dbPTM

PCGF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PCGF6_HUMAN
UniProt AC	Q9BYE7
Protein Name	Polycomb group RING finger protein 6
Gene Name	PCGF6
Organism	Homo sapiens (Human).
Sequence Length	350
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor. [PubMed: 12167161 May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase]
Protein Sequence	MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEGVAVVTAGSVGAA CCCEEEEEECCCCCC	20.78	-
30	Phosphorylation	LPPPPPVSPPALTPA CCCCCCCCCCCCCCC	30.82	26074081
30 (in isoform 3)	Phosphorylation	-	30.82	-
35	Phosphorylation	PVSPPALTPAPAAGE CCCCCCCCCCCCCCC	21.36	22210691
102	Phosphorylation	EEEEEDMSHFSLRLE HHHHHHHCCHHEEEC	33.43	-
105	Phosphorylation	EEDMSHFSLRLEGGR HHHHCCHHEEECCCC	13.73	-
115	Phosphorylation	LEGGRQDSEDEEERL ECCCCCCCCCHHHHH	38.31	29255136
115 (in isoform 3)	Phosphorylation	-	38.31	-
126	Phosphorylation	EERLINLSELTPYIL HHHHHCHHHHHHHHH	26.52	22210691
129	Phosphorylation	LINLSELTPYILCSI HHCHHHHHHHHHHHH	15.25	21406692
131	Phosphorylation	NLSELTPYILCSICK CHHHHHHHHHHHHHC	10.99	21406692
135	Phosphorylation	LTPYILCSICKGYLI HHHHHHHHHHCCCCC	27.81	21406692
145	Phosphorylation	KGYLIDATTITECLH CCCCCCCHHHHHHHH	18.25	27251275
146	Phosphorylation	GYLIDATTITECLHT CCCCCCHHHHHHHHH	27.85	27251275
148	Phosphorylation	LIDATTITECLHTFC CCCCHHHHHHHHHHH	20.67	27251275
153	Phosphorylation	TITECLHTFCKSCIV HHHHHHHHHHHHHHH	20.13	27251275
164	Phosphorylation	SCIVRHFYYSNRCPK HHHHHHHHCCCCCCC	10.40	-
205 (in isoform 3)	Phosphorylation	-	52.22	-
208	Ubiquitination	NLEEREKKQMHDFYK CHHHHHHHHHHHHHH	48.37	27667366
209 (in isoform 3)	Phosphorylation	-	45.57	-
214	Phosphorylation	KKQMHDFYKERGLEV HHHHHHHHHHCCCCC	20.28	26074081
215 (in isoform 3)	Ubiquitination	-	40.71	21890473
215	Ubiquitination	KQMHDFYKERGLEVP HHHHHHHHHCCCCCC	40.71	23000965
220	Ubiquitination	FYKERGLEVPKPAVP HHHHCCCCCCCCCCC	60.65	23000965
223	Sumoylation	ERGLEVPKPAVPQPV HCCCCCCCCCCCCCC	51.27	28112733
232	Phosphorylation	AVPQPVPSSKGRSKK CCCCCCCCCCCCCHH	44.94	25159151
233	Phosphorylation	VPQPVPSSKGRSKKV CCCCCCCCCCCCHHH	32.81	25159151
234	Ubiquitination	PQPVPSSKGRSKKVL CCCCCCCCCCCHHHH	63.78	27667366
234	Sumoylation	PQPVPSSKGRSKKVL CCCCCCCCCCCHHHH	63.78	28112733
237	Phosphorylation	VPSSKGRSKKVLESV CCCCCCCCHHHHHHH	45.56	26074081
239	Ubiquitination	SSKGRSKKVLESVFR CCCCCCHHHHHHHHC	53.98	21890473
241 (in isoform 1)	Ubiquitination	-	5.80	21890473
280	Phosphorylation	EKKFVRVSGEATIGH CCCEEEEECCEEHHH	21.98	20068231
284	Phosphorylation	VRVSGEATIGHVEKF EEEECCEEHHHHHHH	24.16	20068231
290	Ubiquitination	ATIGHVEKFLRRKMG EEHHHHHHHHHHHCC	48.92	23000965
292 (in isoform 1)	Ubiquitination	-	8.41	21890473
295	Ubiquitination	VEKFLRRKMGLDPAC HHHHHHHHCCCCCCC	30.77	23000965
345	Phosphorylation	LHYGLVVSPLKIT-- EEEEEEEECCCCC--	19.62	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
30	S	Phosphorylation	Kinase	CDK7	P50613	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
30	S	Phosphorylation		12167161
Phosphorylated on Ser-30 by CDK7 in vitro.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PCGF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F6_HUMAN	E2F6	physical	11171983
LMBL2_HUMAN	L3MBTL2	physical	21596310
RING2_HUMAN	RNF2	physical	22325352
RING1_HUMAN	RING1	physical	22325352
RYBP_HUMAN	RYBP	physical	22325352
YAF2_HUMAN	YAF2	physical	22325352
LMBL2_HUMAN	L3MBTL2	physical	22325352
CBX3_HUMAN	CBX3	physical	22325352
E2F6_HUMAN	E2F6	physical	22325352
TFDP1_HUMAN	TFDP1	physical	22325352
WDR5_HUMAN	WDR5	physical	22325352
MAX_HUMAN	MAX	physical	22325352
MGAP_HUMAN	MGA	physical	22325352
HDAC1_HUMAN	HDAC1	physical	22325352
BMI1_HUMAN	BMI1	physical	12167161
RING1_HUMAN	RING1	physical	12167161
RING2_HUMAN	RNF2	physical	12167161
RING2_HUMAN	RNF2	physical	22493164
RING1_HUMAN	RING1	physical	22493164
PEX10_HUMAN	PEX10	physical	22493164
C170B_HUMAN	CEP170B	physical	26186194
WDR76_HUMAN	WDR76	physical	26186194
ZKSC1_HUMAN	ZKSCAN1	physical	26186194
CEP78_HUMAN	CEP78	physical	26186194
RICTR_HUMAN	RICTOR	physical	26186194
EFL1_HUMAN	EFTUD1	physical	26186194
APBB1_HUMAN	APBB1	physical	26186194
MGAP_HUMAN	MGA	physical	26186194
KAISO_HUMAN	ZBTB33	physical	26186194
MSD2_HUMAN	MSANTD2	physical	26186194
WDR5_HUMAN	WDR5	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
DDX51_HUMAN	DDX51	physical	26186194
RPP38_HUMAN	RPP38	physical	26186194
EI2BB_HUMAN	EIF2B2	physical	21516116
PNMA1_HUMAN	PNMA1	physical	21516116
RING2_HUMAN	RNF2	physical	26151332
PCGF6_HUMAN	PCGF6	physical	26151332
UB2D3_HUMAN	UBE2D3	physical	26151332
LMBL2_HUMAN	L3MBTL2	physical	28514442
RYBP_HUMAN	RYBP	physical	28514442
BCORL_HUMAN	BCORL1	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
TFDP2_HUMAN	TFDP2	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
RING2_HUMAN	RNF2	physical	28514442
RING1_HUMAN	RING1	physical	28514442
UBP33_HUMAN	USP33	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
CBX4_HUMAN	CBX4	physical	28514442
CBX8_HUMAN	CBX8	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
AUTS2_HUMAN	AUTS2	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
CBX1_HUMAN	CBX1	physical	28514442
UBP7_HUMAN	USP7	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
CSK2B_HUMAN	CSNK2B	physical	28514442
CBX3_HUMAN	CBX3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PCGF6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"MBLR, a new RING finger protein resembling mammalian Polycomb geneproducts, is regulated by cell cycle-dependent phosphorylation."; Akasaka T., Takahashi N., Suzuki M., Koseki H., Bodmer R., Koga H.; Genes Cells 7:835-850(2002). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN TRANSCRIPTIONALREPRESSION, INTERACTION WITH BMI1; RING1 AND RNF2, PHOSPHORYLATION ATSER-30, MUTAGENESIS OF SER-30; SER-57; SER-59 AND SER-69, VARIANTPRO-PRO-23 INS, AND SUBCELLULAR LOCATION.	12167161 [Abstract]

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