EXOG_HUMAN - dbPTM
EXOG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EXOG_HUMAN
UniProt AC Q9Y2C4
Protein Name Nuclease EXOG, mitochondrial
Gene Name EXOG
Organism Homo sapiens (Human).
Sequence Length 368
Subcellular Localization Mitochondrion inner membrane .
Protein Description Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity..
Protein Sequence MAIKSIASRLRGSRRFLSGFVAGAVVGAAGAGLAALQFFRSQGAEGALTGKQPDGSAEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKAKEQSGTQIRKPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Ubiquitination----MAIKSIASRLR
----CCHHHHHHHHH		26.6921890473
5Phosphorylation---MAIKSIASRLRG
---CCHHHHHHHHHH		19.7821406692
59AcetylationQPDGSAEKAVLEQFG
CCCCCHHHHHHHHHC		43.4423954790
100AcetylationWVLEHISKSKIMGDA
HHHHHHCCCCCCCCC		55.9825953088
148AcetylationMAPAGNNKFSSKAMA
CCCCCCCCCCHHHHH		51.1025953088
150PhosphorylationPAGNNKFSSKAMAET
CCCCCCCCHHHHHHH		32.3229978859
151PhosphorylationAGNNKFSSKAMAETF
CCCCCCCHHHHHHHE		27.8029978859
157PhosphorylationSSKAMAETFYLSNIV
CHHHHHHHEEHHCCC		14.1929978859
159PhosphorylationKAMAETFYLSNIVPQ
HHHHHHEEHHCCCCC		19.3529978859
161PhosphorylationMAETFYLSNIVPQDF
HHHHEEHHCCCCCCC		17.0929978859
172PhosphorylationPQDFDNNSGYWNRIE
CCCCCCCCCHHHHHH		39.2429978859
174PhosphorylationDFDNNSGYWNRIEMY
CCCCCCCHHHHHHHH		10.1829978859
186PhosphorylationEMYCRELTERFEDVW
HHHHHHHHHHCCCEE		21.9926437602
207UbiquitinationTLPQTRGDGKKIVSY
ECCCCCCCCCEEEEE		63.5524816145
217UbiquitinationKIVSYQVIGEDNVAV
EEEEEEEECCCCEEC		2.7024816145
226PhosphorylationEDNVAVPSHLYKVIL
CCCEECCHHHHHHHH		21.3722210691
230UbiquitinationAVPSHLYKVILARRS
ECCHHHHHHHHHCCC		29.20-
254UbiquitinationGAFVVPNEAIGFQPQ
CEEEECCCCCCCCCC		35.2824816145
307UbiquitinationKLLDFQEFTLYLSTR
EECCHHHEEEEEECC		3.8724816145
327UbiquitinationRSVLRLEKIMENLKN
HHHHHHHHHHHHHHC		52.52-
327AcetylationRSVLRLEKIMENLKN
HHHHHHHHHHHHHHC		52.5225953088
333UbiquitinationEKIMENLKNAEIEPD
HHHHHHHHCCCCCCC		66.74-
349UbiquitinationYFMSRYEKKLEELKA
HHHHHHHHHHHHHHH		54.44-
350UbiquitinationFMSRYEKKLEELKAK
HHHHHHHHHHHHHHH		49.55-
355UbiquitinationEKKLEELKAKEQSGT
HHHHHHHHHHHHHCC		61.77-
355AcetylationEKKLEELKAKEQSGT
HHHHHHHHHHHHHCC		61.7725953088
357UbiquitinationKLEELKAKEQSGTQI
HHHHHHHHHHHCCCC		55.4924816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EXOG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EXOG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EXOG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EXOG_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EXOG_HUMAN

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Related Literatures of Post-Translational Modification

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