dbPTM

PRDM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRDM2_HUMAN
UniProt AC	Q13029
Protein Name	PR domain zinc finger protein 2
Gene Name	PRDM2
Organism	Homo sapiens (Human).
Sequence Length	1718
Subcellular Localization	Nucleus .
Protein Description	S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene..
Protein Sequence	MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TTEPVAATETLAEVP CCCCCCCCHHHHHCC	21.55	29507054
14	Phosphorylation	EPVAATETLAEVPEH CCCCCCHHHHHCCHH	27.24	29507054
47	Phosphorylation	TRIGVWATKPILKGK CEEEEEECCCHHCCC	22.95	-
63	Ubiquitination	FGPFVGDKKKRSQVK CCCCCCCHHHHHHHC	55.02	29967540
165	Phosphorylation	SARSKRSSPKSRKGK HHHHHCCCCCCHHCC	40.14	27134283
168	Phosphorylation	SKRSSPKSRKGKKKS HHCCCCCCHHCCHHH	42.48	27134283
174 (in isoform 4)	Phosphorylation	-	61.94	25159151
175	Phosphorylation	SRKGKKKSQENKNKG CHHCCHHHHHCCCCC	52.16	30622161
198	Phosphorylation	KTSEPDFTSANMRDS CCCCCCCCCCHHCCC	34.02	-
199	Phosphorylation	TSEPDFTSANMRDSA CCCCCCCCCHHCCCC	20.03	-
347	Sumoylation	AMQIPRTKEEANGDV CCCCCCCHHHHCCCC	55.63	28112733
384	Phosphorylation	RHMHIHISTVNHAFK HHEEEEEEECCHHCC	16.49	29978859
385	Phosphorylation	HMHIHISTVNHAFKC HEEEEEEECCHHCCC	25.40	29978859
421	Phosphorylation	AGLKRKPSQTLQPSE HHCCCCCCCCCCCCH	38.54	23401153
423	Phosphorylation	LKRKPSQTLQPSEDL CCCCCCCCCCCCHHH	31.53	30266825
425	Ubiquitination	RKPSQTLQPSEDLAD CCCCCCCCCCHHHCC	42.75	29967540
427	Phosphorylation	PSQTLQPSEDLADGK CCCCCCCCHHHCCCC	30.68	28387310
436	Phosphorylation	DLADGKASGENVASK HHCCCCCCCCCCCCC	50.56	26074081
442	Phosphorylation	ASGENVASKDDSSPP CCCCCCCCCCCCCCC	32.13	30108239
446	Phosphorylation	NVASKDDSSPPSLGP CCCCCCCCCCCCCCC	55.68	25159151
447	Phosphorylation	VASKDDSSPPSLGPD CCCCCCCCCCCCCCC	48.07	25159151
450	Phosphorylation	KDDSSPPSLGPDCLI CCCCCCCCCCCCEEE	49.71	25262027
460	Phosphorylation	PDCLIMNSEKASQDT CCEEEECCCCCCCCC	24.08	26074081
470	Phosphorylation	ASQDTINSSVVEENG CCCCCCCCHHHHHCC	22.21	25627689
471	Phosphorylation	SQDTINSSVVEENGE CCCCCCCHHHHHCCC	26.20	21815630
499	Ubiquitination	FGTHTNMRRHQRRVH HCCCHHHHHHHHHHH	34.69	29967540
508	Methylation	HQRRVHERHLIPKGV HHHHHHHHHCCCCCC	18.29	24390907
516	Methylation	HLIPKGVRRKGGLEE HCCCCCCCCCCCCCC	43.17	24390919
542	Phosphorylation	QNVYVPSTEPEEEGE CCEECCCCCCHHCCC	49.87	33259812
559	Ubiquitination	DVYIMDISSNISENL CEEEEECCCCCCCCC	17.05	29967540
573	Ubiquitination	LNYYIDGKIQTNNNT CCEEECCEEECCCCC	28.08	29967540
595	Phosphorylation	MESASADLYGINCLL EEECCCCEECCCEEE	4.16	32142685
626	Ubiquitination	PVTEDLPKEPLGSTN CCCCCCCCCCCCCCC	78.31	29967540
631	Phosphorylation	LPKEPLGSTNSEAKK CCCCCCCCCCHHHHH	31.90	30631047
632	Phosphorylation	PKEPLGSTNSEAKKR CCCCCCCCCHHHHHH	40.75	28555341
634	Phosphorylation	EPLGSTNSEAKKRRT CCCCCCCHHHHHHHC	38.73	30631047
641	Phosphorylation	SEAKKRRTASPPALP HHHHHHHCCCCCCCC	35.20	30266825
643	Phosphorylation	AKKRRTASPPALPKI HHHHHCCCCCCCCCC	30.70	25159151
651	Sumoylation	PPALPKIKAETDSDP CCCCCCCEECCCCCC	46.42	28112733
690	Acetylation	KSVYLSSKLKQLLQT HHHHHHHHHHHHHHC	57.22	25953088
690	Sumoylation	KSVYLSSKLKQLLQT HHHHHHHHHHHHHHC	57.22	28112733
692	Sumoylation	VYLSSKLKQLLQTQD HHHHHHHHHHHHCCC	42.51	28112733
700	Ubiquitination	QLLQTQDKLTPAGIS HHHHCCCCCCCCCCC	44.43	29967540
702	Phosphorylation	LQTQDKLTPAGISAT HHCCCCCCCCCCCHH	19.48	-
720	Phosphorylation	KLGPVCVSAPASMLP HHCCEEEECCHHHCC	24.33	24719451
737	Phosphorylation	SSRFKRRTSSPPSSP CHHHCCCCCCCCCCC	37.27	30266825
738	Phosphorylation	SRFKRRTSSPPSSPQ HHHCCCCCCCCCCCC	38.75	30266825
739	Phosphorylation	RFKRRTSSPPSSPQH HHCCCCCCCCCCCCC	39.97	23401153
742	Phosphorylation	RRTSSPPSSPQHSPA CCCCCCCCCCCCCHH	59.02	23401153
743	Phosphorylation	RTSSPPSSPQHSPAL CCCCCCCCCCCCHHH	34.06	30266825
747	Phosphorylation	PPSSPQHSPALRDFG CCCCCCCCHHHHHCC	13.46	30278072
760	Ubiquitination	FGKPSDGKAAWTDAG CCCCCCCCCCCCCCC	39.66	29967540
764	Phosphorylation	SDGKAAWTDAGLTSK CCCCCCCCCCCCCCC	15.96	29759185
769	Phosphorylation	AWTDAGLTSKKSKLE CCCCCCCCCCHHHHC	37.27	29759185
770	Phosphorylation	WTDAGLTSKKSKLES CCCCCCCCCHHHHCC	43.03	29759185
771	Acetylation	TDAGLTSKKSKLESH CCCCCCCCHHHHCCC	56.69	25953088
774	Sumoylation	GLTSKKSKLESHSDS CCCCCHHHHCCCCCC	66.22	28112733
774	Ubiquitination	GLTSKKSKLESHSDS CCCCCHHHHCCCCCC	66.22	29967540
777	Phosphorylation	SKKSKLESHSDSPAW CCHHHHCCCCCCCCH	38.43	20873877
779	Phosphorylation	KSKLESHSDSPAWSL HHHHCCCCCCCCHHC	49.41	27794612
781	Phosphorylation	KLESHSDSPAWSLSG HHCCCCCCCCHHCCC	21.38	20873877
785	Phosphorylation	HSDSPAWSLSGRDER CCCCCCHHCCCCCCC	18.11	20873877
787	Phosphorylation	DSPAWSLSGRDERET CCCCHHCCCCCCCCC	26.68	25627689
794	Phosphorylation	SGRDERETVSPPCFD CCCCCCCCCCCCCCC	32.29	30266825
796	Phosphorylation	RDERETVSPPCFDEY CCCCCCCCCCCCCCH	30.46	23401153
803	Phosphorylation	SPPCFDEYKMSKEWT CCCCCCCHHCCCCCC	17.52	26552605
846	Phosphorylation	KTPVQWESVLDLSVH CCCCCCCCEEEHHHC	25.64	-
851	Phosphorylation	WESVLDLSVHKKHCS CCCEEEHHHCHHHCC	23.11	23898821
866	Sumoylation	DSEGKEFKESHSVQP HHCCCCHHHHHCCCC	60.44	28112733
874	Phosphorylation	ESHSVQPTCSAVKKR HHHCCCCCCHHHHCC	11.29	29396449
876	Phosphorylation	HSVQPTCSAVKKRKP HCCCCCCHHHHCCCC	38.28	25159151
879	Sumoylation	QPTCSAVKKRKPTTC CCCCHHHHCCCCCCH	46.72	28112733
885	Phosphorylation	VKKRKPTTCMLQKVL HHCCCCCCHHHHHHH	12.40	-
896	Phosphorylation	QKVLLNEYNGIDLPV HHHHHHHCCCCCCCC	20.02	20164059
910	Phosphorylation	VENPADGTRSPSPCK CCCCCCCCCCCCCCC	28.64	30278072
912	Phosphorylation	NPADGTRSPSPCKSL CCCCCCCCCCCCCCC	29.57	30278072
914	Phosphorylation	ADGTRSPSPCKSLEA CCCCCCCCCCCCCCC	44.15	30278072
918	Phosphorylation	RSPSPCKSLEAQPDP CCCCCCCCCCCCCCC	37.85	26074081
1054	Phosphorylation	GPPTLSSSSSSSSSS CCCCCCCCCCCCCCC	30.75	18669648
1055	Phosphorylation	PPTLSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1056	Phosphorylation	PTLSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1057	Phosphorylation	TLSSSSSSSSSSSSF CCCCCCCCCCCCCCC	35.87	-
1065	Phosphorylation	SSSSSSFSSSSSSSS CCCCCCCCCCCCCCC	31.12	18669648
1099	Phosphorylation	EASLPMISFKQEELE EEECCEEEECHHHHH	21.82	24719451
1118	Phosphorylation	KPREEPQSAAEQDVV CCCCCCCCHHHCCCE	39.91	27251275
1141	Phosphorylation	FVCNVCESPFLSIKD CEECCCCCCCCCHHH	18.80	25159151
1147	Sumoylation	ESPFLSIKDLTKHLS CCCCCCHHHHHHHHC	43.22	28112733
1151	Sumoylation	LSIKDLTKHLSIHAE CCHHHHHHHHCCCHH	50.25	28112733
1247	Phosphorylation	AHVEHMQSLPEDPLE HHHHHHHCCCCCCCC	38.01	27251275
1255	Phosphorylation	LPEDPLETSKEEEEL CCCCCCCCCHHHHHH	53.43	26657352
1256	Phosphorylation	PEDPLETSKEEEELN CCCCCCCCHHHHHHC	28.79	25849741
1257	Sumoylation	EDPLETSKEEEELND CCCCCCCHHHHHHCC	76.26	28112733
1265	Phosphorylation	EEEELNDSSEELYTT HHHHHCCCHHHHHHH	38.28	28355574
1266	Phosphorylation	EEELNDSSEELYTTI HHHHCCCHHHHHHHH	37.64	25159151
1270	Phosphorylation	NDSSEELYTTIKIMA CCCHHHHHHHHHHHH	12.71	30108239
1271	Phosphorylation	DSSEELYTTIKIMAS CCHHHHHHHHHHHHC	34.37	30108239
1272	Phosphorylation	SSEELYTTIKIMASG CHHHHHHHHHHHHCC	13.50	30108239
1281	Sumoylation	KIMASGIKTKDPDVR HHHHCCCCCCCCCCC	53.71	28112733
1295	Phosphorylation	RLGLNQHYPSFKPPP CCCCCCCCCCCCCCC	7.27	-
1297	Phosphorylation	GLNQHYPSFKPPPFQ CCCCCCCCCCCCCCC	38.44	-
1357	Phosphorylation	KHILACASASDKKRY HHHHHHCCCCCCCCC	28.34	28348404
1359	Phosphorylation	ILACASASDKKRYTP HHHHCCCCCCCCCCC	47.68	30576142
1406	Phosphorylation	QPKRLNFSVELSKMS CCCCCCEEEEHHHCC	17.38	20860994
1410	Phosphorylation	LNFSVELSKMSSNKL CCEEEEHHHCCCCHH	16.89	30177828
1413	Phosphorylation	SVELSKMSSNKLKLN EEEHHHCCCCHHHHH	34.20	30177828
1414	Phosphorylation	VELSKMSSNKLKLNA EEHHHCCCCHHHHHH	34.19	30177828
1425	Acetylation	KLNALKKKNQLVQKA HHHHHHHHHHHHHHH	48.62	90431
1431	Acetylation	KKNQLVQKAILQKNK HHHHHHHHHHHHCCH	29.89	90435
1453	Phosphorylation	LKNACESSSHICPYC HHHHHHCCCCCCCCC	12.02	30631047
1454	Phosphorylation	KNACESSSHICPYCN HHHHHCCCCCCCCCC	26.59	30631047
1484	Phosphorylation	SCPKKPLSPPKKKVS CCCCCCCCCCCCCCC	47.92	23401153
1491	Phosphorylation	SPPKKKVSHSSKKGG CCCCCCCCCCCCCCC	26.91	20393185
1501	Phosphorylation	SKKGGHSSPASSDKN CCCCCCCCCCCCCCC	20.86	25954137
1509	Phosphorylation	PASSDKNSNSNHRRR CCCCCCCCCCCHHHH	47.58	-
1511	Phosphorylation	SSDKNSNSNHRRRTA CCCCCCCCCHHHHHH	33.56	-
1517	O-linked_Glycosylation	NSNHRRRTADAEIKM CCCHHHHHHHHHHHH	27.38	30379171
1529	Phosphorylation	IKMQSMQTPLGKTRA HHHHHCCCCCCCCCC	16.31	-
1533	Acetylation	SMQTPLGKTRARSSG HCCCCCCCCCCCCCC	42.39	25953088
1539	Phosphorylation	GKTRARSSGPTQVPL CCCCCCCCCCCCCCC	43.15	28555341
1548	Phosphorylation	PTQVPLPSSSFRSKQ CCCCCCCCHHHCCCC	46.42	23186163
1549	Phosphorylation	TQVPLPSSSFRSKQN CCCCCCCHHHCCCCC	31.40	23186163
1550	Phosphorylation	QVPLPSSSFRSKQNV CCCCCCHHHCCCCCC	29.08	23186163
1564	Acetylation	VKFAASVKSKKPSSS CEEEEECCCCCCCCH	54.80	25953088
1569	Phosphorylation	SVKSKKPSSSSLRNS ECCCCCCCCHHCCCC	52.29	25072903
1570	Phosphorylation	VKSKKPSSSSLRNSS CCCCCCCCHHCCCCC	32.26	25072903
1571	Phosphorylation	KSKKPSSSSLRNSSP CCCCCCCHHCCCCCC	37.42	25072903
1572	Phosphorylation	SKKPSSSSLRNSSPI CCCCCCHHCCCCCCC	33.04	25072903
1577	Phosphorylation	SSSLRNSSPIRMAKI CHHCCCCCCCEEEEE	28.09	30576142
1585	Phosphorylation	PIRMAKITHVEGKKP CCEEEEEEEECCCCC	21.11	-
1597	Ubiquitination	KKPKAVAKNHSAQLS CCCCHHHCCCCEECC	48.90	-
1606	Acetylation	HSAQLSSKTSRSLHV CCEECCCCCCCCEEH	47.33	25953088
1606	Ubiquitination	HSAQLSSKTSRSLHV CCEECCCCCCCCEEH	47.33	-
1617	Acetylation	SLHVRVQKSKAVLQS CEEHHHHHHHHHHHC	51.58	25953088
1619	Acetylation	HVRVQKSKAVLQSKS EHHHHHHHHHHHCHH	49.93	25953088
1625	Acetylation	SKAVLQSKSTLASKK HHHHHHCHHHHHCCC	34.20	25953088
1626	O-linked_Glycosylation	KAVLQSKSTLASKKR HHHHHCHHHHHCCCC	33.62	30379171
1641	Phosphorylation	TDRFNIKSRERSGGP CCCCCCCCCCCCCCC	35.26	-
1645	Phosphorylation	NIKSRERSGGPVTRS CCCCCCCCCCCCCHH	43.26	22210691
1650	Phosphorylation	ERSGGPVTRSLQLAA CCCCCCCCHHHHHHH	20.06	22210691
1652	Phosphorylation	SGGPVTRSLQLAAAA CCCCCCHHHHHHHHC	15.88	-
1662	Phosphorylation	LAAAADLSENKREDG HHHHCCCCCCCCCCC	39.40	22210691
1681	Phosphorylation	ELKDFSYSLRLASRC HHHHHHHHHHHHHHC	13.05	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRDM2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRDM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRDM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	10706618
RB_HUMAN	RB1	physical	7538672
PRDM2_HUMAN	PRDM2	physical	9632640
EP300_HUMAN	EP300	physical	15282304
SRC_HUMAN	SRC	physical	15282304
P53_HUMAN	TP53	physical	20594067
RB_HUMAN	RB1	physical	9223517
E2F1_HUMAN	E2F1	physical	9223517
H31T_HUMAN	HIST3H3	physical	18082620
H31_HUMAN	HIST1H3A	physical	15964548

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRDM2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739 AND SER-743, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-641 AND SER-643, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY.	15302935 [Abstract]