PCGF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCGF5_HUMAN
• UniProt AC: Q86SE9
• Protein Name: Polycomb group RING finger protein 5
• Gene Name: PCGF5
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [PubMed: 26151332 Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity]
• Protein Sequence: MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LVKDFNPYITCYICK HHCCCCCCCEEEEEC	15.23	28152594
17	Phosphorylation	KDFNPYITCYICKGY CCCCCCCEEEEECCE	8.07	28152594
175	Phosphorylation	STRVTVGTIKKFLSL CCEEEHHHHHHHHHE	25.86	28060719
228	Phosphorylation	NFRCLNCSASQVCSQ CEEECCCCHHHHHCC	29.86	22210691
230	Phosphorylation	RCLNCSASQVCSQDG EECCCCHHHHHCCCC	13.57	22210691
249	Phosphorylation	SYPMVLQYRPRIDFG CCCEEEEECCCCCCC	20.58	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCGF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCGF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCGF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING2_HUMAN	RNF2	physical	22325352
RING1_HUMAN	RING1	physical	22325352
RYBP_HUMAN	RYBP	physical	22325352
YAF2_HUMAN	YAF2	physical	22325352
AUTS2_HUMAN	AUTS2	physical	22325352
FBRS_HUMAN	FBRS	physical	22325352
FBSL_HUMAN	FBRSL1	physical	22325352
CSK21_HUMAN	CSNK2A1	physical	22325352
CSK22_HUMAN	CSNK2A2	physical	22325352
CSK2B_HUMAN	CSNK2B	physical	22325352
ANM6_HUMAN	PRMT6	physical	23455924
RING2_HUMAN	RNF2	physical	22493164
RING1_HUMAN	RING1	physical	22493164
TRIM8_HUMAN	TRIM8	physical	22493164
AUTS2_HUMAN	AUTS2	physical	26186194
RYBP_HUMAN	RYBP	physical	26186194
FBRS_HUMAN	FBRS	physical	26186194
CSK22_HUMAN	CSNK2A2	physical	26186194
CSK21_HUMAN	CSNK2A1	physical	26186194
CSK2B_HUMAN	CSNK2B	physical	26186194
RING2_HUMAN	RNF2	physical	26186194
RING1_HUMAN	RING1	physical	26186194
YAF2_HUMAN	YAF2	physical	26186194
AUTS2_HUMAN	AUTS2	physical	25519132
RING2_HUMAN	RNF2	physical	25519132
RING2_HUMAN	RNF2	physical	26151332
PCGF5_HUMAN	PCGF5	physical	26151332
UB2D3_HUMAN	UBE2D3	physical	26151332
CSK22_HUMAN	CSNK2A2	physical	28514442
RYBP_HUMAN	RYBP	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
AUTS2_HUMAN	AUTS2	physical	28514442
YAF2_HUMAN	YAF2	physical	28514442
RING2_HUMAN	RNF2	physical	28514442
RING1_HUMAN	RING1	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
CSK2B_HUMAN	CSNK2B	physical	28514442
NISCH_HUMAN	NISCH	physical	27173435
K1671_HUMAN	KIAA1671	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.