H31T_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H31T_HUMAN
• UniProt AC: Q16695
• Protein Name: Histone H3.1t
• Gene Name: HIST3H3
• Organism: Homo sapiens (Human).
• Sequence Length: 136
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTIMPKDIQLARRIRGERA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Asymmetric dimethylarginine	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
3	Citrullination	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
3	Methylation	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
4	Phosphorylation	----MARTKQTARKS ----CCCCCHHHHHC	20.26	17938195
5	Allysine	---MARTKQTARKST ---CCCCCHHHHHCC	39.85	-
5	Acetylation	---MARTKQTARKST ---CCCCCHHHHHCC	39.85	-
5	Deamination	---MARTKQTARKST ---CCCCCHHHHHCC	39.85	-
5	Methylation	---MARTKQTARKST ---CCCCCHHHHHCC	39.85	15628137
5	Other	---MARTKQTARKST ---CCCCCHHHHHCC	39.85	-
6	Formation of an isopeptide bond	--MARTKQTARKSTG --CCCCCHHHHHCCC	39.52	-
6	Serotonylation	--MARTKQTARKSTG --CCCCCHHHHHCCC	39.52	-
7	Phosphorylation	-MARTKQTARKSTGG -CCCCCHHHHHCCCC	29.95	20228790
9	Citrullination	ARTKQTARKSTGGKA CCCCHHHHHCCCCCC	36.52	-
9	Citrullination	ARTKQTARKSTGGKA CCCCHHHHHCCCCCC	36.52	-
9	Methylation	ARTKQTARKSTGGKA CCCCHHHHHCCCCCC	36.52	-
10	"N6,N6,N6-trimethyllysine"	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	-
10	Acetylation	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	9854409
10	Lactoylation	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	-
10	Methylation	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	-
10	Other	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	-
10	Ubiquitination	RTKQTARKSTGGKAP CCCHHHHHCCCCCCC	50.32	22817900
11	ADP-ribosylation	TKQTARKSTGGKAPR CCHHHHHCCCCCCCH	27.08	-
11	Phosphorylation	TKQTARKSTGGKAPR CCHHHHHCCCCCCCH	27.08	10469656
12	Phosphorylation	KQTARKSTGGKAPRK CHHHHHCCCCCCCHH	53.65	26074081
15	Sumoylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	-
15	Acetylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	9854417
15	Glutarylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	-
15	Lactoylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	-
15	Methylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	-
15	Other	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	-
15	Succinylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	10911985
15	Sumoylation	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	10911985
15	Ubiquitination	ARKSTGGKAPRKQLA HHHCCCCCCCHHHHH	57.47	27667366
18	Asymmetric dimethylarginine	STGGKAPRKQLATKV CCCCCCCHHHHHHHH	44.18	-
18	Citrullination	STGGKAPRKQLATKV CCCCCCCHHHHHHHH	44.18	-
18	Methylation	STGGKAPRKQLATKV CCCCCCCHHHHHHHH	44.18	-
19	Acetylation	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	19608861
19	Butyrylation	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	-
19	Glutarylation	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	-
19	Lactoylation	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	-
19	Methylation	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	-
19	Other	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	-
19	Ubiquitination	TGGKAPRKQLATKVA CCCCCCHHHHHHHHH	48.91	22817900
24	Acetylation	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	19608861
24	Butyrylation	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	-
24	Glutarylation	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	-
24	Lactoylation	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	-
24	Methylation	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	-
24	Other	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	-
24	Ubiquitination	PRKQLATKVARKSAP CHHHHHHHHHHHCCC	28.43	22817900
27	Citrullination	QLATKVARKSAPATG HHHHHHHHHCCCCCC	36.13	-
27	Citrullination	QLATKVARKSAPATG HHHHHHHHHCCCCCC	36.13	-
28	"N6,N6,N6-trimethyllysine"	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	-
28	Acetylation	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	11478441
28	Glutarylation	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	-
28	Lactoylation	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	-
28	Methylation	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	19608861
28	Other	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	-
28	Ubiquitination	LATKVARKSAPATGG HHHHHHHHCCCCCCC	41.03	24816145
29	ADP-ribosylation	ATKVARKSAPATGGV HHHHHHHCCCCCCCC	33.65	-
29	Phosphorylation	ATKVARKSAPATGGV HHHHHHHCCCCCCCC	33.65	25159151
33	Phosphorylation	ARKSAPATGGVKKPH HHHCCCCCCCCCCCC	33.15	28176443
37	"N6,N6,N6-trimethyllysine"	APATGGVKKPHRYRP CCCCCCCCCCCCCCC	64.95	-
37	Acetylation	APATGGVKKPHRYRP CCCCCCCCCCCCCCC	64.95	11619301
37	Methylation	APATGGVKKPHRYRP CCCCCCCCCCCCCCC	64.95	-
37	Other	APATGGVKKPHRYRP CCCCCCCCCCCCCCC	64.95	-
37	Ubiquitination	APATGGVKKPHRYRP CCCCCCCCCCCCCCC	64.95	23000965
38	"N6,N6-dimethyllysine"	PATGGVKKPHRYRPG CCCCCCCCCCCCCCC	43.58	-
38	Methylation	PATGGVKKPHRYRPG CCCCCCCCCCCCCCC	43.58	-
38	Ubiquitination	PATGGVKKPHRYRPG CCCCCCCCCCCCCCC	43.58	23000965
41	Dimethylation	GGVKKPHRYRPGTVA CCCCCCCCCCCCCHH	37.37	-
41	Methylation	GGVKKPHRYRPGTVA CCCCCCCCCCCCCHH	37.37	54548177
42	Nitration	GVKKPHRYRPGTVAL CCCCCCCCCCCCHHH	20.37	-
42	Phosphorylation	GVKKPHRYRPGTVAL CCCCCCCCCCCCHHH	20.37	28152594
43	Methylation	VKKPHRYRPGTVALR CCCCCCCCCCCHHHH	24.11	-
46	Phosphorylation	PHRYRPGTVALREIR CCCCCCCCHHHHHHH	12.80	30266825
50	Methylation	RPGTVALREIRRYQK CCCCHHHHHHHHHHH	27.79	-
55	Phosphorylation	ALREIRRYQKSTELL HHHHHHHHHHCHHHH	15.50	22817900
57	"N6,N6,N6-trimethyllysine"	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Acetylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	15628137
57	Glutarylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Lactoylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Methylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Other	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Succinylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	21890473
57	Sumoylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
57	Ubiquitination	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	23000965
58	Phosphorylation	EIRRYQKSTELLIRK HHHHHHHCHHHHHHH	16.16	23401153
59	Phosphorylation	IRRYQKSTELLIRKL HHHHHHCHHHHHHHC	37.37	30266825
64	Methylation	KSTELLIRKLPFQRL HCHHHHHHHCHHHHH	34.13	-
65	Methylation	STELLIRKLPFQRLM CHHHHHHHCHHHHHH	54.22	-
65	Other	STELLIRKLPFQRLM CHHHHHHHCHHHHHH	54.22	-
80	"N6,N6,N6-trimethyllysine"	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Acetylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	9854425
80	Glutarylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Lactoylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Methylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Other	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Succinylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	21890473
80	Sumoylation	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	-
80	Ubiquitination	REIAQDFKTDLRFQS HHHHHHHCCCHHHHH	49.79	23000965
81	Phosphorylation	EIAQDFKTDLRFQSS HHHHHHCCCHHHHHH	40.01	23401153
84	Methylation	QDFKTDLRFQSSAVM HHHCCCHHHHHHHHH	30.30	-
87	Phosphorylation	KTDLRFQSSAVMALQ CCCHHHHHHHHHHHH	19.97	-
88	Phosphorylation	TDLRFQSSAVMALQE CCHHHHHHHHHHHHH	17.69	-
99	Phosphorylation	ALQEACESYLVGLFE HHHHHHHHHHHHHHC	24.53	-
108	Phosphorylation	LVGLFEDTNLCVIHA HHHHHCCCCEEEEEE	23.93	-
116	Acetylation	NLCVIHAKRVTIMPK CEEEEEEEECEECHH	32.99	-
116	Glutarylation	NLCVIHAKRVTIMPK CEEEEEEEECEECHH	32.99	-
119	Phosphorylation	VIHAKRVTIMPKDIQ EEEEEECEECHHHHH	18.65	20068231
121	Sulfoxidation	HAKRVTIMPKDIQLA EEEECEECHHHHHHH	2.17	28183972
123	Sumoylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
123	Acetylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	11381985
123	Glutarylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
123	Methylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
123	Other	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
123	Succinylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	21890473
123	Sumoylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
123	Ubiquitination	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	23000965
129	Methylation	PKDIQLARRIRGERA HHHHHHHHHHHCCCC	43.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	T	Phosphorylation	Kinase	GSG2	Q8TF76	GPS
7	T	Phosphorylation	Kinase	PKC	-	Uniprot
11	S	Phosphorylation	Kinase	ALTERNATE	-	Uniprot
12	T	Phosphorylation	Kinase	PKC	-	Uniprot
29	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
29	S	Phosphorylation	Kinase	AURKC	Q9UQB9	GPS
29	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
29	S	Phosphorylation	Kinase	ALTERNATE	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	RAG1	P15918	PMID:20122409

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
3	R	Methylation	Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3).	-
4	T	Phosphorylation	Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase.	-
5	K	ubiquitylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
5	K	Acetylation	Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4.	-
5	K	Methylation	Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3).	-
5	K	Methylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
5	K	Methylation	Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4.	-
5	K	Methylation	Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation.	-
5	K	Phosphorylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
5	K	Methylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
7	T	Phosphorylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
7	T	Methylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
9	R	Methylation	Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression.	-
9	R	Methylation	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
9	R	Methylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
9	R	Citrullination	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
9	R	Acetylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Phosphorylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
10	K	Phosphorylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
10	K	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Phosphorylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Methylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Methylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Acetylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Acetylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Acetylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Acetylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
10	K	Methylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.	-
11	S	Acetylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Acetylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Acetylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
11	S	Methylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Methylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Phosphorylation	In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.	-
11	S	Phosphorylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Phosphorylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
12	T	Phosphorylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
12	T	Methylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
12	T	Phosphorylation	At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1.	-
18	R	Citrullination	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
18	R	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
18	R	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
18	R	Methylation	Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation.	-
18	R	Methylation	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
19	K	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	19608861
19	K	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	19608861
24	K	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	19608861
24	K	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	19608861
28	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.	-
28	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.	-
29	S	Phosphorylation	Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation.	18691976
37	K	Methylation	Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation.	-
57	K	Methylation	Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).	-
80	K	Methylation	Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1.	-
80	K	Methylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
80	K	Methylation	Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation.	-
80	K	ubiquitylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
80	K	Succinylation	Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes.	29211711
120	K	ubiquitylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
120	K	Methylation	Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'.	-
123	K	Succinylation	Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.	27436229
123	K	Acetylation	Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H31T_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF1A_HUMAN	TAF1A	physical	11163245
SET_HUMAN	SET	physical	11163245
AN32A_HUMAN	ANP32A	physical	11163245
HAT1_HUMAN	HAT1	physical	20953179
RBBP7_HUMAN	RBBP7	physical	20953179
HSP7C_HUMAN	HSPA8	physical	20953179
HS90A_HUMAN	HSP90AA1	physical	20953179
IPO4_HUMAN	IPO4	physical	20953179
ASF1B_HUMAN	ASF1B	physical	20953179
RBBP4_HUMAN	RBBP4	physical	20953179
CAF1B_HUMAN	CHAF1B	physical	20953179
MCM7_HUMAN	MCM7	physical	20953179
ASF1A_HUMAN	ASF1A	physical	17242207
TDRD3_HUMAN	TDRD3	physical	21172665
SMN_HUMAN	SMN1	physical	21172665
SPF30_HUMAN	SMNDC1	physical	21172665
SPF30_SCHPO	spf30	physical	21172665
KMT2A_HUMAN	KMT2A	physical	21135039
WDR5_HUMAN	WDR5	physical	21135039
CBX3_HUMAN	CBX3	physical	21047797
CBX7_HUMAN	CBX7	physical	21047797
CBX8_HUMAN	CBX8	physical	21047797
CBX1_HUMAN	CBX1	physical	21047797
CBX2_HUMAN	CBX2	physical	21047797
CBX5_HUMAN	CBX5	physical	21047797
CBX6_HUMAN	CBX6	physical	21047797
PHF8_HUMAN	PHF8	physical	21029866
SUZ12_HUMAN	SUZ12	physical	21029866
CBX5_HUMAN	CBX5	physical	21029866
PRS8_HUMAN	PSMC5	physical	18662994
CBX5_HUMAN	CBX5	physical	23281010
BIRC5_HUMAN	BIRC5	physical	23281010
ERAP1_HUMAN	ERAP1	physical	23281010
KIF2C_HUMAN	KIF2C	physical	23281010
KIF2A_HUMAN	KIF2A	physical	23281010
PPM1G_HUMAN	PPM1G	physical	23281010
MBD3_HUMAN	MBD3	physical	23281010
JADE2_HUMAN	JADE2	physical	23281010
RBBP7_HUMAN	RBBP7	physical	23281010
HAT1_HUMAN	HAT1	physical	23281010
JADE3_HUMAN	JADE3	physical	23281010
RBBP4_HUMAN	RBBP4	physical	23281010
UHRF1_HUMAN	UHRF1	physical	23281010
MTA1_HUMAN	MTA1	physical	23281010
MTA2_HUMAN	MTA2	physical	23281010
REQU_HUMAN	DPF2	physical	23281010
TAF1_HUMAN	TAF1	physical	17884155
CBX5_HUMAN	CBX5	physical	17884155
TAF1B_HUMAN	TAF1B	physical	17884155
TAF2_HUMAN	TAF2	physical	17884155
TAF3_HUMAN	TAF3	physical	17884155
TAF4_HUMAN	TAF4	physical	17884155
TAF4B_HUMAN	TAF4B	physical	17884155
TAF5_HUMAN	TAF5	physical	17884155
TAF6_HUMAN	TAF6	physical	17884155
TAF7_HUMAN	TAF7	physical	17884155
TAF8_HUMAN	TAF8	physical	17884155
TAF9_HUMAN	TAF9	physical	17884155
TAF9B_HUMAN	TAF9B	physical	17884155
TAF10_HUMAN	TAF10	physical	17884155
TAF11_HUMAN	TAF11	physical	17884155
TAF12_HUMAN	TAF12	physical	17884155
TAF13_HUMAN	TAF13	physical	17884155
TAF3_HUMAN	TAF3	physical	20953165
AIRE_HUMAN	AIRE	physical	20953165
PF21A_HUMAN	PHF21A	physical	20953165
PHF2_HUMAN	PHF2	physical	20953165
PHF8_HUMAN	PHF8	physical	20953165
BPTF_HUMAN	BPTF	physical	20953165
ING2_HUMAN	ING2	physical	20953165
ING4_HUMAN	ING4	physical	20953165
TAF5_HUMAN	TAF5	physical	20953165
TAF6_HUMAN	TAF6	physical	20953165
PHF7_HUMAN	PHF7	physical	22595675
ING2_HUMAN	ING2	physical	22595675
NSD3_HUMAN	WHSC1L1	physical	23269674
UHRF1_HUMAN	UHRF1	physical	24813945
WDR5_HUMAN	WDR5	physical	24793694
ASH2L_HUMAN	ASH2L	physical	24793694
RET5_HUMAN	RBP5	physical	24793694
POGZ_HUMAN	POGZ	physical	20850016
CBX5_HUMAN	CBX5	physical	20850016
KAT2A_HUMAN	KAT2A	physical	20850016
SGF29_HUMAN	CCDC101	physical	20850016
PHF8_HUMAN	PHF8	physical	20850016
GLYR1_HUMAN	GLYR1	physical	20850016
TAF13_HUMAN	TAF13	physical	20850016
TAF11_HUMAN	TAF11	physical	20850016
TAF8_HUMAN	TAF8	physical	20850016
TAF6_HUMAN	TAF6	physical	20850016
TAF12_HUMAN	TAF12	physical	20850016
TAF7_HUMAN	TAF7	physical	20850016
TAF5_HUMAN	TAF5	physical	20850016
TAF4_HUMAN	TAF4	physical	20850016
TAF4B_HUMAN	TAF4B	physical	20850016
TAF1_HUMAN	TAF1	physical	20850016
TAF3_HUMAN	TAF3	physical	20850016
TAF9_HUMAN	TAF9	physical	20850016
TAF2_HUMAN	TAF2	physical	20850016
TAF10_HUMAN	TAF10	physical	20850016
HMGX4_HUMAN	HMGXB4	physical	20850016
PPIB_HUMAN	PPIB	physical	20850016
BPTF_HUMAN	BPTF	physical	20850016
TAF9B_HUMAN	TAF9B	physical	20850016
BAP18_HUMAN	C17orf49	physical	20850016
SUPT3_HUMAN	SUPT3H	physical	20850016
TAF5L_HUMAN	TAF5L	physical	20850016
TADA1_HUMAN	TADA1	physical	20850016
TAF6L_HUMAN	TAF6L	physical	20850016
SP20H_HUMAN	SUPT20H	physical	20850016
CHD1_HUMAN	CHD1	physical	20850016
SIN3A_HUMAN	SIN3A	physical	20850016
DPY30_HUMAN	DPY30	physical	20850016
TADA3_HUMAN	TADA3	physical	20850016
DIDO1_HUMAN	DIDO1	physical	20850016
KDM5A_HUMAN	KDM5A	physical	20850016
SIN3B_HUMAN	SIN3B	physical	20850016
PHF12_HUMAN	PHF12	physical	20850016
GATD1_HUMAN	GATAD1	physical	20850016
EMSY_HUMAN	C11orf30	physical	20850016
CHD6_HUMAN	CHD6	physical	20850016
TBP_HUMAN	TBP	physical	20850016
DEK_HUMAN	DEK	physical	20850016
MO4L1_HUMAN	MORF4L1	physical	20850016
RBBP4_HUMAN	RBBP4	physical	20850016
HDAC1_HUMAN	HDAC1	physical	20850016
RBP56_HUMAN	TAF15	physical	20850016
CDYL_HUMAN	CDYL	physical	20850016
CDYL2_HUMAN	CDYL2	physical	20850016
CBX3_HUMAN	CBX3	physical	20850016
PTBP1_HUMAN	PTBP1	physical	20850016
PHC2_HUMAN	PHC2	physical	20850016
CHAP1_HUMAN	CHAMP1	physical	20850016
BMI1_HUMAN	BMI1	physical	20850016
LRIF1_HUMAN	LRIF1	physical	20850016
LRWD1_HUMAN	LRWD1	physical	20850016
CAF1A_HUMAN	CHAF1A	physical	20850016
ORC2_HUMAN	ORC2	physical	20850016
PCGF6_HUMAN	PCGF6	physical	20850016
ORC3_HUMAN	ORC3	physical	20850016
CBX4_HUMAN	CBX4	physical	20850016
ORC4_HUMAN	ORC4	physical	20850016
CAF1B_HUMAN	CHAF1B	physical	20850016
ORC5_HUMAN	ORC5	physical	20850016
RING2_HUMAN	RNF2	physical	20850016
NONO_HUMAN	NONO	physical	20850016
PHC3_HUMAN	PHC3	physical	20850016
MIER1_HUMAN	MIER1	physical	20850016
CBX1_HUMAN	CBX1	physical	20850016
RING1_HUMAN	RING1	physical	20850016
ADNP_HUMAN	ADNP	physical	20850016
ROAA_HUMAN	HNRNPAB	physical	20850016
CBX8_HUMAN	CBX8	physical	20850016
ROA1_HUMAN	HNRNPA1	physical	20850016
MGAP_HUMAN	MGA	physical	20850016
NUCL_HUMAN	NCL	physical	20850016
HNRPK_HUMAN	HNRNPK	physical	20850016
SFPQ_HUMAN	SFPQ	physical	20850016
HNRPL_HUMAN	HNRNPL	physical	20850016
ROA2_HUMAN	HNRNPA2B1	physical	20850016
HNRPR_HUMAN	HNRNPR	physical	20850016
AHDC1_HUMAN	AHDC1	physical	20850016
ZMYM4_HUMAN	ZMYM4	physical	20850016
CHD4_HUMAN	CHD4	physical	20850016
CBX2_HUMAN	CBX2	physical	20850016
NSD2_HUMAN	WHSC1	physical	20850016
PHF1_HUMAN	PHF1	physical	23273982
H2AY_HUMAN	H2AFY	physical	25306110
PHRF1_HUMAN	PHRF1	physical	25855964
ANM5_HUMAN	PRMT5	physical	25713080
NBN_HUMAN	NBN	physical	25823024
MRE11_HUMAN	MRE11A	physical	25823024
RAD50_HUMAN	RAD50	physical	25823024

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-19 AND LYS-24, AND MASSSPECTROMETRY.
PubMed: 19608861

Methylation

"Identifying and quantifying in vivo methylation sites by heavy methylSILAC.";
Ong S.E., Mittler G., Mann M.;
Nat. Methods 1:119-126(2004).
Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT LYS-28, AND MASS SPECTROMETRY.
PubMed: 15782174

Phosphorylation

"Quantitative interaction proteomics and genome-wide profiling ofepigenetic histone marks and their readers.";
Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S.,Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G.,Mann M.;
Cell 142:967-980(2010).
Cited for: PHOSPHORYLATION AT SER-58 AND THR-81.
PubMed: 20850016

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND MASSSPECTROMETRY.
PubMed: 18691976