DIM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIM1_HUMAN
• UniProt AC: Q9UNQ2
• Protein Name: Probable dimethyladenosine transferase
• Gene Name: DIMT1
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, nucleolus .
• Protein Description: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. [PubMed: 25851604 Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity]
• Protein Sequence: MPKVKSGAIGRRRGRQEQRRELKSAGGLMFNTGIGQHILKNPLIINSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPVASKLQVLVGDVLKTDLPFFDTCVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFSIADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Methylation	QEQRRELKSAGGLMF HHHHHHHHHHCCCEE	33.24	-
24	Phosphorylation	EQRRELKSAGGLMFN HHHHHHHHHCCCEEC	44.78	20068231
32	Phosphorylation	AGGLMFNTGIGQHIL HCCCEECCCCCHHHH	20.93	20068231
40	Ubiquitination	GIGQHILKNPLIINS CCCHHHHCCCEECCH	56.78	-
80	Ubiquitination	KLLEKAKKVVACELD HHHHHCCCEEEEECC	46.96	-
96	Ubiquitination	RLVAELHKRVQGTPV HHHHHHHHHHCCCCH	67.88	-
106	Ubiquitination	QGTPVASKLQVLVGD CCCCHHHHHHHHHHH	32.95	21890473
166	Acetylation	FALRLVAKPGDKLYC HHHHHHCCCCCEEEE	41.89	19817485
170	Acetylation	LVAKPGDKLYCRLSI HHCCCCCEEEEEEEC	47.47	27452117
176	Phosphorylation	DKLYCRLSINTQLLA CEEEEEEECCHHHHH	8.40	27174698
179	Phosphorylation	YCRLSINTQLLARVD EEEEECCHHHHHHHH	20.94	27174698
201	Acetylation	NNFRPPPKVESSVVR CCCCCCCCCCCCEEE	65.49	26051181
243	Ubiquitination	KTLSAAFKSSAVQQL CCHHHHHHCHHHHHH	38.48	-
244	O-linked_Glycosylation	TLSAAFKSSAVQQLL CHHHHHHCHHHHHHH	19.64	29351928
244	Phosphorylation	TLSAAFKSSAVQQLL CHHHHHHCHHHHHHH	19.64	20860994
245	O-linked_Glycosylation	LSAAFKSSAVQQLLE HHHHHHCHHHHHHHH	32.80	29351928
245	Phosphorylation	LSAAFKSSAVQQLLE HHHHHHCHHHHHHHH	32.80	25599653
253	Ubiquitination	AVQQLLEKNYRIHCS HHHHHHHHCCCEEEE	60.28	21890473
253	Acetylation	AVQQLLEKNYRIHCS HHHHHHHHCCCEEEE	60.28	26051181
260	O-linked_Glycosylation	KNYRIHCSVHNIIIP HCCCEEEEECCEECC	16.55	29351928
281	Phosphorylation	DKIQQILTSTGFSDK HHHHHHHHHCCCCCH	26.35	21406692
282	Phosphorylation	KIQQILTSTGFSDKR HHHHHHHHCCCCCHH	24.08	21406692
283	Phosphorylation	IQQILTSTGFSDKRA HHHHHHHCCCCCHHH	36.69	21406692
286	Phosphorylation	ILTSTGFSDKRARSM HHHHCCCCCHHHHCC	43.50	21406692
288	Ubiquitination	TSTGFSDKRARSMDI HHCCCCCHHHHCCCH	46.92	21890473
288	2-Hydroxyisobutyrylation	TSTGFSDKRARSMDI HHCCCCCHHHHCCCH	46.92	-
292	Phosphorylation	FSDKRARSMDIDDFI CCCHHHHCCCHHHHH	21.59	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DIM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ABCF1_HUMAN	ABCF1	physical	22863883
NELFB_HUMAN	NELFB	physical	22863883
EIF3K_HUMAN	EIF3K	physical	22863883
ROA2_HUMAN	HNRNPA2B1	physical	22863883
HNRPU_HUMAN	HNRNPU	physical	22863883
IF2B3_HUMAN	IGF2BP3	physical	22863883
ILF2_HUMAN	ILF2	physical	22863883
MTAP2_HUMAN	MAP2	physical	22863883
NMT1_HUMAN	NMT1	physical	22863883
PTBP1_HUMAN	PTBP1	physical	22863883
RFC4_HUMAN	RFC4	physical	22863883
RL23A_HUMAN	RPL23A	physical	22863883
YBOX1_HUMAN	YBX1	physical	22863883
DDX52_HUMAN	DDX52	physical	26344197
DDX55_HUMAN	DDX55	physical	26344197
DKC1_HUMAN	DKC1	physical	26344197
GRWD1_HUMAN	GRWD1	physical	26344197
RS11_HUMAN	RPS11	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.