dbPTM

BRPF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRPF1_HUMAN
UniProt AC	P55201
Protein Name	Peregrin {ECO:0000305}
Gene Name	BRPF1 {ECO:0000312\|HGNC:HGNC:14255}
Organism	Homo sapiens (Human).
Sequence Length	1214
Subcellular Localization	Nucleus . Cytoplasm . Localization to the nucleus depends on KAT6A, ING5 and MEAF6.
Protein Description	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. [PubMed: 16387653]
Protein Sequence	MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSSRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MGVDFDVKTFCHNLR CCCCCCHHHHHHHHC	37.41	29967540
18	Acetylation	CHNLRATKPPYECPV HHHHCCCCCCCCCCH	42.90	25953088
32	Phosphorylation	VETCRKVYKSYSGIE HHHHHHHHHHCCCCE	9.39	-
35	Phosphorylation	CRKVYKSYSGIEYHL HHHHHHHCCCCEEEE	13.53	-
43	Phosphorylation	SGIEYHLYHYDHDNP CCCEEEEECCCCCCC	5.75	-
45	Phosphorylation	IEYHLYHYDHDNPPP CEEEEECCCCCCCCC	11.04	-
56	Phosphorylation	NPPPPQQTPLRKHKK CCCCCCCCCCHHHHH	21.02	28555341
56 (in isoform 2)	Phosphorylation	-	21.02	24719451
68	Phosphorylation	HKKKGRQSRPANKQS HHHCCCCCCCCCCCC	38.58	27174698
73	Acetylation	RQSRPANKQSPSPSE CCCCCCCCCCCCHHH	55.01	25953088
75	Phosphorylation	SRPANKQSPSPSEVS CCCCCCCCCCHHHHC	29.02	22167270
75 (in isoform 2)	Phosphorylation	-	29.02	24719451
77	Phosphorylation	PANKQSPSPSEVSQS CCCCCCCCHHHHCCC	46.43	22167270
77 (in isoform 2)	Phosphorylation	-	46.43	24719451
79	Phosphorylation	NKQSPSPSEVSQSPG CCCCCCHHHHCCCCC	55.77	25850435
79 (in isoform 2)	Phosphorylation	-	55.77	24719451
82	Phosphorylation	SPSPSEVSQSPGREV CCCHHHHCCCCCHHH	22.38	23663014
82 (in isoform 2)	Phosphorylation	-	22.38	27251275
84	Phosphorylation	SPSEVSQSPGREVMS CHHHHCCCCCHHHHH	23.09	30266825
84 (in isoform 2)	Phosphorylation	-	23.09	24719451
91	Phosphorylation	SPGREVMSYAQAQRM CCCHHHHHHHHHHHC	23.61	20068231
111	Phosphorylation	HGRVHRISIFDNLDV CCCEEEEEEECCCCC	19.70	30278072
120	Phosphorylation	FDNLDVVSEDEEAPE ECCCCCCCCCCCCCC	38.90	30266825
120 (in isoform 2)	Phosphorylation	-	38.90	24719451
134	Phosphorylation	EEAPENGSNKENTET CCCCCCCCCCCCCCC	57.20	26074081
139	Phosphorylation	NGSNKENTETPAATP CCCCCCCCCCCCCCC	42.18	27050516
141	Phosphorylation	SNKENTETPAATPKS CCCCCCCCCCCCCCC	19.05	29255136
145	Phosphorylation	NTETPAATPKSGKHK CCCCCCCCCCCCCCC	33.10	29255136
145 (in isoform 2)	Phosphorylation	-	33.10	27251275
147	Acetylation	ETPAATPKSGKHKNK CCCCCCCCCCCCCCC	68.44	7430951
148	Phosphorylation	TPAATPKSGKHKNKE CCCCCCCCCCCCCCC	55.03	28258704
150	Acetylation	AATPKSGKHKNKEKR CCCCCCCCCCCCCCC	59.50	26051181
152	Acetylation	TPKSGKHKNKEKRKD CCCCCCCCCCCCCCC	73.52	26051181
154	Acetylation	KSGKHKNKEKRKDSN CCCCCCCCCCCCCCC	70.21	26051181
171	Phosphorylation	HHHNVSASTTPKLPE CCCCCCCCCCCCCCH	25.88	29116813
188	Phosphorylation	YRELEQDTPDAPPRP HHHHHCCCCCCCCCC	23.82	25159151
188 (in isoform 2)	Phosphorylation	-	23.82	24719451
234	Phosphorylation	IMNERRKTEGVSPIP HHCCCCCCCCCCCCC	35.84	22617229
238	Phosphorylation	RRKTEGVSPIPQEIF CCCCCCCCCCCHHHH	28.15	25159151
238 (in isoform 2)	Phosphorylation	-	28.15	24719451
247	Phosphorylation	IPQEIFEYLMDRLEK CCHHHHHHHHHHHHH	9.14	24532841
323	Phosphorylation	LCRRCLQSPSRAVDC HHHHHCCCCCCCEEE	16.34	26699800
429	Phosphorylation	KMEPVRETGANGTSF EEEECCCCCCCCCCE	30.91	-
434	Phosphorylation	RETGANGTSFSVRKT CCCCCCCCCEEEEEE	26.80	28555341
435	Phosphorylation	ETGANGTSFSVRKTA CCCCCCCCEEEEEEE	19.54	17081983
437	Phosphorylation	GANGTSFSVRKTAYC CCCCCCEEEEEEEEC	22.30	-
443	Phosphorylation	FSVRKTAYCDIHTPP EEEEEEEECCCCCCC	8.90	27251275
448	Phosphorylation	TAYCDIHTPPGSARR EEECCCCCCCCCHHC	31.35	21712546
448 (in isoform 2)	Phosphorylation	-	31.35	24719451
452	Phosphorylation	DIHTPPGSARRLPAL CCCCCCCCHHCCCCC	25.11	25849741
452 (in isoform 2)	Phosphorylation	-	25.11	24719451
460	Phosphorylation	ARRLPALSHSEGEED HHCCCCCCCCCCCCC	27.37	23927012
460 (in isoform 2)	Phosphorylation	-	27.37	24719451
462	Phosphorylation	RLPALSHSEGEEDED CCCCCCCCCCCCCCC	43.87	23927012
462 (in isoform 2)	Phosphorylation	-	43.87	24719451
476	Acetylation	DEEEDEGKGWSSEKV CCCCCCCCCCCHHHH	55.98	23236377
479	Phosphorylation	EDEGKGWSSEKVKKA CCCCCCCCHHHHHHH	36.97	23927012
480	Phosphorylation	DEGKGWSSEKVKKAK CCCCCCCHHHHHHHH	34.62	23927012
523	Ubiquitination	IPPHRLSKITNRLTI CCHHHHHHHHCCHHH	59.13	29967540
542	Phosphorylation	QFMQRLHSYWTLKRQ HHHHHHHHHHHHHHH	27.27	-
545	Phosphorylation	QRLHSYWTLKRQSRN HHHHHHHHHHHHCCC	17.73	-
547	Methylation	LHSYWTLKRQSRNGV HHHHHHHHHHCCCCH	40.80	115974795
550	Phosphorylation	YWTLKRQSRNGVPLL HHHHHHHCCCCHHHH	31.57	28188228
562	Phosphorylation	PLLRRLQTHLQSQRN HHHHHHHHHHHHHCC	29.19	28555341
577	Phosphorylation	CDQVGRDSEDKNWAL HHHCCCCCHHHCHHH	46.46	30576142
577 (in isoform 2)	Phosphorylation	-	46.46	24719451
580	Acetylation	VGRDSEDKNWALKEQ CCCCCHHHCHHHHHH	50.79	23749302
585	Acetylation	EDKNWALKEQLKSWQ HHHCHHHHHHHHHHH	35.35	26051181
640	Phosphorylation	FLILLRKTLEQLQEK HHHHHHHHHHHHHHC	29.15	22210691
710	Acetylation	NCLKYNAKDTIFYRA HHHHCCCCCCEEHHH	52.33	26051181
745	Phosphorylation	KMGIDFETGMHIPHS HCCCCCCCCCCCCHH	39.54	21406692
752	Phosphorylation	TGMHIPHSLAGDEAT CCCCCCHHHCCCCCC	17.98	21406692
759	Phosphorylation	SLAGDEATHHTEDAA HHCCCCCCCCCCCHH	16.49	21406692
762	Phosphorylation	GDEATHHTEDAAEEE CCCCCCCCCCHHHHH	28.14	21406692
800	Acetylation	LDEVNASKQSVGRSR HHHHCCCHHHHCHHH	44.15	25953088
800	Ubiquitination	LDEVNASKQSVGRSR HHHHCCCHHHHCHHH	44.15	29967540
806	Ubiquitination	SKQSVGRSRRAKMIK CHHHHCHHHHHHHHH	21.86	29967540
822	Acetylation	EMTALRRKLAHQRET HHHHHHHHHHHHHHH	43.52	26051181
829	Phosphorylation	KLAHQRETGRDGPER HHHHHHHHCCCCCHH	39.44	-
840	Phosphorylation	GPERHGPSSRGSLTP CCHHCCCCCCCCCCC	36.94	24247654
841	Phosphorylation	PERHGPSSRGSLTPH CHHCCCCCCCCCCCC	43.74	28555341
844	Phosphorylation	HGPSSRGSLTPHPAA CCCCCCCCCCCCCCC	28.14	23401153
846	Phosphorylation	PSSRGSLTPHPAACD CCCCCCCCCCCCCCC	22.65	30266825
852 (in isoform 2)	Phosphorylation	-	7.89	27251275
854	Acetylation	PHPAACDKDGQTDSA CCCCCCCCCCCCCCC	64.74	26051181
857	Phosphorylation	AACDKDGQTDSAAEE CCCCCCCCCCCCHHH	52.87	33259812
858	Phosphorylation	ACDKDGQTDSAAEES CCCCCCCCCCCHHHC	37.13	23401153
858 (in isoform 4)	Phosphorylation	-	37.13	29116813
860	Phosphorylation	DKDGQTDSAAEESSS CCCCCCCCCHHHCCC	32.53	23401153
860 (in isoform 4)	Phosphorylation	-	32.53	29116813
864	Phosphorylation	QTDSAAEESSSQETS CCCCCHHHCCCHHHH	51.71	33259812
864 (in isoform 2)	Phosphorylation	-	51.71	24719451
865	Phosphorylation	TDSAAEESSSQETSK CCCCHHHCCCHHHHC	27.13	30266825
866	Phosphorylation	DSAAEESSSQETSKG CCCHHHCCCHHHHCC	39.04	30266825
866 (in isoform 2)	Phosphorylation	-	39.04	24719451
867	Phosphorylation	SAAEESSSQETSKGL CCHHHCCCHHHHCCC	41.12	30266825
870	Phosphorylation	EESSSQETSKGLGPN HHCCCHHHHCCCCCC	28.27	23663014
871	Phosphorylation	ESSSQETSKGLGPNM HCCCHHHHCCCCCCC	24.79	30266825
879	Phosphorylation	KGLGPNMSSTPAHEV CCCCCCCCCCCHHHC	37.39	27174698
880	Phosphorylation	GLGPNMSSTPAHEVG CCCCCCCCCCHHHCC	27.86	27174698
881	Phosphorylation	LGPNMSSTPAHEVGR CCCCCCCCCHHHCCC	19.72	28985074
886 (in isoform 2)	Phosphorylation	-	5.33	27251275
890	Phosphorylation	AHEVGRRTSVLFSKK HHHCCCCCEEEEECC	23.09	23401153
891	Phosphorylation	HEVGRRTSVLFSKKN HHCCCCCEEEEECCC	18.27	25159151
895	Phosphorylation	RRTSVLFSKKNPKTA CCCEEEEECCCCCCC	38.26	25159151
896	Acetylation	RTSVLFSKKNPKTAG CCEEEEECCCCCCCC	49.59	21466224
896 (in isoform 2)	Phosphorylation	-	49.59	24719451
897	Acetylation	TSVLFSKKNPKTAGP CEEEEECCCCCCCCC	76.82	21466224
897 (in isoform 2)	Phosphorylation	-	76.82	27251275
900	Acetylation	LFSKKNPKTAGPPKR EEECCCCCCCCCCCC	61.47	21466224
901	Phosphorylation	FSKKNPKTAGPPKRP EECCCCCCCCCCCCC	37.80	20860994
902	Acetylation	SKKNPKTAGPPKRPG ECCCCCCCCCCCCCC	34.32	19608861
917	Phosphorylation	RPPKNRESQMTPSHG CCCCCCCCCCCCCCC	23.24	26055452
920	Phosphorylation	KNRESQMTPSHGGSP CCCCCCCCCCCCCCC	17.63	30266825
922	Phosphorylation	RESQMTPSHGGSPVG CCCCCCCCCCCCCCC	26.12	23401153
925	Phosphorylation	QMTPSHGGSPVGPPQ CCCCCCCCCCCCCCC	24.29	32142685
926	Phosphorylation	MTPSHGGSPVGPPQL CCCCCCCCCCCCCCC	22.47	30266825
926 (in isoform 2)	Phosphorylation	-	22.47	24719451
928 (in isoform 2)	Phosphorylation	-	22.50	27251275
932	Phosphorylation	GSPVGPPQLPIMSSL CCCCCCCCCCCHHHH	64.10	32142685
932 (in isoform 2)	Phosphorylation	-	64.10	24719451
937	Phosphorylation	PPQLPIMSSLRQRKR CCCCCCHHHHHHHHC	27.26	21712546
938	Phosphorylation	PQLPIMSSLRQRKRG CCCCCHHHHHHHHCC	15.36	20068231
961	Phosphorylation	SDSDSDKSTEDPPMD CCCCCCCCCCCCCCC	41.86	25627689
962	Phosphorylation	DSDSDKSTEDPPMDL CCCCCCCCCCCCCCC	50.58	25627689
982	Acetylation	SGGNQPVKKSFLVYR CCCCCCCCCEEEEEE	49.75	25953088
984	Phosphorylation	GNQPVKKSFLVYRND CCCCCCCEEEEEECC	20.35	29214152
1008	Phosphorylation	SESSSSSSSSAASDR CCCCCCCCCCCCCCC	30.20	28985074
1017	Phosphorylation	SAASDRTSTTPSKQG CCCCCCCCCCCCCCC	31.04	28985074
1018	Phosphorylation	AASDRTSTTPSKQGR CCCCCCCCCCCCCCC	41.96	23322592
1027	Acetylation	PSKQGRGKPSFSRGT CCCCCCCCCCCCCCC	35.81	23749302
1034	Phosphorylation	KPSFSRGTFPEDSSE CCCCCCCCCCCCCCC	34.60	27732954
1039	Phosphorylation	RGTFPEDSSEDTSGT CCCCCCCCCCCCCCC	33.68	27732954
1040	Phosphorylation	GTFPEDSSEDTSGTE CCCCCCCCCCCCCCC	52.38	27732954
1043	Phosphorylation	PEDSSEDTSGTENEA CCCCCCCCCCCCCEE	25.63	27732954
1044	Phosphorylation	EDSSEDTSGTENEAY CCCCCCCCCCCCEEE	56.91	27732954
1046	Phosphorylation	SSEDTSGTENEAYSV CCCCCCCCCCEEEEC	35.09	27732954
1051	Phosphorylation	SGTENEAYSVGTGRG CCCCCEEEECCCCCC	9.56	27732954
1052	Phosphorylation	GTENEAYSVGTGRGV CCCCEEEECCCCCCC	22.56	27732954
1055	Phosphorylation	NEAYSVGTGRGVGHS CEEEECCCCCCCCHH	22.88	27732954
1067	Phosphorylation	GHSMVRKSLGRGAGW CHHHHHHHCCCCCCC	26.03	22199227
1076	Phosphorylation	GRGAGWLSEDEDSPL CCCCCCCCCCCCCCC	36.17	25159151
1081	Phosphorylation	WLSEDEDSPLDALDL CCCCCCCCCCHHHHH	25.89	28464451
1082 (in isoform 2)	Phosphorylation	-	46.73	24719451
1173	Acetylation	GVNQDLDKEKMLEGR CCCCCCCHHHHHHCH	67.54	26051181
1187	Phosphorylation	RKSNIRKSVQIAYHR HHHHHHHHHHHHHHH	14.92	25159151
1213	Phosphorylation	QSSETSDSD------ CCCCCCCCC------	45.01	18491316

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRPF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRPF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRPF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PBIP1_HUMAN	PBXIP1	physical	20211142
ING5_HUMAN	ING5	physical	18794358
KAT6A_HUMAN	KAT6A	physical	18794358
EAF6_HUMAN	MEAF6	physical	18794358
KAT6A_HUMAN	KAT6A	physical	18469222
H31_HUMAN	HIST1H3A	physical	20400950
H32_HUMAN	HIST2H3C	physical	21720545

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRPF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-1187, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462 ANDSER-922, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.	15302935 [Abstract]