UniProt ID | PCGF5_HUMAN | |
---|---|---|
UniProt AC | Q86SE9 | |
Protein Name | Polycomb group RING finger protein 5 | |
Gene Name | PCGF5 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 256 | |
Subcellular Localization | Nucleus . Nucleus, nucleoplasm . Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. | |
Protein Description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [PubMed: 26151332 Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity] | |
Protein Sequence | MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
15 | Phosphorylation | LVKDFNPYITCYICK HHCCCCCCCEEEEEC | 15.23 | 28152594 | |
17 | Phosphorylation | KDFNPYITCYICKGY CCCCCCCEEEEECCE | 8.07 | 28152594 | |
175 | Phosphorylation | STRVTVGTIKKFLSL CCEEEHHHHHHHHHE | 25.86 | 28060719 | |
228 | Phosphorylation | NFRCLNCSASQVCSQ CEEECCCCHHHHHCC | 29.86 | 22210691 | |
230 | Phosphorylation | RCLNCSASQVCSQDG EECCCCHHHHHCCCC | 13.57 | 22210691 | |
249 | Phosphorylation | SYPMVLQYRPRIDFG CCCEEEEECCCCCCC | 20.58 | 22210691 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCGF5_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCGF5_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCGF5_HUMAN !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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