PCGF5_HUMAN - dbPTM
PCGF5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCGF5_HUMAN
UniProt AC Q86SE9
Protein Name Polycomb group RING finger protein 5
Gene Name PCGF5
Organism Homo sapiens (Human).
Sequence Length 256
Subcellular Localization Nucleus . Nucleus, nucleoplasm . Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
Protein Description Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [PubMed: 26151332 Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity]
Protein Sequence MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationLVKDFNPYITCYICK
HHCCCCCCCEEEEEC
15.2328152594
17PhosphorylationKDFNPYITCYICKGY
CCCCCCCEEEEECCE
8.0728152594
175PhosphorylationSTRVTVGTIKKFLSL
CCEEEHHHHHHHHHE
25.8628060719
228PhosphorylationNFRCLNCSASQVCSQ
CEEECCCCHHHHHCC
29.8622210691
230PhosphorylationRCLNCSASQVCSQDG
EECCCCHHHHHCCCC
13.5722210691
249PhosphorylationSYPMVLQYRPRIDFG
CCCEEEEECCCCCCC
20.5822210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCGF5_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCGF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCGF5_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RING2_HUMANRNF2physical
22325352
RING1_HUMANRING1physical
22325352
RYBP_HUMANRYBPphysical
22325352
YAF2_HUMANYAF2physical
22325352
AUTS2_HUMANAUTS2physical
22325352
FBRS_HUMANFBRSphysical
22325352
FBSL_HUMANFBRSL1physical
22325352
CSK21_HUMANCSNK2A1physical
22325352
CSK22_HUMANCSNK2A2physical
22325352
CSK2B_HUMANCSNK2Bphysical
22325352
ANM6_HUMANPRMT6physical
23455924
RING2_HUMANRNF2physical
22493164
RING1_HUMANRING1physical
22493164
TRIM8_HUMANTRIM8physical
22493164
AUTS2_HUMANAUTS2physical
26186194
RYBP_HUMANRYBPphysical
26186194
FBRS_HUMANFBRSphysical
26186194
CSK22_HUMANCSNK2A2physical
26186194
CSK21_HUMANCSNK2A1physical
26186194
CSK2B_HUMANCSNK2Bphysical
26186194
RING2_HUMANRNF2physical
26186194
RING1_HUMANRING1physical
26186194
YAF2_HUMANYAF2physical
26186194
AUTS2_HUMANAUTS2physical
25519132
RING2_HUMANRNF2physical
25519132
RING2_HUMANRNF2physical
26151332
PCGF5_HUMANPCGF5physical
26151332
UB2D3_HUMANUBE2D3physical
26151332
CSK22_HUMANCSNK2A2physical
28514442
RYBP_HUMANRYBPphysical
28514442
FBRS_HUMANFBRSphysical
28514442
AUTS2_HUMANAUTS2physical
28514442
YAF2_HUMANYAF2physical
28514442
RING2_HUMANRNF2physical
28514442
RING1_HUMANRING1physical
28514442
CSK21_HUMANCSNK2A1physical
28514442
CSK2B_HUMANCSNK2Bphysical
28514442
NISCH_HUMANNISCHphysical
27173435
K1671_HUMANKIAA1671physical
27173435

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCGF5_HUMAN

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Related Literatures of Post-Translational Modification

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