AUTS2_HUMAN - dbPTM
AUTS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AUTS2_HUMAN
UniProt AC Q8WXX7
Protein Name Autism susceptibility gene 2 protein
Gene Name AUTS2
Organism Homo sapiens (Human).
Sequence Length 1259
Subcellular Localization Nucleus . Cytoplasm, cytoskeleton . Cell projection, growth cone . Detected both in cytoplasm and nucleus. Colocalizes with RAC1 at actin-rich growth cones. Detected on the promoter region of actively transcribed genes.
Protein Description Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. [PubMed: 25519132 The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B]
Protein Sequence MDGPTRGHGLRKKRRSRSQRDRERRSRGGLGAGAAGGGGAGRTRALSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVALKPQERVEKRQTPLTKKKREALTNGLSFHSKKSRLSHPHHYSSDRENDRNLCQHLGKRKKMPKALRQLKPGQNSCRDSDSESASGESKGFHRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVIVNKDPELGVGTLPEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRERPPSHTLKDIEAR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Methylation--MDGPTRGHGLRKK
--CCCCCCCCHHHHH		37.94-
26PhosphorylationQRDRERRSRGGLGAG
HHHHHHHHHCCCCCC		41.3128555341
27MethylationRDRERRSRGGLGAGA
HHHHHHHHCCCCCCC		41.19-
47PhosphorylationAGRTRALSLASSSGS
CHHHHHHHHHHCCCC		22.3928111955
50PhosphorylationTRALSLASSSGSDKE
HHHHHHHHCCCCCCC		30.2628111955
51PhosphorylationRALSLASSSGSDKED
HHHHHHHCCCCCCCC		32.8628111955
52PhosphorylationALSLASSSGSDKEDN
HHHHHHCCCCCCCCC		39.5628111955
54PhosphorylationSLASSSGSDKEDNGK
HHHHCCCCCCCCCCC		47.6728111955
64PhosphorylationEDNGKPPSSAPSRPR
CCCCCCCCCCCCCCC		47.8928111955
65PhosphorylationDNGKPPSSAPSRPRP
CCCCCCCCCCCCCCC		50.3928111955
68PhosphorylationKPPSSAPSRPRPPRR
CCCCCCCCCCCCCCC		55.4228111955
80PhosphorylationPRRKRRESTSAEEDI
CCCCCCCCCCCCHHH		26.3327732954
81PhosphorylationRRKRRESTSAEEDII
CCCCCCCCCCCHHHH		27.4827732954
82PhosphorylationRKRRESTSAEEDIID
CCCCCCCCCCHHHHH		42.8527732954
94PhosphorylationIIDGFAMTSFVTFEA
HHHHCHHHCEEHHHH		18.6427732954
95PhosphorylationIDGFAMTSFVTFEAL
HHHCHHHCEEHHHHH		12.4827732954
98PhosphorylationFAMTSFVTFEALEKD
CHHHCEEHHHHHHHH		17.4727732954
143PhosphorylationHSKKSRLSHPHHYSS
CCHHHCCCCCCCCCC		33.5927732954
148PhosphorylationRLSHPHHYSSDREND
CCCCCCCCCCCCHHH		13.5627732954
149PhosphorylationLSHPHHYSSDRENDR
CCCCCCCCCCCHHHH		22.7727732954
150PhosphorylationSHPHHYSSDRENDRN
CCCCCCCCCCHHHHH		33.2627732954
201PhosphorylationSKGFHRSSSRERLSD
CCCCCCCCCCCCCCC		33.1130576142
202 (in isoform 3)Phosphorylation-39.1322468782
202PhosphorylationKGFHRSSSRERLSDS
CCCCCCCCCCCCCCC		39.1330576142
210PhosphorylationRERLSDSSAPSSLGT
CCCCCCCCCCCCCCC		49.5430576142
217 (in isoform 3)Phosphorylation-33.7222468782
255PhosphorylationDPELGVGTLPEHDSQ
CCCCCCCCCCCCCCC		36.4127732954
261PhosphorylationGTLPEHDSQDAGPIV
CCCCCCCCCCCCCCC		31.6927732954
319PhosphorylationEPQLRAPSPDPDLVQ
CCCCCCCCCCCCHHH		40.7330266825
505O-linked_GlycosylationLNTRFLASQSADRGA
HHHHHHHHHCCCCCC		27.1529351928
505PhosphorylationLNTRFLASQSADRGA
HHHHHHHHHCCCCCC		27.1530631047
507PhosphorylationTRFLASQSADRGASL
HHHHHHHCCCCCCCC		29.6430631047
510MethylationLASQSADRGASLGPP
HHHHCCCCCCCCCCC		42.15-
513PhosphorylationQSADRGASLGPPPYL
HCCCCCCCCCCCCCC		36.3628555341
578PhosphorylationVDPFYRHSLFHSYPP
CCHHHHHHHHHHCCC		24.59-
673PhosphorylationKVKKQMQSDPHKLDF
HHHHHHCCCCCCCCC		48.0129396449
799PhosphorylationPWNRLHRTPPSFPTP
CHHHHCCCCCCCCCC		28.8927732954
802PhosphorylationRLHRTPPSFPTPPPW
HHCCCCCCCCCCCCC		45.0927080861
805PhosphorylationRTPPSFPTPPPWLKP
CCCCCCCCCCCCCCC		46.5527080861
832PhosphorylationDRDRDVDKRDSSVSK
HHCCCCCCCCCCCCC		58.9332645325
852PhosphorylationESVEKRHSSHPSPAP
HHHHHHHCCCCCCCC		34.0822496350
853PhosphorylationSVEKRHSSHPSPAPV
HHHHHHCCCCCCCCC		33.0422496350
856PhosphorylationKRHSSHPSPAPVLPV
HHHCCCCCCCCCCCC		28.4230576142
898PhosphorylationKERERDHSESRKDLA
CHHHCCCHHHHHHHH		41.37-
941PhosphorylationKQLARVPSPYVRTPV
HHHHCCCCCCCCCCC		26.4619664994
943PhosphorylationLARVPSPYVRTPVVE
HHCCCCCCCCCCCHH		13.6026074081
946PhosphorylationVPSPYVRTPVVESAR
CCCCCCCCCCHHCCC		15.4723312004
951PhosphorylationVRTPVVESARPNSTS
CCCCCHHCCCCCCCC		20.2630108239
956PhosphorylationVESARPNSTSSREAE
HHCCCCCCCCCCCCC		32.1430576142
957PhosphorylationESARPNSTSSREAEP
HCCCCCCCCCCCCCC		37.0430576142
958PhosphorylationSARPNSTSSREAEPR
CCCCCCCCCCCCCCC		27.5030108239
959PhosphorylationARPNSTSSREAEPRK
CCCCCCCCCCCCCCC		33.9430108239
971PhosphorylationPRKGEPAYENPKKSS
CCCCCCCCCCCCCCC		27.2727642862
1053PhosphorylationMTPFMGISPLPGGER
CCCCCCCCCCCCCCC		18.0424719451
1092MethylationHRRDPLGRDFLLRND
CCCCCCCCCCHHCCC		38.91-
1103MethylationLRNDPLHRLSTPRLY
HCCCHHHHCCCCCHH		37.71-
1105PhosphorylationNDPLHRLSTPRLYEA
CCHHHHCCCCCHHHC		36.0024719451
1106PhosphorylationDPLHRLSTPRLYEAD
CHHHHCCCCCHHHCC		19.6124719451
1108MethylationLHRLSTPRLYEADRS
HHHCCCCCHHHCCCC		50.41-
1114MethylationPRLYEADRSFRDREP
CCHHHCCCCCCCCCC		44.75-
1145MethylationDPRREHERGGHLDER
CCCCHHHCCCCCCHH		59.30-
1162PhosphorylationLHMLREDYEHTRLHS
HHHHHHHHCHHCHHC		12.5928796482
1174PhosphorylationLHSVHPASLDGHLPH
HHCCCHHHCCCCCCC		31.2932142685
1183PhosphorylationDGHLPHPSLITPGLP
CCCCCCHHHCCCCCC		29.3928348404
1186PhosphorylationLPHPSLITPGLPSMH
CCCHHHCCCCCCCCC		19.3228348404
1194PhosphorylationPGLPSMHYPRISPTA
CCCCCCCCCCCCCCC		5.8833259812
1198PhosphorylationSMHYPRISPTAGNQN
CCCCCCCCCCCCCCC		19.9230266825
1200PhosphorylationHYPRISPTAGNQNGL
CCCCCCCCCCCCCCC		40.1730266825
1201PhosphorylationYPRISPTAGNQNGLL
CCCCCCCCCCCCCCC		20.5132142685
1209PhosphorylationGNQNGLLNKTPPTAA
CCCCCCCCCCCCCHH		51.7232142685
1211PhosphorylationQNGLLNKTPPTAALS
CCCCCCCCCCCHHHC		33.1720363803
1214PhosphorylationLLNKTPPTAALSAPP
CCCCCCCCHHHCCCC		26.2626074081
1218PhosphorylationTPPTAALSAPPPLIS
CCCCHHHCCCCCCEE		33.7233259812
1225PhosphorylationSAPPPLISTLGGRPV
CCCCCCEECCCCCCC		25.8423898821
1226PhosphorylationAPPPLISTLGGRPVS
CCCCCEECCCCCCCC		23.5622115753
1233PhosphorylationTLGGRPVSPRRTTPL
CCCCCCCCCCCCCCC		18.5122617229
1237PhosphorylationRPVSPRRTTPLSAEI
CCCCCCCCCCCCHHH		33.7630108239
1238PhosphorylationPVSPRRTTPLSAEIR
CCCCCCCCCCCHHHH		22.0320363803
1241PhosphorylationPRRTTPLSAEIRERP
CCCCCCCCHHHHHCC		25.6720363803
1250PhosphorylationEIRERPPSHTLKDIE
HHHHCCCCCCCCHHH		31.6122817900
1254AcetylationRPPSHTLKDIEAR--
CCCCCCCCHHHCC--		58.7925953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AUTS2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AUTS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AUTS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCGF5_HUMANPCGF5physical
25519132
RING1_HUMANRING1physical
25519132
RING2_HUMANRNF2physical
25519132
RYBP_HUMANRYBPphysical
25519132
YAF2_HUMANYAF2physical
25519132
CSK21_HUMANCSNK2A1physical
25519132
CSK22_HUMANCSNK2A2physical
25519132
CSK2B_HUMANCSNK2Bphysical
25519132
DCAF7_HUMANDCAF7physical
25519132
FBRS_HUMANFBRSphysical
25519132
PCGF3_HUMANPCGF3physical
25519132
EP300_HUMANEP300physical
25519132
RERE_HUMANREREphysical
25519132
RBM14_HUMANRBM14physical
25519132
ZN608_HUMANZNF608physical
25519132
ZN609_HUMANZNF609physical
25519132
TLE3_HUMANTLE3physical
25519132
WDR5_HUMANWDR5physical
25519132
PCGF6_HUMANPCGF6physical
25519132
ATN1_HUMANATN1physical
25519132
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615834Mental retardation, autosomal dominant 26 (MRD26)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AUTS2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1233, AND MASSSPECTROMETRY.

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