dbPTM

KIF2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KIF2C_HUMAN
UniProt AC	Q99661
Protein Name	Kinesin-like protein KIF2C
Gene Name	KIF2C
Organism	Homo sapiens (Human).
Sequence Length	725
Subcellular Localization	Cytoplasm, cytoskeleton . Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MA
Protein Description	In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. [PubMed: 21820309 Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis]
Protein Sequence	MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRSRSTRMSTVSELRITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEIPLRMVSEEMEEQVHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEEKAMEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMDSSLQA ------CCCCHHHHH	15.53	22814378
5	Phosphorylation	---MAMDSSLQARLF ---CCCCHHHHHHHC	21.62	20860994
6	Phosphorylation	--MAMDSSLQARLFP --CCCCHHHHHHHCC	21.89	25159151
18	Acetylation	LFPGLAIKIQRSNGL HCCCEEEEEEECCCC	27.46	25953088
18	Ubiquitination	LFPGLAIKIQRSNGL HCCCEEEEEEECCCC	27.46	-
22	Phosphorylation	LAIKIQRSNGLIHSA EEEEEEECCCCEEEC	20.90	30266825
28	Phosphorylation	RSNGLIHSANVRTVN ECCCCEEECEEEEEE	17.97	30266825
33	Phosphorylation	IHSANVRTVNLEKSC EEECEEEEEECCCCE	14.95	-
36 (in isoform 2)	Ubiquitination	-	8.35	21890473
52	Ubiquitination	WAEGGATKGKEIDFD EECCCCCCCCCCCHH	68.41	-
54	Ubiquitination	EGGATKGKEIDFDDV CCCCCCCCCCCHHHH	53.72	-
77	Ubiquitination	QLLPLHPKDNLPLQE HHCCCCCCCCCCCCC	48.80	-
87	Phosphorylation	LPLQENVTIQKQKRR CCCCCCCCCCCHHHH	29.31	30576142
90	Ubiquitination	QENVTIQKQKRRSVN CCCCCCCCHHHHCCC	54.67	21906983
90 (in isoform 1)	Ubiquitination	-	54.67	21890473
95	Phosphorylation	IQKQKRRSVNSKIPA CCCHHHHCCCCCCCC	29.68	21712546
98	Phosphorylation	QKRRSVNSKIPAPKE HHHHCCCCCCCCCHH	29.79	26434776
99	Acetylation	KRRSVNSKIPAPKES HHHCCCCCCCCCHHH	47.72	25953088
99	Ubiquitination	KRRSVNSKIPAPKES HHHCCCCCCCCCHHH	47.72	-
104	Ubiquitination	NSKIPAPKESLRSRS CCCCCCCHHHHHCCC	63.14	-
106	Phosphorylation	KIPAPKESLRSRSTR CCCCCHHHHHCCCCC	34.90	30266825
109	Phosphorylation	APKESLRSRSTRMST CCHHHHHCCCCCCCE	35.56	22817900
111	Phosphorylation	KESLRSRSTRMSTVS HHHHHCCCCCCCEEE	22.93	25159151
112	Phosphorylation	ESLRSRSTRMSTVSE HHHHCCCCCCCEEEE	29.31	22199227
114	Sulfoxidation	LRSRSTRMSTVSELR HHCCCCCCCEEEEEE	3.89	21406390
115	Phosphorylation	RSRSTRMSTVSELRI HCCCCCCCEEEEEEE	23.51	29255136
116	Phosphorylation	SRSTRMSTVSELRIT CCCCCCCEEEEEEEE	20.78	29255136
118	Phosphorylation	STRMSTVSELRITAQ CCCCCEEEEEEEEEE	30.88	22199227
129	Sulfoxidation	ITAQENDMEVELPAA EEEECCCEEEECCCC	10.55	21406390
139	Phosphorylation	ELPAAANSRKQFSVP ECCCCCCCCCCCCCC	35.81	28985074
141	Ubiquitination	PAAANSRKQFSVPPA CCCCCCCCCCCCCCC	56.36	-
144	Phosphorylation	ANSRKQFSVPPAPTR CCCCCCCCCCCCCCC	31.08	22210691
150	Phosphorylation	FSVPPAPTRPSCPAV CCCCCCCCCCCCCCC	58.27	25159151
153	Phosphorylation	PPAPTRPSCPAVAEI CCCCCCCCCCCCEEC	29.46	25159151
166	Phosphorylation	EIPLRMVSEEMEEQV ECCHHHCCHHHHHHH	20.63	22617229
175	Phosphorylation	EMEEQVHSIRGSSSA HHHHHHHHHCCCCCC	18.35	25159151
177	Methylation	EEQVHSIRGSSSANP HHHHHHHCCCCCCCC	41.79	115481249
179	Phosphorylation	QVHSIRGSSSANPVN HHHHHCCCCCCCCCH	15.98	25159151
180	Phosphorylation	VHSIRGSSSANPVNS HHHHCCCCCCCCCHH	35.97	25262027
181	Phosphorylation	HSIRGSSSANPVNSV HHHCCCCCCCCCHHH	33.49	29396449
187	Phosphorylation	SSANPVNSVRRKSCL CCCCCCHHHHHHHHH	19.75	23401153
192	Phosphorylation	VNSVRRKSCLVKEVE CHHHHHHHHHHHHHH	15.75	29496963
196	Acetylation	RRKSCLVKEVEKMKN HHHHHHHHHHHHHHC	42.99	26051181
196	Ubiquitination	RRKSCLVKEVEKMKN HHHHHHHHHHHHHHC	42.99	-
223	Phosphorylation	RMKRAQEYDSSFPNW HHHHHHHHHCCCCCH	14.72	28796482
234	Methylation	FPNWEFARMIKEFRA CCCHHHHHHHHHHHH	32.45	115481259
237	Ubiquitination	WEFARMIKEFRATLE HHHHHHHHHHHHHHE	41.27	-
270	Ubiquitination	VRKRPLNKQELAKKE EECCCCCHHHHHHHC	53.48	-
275	Acetylation	LNKQELAKKEIDVIS CCHHHHHHHCCCEEE	64.66	28734223
276	Acetylation	NKQELAKKEIDVISI CHHHHHHHCCCEEEE	55.05	26051181
276	Ubiquitination	NKQELAKKEIDVISI CHHHHHHHCCCEEEE	55.05	-
285	Phosphorylation	IDVISIPSKCLLLVH CCEEEECCCCEEEEC	34.04	24719451
286	Ubiquitination	DVISIPSKCLLLVHE CEEEECCCCEEEECC	24.44	-
287	Glutathionylation	VISIPSKCLLLVHEP EEEECCCCEEEECCC	3.67	22555962
295	Acetylation	LLLVHEPKLKVDLTK EEEECCCCCEEEHHH	58.94	26051181
295	Ubiquitination	LLLVHEPKLKVDLTK EEEECCCCCEEEHHH	58.94	-
297	Ubiquitination	LVHEPKLKVDLTKYL EECCCCCEEEHHHHH	39.57	-
301	Phosphorylation	PKLKVDLTKYLENQA CCCEEEHHHHHHHCC	17.12	21857030
311 (in isoform 2)	Ubiquitination	-	7.56	21890473
328	Phosphorylation	NEVVYRFTARPLVQT CCEEEEEECCCHHHH	16.86	28674151
341	Ubiquitination	QTIFEGGKATCFAYG HHHHCCCEEEEEEEC	51.91	-
347	Phosphorylation	GKATCFAYGQTGSGK CEEEEEEECCCCCCC	6.90	29496907
354	Ubiquitination	YGQTGSGKTHTMGGD ECCCCCCCCEECCCC	38.54	-
361 (in isoform 2)	Ubiquitination	-	31.75	21890473
365	Methylation	MGGDLSGKAQNASKG CCCCCCCCCCHHHCC	43.34	42355277
365	Ubiquitination	MGGDLSGKAQNASKG CCCCCCCCCCHHHCC	43.34	21906983
365 (in isoform 1)	Ubiquitination	-	43.34	21890473
371	Ubiquitination	GKAQNASKGIYAMAS CCCCHHHCCHHEEEC	47.09	-
372 (in isoform 2)	Ubiquitination	-	18.68	21890473
374	Phosphorylation	QNASKGIYAMASRDV CHHHCCHHEEECCCE	10.05	27642862
385	Acetylation	SRDVFLLKNQPCYRK CCCEEEECCCHHHHH	56.54	26051181
385	Ubiquitination	SRDVFLLKNQPCYRK CCCEEEECCCHHHHH	56.54	-
398	Phosphorylation	RKLGLEVYVTFFEIY HHCCCEEEEEEEEEE	5.61	-
405	Phosphorylation	YVTFFEIYNGKLFDL EEEEEEEECCCHHHH	15.63	-
415	Acetylation	KLFDLLNKKAKLRVL CHHHHHCCCCCEEEE	54.82	25953088
415	Ubiquitination	KLFDLLNKKAKLRVL CHHHHHCCCCCEEEE	54.82	21906983
415 (in isoform 1)	Ubiquitination	-	54.82	21890473
416	Ubiquitination	LFDLLNKKAKLRVLE HHHHHCCCCCEEEEC	50.08	-
426	Ubiquitination	LRVLEDGKQQVQVVG EEEECCCCCEEEEEE	50.29	21906983
426 (in isoform 1)	Ubiquitination	-	50.29	21890473
453	Phosphorylation	IKMIDMGSACRTSGQ HHHHCCCCCHHCCCC	19.98	22199227
457	Phosphorylation	DMGSACRTSGQTFAN CCCCCHHCCCCCCCC	36.77	28450419
458	Phosphorylation	MGSACRTSGQTFANS CCCCHHCCCCCCCCC	15.00	28450419
461	Phosphorylation	ACRTSGQTFANSNSS CHHCCCCCCCCCCCC	28.39	28450419
464 (in isoform 2)	Ubiquitination	-	37.22	21890473
487	Ubiquitination	AKGRMHGKFSLVDLA HCCCCCCEEEEEECC	19.66	-
489	Phosphorylation	GRMHGKFSLVDLAGN CCCCCEEEEEECCCC	30.85	-
498	Methylation	VDLAGNERGADTSSA EECCCCCCCCCCCHH	49.99	115481229
518	Ubiquitination	MEGAEINKSLLALKE HCHHHHHHHHHHHHH	48.41	21890473
518 (in isoform 1)	Ubiquitination	-	48.41	21890473
519	Phosphorylation	EGAEINKSLLALKEC CHHHHHHHHHHHHHH	24.91	23401153
524	Ubiquitination	NKSLLALKECIRALG HHHHHHHHHHHHHHC	44.95	-
526	Glutathionylation	SLLALKECIRALGQN HHHHHHHHHHHHCCC	2.14	22555962
534	Ubiquitination	IRALGQNKAHTPFRE HHHHCCCCCCCCCCH	33.39	-
537	Phosphorylation	LGQNKAHTPFRESKL HCCCCCCCCCCHHHH	29.05	22817900
543	Acetylation	HTPFRESKLTQVLRD CCCCCHHHHHHHHHH	51.29	25953088
543	Ubiquitination	HTPFRESKLTQVLRD CCCCCHHHHHHHHHH	51.29	-
549	Methylation	SKLTQVLRDSFIGEN HHHHHHHHHHCCCCC	38.38	-
551	Phosphorylation	LTQVLRDSFIGENSR HHHHHHHHCCCCCCC	16.60	23186163
589	Phosphorylation	ADRVKELSPHSGPSG HHHHHHCCCCCCCCH	22.97	26074081
592	Phosphorylation	VKELSPHSGPSGEQL HHHCCCCCCCCHHHE	56.64	26074081
595	Phosphorylation	LSPHSGPSGEQLIQM CCCCCCCCHHHEEEE	59.49	26074081
604	Phosphorylation	EQLIQMETEEMEACS HHEEEECHHHHHHHH	31.72	20068231
611	Phosphorylation	TEEMEACSNGALIPG HHHHHHHHCCCCCCC	45.40	20068231
621	Phosphorylation	ALIPGNLSKEEEELS CCCCCCCCHHHHHHH	41.86	20068231
628	Phosphorylation	SKEEEELSSQMSSFN CHHHHHHHHHHHHHH	23.08	22199227
629	Phosphorylation	KEEEELSSQMSSFNE HHHHHHHHHHHHHHH	42.39	17525332
632	Phosphorylation	EELSSQMSSFNEAMT HHHHHHHHHHHHHHH	24.92	25159151
633	Phosphorylation	ELSSQMSSFNEAMTQ HHHHHHHHHHHHHHH	27.09	25159151
639	Phosphorylation	SSFNEAMTQIRELEE HHHHHHHHHHHHHHH	28.08	29523821
647	Ubiquitination	QIRELEEKAMEELKE HHHHHHHHHHHHHHH	43.59	-
692	Acetylation	SALAQQAKHFSALRD HHHHHHHHHHHHHHH	40.62	25953088
692	Ubiquitination	SALAQQAKHFSALRD HHHHHHHHHHHHHHH	40.62	-
702	Acetylation	SALRDVIKALRLAMQ HHHHHHHHHHHHHHH	41.01	25953088
702	Ubiquitination	SALRDVIKALRLAMQ HHHHHHHHHHHHHHH	41.01	-
715	Phosphorylation	MQLEEQASRQISSKK HHHHHHHHHHHHHCC	25.14	30266825
719	Phosphorylation	EQASRQISSKKRPQ- HHHHHHHHHCCCCC-	27.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
95	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
109	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
111	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
111	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
115	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
192	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
192	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
537	T	Phosphorylation	Kinase	CDK1	P06493	PSP
621	S	Phosphorylation	Kinase	PLK1	P53350	PSP
632	S	Phosphorylation	Kinase	PLK1	P53350	PSP
633	S	Phosphorylation	Kinase	PLK1	P53350	PSP
715	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KIF2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KIF2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF2C_HUMAN	KIF2C	physical	11466324
A4_HUMAN	APP	physical	21832049
ZN566_HUMAN	ZNF566	physical	21988832
PLK1_HUMAN	PLK1	physical	24931513
AATC_HUMAN	GOT1	physical	26344197
HSP7E_HUMAN	HSPA14	physical	26344197
PCBP2_HUMAN	PCBP2	physical	26344197
WDR5_HUMAN	WDR5	physical	26344197
CENPB_HUMAN	CENPB	physical	26496610
T2FA_HUMAN	GTF2F1	physical	26496610
KIF2A_HUMAN	KIF2A	physical	26496610
MBD1_HUMAN	MBD1	physical	26496610
RL5_HUMAN	RPL5	physical	26496610
RL7_HUMAN	RPL7	physical	26496610
RL9_HUMAN	RPL9	physical	26496610
RS25_HUMAN	RPS25	physical	26496610
BRPF1_HUMAN	BRPF1	physical	26496610
ADAM9_HUMAN	ADAM9	physical	26496610
ESPL1_HUMAN	ESPL1	physical	26496610
CE170_HUMAN	CEP170	physical	26496610
SRGP3_HUMAN	SRGAP3	physical	26496610
POP1_HUMAN	POP1	physical	26496610
RRP12_HUMAN	RRP12	physical	26496610
CAB45_HUMAN	SDF4	physical	26496610
TBCD7_HUMAN	TBC1D7	physical	26496610
TEX10_HUMAN	TEX10	physical	26496610
BOREA_HUMAN	CDCA8	physical	26496610
BCCIP_HUMAN	BCCIP	physical	26496610
WDR18_HUMAN	WDR18	physical	26496610
ZN668_HUMAN	ZNF668	physical	26496610
PCGF5_HUMAN	PCGF5	physical	26496610
RM52_HUMAN	MRPL52	physical	26496610
SMS2_HUMAN	SGMS2	physical	26496610
WDR62_HUMAN	WDR62	physical	26496610
K2C79_HUMAN	KRT79	physical	26496610
MARE1_HUMAN	MAPRE1	physical	27173435
MARE3_HUMAN	MAPRE3	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KIF2C_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-166, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-179, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628; SER-629; SER-632AND SER-633, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Aurora B regulates MCAK at the mitotic centromere."; Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K.,Wordeman L., Swedlow J.R.; Dev. Cell 6:253-268(2004). Cited for: PHOSPHORYLATION AT SER-95 BY AURKB, AND SUBCELLULAR LOCATION.	14960279 [Abstract]