EI2BB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EI2BB_HUMAN
• UniProt AC: P49770
• Protein Name: Translation initiation factor eIF-2B subunit beta
• Gene Name: EIF2B2
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Protein Description: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
• Protein Sequence: MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPGSAAKGSEL ----CCCCCCCCHHH	21.12	23312004
7	Ubiquitination	-MPGSAAKGSELSER -CCCCCCCCHHHHHH	63.79	-
9	Phosphorylation	PGSAAKGSELSERIE CCCCCCCHHHHHHHH	34.36	23312004
17	Phosphorylation	ELSERIESFVETLKR HHHHHHHHHHHHHHH	32.02	29083192
21	Phosphorylation	RIESFVETLKRGGGP HHHHHHHHHHHCCCC	32.07	29083192
23	Ubiquitination	ESFVETLKRGGGPRS HHHHHHHHHCCCCCC	57.31	-
47	Phosphorylation	GLLRQIITDHRWSNA HHHHHHHHHCCCCCH	27.64	-
69	Phosphorylation	RREGRRMTAAQPSET HHHCCCCCCCCCCCC	19.61	25332170
87	Ubiquitination	NMVRRVLKIIREEYG HHHHHHHHHHHHHHH	32.98	-
100	Phosphorylation	YGRLHGRSDESDQQE HHHHCCCCCCCHHHH	50.77	23663014
103	Phosphorylation	LHGRSDESDQQESLH HCCCCCCCHHHHHHH	45.79	23401153
108	Phosphorylation	DESDQQESLHKLLTS CCCHHHHHHHHHHHC	31.28	29396449
173	Phosphorylation	MTIGFSRTVEAFLKE EEECCHHHHHHHHHH	22.84	26657352
179	Ubiquitination	RTVEAFLKEAARKRK HHHHHHHHHHHHHCC	38.56	21890473
214	Phosphorylation	LSKAGIETTVMTDAA HHHCCCCEEHHCHHH	23.83	21406692
215	Phosphorylation	SKAGIETTVMTDAAI HHCCCCEEHHCHHHH	8.76	21406692
218	Phosphorylation	GIETTVMTDAAIFAV CCCEEHHCHHHHHHH	20.39	21406692
227	Phosphorylation	AAIFAVMSRVNKVII HHHHHHHHHCCEEEE	26.86	20860994
231	Ubiquitination	AVMSRVNKVIIGTKT HHHHHCCEEEEECHH	31.77	-
236	Phosphorylation	VNKVIIGTKTILANG CCEEEEECHHHHHCC	18.01	20068231
237	Ubiquitination	NKVIIGTKTILANGA CEEEEECHHHHHCCH	28.49	21890473
238	Phosphorylation	KVIIGTKTILANGAL EEEEECHHHHHCCHH	22.51	20068231
273	Ubiquitination	IVCAPMFKLSPQFPN EEEEECCCCCCCCCC	41.63	-
284	Phosphorylation	QFPNEEDSFHKFVAP CCCCCCCCCCCCCCC	32.31	28555341
287	Ubiquitination	NEEDSFHKFVAPEEV CCCCCCCCCCCCHHH	39.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EI2BB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EI2BB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EI2BB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EI2BE_HUMAN	EIF2B5	physical	10858531
A4_HUMAN	APP	physical	21832049
EI2BE_HUMAN	EIF2B5	physical	22939629
EI2BD_HUMAN	EIF2B4	physical	22939629
EI2BG_HUMAN	EIF2B3	physical	22939629
ABCF1_HUMAN	ABCF1	physical	22863883
CN166_HUMAN	C14orf166	physical	22863883
RTCB_HUMAN	RTCB	physical	22863883
NELFB_HUMAN	NELFB	physical	22863883
YBOX3_HUMAN	YBX3	physical	22863883
DDX1_HUMAN	DDX1	physical	22863883
DHX9_HUMAN	DHX9	physical	22863883
DIM1_HUMAN	DIMT1	physical	22863883
EDC4_HUMAN	EDC4	physical	22863883
EIF3K_HUMAN	EIF3K	physical	22863883
ROA2_HUMAN	HNRNPA2B1	physical	22863883
HNRPM_HUMAN	HNRNPM	physical	22863883
HNRPU_HUMAN	HNRNPU	physical	22863883
IF2B3_HUMAN	IGF2BP3	physical	22863883
ILF2_HUMAN	ILF2	physical	22863883
MRE11_HUMAN	MRE11A	physical	22863883
NMT1_HUMAN	NMT1	physical	22863883
PTBP1_HUMAN	PTBP1	physical	22863883
SYQ_HUMAN	QARS	physical	22863883
RFC4_HUMAN	RFC4	physical	22863883
SPTB2_HUMAN	SPTBN1	physical	22863883
WNK1_HUMAN	WNK1	physical	22863883
YBOX1_HUMAN	YBX1	physical	22863883
MR1L1_HUMAN	MRFAP1L1	physical	25416956
CI072_HUMAN	C9orf72	physical	25416956
EI2BA_HUMAN	EIF2B1	physical	26344197
EI2BG_HUMAN	EIF2B3	physical	26344197
EI2BD_HUMAN	EIF2B4	physical	26344197
IF5_HUMAN	EIF5	physical	26344197
EI2BA_HUMAN	EIF2B1	physical	28514442
RL40_HUMAN	UBA52	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
EXOG_HUMAN	EXOG	physical	28514442
GOLM1_HUMAN	GOLM1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
NTCP7_HUMAN	SLC10A7	physical	28514442
B3GL2_HUMAN	B3GALNT2	physical	28514442
MFS4B_HUMAN	KIAA1919	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
ENPP1_HUMAN	ENPP1	physical	28514442
EI2BA_HUMAN	EIF2B1	physical	27173435
BZW2_HUMAN	BZW2	physical	27173435
MCU_HUMAN	MCU	physical	27173435
EI2BG_HUMAN	EIF2B3	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603896: Leukodystrophy with vanishing white matter (VWM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.