP53	physical	7686617
P73_HUMAN	TP73	physical	10207051
CDN2A_HUMAN	CDKN2A	physical	12085228
ARF_HUMAN	CDKN2A	physical	12085228
CDN2A_HUMAN	CDKN2A	physical	9529248
ARF_HUMAN	CDKN2A	physical	9529248
TBP_HUMAN	TBP	physical	9271120
HIF1A_HUMAN	HIF1A	physical	10640274
MTBP_HUMAN	MTBP	physical	10906133
P53_HUMAN	TP53	physical	12208736
FKBP3_HUMAN	FKBP3	physical	19166840
MDM2_HUMAN	MDM2	physical	19166840
RYBP_HUMAN	RYBP	physical	19098711
P53_HUMAN	TP53	physical	19098711
RIR2B_HUMAN	RRM2B	physical	19015526
RL26_HUMAN	RPL26	physical	18951086
GNAS3_HUMAN	GNAS	physical	18948082
GNAS2_HUMAN	GNAS	physical	18948082
ALEX_HUMAN	GNAS	physical	18948082
GNAS1_HUMAN	GNAS	physical	18948082
FOXO4_HUMAN	FOXO4	physical	18665269
P53_HUMAN	TP53	physical	18665269
IGF1R_HUMAN	IGF1R	physical	18632619
CDN2A_HUMAN	CDKN2A	physical	18583933
ARF_HUMAN	CDKN2A	physical	18583933
DAXX_HUMAN	DAXX	physical	18583933
DYR_HUMAN	DHFR	physical	18451149
GNL3_HUMAN	GNL3	physical	18426907
RL5_HUMAN	RPL5	physical	18426907
RL11_HUMAN	RPL11	physical	18426907
PSD10_HUMAN	PSMD10	physical	18332869
P53_HUMAN	TP53	physical	18332869
PSME3_HUMAN	PSME3	physical	18309296
P53_HUMAN	TP53	physical	18309296
MDM4_HUMAN	MDM4	physical	18219319
NUMB_HUMAN	NUMB	physical	18172499
P53_HUMAN	TP53	physical	18172499
P53_HUMAN	TP53	physical	18485870
PPM1D_HUMAN	PPM1D	physical	17936559
MDM2_HUMAN	MDM2	physical	17936559
P53_HUMAN	TP53	physical	17908790
CSN5_HUMAN	COPS5	physical	17879958
1433S_HUMAN	SFN	physical	17546054
P53_HUMAN	TP53	physical	17525743
RBBP6_HUMAN	RBBP6	physical	17470788
P53_HUMAN	TP53	physical	17380154
UBP7_HUMAN	USP7	physical	17380154
P53_HUMAN	TP53	physical	17139261
CADH1_HUMAN	CDH1	physical	16980628
MDM2_HUMAN	MDM2	physical	16965791
1433T_HUMAN	YWHAQ	physical	16943424
P53_HUMAN	TP53	physical	16866370
P53_HUMAN	TP53	physical	16857591
MDM2_HUMAN	MDM2	physical	16803902
P53_HUMAN	TP53	physical	16579792
P53_HUMAN	TP53	physical	16547496
IFIX_HUMAN	PYHIN1	physical	16479015
MDM2_HUMAN	MDM2	physical	16714300
UBP7_HUMAN	USP7	physical	16402859
MDM4_HUMAN	MDM4	physical	16227609
DDX17_HUMAN	DDX17	physical	17226766
E2F1_HUMAN	E2F1	physical	16170383
P53_HUMAN	TP53	physical	19085961
TIF1B_HUMAN	TRIM28	physical	16107876
P53_HUMAN	TP53	physical	16107876
CDN2A_HUMAN	CDKN2A	physical	16107876
ARF_HUMAN	CDKN2A	physical	16107876
PSD10_HUMAN	PSMD10	physical	16023600
P53_HUMAN	TP53	physical	16023600
UBC_HUMAN	UBC	physical	16023600
P53_HUMAN	TP53	physical	15933712
ATF3_HUMAN	ATF3	physical	15933712
MTBP_HUMAN	MTBP	physical	15632057
H2B2E_HUMAN	HIST2H2BE	physical	15546622
RL5_HUMAN	RPL5	physical	15314173
RL11_HUMAN	RPL11	physical	15314173
RL23_HUMAN	RPL23	physical	15314173
RL5_HUMAN	RPL5	physical	15308643
RL11_HUMAN	RPL11	physical	15308643
RL23_HUMAN	RPL23	physical	15308643
P53_HUMAN	TP53	physical	15308643
P53_HUMAN	TP53	physical	16624812
TYY1_HUMAN	YY1	physical	15210108
AKT1_HUMAN	AKT1	physical	12145204
P53_HUMAN	TP53	physical	15064742
RD23A_HUMAN	RAD23A	physical	15064742
KAT2B_HUMAN	KAT2B	physical	14769800
CDN1A_HUMAN	CDKN1A	physical	14761977
MDM2_HUMAN	MDM2	physical	14596917
P53_HUMAN	TP53	physical	14596917
P53_HUMAN	TP53	physical	12944468
TAT_HV1H2	tat	physical	12883554
MDM4_HUMAN	MDM4	physical	12860999
IGF1R_HUMAN	IGF1R	physical	12821780
P53_MOUSE	Trp53	physical	12771937
ANDR_HUMAN	AR	physical	15640443
HDAC1_HUMAN	HDAC1	physical	15640443
P53_HUMAN	TP53	physical	15154850
P53_HUMAN	TP53	physical	15908921
P53_HUMAN	TP53	physical	11925449
CDN2A_MOUSE	Cdkn2a	physical	11718560
ARF_MOUSE	Cdkn2a	physical	11718560
P53_HUMAN	TP53	physical	11713288
PSD10_HUMAN	PSMD10	physical	17904523
P53_HUMAN	TP53	physical	11431470
P53_HUMAN	TP53	physical	21454483
UBC9_HUMAN	UBE2I	physical	11384992
MDM4_HUMAN	MDM4	physical	20473904
CDN2A_HUMAN	CDKN2A	physical	11223036
ARF_HUMAN	CDKN2A	physical	11223036
P53_HUMAN	TP53	physical	11046142
CDN2A_HUMAN	CDKN2A	physical	10822382
ARF_HUMAN	CDKN2A	physical	10822382
P53_HUMAN	TP53	physical	10488081
H31T_HUMAN	HIST3H3	physical	20588255
EHMT1_HUMAN	EHMT1	physical	20588255
SUV91_HUMAN	SUV39H1	physical	20588255
P53_HUMAN	TP53	physical	20588255
P53_HUMAN	TP53	physical	11597128
ARRB2_HUMAN	ARRB2	physical	11588219
ADRB2_HUMAN	ADRB2	physical	11588219
TAF1_HUMAN	TAF1	physical	17237821
SIVA_HUMAN	SIVA1	physical	19590512
P53_HUMAN	TP53	physical	19837670
MTA1_HUMAN	MTA1	physical	19837670
UBP7_HUMAN	USP7	physical	20713061
MDM4_HUMAN	MDM4	physical	19432880
VIF_HV1B1	vif	physical	19128510
VIF_HV1BR	vif	physical	19128510
VIF_HV1H2	vif	physical	19128510
MDM2_HUMAN	MDM2	physical	17301054
MDM4_HUMAN	MDM4	physical	17301054
RS27A_HUMAN	RPS27A	physical	21561866
G3BP2_HUMAN	G3BP2	physical	17297477
PK1IP_HUMAN	PAK1IP1	physical	21097889
RL5_HUMAN	RPL5	physical	21097889
RL11_HUMAN	RPL11	physical	21097889
P53_HUMAN	TP53	physical	19411846
KS6B1_HUMAN	RPS6KB1	physical	20657550
P53_HUMAN	TP53	physical	20657550
P63_HUMAN	TP63	physical	21088494
P53_HUMAN	TP53	physical	21088494
P73_HUMAN	TP73	physical	21088494
P53_HUMAN	TP53	physical	17301054
UBP10_HUMAN	USP10	physical	20096447
PSMD2_HUMAN	PSMD2	physical	20479273
PRS4_HUMAN	PSMC1	physical	20479273
PSMD4_HUMAN	PSMD4	physical	20479273
PRS6A_HUMAN	PSMC3	physical	20479273
PRS8_HUMAN	PSMC5	physical	20479273
PRS10_HUMAN	PSMC6	physical	20479273
PSA7_HUMAN	PSMA7	physical	20479273
PSMD1_HUMAN	PSMD1	physical	20479273
GNL3_HUMAN	GNL3	physical	21132010
GNL3L_HUMAN	GNL3L	physical	21132010
TERT_HUMAN	TERT	physical	20453884
APEX1_HUMAN	APEX1	physical	19219073
SOX4_HUMAN	SOX4	physical	19234109
P53_HUMAN	TP53	physical	19568783
UBE4B_HUMAN	UBE4B	physical	21317885
BI2L1_HUMAN	BAIAP2L1	physical	21887275
P53_HUMAN	TP53	physical	21887275
RL11_HUMAN	RPL11	physical	20554519
RL5_HUMAN	RPL5	physical	20554519
P53_HUMAN	TP53	physical	16845383
DAXX_HUMAN	DAXX	physical	16845383
MDM2_HUMAN	MDM2	physical	16845383
UBP7_HUMAN	USP7	physical	16845383
FOXO4_HUMAN	FOXO4	physical	20874444
P53_HUMAN	TP53	physical	20173098
RS7_HUMAN	RPS7	physical	19683495
MDM4_HUMAN	MDM4	physical	19683495
MDM2_HUMAN	MDM2	physical	19683495
ERBB3_HUMAN	ERBB3	physical	21930127
AKT1_HUMAN	AKT1	physical	21930127
PA2G4_HUMAN	PA2G4	physical	21930127
HEXI1_HUMAN	HEXIM1	physical	19617712
CDK9_HUMAN	CDK9	physical	19617712
MDM2_HUMAN	MDM2	physical	21084285
P53_HUMAN	TP53	physical	21084285
DYRK2_HUMAN	DYRK2	physical	19965871
ATF3_HUMAN	ATF3	physical	20592017
HS90A_HUMAN	HSP90AA1	physical	20540933
HSP74_HUMAN	HSPA4	physical	20540933
HSP7C_HUMAN	HSPA8	physical	20540933
LAMP2_HUMAN	LAMP2	physical	20540933
RS3_HUMAN	RPS3	physical	19656744
P53_HUMAN	TP53	physical	19656744
UBP2_HUMAN	USP2	physical	17290220
P53_HUMAN	TP53	physical	17290220
TRI13_HUMAN	TRIM13	physical	21333377
P53_HUMAN	TP53	physical	19857530
MDM4_HUMAN	MDM4	physical	19619542
MDM2_HUMAN	MDM2	physical	19619542
P53_HUMAN	TP53	physical	19816404
MDM2_HUMAN	MDM2	physical	20479273
P53_HUMAN	TP53	physical	20479273
XRCC6_HUMAN	XRCC6	physical	19247369
PSMD4_HUMAN	PSMD4	physical	19240029
GORAB_HUMAN	GORAB	physical	20598683
FOXO1_HUMAN	FOXO1	physical	19321440
FOXO3_HUMAN	FOXO3	physical	19321440
UCHL1_HUMAN	UCHL1	physical	20395212
CDN2A_HUMAN	CDKN2A	physical	20395212
ARF_HUMAN	CDKN2A	physical	20395212
P53_HUMAN	TP53	physical	20395212
S10A1_HUMAN	S100A1	physical	20591429
S10A2_HUMAN	S100A2	physical	20591429
S10A4_HUMAN	S100A4	physical	20591429
S10A6_HUMAN	S100A6	physical	20591429
S100B_HUMAN	S100B	physical	20591429
P53_HUMAN	TP53	physical	21986495
UBP7_HUMAN	USP7	physical	20816748
P53_HUMAN	TP53	physical	21478269
CUL1_HUMAN	CUL1	physical	20708156
FBW1A_HUMAN	BTRC	physical	20708156
KC1D_HUMAN	CSNK1D	physical	20708156
RFWD2_HUMAN	RFWD2	physical	20333547
ZN363_HUMAN	RCHY1	physical	20333547
MDM4_HUMAN	MDM4	physical	22120712
CDN2A_HUMAN	CDKN2A	physical	22120712
ARF_HUMAN	CDKN2A	physical	22120712
SMUF1_HUMAN	SMURF1	physical	20484049
P53_HUMAN	TP53	physical	20484049
MDM2_HUMAN	MDM2	physical	20484049
MDM4_HUMAN	MDM4	physical	20484049
NOTC4_HUMAN	NOTCH4	physical	21402876
KC1A_HUMAN	CSNK1A1	physical	19759023
P53_HUMAN	TP53	physical	20124408
P53_HUMAN	TP53	physical	22124327
PDLI7_HUMAN	PDLIM7	physical	21060154
P53_HUMAN	TP53	physical	21060154
MDM2_HUMAN	MDM2	physical	21060154
SENP3_HUMAN	SENP3	physical	21316347
P53_HUMAN	TP53	physical	21316347
MDM4_HUMAN	MDM4	physical	21925390
P53_HUMAN	TP53	physical	21925390
RL5_HUMAN	RPL5	physical	21925390
P53_HUMAN	TP53	physical	22157679
PDE4D_HUMAN	PDE4D	physical	19372219
NUCL_HUMAN	NCL	physical	22103682
P53_HUMAN	TP53	physical	22103682
NOTC1_HUMAN	NOTCH1	physical	22128911
P53_HUMAN	TP53	physical	21965653
RL26_HUMAN	RPL26	physical	20542919
P53_HUMAN	TP53	physical	20542919
PSME3_HUMAN	PSME3	physical	21084564
P53_HUMAN	TP53	physical	21084564
KAT5_HUMAN	KAT5	physical	18264029
RASF1_HUMAN	RASSF1	physical	18566590
DAXX_HUMAN	DAXX	physical	18566590
UBP7_HUMAN	USP7	physical	18566590
P53_HUMAN	TP53	physical	18566590
ARRB2_HUMAN	ARRB2	physical	21389118
P53_HUMAN	TP53	physical	15058298
PA2G4_HUMAN	PA2G4	physical	21098709
P53_HUMAN	TP53	physical	21098709
ANDR_HUMAN	AR	physical	21157430
P53_HUMAN	TP53	physical	20694676
MDM4_MOUSE	Mdm4	physical	21572037
P53_HUMAN	TP53	physical	21572037
P53_HUMAN	TP53	physical	20659896
P53_HUMAN	TP53	physical	22227409
P53_HUMAN	TP53	physical	15013777
RB_HUMAN	RB1	physical	21990374
P53_HUMAN	TP53	physical	11486026
ARRB1_HUMAN	ARRB1	physical	15878855
ARRB2_HUMAN	ARRB2	physical	15878855
RS14_HUMAN	RPS14	physical	22525275
P53_HUMAN	TP53	physical	22525275
P53_HUMAN	TP53	physical	22487680
P73_HUMAN	TP73	physical	18499675
PSMD4_HUMAN	PSMD4	physical	22659184
PRS6A_HUMAN	PSMC3	physical	22659184
PSB6_HUMAN	PSMB6	physical	22659184
PSA7L_HUMAN	PSMA8	physical	22659184
RASF3_HUMAN	RASSF3	physical	22593196
NR0B2_HUMAN	NR0B2	physical	22575647
P53_HUMAN	TP53	physical	22575647
PSA7_HUMAN	PSMA7	physical	16337594
P53_HUMAN	TP53	physical	17666403
UBE2A_HUMAN	UBE2A	physical	22083959
LATS1_HUMAN	LATS1	physical	22195963
P53_HUMAN	TP53	physical	9450543
P53_HUMAN	TP53	physical	22444248
P63_HUMAN	TP63	physical	20571051
MDM2_HUMAN	MDM2	physical	17170710
UB2D1_HUMAN	UBE2D1	physical	17170710
RAD50_HUMAN	RAD50	physical	15734743
NBN_HUMAN	NBN	physical	15734743
MRE11_HUMAN	MRE11A	physical	15734743
P53_HUMAN	TP53	physical	20962272
RS14_HUMAN	RPS14	physical	22391559
NBN_HUMAN	NBN	physical	18541670
CDN2A_HUMAN	CDKN2A	physical	18541670
ARF_HUMAN	CDKN2A	physical	18541670
P53_HUMAN	TP53	physical	18541670
P53_HUMAN	TP53	physical	21584881
P53_HUMAN	TP53	physical	17159902
P53_HUMAN	TP53	physical	10827196
MDM4_HUMAN	MDM4	physical	10827196
P53_HUMAN	TP53	physical	16861890
PCNA_HUMAN	PCNA	physical	16861890
1433T_HUMAN	YWHAQ	physical	20086099
P53_HUMAN	TP53	physical	22389628
ESR1_HUMAN	ESR1	physical	17545634
JMY_MOUSE	Jmy	physical	17170761
MDM2_HUMAN	MDM2	physical	22333590
MDM4_HUMAN	MDM4	physical	22333590
UBP7_HUMAN	USP7	physical	16474402
P53_HUMAN	TP53	physical	10640350
P53_HUMAN	TP53	physical	10889512
P53_HUMAN	TP53	physical	22737255
P53_HUMAN	TP53	physical	17848574
1433S_HUMAN	SFN	physical	19166854
P53_HUMAN	TP53	physical	16414131
CDN1A_HUMAN	CDKN1A	physical	20308078
ARRB1_HUMAN	ARRB1	physical	21081496
ARBK1_HUMAN	ADRBK1	physical	21081496
P53_HUMAN	TP53	physical	15950904
MDM2_HUMAN	MDM2	physical	15950904
RL5_HUMAN	RPL5	physical	15314174
RL11_HUMAN	RPL11	physical	15314174
RL5_HUMAN	RPL5	physical	17116689
RL11_HUMAN	RPL11	physical	17116689
RL23_HUMAN	RPL23	physical	17116689
CDN2A_HUMAN	CDKN2A	physical	17116689
ARF_HUMAN	CDKN2A	physical	17116689
P53_HUMAN	TP53	physical	17116689
RB_HUMAN	RB1	physical	20871633
P53_HUMAN	TP53	physical	11285227
P53_HUMAN	TP53	physical	20234175
AATF_HUMAN	AATF	physical	17468107
RL5_HUMAN	RPL5	physical	18560357
RL11_HUMAN	RPL11	physical	18560357
P53_HUMAN	TP53	physical	15001357
HS90A_HUMAN	HSP90AA1	physical	15001357
P53_HUMAN	TP53	physical	11697899
HNRPK_HUMAN	HNRNPK	physical	22825850
E2F1_HUMAN	E2F1	physical	18754770
P53_HUMAN	TP53	physical	15094782
P53_HUMAN	TP53	physical	19160491
CDN2A_MOUSE	Cdkn2a	physical	10713175
ARF_MOUSE	Cdkn2a	physical	10713175
FOXO3_HUMAN	FOXO3	physical	18204439
SUMO1_HUMAN	SUMO1	physical	12297306
RASF5_HUMAN	RASSF5	physical	22173032
P53_HUMAN	TP53	physical	11714701
P63_HUMAN	TP63	physical	11714701
CDN2A_HUMAN	CDKN2A	physical	10801444
ARF_HUMAN	CDKN2A	physical	10801444
MDM2_HUMAN	MDM2	physical	15001357
UB2D2_HUMAN	UBE2D2	physical	20705607
P53_HUMAN	TP53	physical	20705607
P53_HUMAN	TP53	physical	20639885
UB2D2_HUMAN	UBE2D2	physical	22902369
NPM_HUMAN	NPM1	physical	15144954
P53_HUMAN	TP53	physical	15144954
P53_HUMAN	TP53	physical	16678796
NUMB_HUMAN	NUMB	physical	16678796
TELT_HUMAN	TCAP	physical	16678796
PSMD4_HUMAN	PSMD4	physical	22350919
CDN2A_HUMAN	CDKN2A	physical	16173922
ARF_HUMAN	CDKN2A	physical	16173922
CK5P3_HUMAN	CDK5RAP3	physical	16173922
P53_HUMAN	TP53	physical	16173922
P53_HUMAN	TP53	physical	22819825
ARI2_HUMAN	ARIH2	physical	22819825
P53_HUMAN	TP53	physical	22331460
P53_HUMAN	TP53	physical	22948151
KC1A_HUMAN	CSNK1A1	physical	22916255
P53_HUMAN	TP53	physical	22916255
IRF2_HUMAN	IRF2	physical	19032150
RS25_HUMAN	RPS25	physical	22777350
P53_HUMAN	TP53	physical	10435614
TCTP_HUMAN	TPT1	physical	22912717
P53_HUMAN	TP53	physical	22912717
P53_HUMAN	TP53	physical	22920093
P53_HUMAN	TP53	physical	22266868
ANGI_HUMAN	ANG	physical	22266868
CHK2_HUMAN	CHEK2	physical	19176998
RHOA_HUMAN	RHOA	physical	22907703
P53_HUMAN	TP53	physical	22301280
P53_HUMAN	TP53	physical	18813780
CDN2A_HUMAN	CDKN2A	physical	18813780
ARF_HUMAN	CDKN2A	physical	18813780
P53_HUMAN	TP53	physical	18981217
P53_HUMAN	TP53	physical	11112690
P53_HUMAN	TP53	physical	22474335
P53_HUMAN	TP53	physical	18815136
P53_HUMAN	TP53	physical	15824742
MDM4_HUMAN	MDM4	physical	17616658
MDM2_HUMAN	MDM2	physical	17426254
P53_HUMAN	TP53	physical	17426254
MDM4_HUMAN	MDM4	physical	20724842
LATS2_HUMAN	LATS2	physical	17015431
P53_HUMAN	TP53	physical	19081178
PIM1_HUMAN	PIM1	physical	18467333
P53_HUMAN	TP53	physical	18467333
CDN2A_HUMAN	CDKN2A	physical	18467333
ARF_HUMAN	CDKN2A	physical	18467333
MED1_HUMAN	MED1	physical	15848166
P53_HUMAN	TP53	physical	22032989
ERCC8_HUMAN	ERCC8	physical	22032989
ERCC6_HUMAN	ERCC6	physical	22032989
DDB1_HUMAN	DDB1	physical	22032989
CUL4A_HUMAN	CUL4A	physical	22032989
CUL4B_HUMAN	CUL4B	physical	22032989
P53_HUMAN	TP53	physical	8875929
RL11_HUMAN	RPL11	physical	21903592
P53_HUMAN	TP53	physical	19106616
P53_HUMAN	TP53	physical	12381304
MDM2_HUMAN	MDM2	physical	16905769
P53_HUMAN	TP53	physical	16905769
HIPK2_HUMAN	HIPK2	physical	16212962
P53_HUMAN	TP53	physical	11839577
P53_HUMAN	TP53	physical	16870621
P53_HUMAN	TP53	physical	19305137
DAXX_HUMAN	DAXX	physical	15364927
DHRS2_HUMAN	DHRS2	physical	20547751
RL5_HUMAN	RPL5	physical	20547751
RL11_HUMAN	RPL11	physical	20547751
RL23_HUMAN	RPL23	physical	20547751
P53_HUMAN	TP53	physical	17875722
CHK2_HUMAN	CHEK2	physical	15862297
P53_HUMAN	TP53	physical	16159876
ESR1_HUMAN	ESR1	physical	11178989
P53_HUMAN	TP53	physical	9582019
ITCH_HUMAN	ITCH	physical	21093410
MDM2_HUMAN	MDM2	physical	17373842
EF1A1_HUMAN	EEF1A1	physical	17373842
DCD_HUMAN	DCD	physical	17373842
TBB5_HUMAN	TUBB	physical	17373842
TBB2A_HUMAN	TUBB2A	physical	17373842
K1C14_HUMAN	KRT14	physical	17373842
RS20_HUMAN	RPS20	physical	17373842
RL5_HUMAN	RPL5	physical	17373842
G3P_HUMAN	GAPDH	physical	17373842
RL11_HUMAN	RPL11	physical	17373842
CDN1A_HUMAN	CDKN1A	physical	17373842
TBA1C_HUMAN	TUBA1C	physical	17373842
GELS_HUMAN	GSN	physical	17373842
P53_HUMAN	TP53	physical	18604177
P53_HUMAN	TP53	physical	21261729
P73_HUMAN	TP73	physical	21261729
P53_HUMAN	TP53	physical	19411066
XIAP_HUMAN	XIAP	physical	19411066
P53_HUMAN	TP53	physical	19033382
GNL3_HUMAN	GNL3	physical	19033382
HNF4A_HUMAN	HNF4A	physical	22197810
NR0B2_HUMAN	NR0B2	physical	22197810
MDM4_HUMAN	MDM4	physical	10608892
TIF1B_HUMAN	TRIM28	physical	17056014
P73_HUMAN	TP73	physical	10469568
P53_HUMAN	TP53	physical	18234963
RL5_HUMAN	RPL5	physical	17242401
RL11_HUMAN	RPL11	physical	17242401
MDM4_HUMAN	MDM4	physical	12370303
PLK1_HUMAN	PLK1	physical	19833129
NDKB_HUMAN	NME2	physical	21504894
HIPK2_HUMAN	HIPK2	physical	17349959
RB_HUMAN	RB1	physical	15485814
RB_HUMAN	RB1	physical	7791904
P53_HUMAN	TP53	physical	14559824
P53_HUMAN	TP53	physical	22374672
P53_HUMAN	TP53	physical	15242646
NPM_HUMAN	NPM1	physical	23039052
HS90A_HUMAN	HSP90AA1	physical	15001356
NEDD4_HUMAN	NEDD4	physical	15001356
DAPK1_HUMAN	DAPK1	physical	15001356
DAPK3_HUMAN	DAPK3	physical	15001356
KC1D_HUMAN	CSNK1D	physical	22976441
PBX1_HUMAN	PBX1	physical	23044487
P53_HUMAN	TP53	physical	16338390
P53_HUMAN	TP53	physical	21471462
RS7_HUMAN	RPS7	physical	17310983
P53_HUMAN	TP53	physical	17318220
UB2D1_HUMAN	UBE2D1	physical	14671306
P53_HUMAN	TP53	genetic	16201274
UB2D1_HUMAN	UBE2D1	physical	12646252
P53_HUMAN	TP53	physical	20235143
UB2D2_HUMAN	UBE2D2	physical	18665269
UB2D1_HUMAN	UBE2D1	physical	9450543
UB2D1_HUMAN	UBE2D1	physical	22124327
UB2D3_HUMAN	UBE2D3	physical	19656744
UB2D2_HUMAN	UBE2D2	physical	10722742
UB2D1_HUMAN	UBE2D1	physical	17301054
UB2D2_HUMAN	UBE2D2	physical	20874444
UB2D3_HUMAN	UBE2D3	physical	20484049
UB2D2_HUMAN	UBE2D2	physical	19619542
UB2D1_HUMAN	UBE2D1	physical	19965871
UB2D1_HUMAN	UBE2D1	physical	20173098
UB2D1_HUMAN	UBE2D1	physical	21887275
UB2D2_HUMAN	UBE2D2	physical	19219073
UB2D3_HUMAN	UBE2D3	physical	15546622
UB2D3_HUMAN	UBE2D3	physical	21572037
UB2D2_HUMAN	UBE2D2	physical	18451149
UB2D1_HUMAN	UBE2D1	physical	15013777
UB2D3_HUMAN	UBE2D3	physical	11486026
UB2D1_HUMAN	UBE2D1	physical	18632619
UB2D2_HUMAN	UBE2D2	physical	18632619
UB2L3_HUMAN	UBE2L3	physical	16714300
UB2D2_HUMAN	UBE2D2	physical	17159902
UB2D1_HUMAN	UBE2D1	physical	17848574
UB2D2_HUMAN	UBE2D2	physical	15950904
UB2D1_HUMAN	UBE2D1	physical	15001357
UB2D2_HUMAN	UBE2D2	physical	14769800
UB2D1_HUMAN	UBE2D1	physical	22331460
UB2D1_HUMAN	UBE2D1	physical	22916255
UB2D1_HUMAN	UBE2D1	physical	19032150
UB2D3_HUMAN	UBE2D3	physical	20453884
UB2D2_HUMAN	UBE2D2	physical	22301280
UB2D3_HUMAN	UBE2D3	physical	19683495
UB2D2_HUMAN	UBE2D2	physical	21084285
UB2D3_HUMAN	UBE2D3	physical	22032989
UB2D2_HUMAN	UBE2D2	physical	17349959
UB2D2_HUMAN	UBE2D2	physical	19816404
UB2D1_HUMAN	UBE2D1	physical	19247369
UB2D1_HUMAN	UBE2D1	physical	20124408
UB2D3_HUMAN	UBE2D3	physical	21060154
UB2D2_HUMAN	UBE2D2	physical	22157679
UB2D2_HUMAN	UBE2D2	physical	19372219
UB2D3_HUMAN	UBE2D3	physical	21965653
UB2D2_HUMAN	UBE2D2	physical	21965653
UB2E2_HUMAN	UBE2E2	physical	21965653
UB2E3_HUMAN	UBE2E3	physical	21965653
UB2D1_HUMAN	UBE2D1	physical	21157430
UB2D1_HUMAN	UBE2D1	physical	20694676
MDM2_HUMAN	MDM2	physical	22989009
UB2D2_HUMAN	UBE2D2	physical	22989009
P53_HUMAN	TP53	physical	15558054
RS14_HUMAN	RPS14	physical	23246961
P53_HUMAN	TP53	physical	23246961
P53_HUMAN	TP53	physical	23318437
RING2_HUMAN	RNF2	physical	23318437
RL5_HUMAN	RPL5	physical	23169665
RL11_HUMAN	RPL11	physical	23169665
P53_HUMAN	TP53	physical	23169665
P53_HUMAN	TP53	physical	23150668
UB2D1_HUMAN	UBE2D1	physical	23150668
ANDR_HUMAN	AR	physical	23132866
PAK6_HUMAN	PAK6	physical	23132866
HNRPK_HUMAN	HNRNPK	physical	23092970
EF1A1_HUMAN	EEF1A1	physical	23260144
DLG4_HUMAN	DLG4	physical	23260144
NOTC1_HUMAN	NOTCH1	physical	23252402
IRF1_HUMAN	IRF1	physical	23134341
P53_HUMAN	TP53	physical	23134341
NUMB_HUMAN	NUMB	physical	23252402
P53_HUMAN	TP53	physical	23252402
DAXX_HUMAN	DAXX	physical	23405218
SNAI1_HUMAN	SNAI1	physical	20385133
CDN2A_HUMAN	CDKN2A	physical	20713054
ARF_HUMAN	CDKN2A	physical	20713054
P53_HUMAN	TP53	physical	17347673
MDM2_HUMAN	MDM2	physical	17347673
ARBK1_HUMAN	ADRBK1	physical	17006543
RL5_HUMAN	RPL5	physical	21399665
RL11_HUMAN	RPL11	physical	21399665
ANDR_HUMAN	AR	physical	18332867
AKT1_HUMAN	AKT1	physical	18332867
RL11_HUMAN	RPL11	physical	17110929
RL5_HUMAN	RPL5	physical	17110929
RL23_HUMAN	RPL23	physical	17110929
MDM4_HUMAN	MDM4	physical	23028042
P53_HUMAN	TP53	physical	22262183
GA45A_HUMAN	GADD45A	physical	23563151
RABL6_HUMAN	RABL6	physical	23572512
P53_HUMAN	TP53	physical	23572512
EP300_HUMAN	EP300	physical	11070080
P53_HUMAN	TP53	physical	11070080
P53_HUMAN	TP53	physical	20047188
P53_HUMAN	TP53	physical	23671280
MDM2_HUMAN	MDM2	physical	23671280
UB2D1_HUMAN	UBE2D1	physical	23671280
MDM4_HUMAN	MDM4	physical	23671280
RL11_HUMAN	RPL11	physical	23728348
P53_HUMAN	TP53	physical	23728348
RS26_HUMAN	RPS26	physical	23728348
P53_HUMAN	TP53	physical	23776465
RL11_HUMAN	RPL11	physical	23776465
P53_HUMAN	TP53	physical	23826318
UB2D1_HUMAN	UBE2D1	physical	19597489
P53_HUMAN	TP53	physical	19597489
UB2D2_HUMAN	UBE2D2	physical	23871895
MDM2_HUMAN	MDM2	physical	23871895
P53_HUMAN	TP53	physical	23880345
RL37_HUMAN	RPL37	physical	23874713
RS15_HUMAN	RPS15	physical	23874713
RS20_HUMAN	RPS20	physical	23874713
RNF8_HUMAN	RNF8	physical	22493164
MDM4_HUMAN	MDM4	physical	22493164
TRIM4_HUMAN	TRIM4	physical	22493164
TRI23_HUMAN	TRIM23	physical	22493164
TRAF5_HUMAN	TRAF5	physical	22493164
TRIM9_HUMAN	TRIM9	physical	22493164
MKRN3_HUMAN	MKRN3	physical	22493164
MDM2_HUMAN	MDM2	physical	22493164
PHF7_HUMAN	PHF7	physical	22493164
RNF10_HUMAN	RNF10	physical	22493164
RN126_HUMAN	RNF126	physical	22493164
MDM4_HUMAN	MDM4	physical	21988832
SETB1_HUMAN	SETDB1	physical	21988832
YYAP1_HUMAN	YY1AP1	physical	21988832
RL11_HUMAN	RPL11	physical	21988832
NACAM_HUMAN	NACA	physical	21988832
NACA_HUMAN	NACA	physical	21988832
MYD88_HUMAN	MYD88	physical	21988832
TF65_HUMAN	RELA	physical	21988832
RL26_HUMAN	RPL26	physical	21988832
RS7_HUMAN	RPS7	physical	21988832
RS27A_HUMAN	RPS27A	physical	21988832
C560_HUMAN	SDHC	physical	21988832
P53_HUMAN	TP53	physical	21988832
WT1_HUMAN	WT1	physical	21988832
SRBS2_HUMAN	SORBS2	physical	21988832
SHPK_HUMAN	SHPK	physical	21988832
POTE1_HUMAN	POT1	physical	21988832
SESN2_HUMAN	SESN2	physical	21988832
RASF6_HUMAN	RASSF6	physical	24003224
JUND_HUMAN	JUND	physical	20195357
EZRI_HUMAN	EZR	physical	20195357
RYR2_HUMAN	RYR2	physical	20195357
JUN_HUMAN	JUN	physical	20195357
CSTN1_HUMAN	CLSTN1	physical	20195357
A4_HUMAN	APP	physical	20195357
CLUS_HUMAN	CLU	physical	20195357
SREK1_HUMAN	SREK1	physical	20195357
SET_HUMAN	SET	physical	20195357
ENPL_HUMAN	HSP90B1	physical	20195357
CWC25_HUMAN	CWC25	physical	20195357
NUCL_HUMAN	NCL	physical	20195357
ZN133_HUMAN	ZNF133	physical	20195357
KPYM_HUMAN	PKM	physical	20195357
SIVA_HUMAN	SIVA1	physical	22343716
MDM2_HUMAN	MDM2	physical	17989425
P53_HUMAN	TP53	physical	17989425
MDM2_HUMAN	MDM2	physical	16338389
P53_HUMAN	TP53	physical	23483203
EID1_HUMAN	EID1	physical	24167073
UB2D3_HUMAN	UBE2D3	physical	24167073
RL6_HUMAN	RPL6	physical	24174547
XIAP_HUMAN	XIAP	physical	23749209
UBC_HUMAN	UBC	physical	24143256
NOC2L_HUMAN	NOC2L	physical	24413661
JAK1_HUMAN	JAK1	physical	24413661
P53_HUMAN	TP53	physical	24413661
UBE4B_HUMAN	UBE4B	physical	24587254
P53_HUMAN	TP53	physical	24127580
UB2D2_HUMAN	UBE2D2	physical	24127580
IRF1_HUMAN	IRF1	physical	24721577
PGAM1_HUMAN	PGAM1	physical	24567357
PGAM2_HUMAN	PGAM2	physical	24567357
P53_HUMAN	TP53	physical	24567357
UB2D2_HUMAN	UBE2D2	physical	24567357
DNJB1_HUMAN	DNAJB1	physical	24361594
P53_HUMAN	TP53	physical	24361594
GNL3_HUMAN	GNL3	physical	24769896
MDM2_HUMAN	MDM2	physical	24755078
P53_HUMAN	TP53	physical	24842904
UB2D3_HUMAN	UBE2D3	physical	24842904
MDM2_HUMAN	MDM2	physical	24804778
CUL1_HUMAN	CUL1	physical	24804778
ANC2_HUMAN	ANAPC2	physical	24804778
SNAI2_HUMAN	SNAI2	physical	23438693
FHIT_HUMAN	FHIT	physical	15313915
P53_HUMAN	TP53	physical	15313915
MDM2_HUMAN	MDM2	physical	16331255
P53_HUMAN	TP53	physical	16331255
MDM2_HUMAN	MDM2	physical	19132120
P53_HUMAN	TP53	physical	23802716
P53_HUMAN	TP53	physical	23261415
DAXX_HUMAN	DAXX	physical	23038753
RASF1_HUMAN	RASSF1	physical	23038753
P53_HUMAN	TP53	physical	24314634
MDM2_HUMAN	MDM2	physical	24147044
ADAS_HUMAN	AGPS	physical	24147044
A16A1_HUMAN	ALDH16A1	physical	24147044
DDX5_HUMAN	DDX5	physical	24147044
DHX9_HUMAN	DHX9	physical	24147044
ODP2_HUMAN	DLAT	physical	24147044
EDC4_HUMAN	EDC4	physical	24147044
E2AK1_HUMAN	EIF2AK1	physical	24147044
ESYT1_HUMAN	ESYT1	physical	24147044
GTF2I_HUMAN	GTF2I	physical	24147044
HMHA1_HUMAN	HMHA1	physical	24147044
HNRPM_HUMAN	HNRNPM	physical	24147044
HNRPU_HUMAN	HNRNPU	physical	24147044
HORN_HUMAN	HRNR	physical	24147044
HS90A_HUMAN	HSP90AA1	physical	24147044
HS90B_HUMAN	HSP90AB1	physical	24147044
HSP7C_HUMAN	HSPA8	physical	24147044
SYIC_HUMAN	IARS	physical	24147044
IF16_HUMAN	IFI16	physical	24147044
IF2B3_HUMAN	IGF2BP3	physical	24147044
ILF3_HUMAN	ILF3	physical	24147044
SYK_HUMAN	KARS	physical	24147044
CCAR2_HUMAN	CCAR2	physical	24147044
NUCL_HUMAN	NCL	physical	24147044
NEK9_HUMAN	NEK9	physical	24147044
ODO1_HUMAN	OGDH	physical	24147044
OGDHL_HUMAN	OGDHL	physical	24147044
SYRC_HUMAN	RARS	physical	24147044
CTIP_HUMAN	RBBP8	physical	24147044
RECQ1_HUMAN	RECQL	physical	24147044
SF3B1_HUMAN	SF3B1	physical	24147044
SFPQ_HUMAN	SFPQ	physical	24147044
TOP1_HUMAN	TOP1	physical	24147044
TERA_HUMAN	VCP	physical	24147044
XRCC6_HUMAN	XRCC6	physical	24147044
ZN318_HUMAN	ZNF318	physical	24147044
PML_HUMAN	PML	physical	22869143
P53_HUMAN	TP53	physical	25103245
P53_HUMAN	TP53	physical	24998844
SIR6_HUMAN	SIRT6	physical	25074979
P53_HUMAN	TP53	physical	19483087
ZN363_HUMAN	RCHY1	physical	19483087
AATF_HUMAN	AATF	physical	25210797
P53_HUMAN	TP53	physical	15247280
PML_HUMAN	PML	physical	23169665
RL23_HUMAN	RPL23	physical	23169665
RL26_HUMAN	RPL26	physical	23169665
RS6_HUMAN	RPS6	physical	23169665
RS7_HUMAN	RPS7	physical	23169665
P53_HUMAN	TP53	physical	9131587
ARI2_HUMAN	ARIH2	physical	22940738
NUCL_HUMAN	NCL	physical	16751805
P53_HUMAN	TP53	physical	16751805
P53_HUMAN	TP53	physical	19805293
UB2D1_HUMAN	UBE2D1	physical	19805293
P53_HUMAN	TP53	physical	11713287
UB2D2_HUMAN	UBE2D2	physical	11713287
UB2D1_HUMAN	UBE2D1	physical	19240029
P53_HUMAN	TP53	physical	12690203
UB2D1_HUMAN	UBE2D1	physical	12690203
UB2D1_HUMAN	UBE2D1	physical	15242646
UBC12_HUMAN	UBE2M	physical	15242646
MDM4_HUMAN	MDM4	physical	24813712
MDM4_HUMAN	MDM4	physical	25384516
FSBP_HUMAN	RAD54B	physical	25384516
RA54B_HUMAN	RAD54B	physical	25384516
SMCA2_HUMAN	SMARCA2	physical	25384516
P53_HUMAN	TP53	physical	25384516
MDM2_HUMAN	MDM2	physical	11724934
UB2D2_HUMAN	UBE2D2	physical	11724934
ACACA_HUMAN	ACACA	physical	24798327
PTBP1_HUMAN	PTBP1	physical	24798327
IYD1_HUMAN	IYD	physical	24798327
ACTB_HUMAN	ACTB	physical	24798327
HNRPD_HUMAN	HNRNPD	physical	24798327
U2AF2_HUMAN	U2AF2	physical	24798327
FUBP1_HUMAN	FUBP1	physical	24798327
TFR1_HUMAN	TFRC	physical	24798327
EF2_HUMAN	EEF2	physical	24798327
XPO1_HUMAN	XPO1	physical	24798327
K22E_HUMAN	KRT2	physical	24798327
HNRPU_HUMAN	HNRNPU	physical	24798327
EIF3B_HUMAN	EIF3B	physical	24798327
SND1_HUMAN	SND1	physical	24798327
DCAF8_HUMAN	DCAF8	physical	24798327
USO1_HUMAN	USO1	physical	24798327
U5S1_HUMAN	EFTUD2	physical	24798327
DDB1_HUMAN	DDB1	physical	24798327
EXOS6_HUMAN	EXOSC6	physical	24798327
IPO7_HUMAN	IPO7	physical	24798327
DHX9_HUMAN	DHX9	physical	24798327
GTF2I_HUMAN	GTF2I	physical	24798327
SF3B3_HUMAN	SF3B3	physical	24798327
WWOX_HUMAN	WWOX	physical	25447306
HIF1A_HUMAN	HIF1A	physical	25447306
MDM2_HUMAN	MDM2	physical	20705607
MDM4_HUMAN	MDM4	physical	20705607
MDM2_HUMAN	MDM2	physical	15280377
P53_HUMAN	TP53	physical	15280377
TF65_HUMAN	RELA	physical	23839035
UBC_HUMAN	UBC	physical	17170710
P53_HUMAN	TP53	physical	10562557
UB2D2_HUMAN	UBE2D2	physical	10562557
UB2D2_HUMAN	UBE2D2	physical	16338390
ARRB1_HUMAN	ARRB1	physical	11588219
ANDR_HUMAN	AR	physical	12145204
RL11_HUMAN	RPL11	physical	19713960
P53_HUMAN	TP53	physical	14517261
UB2D2_HUMAN	UBE2D2	physical	14517261
MDM2_HUMAN	MDM2	physical	14517261
UBE2N_HUMAN	UBE2N	physical	21965653
UBE2K_HUMAN	UBE2K	physical	21965653
XIAP_HUMAN	XIAP	physical	25888903
MDM2_HUMAN	MDM2	physical	25888903
UB2D1_HUMAN	UBE2D1	physical	25888903
MAGA2_HUMAN	MAGEA2	physical	26001071
P53_HUMAN	TP53	physical	26001071
MDM4_HUMAN	MDM4	physical	26001071
ZN420_HUMAN	ZNF420	physical	25691462
P53_HUMAN	TP53	physical	25512388
MDM4_HUMAN	MDM4	physical	25512388
ELF4_HUMAN	ELF4	physical	25081543
SRC_HUMAN	SRC	physical	25624478
P53_HUMAN	TP53	physical	25624478
UBC12_HUMAN	UBE2M	physical	25624478
T2EB_HUMAN	GTF2E2	physical	9271120
MDM2_HUMAN	MDM2	physical	25809483
MDM4_HUMAN	MDM4	physical	25809483
CDN2A_HUMAN	CDKN2A	physical	25809483
ARF_HUMAN	CDKN2A	physical	25809483
AT2A2_HUMAN	ATP2A2	physical	24583282
BRNP1_HUMAN	BRINP1	physical	24583282
MYDGF_HUMAN	C19orf10	physical	24583282
CALX_HUMAN	CANX	physical	24583282
IRF1_HUMAN	IRF1	physical	24583282
IRF2_HUMAN	IRF2	physical	24583282
CD20_HUMAN	MS4A1	physical	24583282
PDIA3_HUMAN	PDIA3	physical	24583282
PPIB_HUMAN	PPIB	physical	24583282
RAB8A_HUMAN	RAB8A	physical	24583282
RS23_HUMAN	RPS23	physical	24583282
RUVB2_HUMAN	RUVBL2	physical	24583282
SMCA4_HUMAN	SMARCA4	physical	24583282
SMCE1_HUMAN	SMARCE1	physical	24583282
SRS11_HUMAN	SRSF11	physical	24583282
TOP1_HUMAN	TOP1	physical	24583282
TPR_HUMAN	TPR	physical	24583282
UBF1_HUMAN	UBTF	physical	24583282
P73_HUMAN	TP73	physical	26025930
UB2D2_HUMAN	UBE2D2	physical	26025930
ITCH_HUMAN	ITCH	physical	26025930
P63_HUMAN	TP63	physical	25417702
P73_HUMAN	TP73	physical	25417702
ARRB2_HUMAN	ARRB2	physical	26545496
P73_HUMAN	TP73	physical	25301064
MDM4_HUMAN	MDM4	physical	25105592
TBRG1_MOUSE	Tbrg1	physical	24621507
VDR_HUMAN	VDR	physical	25969952
ANDR_HUMAN	AR	physical	26411689
P53_HUMAN	TP53	physical	26673821
P53_HUMAN	TP53	physical	25543083
UB2D1_HUMAN	UBE2D1	physical	25543083
ENPL_HUMAN	HSP90B1	physical	25637791
P53_HUMAN	TP53	physical	25637791
MDM4_HUMAN	MDM4	physical	25659040
MDM2_HUMAN	MDM2	physical	25659040
FBX31_HUMAN	FBXO31	physical	26124108
ANDR_HUMAN	AR	physical	26196320
P53_HUMAN	TP53	physical	26350565
TFP11_HUMAN	TFIP11	physical	26460617
SETD7_HUMAN	SETD7	physical	26317544
RARA_HUMAN	RARA	physical	26776160
DDX24_HUMAN	DDX24	physical	24980433
UB2D2_HUMAN	UBE2D2	physical	24980433
P53_HUMAN	TP53	physical	24980433
UB2L3_HUMAN	UBE2L3	physical	24980433
UB2D1_HUMAN	UBE2D1	physical	24980433
UB2D3_HUMAN	UBE2D3	physical	24980433
UB2E2_HUMAN	UBE2E2	physical	24980433
UB2E3_HUMAN	UBE2E3	physical	24980433
RB_HUMAN	RB1	physical	25703327
P53_HUMAN	TP53	physical	20591651
ARBK1_HUMAN	ADRBK1	physical	26228571
TERT_HUMAN	TERT	physical	26370108
MDM4_HUMAN	MDM4	physical	25825738
P53_HUMAN	TP53	physical	25954860
NAT10_HUMAN	NAT10	physical	26882543
P53_HUMAN	TP53	physical	26882543
MDM4_HUMAN	MDM4	physical	26359458
CCND1_HUMAN	CCND1	physical	27129163
P53_HUMAN	TP53	physical	27129163
RNF12_HUMAN	RLIM	physical	26926424
P53_HUMAN	TP53	physical	27106262
NUMB_HUMAN	NUMB	physical	27106262
UB2D1_HUMAN	UBE2D1	physical	27106262
IEX1_HUMAN	IER3	physical	26973248
FHL2_HUMAN	FHL2	physical	26973248
SUZ12_HUMAN	SUZ12	physical	26748827
EZH2_HUMAN	EZH2	physical	26748827
EED_HUMAN	EED	physical	26748827
RIR1_HUMAN	RRM1	physical	26228206
SNAI2_HUMAN	SNAI2	physical	26992741
RL4_HUMAN	RPL4	physical	26908445
P53_HUMAN	TP53	physical	26908445
RL5_HUMAN	RPL5	physical	26908445
RL11_HUMAN	RPL11	physical	26908445
NOLC1_HUMAN	NOLC1	physical	24124579
DDX42_HUMAN	DDX42	physical	24124579
MTAP2_HUMAN	MAP2	physical	24124579
NUCKS_HUMAN	NUCKS1	physical	24124579
RRP1_HUMAN	RRP1	physical	24124579
RBBP6_HUMAN	RBBP6	physical	24124579
PDS5A_HUMAN	PDS5A	physical	24124579
RL36A_HUMAN	RPL36A	physical	24124579
UBF1_HUMAN	UBTF	physical	24124579
PRPK_HUMAN	TP53RK	physical	24124579
RL15_HUMAN	RPL15	physical	24124579
NPIB3_HUMAN	NPIPB3	physical	24124579
HMGN1_HUMAN	HMGN1	physical	24124579
MLP3A_HUMAN	MAP1LC3A	physical	24124579
PRDM2_HUMAN	PRDM2	physical	24124579
K1551_HUMAN	KIAA1551	physical	24124579
PBIP1_HUMAN	PBXIP1	physical	24488098
P53_HUMAN	TP53	physical	24488098
P53_HUMAN	TP53	physical	20837658
P53_HUMAN	TP53	physical	15550400
SP1_HUMAN	SP1	physical	22378045
P53_HUMAN	TP53	physical	27215386
MDM4_HUMAN	MDM4	physical	27215386
MDM2_HUMAN	MDM2	physical	27215386
MDM4_HUMAN	MDM4	physical	27621617
P53_HUMAN	TP53	physical	27856536
MDM2_HUMAN	MDM2	physical	28166445
P53_HUMAN	TP53	physical	27543608
VIF_HV1B1	vif	physical	27758855
VIF_HV1BR	vif	physical	27758855
VIF_HV1H2	vif	physical	27758855
GTF2I_HUMAN	GTF2I	physical	26656605
SHRPN_HUMAN	SHARPIN	physical	28063307
UBP7_HUMAN	USP7	physical	27452404
ANDR_HUMAN	AR	physical	27903893
UB2D1_HUMAN	UBE2D1	physical	27903893
P53_HUMAN	TP53	physical	27893708
UBP15_HUMAN	USP15	physical	27893708
MDM4_HUMAN	MDM4	physical	27617579
FKB1A_HUMAN	FKBP1A	physical	27617579
RS14_HUMAN	RPS14	physical	27336364
P53_HUMAN	TP53	physical	27336364
TNR16_HUMAN	NGFR	physical	27282385
P53_HUMAN	TP53	physical	27282385
SMG7_HUMAN	SMG7	physical	27462439
P53_HUMAN	TP53	physical	27462439
ORF50_HHV8P	ORF50	physical	27698494
P53_HUMAN	TP53	physical	27811966
RL1D1_HUMAN	RSL1D1	physical	27811966
SIR1_HUMAN	SIRT1	physical	28196907
SIR6_HUMAN	SIRT6	physical	28196907
SIR7_HUMAN	SIRT7	physical	28196907
UBP7_HUMAN	USP7	physical	28196907
MDM2_HUMAN	MDM2	physical	28196907
IMA5_HUMAN	KPNA1	physical	28196907
IMA7_HUMAN	KPNA6	physical	28196907
ANDR_HUMAN	AR	physical	28151478
P53_HUMAN	TP53	physical	28082682
P53_HUMAN	TP53	physical	28223335
MSI2H_HUMAN	MSI2	physical	28223335
NUMB_HUMAN	NUMB	physical	28223335
PHLB3_HUMAN	PHLDB3	physical	28008906
JAK1_HUMAN	JAK1	physical	27362806
ATF4_HUMAN	ATF4	physical	27264869
KPYM_HUMAN	PKM	physical	27264869
UBP7_HUMAN	USP7	physical	26971997
SUV91_HUMAN	SUV39H1	physical	26971997
P53_HUMAN	TP53	physical	15358376
MDM2_HUMAN	MDM2	physical	26720344
P53_HUMAN	TP53	physical	26720344
P53_HUMAN	TP53	physical	28553961
UB2D2_HUMAN	UBE2D2	physical	28553961
P53_HUMAN	TP53	physical	28394340
P53_HUMAN	TP53	physical	28362432
UB2D1_HUMAN	UBE2D1	physical	28362432
P53_HUMAN	TP53	physical	18316739
FOXO3_HUMAN	FOXO3	physical	27886165
P53_HUMAN	TP53	physical	27886165
VEGFA_HUMAN	VEGFA	physical	28274247

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDM2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Sgk1 activates MDM2-dependent p53 degradation and affects cellproliferation, survival, and differentiation."; Amato R., D'Antona L., Porciatti G., Agosti V., Menniti M.,Rinaldo C., Costa N., Bellacchio E., Mattarocci S., Fuiano G.,Soddu S., Paggi M.G., Lang F., Perrotti N.; J. Mol. Med. 87:1221-1239(2009). Cited for: PHOSPHORYLATION AT SER-166 BY SGK1.	19756449 [Abstract]

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