SPTB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTB2_HUMAN
• UniProt AC: Q01082
• Protein Name: Spectrin beta chain, non-erythrocytic 1
• Gene Name: SPTBN1
• Organism: Homo sapiens (Human).
• Sequence Length: 2364
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes..; Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane..
• Protein Sequence: MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTTVATDY ------CCCEEECCC	42.34	19413330
2	Phosphorylation	------MTTTVATDY ------CCCEEECCC	42.34	24732914
3	Phosphorylation	-----MTTTVATDYD -----CCCEEECCCC	31.00	24732914
4	Phosphorylation	----MTTTVATDYDN ----CCCEEECCCCC	18.64	24732914
6 (in isoform 3)	Phosphorylation	-	7.83	25159151
7	Phosphorylation	-MTTTVATDYDNIEI -CCCEEECCCCCCEE	30.65	24732914
7 (in isoform 3)	Phosphorylation	-	30.65	20201521
8 (in isoform 3)	Phosphorylation	-	38.77	28355574
9	Phosphorylation	TTTVATDYDNIEIQQ CCEEECCCCCCEEHH	13.41	24732914
10 (in isoform 3)	Phosphorylation	-	53.06	23927012
14 (in isoform 3)	Phosphorylation	-	3.87	28355574
17 (in isoform 3)	Phosphorylation	-	24.26	20201521
18	Phosphorylation	NIEIQQQYSDVNNRW CCEEHHHHCCCCCCC	11.51	25884760
18 (in isoform 3)	Phosphorylation	-	11.51	23927012
19	Phosphorylation	IEIQQQYSDVNNRWD CEEHHHHCCCCCCCC	30.64	24275569
23 (in isoform 3)	Phosphorylation	-	46.39	28796482
25 (in isoform 3)	Phosphorylation	-	16.47	28796482
33 (in isoform 3)	Ubiquitination	-	56.89	-
36	Phosphorylation	DWDNENSSARLFERS CCCCCCHHHHHHHHH	29.05	-
49	Ubiquitination	RSRIKALADEREAVQ HHHHHHHHHHHHHHH	22.83	21890473
49 (in isoform 3)	Ubiquitination	-	22.83	21890473
62	Malonylation	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	26320211
62	Ubiquitination	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	21890473
62 (in isoform 1)	Ubiquitination	-	44.98	21890473
62 (in isoform 2)	Ubiquitination	-	44.98	21890473
66	Phosphorylation	TFTKWVNSHLARVSC HHHHHHHHHHHHHHH	15.40	28857561
76	Phosphorylation	ARVSCRITDLYTDLR HHHHHHHHHHCHHCC	10.70	24076635
77	Acetylation	RVSCRITDLYTDLRD HHHHHHHHHCHHCCC	34.99	19608861
79	Phosphorylation	SCRITDLYTDLRDGR HHHHHHHCHHCCCCC	10.87	23403867
80	Phosphorylation	CRITDLYTDLRDGRM HHHHHHCHHCCCCCH	35.54	23403867
90	Acetylation	RDGRMLIKLLEVLSG CCCCHHHHHHHHHCC	42.95	19608861
96	Phosphorylation	IKLLEVLSGERLPKP HHHHHHHCCCCCCCC	43.73	21406692
102	Acetylation	LSGERLPKPTKGRMR HCCCCCCCCCCCCCC	70.66	26051181
105	Ubiquitination	ERLPKPTKGRMRIHC CCCCCCCCCCCCHHH	53.71	-
111	Acetylation	TKGRMRIHCLENVDK CCCCCCHHHHCCHHH	10.35	19608861
111	Ubiquitination	TKGRMRIHCLENVDK CCCCCCHHHHCCHHH	10.35	19608861
118	Acetylation	HCLENVDKALQFLKE HHHCCHHHHHHHHHH	46.87	54421583
118	Ubiquitination	HCLENVDKALQFLKE HHHCCHHHHHHHHHH	46.87	-
124	Acetylation	DKALQFLKEQRVHLE HHHHHHHHHCCCCCC	53.76	19608861
124	Ubiquitination	DKALQFLKEQRVHLE HHHHHHHHHCCCCCC	53.76	19608861
133	Sulfoxidation	QRVHLENMGSHDIVD CCCCCCCCCCCCCCC	4.20	28183972
163	Phosphorylation	RFQIQDISVETEDNK HHHHCCCCCCCCCCC	23.38	24732914
166	Phosphorylation	IQDISVETEDNKEKK HCCCCCCCCCCCCCC	46.62	24732914
183	Glutathionylation	KDALLLWCQMKTAGY HHHHHHHHHHHCCCC	2.60	22555962
199	Phosphorylation	NVNIHNFTTSWRDGM CCCCCCCCCCCCCCH	25.82	27251275
200	Phosphorylation	VNIHNFTTSWRDGMA CCCCCCCCCCCCCHH	23.35	27251275
201	Phosphorylation	NIHNFTTSWRDGMAF CCCCCCCCCCCCHHH	19.63	28857561
211	Acetylation	DGMAFNALIHKHRPD CCHHHHHHHHHCCCC	4.40	19608861
214	Sumoylation	AFNALIHKHRPDLID HHHHHHHHCCCCCCC	34.02	-
214	Ubiquitination	AFNALIHKHRPDLID HHHHHHHHCCCCCCC	34.02	-
224	Acetylation	PDLIDFDKLKKSNAH CCCCCHHHHCCCCCC	63.30	26051181
224	Ubiquitination	PDLIDFDKLKKSNAH CCCCCHHHHCCCCCC	63.30	19608861
227	Acetylation	IDFDKLKKSNAHYNL CCHHHHCCCCCCCCH	60.42	26051181
227	Ubiquitination	IDFDKLKKSNAHYNL CCHHHHCCCCCCCCH	60.42	-
228	Phosphorylation	DFDKLKKSNAHYNLQ CHHHHCCCCCCCCHH	37.35	20068231
232	Phosphorylation	LKKSNAHYNLQNAFN HCCCCCCCCHHHHHH	18.37	20068231
249	Ubiquitination	EQHLGLTKLLDPEDI HHHCCCCCCCCHHHC	52.69	-
257	Phosphorylation	LLDPEDISVDHPDEK CCCHHHCCCCCCCHH	33.54	30266825
265	O-linked_Glycosylation	VDHPDEKSIITYVVT CCCCCHHHHHHHHHH	19.71	20068230
265	Phosphorylation	VDHPDEKSIITYVVT CCCCCHHHHHHHHHH	19.71	26074081
268	Phosphorylation	PDEKSIITYVVTYYH CCHHHHHHHHHHHHH	14.48	26074081
269	Phosphorylation	DEKSIITYVVTYYHY CHHHHHHHHHHHHHH	5.19	26074081
272	Phosphorylation	SIITYVVTYYHYFSK HHHHHHHHHHHHHHH	14.33	26074081
273	Phosphorylation	IITYVVTYYHYFSKM HHHHHHHHHHHHHHH	4.07	26074081
274	Phosphorylation	ITYVVTYYHYFSKMK HHHHHHHHHHHHHHH	4.81	26074081
276	Phosphorylation	YVVTYYHYFSKMKAL HHHHHHHHHHHHHHH	8.07	26356563
278	Phosphorylation	VTYYHYFSKMKALAV HHHHHHHHHHHHHHH	25.36	26356563
288	Ubiquitination	KALAVEGKRIGKVLD HHHHHCCHHHHHHHH	27.60	-
292	Acetylation	VEGKRIGKVLDNAIE HCCHHHHHHHHHHHH	36.93	26051181
292	Malonylation	VEGKRIGKVLDNAIE HCCHHHHHHHHHHHH	36.93	26320211
292	Ubiquitination	VEGKRIGKVLDNAIE HCCHHHHHHHHHHHH	36.93	-
329	Acetylation	IIILNNRKFANSLVG HHHHCCHHHHHHHHH	51.45	25953088
333	Phosphorylation	NNRKFANSLVGVQQQ CCHHHHHHHHHHHHH	22.47	27251275
346	Phosphorylation	QQLQAFNTYRTVEKP HHHHHHHCCCCCCCC	14.13	24076635
359	Ubiquitination	KPPKFTEKGNLEVLL CCCCCCCCCCEEEEE	50.47	-
381	Phosphorylation	RANNQKVYMPREGKL HCCCCEEECCCCCCC	14.40	-
387	Ubiquitination	VYMPREGKLISDINK EECCCCCCCHHHHHH	37.58	-
390	Phosphorylation	PREGKLISDINKAWE CCCCCCHHHHHHHHH	42.76	24076635
419	Ubiquitination	NELIRQEKLEQLARR HHHHHHHHHHHHHHH	49.32	-
439	Phosphorylation	AMRETWLSENQRLVS HHHHHHHCHHHHHHC	26.51	25867546
446	Phosphorylation	SENQRLVSQDNFGFD CHHHHHHCCCCCCCC	36.09	28857561
462	Ubiquitination	PAVEAATKKHEAIET HHHHHHHHHHHHHHC	47.62	-
462 (in isoform 2)	Ubiquitination	-	47.62	-
463	Ubiquitination	AVEAATKKHEAIETD HHHHHHHHHHHHHCH	42.18	-
469	Phosphorylation	KKHEAIETDIAAYEE HHHHHHHCHHHHHHH	26.96	-
474	Phosphorylation	IETDIAAYEERVQAV HHCHHHHHHHHHHHH	14.86	-
493	Phosphorylation	RELEAENYHDIKRIT HHHHHHCCCCHHHHH	7.74	25159151
497	Acetylation	AENYHDIKRITARKD HHCCCCHHHHHCCCC	43.75	25825284
497	Succinylation	AENYHDIKRITARKD HHCCCCHHHHHCCCC	43.75	23954790
497	Ubiquitination	AENYHDIKRITARKD HHCCCCHHHHHCCCC	43.75	-
526	Sulfoxidation	ARRQRLEMNLGLQKI HHHHHHHHHHHHHHH	6.25	21406390
537	Sulfoxidation	LQKIFQEMLYIMDWM HHHHHHHHHHHHHHH	2.09	28183972
539	Phosphorylation	KIFQEMLYIMDWMDE HHHHHHHHHHHHHHH	7.90	30387612
541	Sulfoxidation	FQEMLYIMDWMDEMK HHHHHHHHHHHHHCE	1.76	28183972
553	Phosphorylation	EMKVLVLSQDYGKHL HCEEEEECCCHHHHH	17.33	20068231
556	Phosphorylation	VLVLSQDYGKHLLGV EEEECCCHHHHHCCH	22.04	20068231
558	Acetylation	VLSQDYGKHLLGVED EECCCHHHHHCCHHH	25.50	21466224
558	Ubiquitination	VLSQDYGKHLLGVED EECCCHHHHHCCHHH	25.50	-
580	Ubiquitination	VEADIGIQAERVRGV EECCCCCCHHHHCCC	31.77	21890473
580 (in isoform 3)	Ubiquitination	-	31.77	21890473
593	Acetylation	GVNASAQKFATDGEG CCCCCCCCCCCCCCC	36.36	25953088
593	Ubiquitination	GVNASAQKFATDGEG CCCCCCCCCCCCCCC	36.36	21890473
593 (in isoform 1)	Ubiquitination	-	36.36	21890473
593 (in isoform 2)	Ubiquitination	-	36.36	21890473
602	Acetylation	ATDGEGYKPCDPQVI CCCCCCCCCCCHHHH	50.45	26051181
602	Ubiquitination	ATDGEGYKPCDPQVI CCCCCCCCCCCHHHH	50.45	-
616	Sulfoxidation	IRDRVAHMEFCYQEL HHHHHHHHHHHHHHH	2.81	30846556
620	Phosphorylation	VAHMEFCYQELCQLA HHHHHHHHHHHHHHH	15.44	-
646 (in isoform 3)	Ubiquitination	-	24.29	-
659	Ubiquitination	GWIREKEKILSSDDY CCHHHHHHHCCCCCC	61.08	-
662	Phosphorylation	REKEKILSSDDYGKD HHHHHHCCCCCCCCC	34.88	25137130
663	Phosphorylation	EKEKILSSDDYGKDL HHHHHCCCCCCCCCH	30.93	21815630
666	Phosphorylation	KILSSDDYGKDLTSV HHCCCCCCCCCHHHH	30.94	29759185
668	Acetylation	LSSDDYGKDLTSVMR CCCCCCCCCHHHHHH	43.25	26051181
668	Ubiquitination	LSSDDYGKDLTSVMR CCCCCCCCCHHHHHH	43.25	-
678	Phosphorylation	TSVMRLLSKHRAFED HHHHHHHHHCHHHCH	30.89	29514088
681	Methylation	MRLLSKHRAFEDEMS HHHHHHCHHHCHHHC	44.71	115917669
687	Sulfoxidation	HRAFEDEMSGRSGHF CHHHCHHHCCCCCHH	8.77	30846556
688	Phosphorylation	RAFEDEMSGRSGHFE HHHCHHHCCCCCHHH	29.07	28674419
699	Acetylation	GHFEQAIKEGEDMIA CHHHHHHHHCCCCHH	63.78	26051181
714	Acetylation	EEHFGSEKIRERIIY HHHCCCHHHHHHHHH	49.08	26051181
714	Malonylation	EEHFGSEKIRERIIY HHHCCCHHHHHHHHH	49.08	26320211
714	Ubiquitination	EEHFGSEKIRERIIY HHHCCCHHHHHHHHH	49.08	-
721	Phosphorylation	KIRERIIYIREQWAN HHHHHHHHHHHHHCC	7.49	-
733	Phosphorylation	WANLEQLSAIRKKRL HCCHHHHHHHHHHHH	22.73	28258704
768	Phosphorylation	LDILKIVSSSDVGHD HHHHHHHCCCCCCCC	27.83	23403867
769	Phosphorylation	DILKIVSSSDVGHDE HHHHHHCCCCCCCCC	21.47	28152594
770	Phosphorylation	ILKIVSSSDVGHDEY HHHHHCCCCCCCCCC	28.89	28152594
777	Phosphorylation	SDVGHDEYSTQSLVK CCCCCCCCCHHHHHH	24.07	30108239
778	Phosphorylation	DVGHDEYSTQSLVKK CCCCCCCCHHHHHHH	20.23	28152594
779	Phosphorylation	VGHDEYSTQSLVKKH CCCCCCCHHHHHHHC	22.67	28152594
781	Phosphorylation	HDEYSTQSLVKKHKD CCCCCHHHHHHHCHH	34.91	23403867
784	Acetylation	YSTQSLVKKHKDVAE CCHHHHHHHCHHHHH	55.22	25953088
784	Ubiquitination	YSTQSLVKKHKDVAE CCHHHHHHHCHHHHH	55.22	-
787	Acetylation	QSLVKKHKDVAEEIA HHHHHHCHHHHHHHH	63.88	26051181
796	Phosphorylation	VAEEIANYRPTLDTL HHHHHHHCCCCHHHH	14.67	24732914
799	Phosphorylation	EIANYRPTLDTLHEQ HHHHCCCCHHHHHHH	28.41	24732914
802	Phosphorylation	NYRPTLDTLHEQASA HCCCCHHHHHHHHHC	32.88	24732914
808	Phosphorylation	DTLHEQASALPQEHA HHHHHHHHCCCHHHH	29.99	24732914
817	Phosphorylation	LPQEHAESPDVRGRL CCHHHHCCCCHHHHH	27.47	25159151
819 (in isoform 3)	Ubiquitination	-	52.61	-
825	Phosphorylation	PDVRGRLSGIEERYK CCHHHHHCCHHHHHH	36.04	30266825
831	Phosphorylation	LSGIEERYKEVAELT HCCHHHHHHHHHHHH	18.12	21406692
832	Acetylation	SGIEERYKEVAELTR CCHHHHHHHHHHHHH	52.51	26051181
832	Ubiquitination	SGIEERYKEVAELTR CCHHHHHHHHHHHHH	52.51	-
838	Phosphorylation	YKEVAELTRLRKQAL HHHHHHHHHHHHHHH	21.11	21406692
842	Malonylation	AELTRLRKQALQDTL HHHHHHHHHHHHHHH	44.51	26320211
842	Ubiquitination	AELTRLRKQALQDTL HHHHHHHHHHHHHHH	44.51	-
852	Phosphorylation	LQDTLALYKMFSEAD HHHHHHHHHHCCCHH	8.52	29438985
856	Phosphorylation	LALYKMFSEADACEL HHHHHHCCCHHHCHH	28.51	28348404
898	Sulfoxidation	FESLEPEMNNQASRV HHHCCHHHCCHHHHH	9.26	21406390
903	Phosphorylation	PEMNNQASRVAVVNQ HHHCCHHHHHHHHHH	19.95	28857561
911	Acetylation	RVAVVNQIARQLMHS HHHHHHHHHHHHHHC	2.62	19608861
924	Acetylation	HSGHPSEKEIKAQQD HCCCCCHHHHHHHHH	69.91	19608861
924	Ubiquitination	HSGHPSEKEIKAQQD HCCCCCHHHHHHHHH	69.91	19608861
932	Acetylation	EIKAQQDKLNTRWSQ HHHHHHHHHHHHHHH	39.02	25953088
938	Phosphorylation	DKLNTRWSQFRELVD HHHHHHHHHHHHHHH	19.02	23403867
968	Acetylation	HLECNETKSWIREKT HHCCCCCHHHHHHHH	37.30	26051181
976	Ubiquitination	SWIREKTKVIESTQD HHHHHHHHHHHHCHH	52.89	-
992	Sulfoxidation	GNDLAGVMALQRKLT CHHHHHHHHHHHHHH	2.77	21406390
997	Ubiquitination	GVMALQRKLTGMERD HHHHHHHHHHCCHHH	37.12	-
999	Phosphorylation	MALQRKLTGMERDLV HHHHHHHHCCHHHHH	37.20	26074081
1011	Ubiquitination	DLVAIEAKLSDLQKE HHHHHHHHHHHHHHH	35.42	-
1013	Phosphorylation	VAIEAKLSDLQKEAE HHHHHHHHHHHHHHH	35.25	27251275
1017	Ubiquitination	AKLSDLQKEAEKLES HHHHHHHHHHHHHHH	67.21	-
1021	Acetylation	DLQKEAEKLESEHPD HHHHHHHHHHHCCHH	65.68	25953088
1021	Ubiquitination	DLQKEAEKLESEHPD HHHHHHHHHHHCCHH	65.68	-
1035	Phosphorylation	DQAQAILSRLAEISD HHHHHHHHHHHHHHH	21.09	25307156
1041	Phosphorylation	LSRLAEISDVWEEMK HHHHHHHHHHHHHHH	20.02	24667141
1048	Ubiquitination	SDVWEEMKTTLKNRE HHHHHHHHHHHHHHH	41.45	-
1048 (in isoform 2)	Ubiquitination	-	41.45	-
1049	Phosphorylation	DVWEEMKTTLKNREA HHHHHHHHHHHHHHH	35.73	-
1057	Phosphorylation	TLKNREASLGEASKL HHHHHHHHHHHHHHH	31.96	21815630
1063	Acetylation	ASLGEASKLQQFLRD HHHHHHHHHHHHHHC	58.31	25953088
1063	Ubiquitination	ASLGEASKLQQFLRD HHHHHHHHHHHHHHC	58.31	-
1063 (in isoform 2)	Ubiquitination	-	58.31	-
1076	Phosphorylation	RDLDDFQSWLSRTQT HCHHHHHHHHHHHHH	29.94	21712546
1079	Phosphorylation	DDFQSWLSRTQTAIA HHHHHHHHHHHHHHH	27.33	21712546
1083	Phosphorylation	SWLSRTQTAIASEDM HHHHHHHHHHHCCCC	21.30	22210691
1090	Sulfoxidation	TAIASEDMPNTLTEA HHHHCCCCCCCHHHH	2.12	28465586
1093	Phosphorylation	ASEDMPNTLTEAEKL HCCCCCCCHHHHHHH	29.23	24076635
1095	Phosphorylation	EDMPNTLTEAEKLLT CCCCCCHHHHHHHHH	30.98	-
1099	Ubiquitination	NTLTEAEKLLTQHEN CCHHHHHHHHHHHHH	56.71	-
1108	Sumoylation	LTQHENIKNEIDNYE HHHHHHHHHHHHCHH	61.17	-
1108	Acetylation	LTQHENIKNEIDNYE HHHHHHHHHHHHCHH	61.17	26051181
1108	Ubiquitination	LTQHENIKNEIDNYE HHHHHHHHHHHHCHH	61.17	-
1114	Phosphorylation	IKNEIDNYEEDYQKM HHHHHHCHHHHHHHH	19.56	28674419
1118	Phosphorylation	IDNYEEDYQKMRDMG HHCHHHHHHHHHHHH	17.20	28674419
1129	Phosphorylation	RDMGEMVTQGQTDAQ HHHHHHHHCCCHHHH	26.18	20068231
1133	Phosphorylation	EMVTQGQTDAQYMFL HHHHCCCHHHHHHHH	39.88	22210691
1137	Phosphorylation	QGQTDAQYMFLRQRL CCCHHHHHHHHHHHH	7.49	20068231
1166	Phosphorylation	ENRQNLLSQSHAYQQ HHHHHHHHHHHHHHH	32.57	28442448
1168	Phosphorylation	RQNLLSQSHAYQQFL HHHHHHHHHHHHHHH	13.50	26356563
1171	Phosphorylation	LLSQSHAYQQFLRDT HHHHHHHHHHHHHHH	9.45	26356563
1209	Ubiquitination	EGAEAAIKKQEDFMT HHHHHHHHHHHHHCC	43.61	-
1215	Sulfoxidation	IKKQEDFMTTMDANE HHHHHHHCCCCCCCH	4.76	30846556
1216	Phosphorylation	KKQEDFMTTMDANEE HHHHHHCCCCCCCHH	20.97	25850435
1217	Phosphorylation	KQEDFMTTMDANEEK HHHHHCCCCCCCHHH	10.98	25850435
1218	Sulfoxidation	QEDFMTTMDANEEKI HHHHCCCCCCCHHHH	3.17	30846556
1233	Methylation	NAVVETGRRLVSDGN HHHHHCCCHHHHCCC	35.86	115917657
1237	Phosphorylation	ETGRRLVSDGNINSD HCCCHHHHCCCCCHH	44.38	21815630
1243	Phosphorylation	VSDGNINSDRIQEKV HHCCCCCHHHHHHHH	25.19	-
1245	Methylation	DGNINSDRIQEKVDS CCCCCHHHHHHHHHH	32.10	115917661
1249	Acetylation	NSDRIQEKVDSIDDR CHHHHHHHHHHCHHH	34.66	26051181
1249	Malonylation	NSDRIQEKVDSIDDR CHHHHHHHHHHCHHH	34.66	26320211
1249	Ubiquitination	NSDRIQEKVDSIDDR CHHHHHHHHHHCHHH	34.66	-
1252	Phosphorylation	RIQEKVDSIDDRHRK HHHHHHHHCHHHHHH	30.79	28857561
1259	Sumoylation	SIDDRHRKNRETASE HCHHHHHHCHHHHHH	54.99	-
1263	Phosphorylation	RHRKNRETASELLMR HHHHCHHHHHHHHHH	32.04	22985185
1265	Phosphorylation	RKNRETASELLMRLK HHCHHHHHHHHHHHH	35.88	22985185
1269	Sulfoxidation	ETASELLMRLKDNRD HHHHHHHHHHHCCHH	8.03	21406390
1272	Sumoylation	SELLMRLKDNRDLQK HHHHHHHHCCHHHHH	42.46	-
1297	Phosphorylation	WINEKMLTAQDMSYD HHCHHHCHHHCCCHH	20.83	20068231
1302	Phosphorylation	MLTAQDMSYDEARNL HCHHHCCCHHHHHHH	37.41	20068231
1303	Phosphorylation	LTAQDMSYDEARNLH CHHHCCCHHHHHHHH	15.92	20068231
1322 (in isoform 3)	Ubiquitination	-	32.83	-
1325	Phosphorylation	AFMAELASNKEWLDK HHHHHHHHCHHHHHH	62.14	24144214
1327	Acetylation	MAELASNKEWLDKIE HHHHHHCHHHHHHHH	48.01	26051181
1332	Acetylation	SNKEWLDKIEKEGMQ HCHHHHHHHHHHHHH	51.07	26051181
1335	Ubiquitination	EWLDKIEKEGMQLIS HHHHHHHHHHHHHHC	64.14	-
1338	Sulfoxidation	DKIEKEGMQLISEKP HHHHHHHHHHHCCCC	2.84	21406390
1342	Phosphorylation	KEGMQLISEKPETEA HHHHHHHCCCCCCHH	48.43	24719451
1344	Acetylation	GMQLISEKPETEAVV HHHHHCCCCCCHHHH	41.17	26051181
1344	Ubiquitination	GMQLISEKPETEAVV HHHHHCCCCCCHHHH	41.17	-
1344 (in isoform 2)	Ubiquitination	-	41.17	-
1347 (in isoform 3)	Ubiquitination	-	37.46	21890473
1352	Ubiquitination	PETEAVVKEKLTGLH CCCHHHHHHHCHHHH	42.40	-
1352 (in isoform 2)	Ubiquitination	-	42.40	-
1354	Acetylation	TEAVVKEKLTGLHKM CHHHHHHHCHHHHHH	45.70	25953088
1356	O-linked_Glycosylation	AVVKEKLTGLHKMWE HHHHHHCHHHHHHHH	49.09	20068230
1360	Acetylation	EKLTGLHKMWEVLES HHCHHHHHHHHHHHH	51.23	25953088
1360	Ubiquitination	EKLTGLHKMWEVLES HHCHHHHHHHHHHHH	51.23	21906983
1360 (in isoform 1)	Ubiquitination	-	51.23	21890473
1360 (in isoform 2)	Ubiquitination	-	51.23	21890473
1361	Sulfoxidation	KLTGLHKMWEVLEST HCHHHHHHHHHHHHC	2.28	28183972
1372	Ubiquitination	LESTTQTKAQRLFDA HHHCCHHHHHHHHCC	32.48	-
1381	Ubiquitination	QRLFDANKAELFTQS HHHHCCCHHHHHHHH	44.98	-
1386	Phosphorylation	ANKAELFTQSCADLD CCHHHHHHHHHHHHH	32.00	29514088
1388	Phosphorylation	KAELFTQSCADLDKW HHHHHHHHHHHHHHH	14.28	29514088
1394	Ubiquitination	QSCADLDKWLHGLES HHHHHHHHHHHHHHH	59.98	-
1397	Acetylation	ADLDKWLHGLESQIQ HHHHHHHHHHHHHHC	37.36	19413330
1401	Phosphorylation	KWLHGLESQIQSDDY HHHHHHHHHHCCCCC	37.31	24275569
1405	Phosphorylation	GLESQIQSDDYGKDL HHHHHHCCCCCCCCC	33.79	-
1410	Acetylation	IQSDDYGKDLTSVNI HCCCCCCCCCHHHHH	43.25	19413330
1413	Phosphorylation	DDYGKDLTSVNILLK CCCCCCCHHHHHHHH	40.54	21406692
1414	Phosphorylation	DYGKDLTSVNILLKK CCCCCCHHHHHHHHH	22.06	21406692
1421	Ubiquitination	SVNILLKKQQMLENQ HHHHHHHHHHHHHHH	45.81	-
1424	Sulfoxidation	ILLKKQQMLENQMEV HHHHHHHHHHHHHHH	4.73	21406390
1434	Ubiquitination	NQMEVRKKEIEELQS HHHHHHHHHHHHHHH	54.05	-
1447	Phosphorylation	QSQAQALSQEGKSTD HHHHHHHHHCCCCCH	29.24	25159151
1451	Ubiquitination	QALSQEGKSTDEVDS HHHHHCCCCCHHHHH	49.80	-
1452	O-linked_Glycosylation	ALSQEGKSTDEVDSK HHHHCCCCCHHHHHH	52.53	20068230
1452	Phosphorylation	ALSQEGKSTDEVDSK HHHHCCCCCHHHHHH	52.53	22817901
1459	Acetylation	STDEVDSKRLTVQTK CCHHHHHHHHHHHHH	47.14	26051181
1462	Phosphorylation	EVDSKRLTVQTKFME HHHHHHHHHHHHHHH	18.01	30266825
1468	Sulfoxidation	LTVQTKFMELLEPLN HHHHHHHHHHHHHHH	3.65	21406390
1478	Ubiquitination	LEPLNERKHNLLASK HHHHHHHHHHHHHCH	30.57	-
1485	Acetylation	KHNLLASKEIHQFNR HHHHHHCHHHHHCCC	55.89	25825284
1485	Ubiquitination	KHNLLASKEIHQFNR HHHHHHCHHHHHCCC	55.89	-
1529	Phosphorylation	LLIKKNQTLQKEIQG HHHHHCHHHHHHHCC	40.32	28857561
1532	Ubiquitination	KKNQTLQKEIQGHQP HHCHHHHHHHCCCCC	60.95	-
1548	Phosphorylation	IDDIFERSQNIVTDS HHHHHHHHHCCCCCC	22.00	23403867
1553	Phosphorylation	ERSQNIVTDSSSLSA HHHHCCCCCCCCCCH	26.77	28857561
1555	Phosphorylation	SQNIVTDSSSLSAEA HHCCCCCCCCCCHHH	16.68	30108239
1556	Phosphorylation	QNIVTDSSSLSAEAI HCCCCCCCCCCHHHH	37.80	26657352
1557	Phosphorylation	NIVTDSSSLSAEAIR CCCCCCCCCCHHHHH	30.23	23911959
1559	Phosphorylation	VTDSSSLSAEAIRQR CCCCCCCCHHHHHHH	26.47	30108239
1571	Ubiquitination	RQRLADLKQLWGLLI HHHHHHHHHHHHHHH	43.84	-
1583	Acetylation	LLIEETEKRHRRLEE HHHHHHHHHHHHHHH	62.01	26051181
1609	Phosphorylation	AEAEAWMSEQELYMM HHHHHHHCHHHHHHH	25.98	29802988
1614	Phosphorylation	WMSEQELYMMSEEKA HHCHHHHHHHCHHHH	7.04	29802988
1630	Sulfoxidation	DEQSAVSMLKKHQIL CHHHHHHHHHHHHHH	5.24	21406390
1632	Acetylation	QSAVSMLKKHQILEQ HHHHHHHHHHHHHHH	39.30	25953088
1633	Acetylation	SAVSMLKKHQILEQA HHHHHHHHHHHHHHH	36.46	26051181
1633	Ubiquitination	SAVSMLKKHQILEQA HHHHHHHHHHHHHHH	36.46	-
1644	Phosphorylation	LEQAVEDYAETVHQL HHHHHHHHHHHHHHH	7.88	21253578
1647	Phosphorylation	AVEDYAETVHQLSKT HHHHHHHHHHHHHHH	18.34	-
1653	Acetylation	ETVHQLSKTSRALVA HHHHHHHHHHHHHHC	60.14	25953088
1653	Ubiquitination	ETVHQLSKTSRALVA HHHHHHHHHHHHHHC	60.14	-
1662	Phosphorylation	SRALVADSHPESERI HHHHHCCCCCHHHHH	31.07	28857561
1665 (in isoform 3)	Ubiquitination	-	60.86	-
1666	Phosphorylation	VADSHPESERISMRQ HCCCCCHHHHHHHCH	36.30	23186163
1670	Phosphorylation	HPESERISMRQSKVD CCHHHHHHHCHHHHH	17.71	23312004
1671	Ubiquitination	PESERISMRQSKVDK CHHHHHHHCHHHHHH	4.15	21890473
1671 (in isoform 3)	Ubiquitination	-	4.15	21890473
1678	Acetylation	MRQSKVDKLYAGLKD HCHHHHHHHHHHHHH	46.51	26051181
1678	Ubiquitination	MRQSKVDKLYAGLKD HCHHHHHHHHHHHHH	46.51	-
1680	Phosphorylation	QSKVDKLYAGLKDLA HHHHHHHHHHHHHHH	12.36	30108239
1684	Acetylation	DKLYAGLKDLAEERR HHHHHHHHHHHHHHC	50.18	25953088
1684	Ubiquitination	DKLYAGLKDLAEERR HHHHHHHHHHHHHHC	50.18	21890473
1684 (in isoform 1)	Ubiquitination	-	50.18	21890473
1684 (in isoform 2)	Ubiquitination	-	50.18	21890473
1723	Phosphorylation	EREVVAGSHELGQDY HCCCCCCCCCCCCCH	12.21	30108239
1730	Phosphorylation	SHELGQDYEHVTMLQ CCCCCCCHHHHHHHH	10.47	24927040
1734	Phosphorylation	GQDYEHVTMLQERFR CCCHHHHHHHHHHHH	17.67	30108239
1735	Sulfoxidation	QDYEHVTMLQERFRE CCHHHHHHHHHHHHH	3.37	30846556
1771	Phosphorylation	ELINSGHSDAATIAE HHHHCCCCCHHHHHH	32.25	24076635
1802	Acetylation	DTRTQILAASYELHK HHHHHHHHHHHHHHH	8.94	19608861
1804	Phosphorylation	RTQILAASYELHKFY HHHHHHHHHHHHHHH	17.34	23312004
1805	Phosphorylation	TQILAASYELHKFYH HHHHHHHHHHHHHHH	20.13	21253578
1809	Acetylation	AASYELHKFYHDAKE HHHHHHHHHHHHHHH	61.31	25825284
1811	Phosphorylation	SYELHKFYHDAKEIF HHHHHHHHHHHHHHH	12.00	20736484
1815	Acetylation	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	19608861
1815	Malonylation	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	26320211
1815	Succinylation	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	23954790
1815	Ubiquitination	HKFYHDAKEIFGRIQ HHHHHHHHHHHHHHH	58.35	19608861
1827	Malonylation	RIQDKHKKLPEELGR HHHHHHCCCCHHHCC	69.83	26320211
1841	Phosphorylation	RDQNTVETLQRMHTT CCHHHHHHHHHHHHH	24.69	28857561
1874	Phosphorylation	AARLQAAYAGDKADD HHHHHHHHHCCCHHH	17.71	28152594
1878	Ubiquitination	QAAYAGDKADDIQKR HHHHHCCCHHHHHHH	53.44	-
1884	Acetylation	DKADDIQKRENEVLE CCHHHHHHHHHHHHH	63.11	26051181
1900	Acetylation	WKSLLDACESRRVRL HHHHHHHHHHCCEEE	4.94	19608861
1902	Phosphorylation	SLLDACESRRVRLVD HHHHHHHHCCEEEEE	25.85	21815630
1913	Acetylation	RLVDTGDKFRFFSMV EEEECCCHHHHHHHH	39.52	19608861
1913	Malonylation	RLVDTGDKFRFFSMV EEEECCCHHHHHHHH	39.52	26320211
1919	Sulfoxidation	DKFRFFSMVRDLMLW CHHHHHHHHHHHHHH	2.12	21406390
1944	Phosphorylation	QEKPRDVSSVELLMN CCCCCCCCHHHHHHH	32.71	30266825
1945	Phosphorylation	EKPRDVSSVELLMNN CCCCCCCHHHHHHHC	21.32	30266825
1950	Sulfoxidation	VSSVELLMNNHQGIK CCHHHHHHHCCCCHH	8.04	30846556
1957	Sumoylation	MNNHQGIKAEIDARN HHCCCCHHEEECCCC	46.95	-
1966	Phosphorylation	EIDARNDSFTTCIEL EECCCCCCCHHHHHH	28.21	24076635
1968	Phosphorylation	DARNDSFTTCIELGK CCCCCCCHHHHHHHH	25.39	24076635
1969	Phosphorylation	ARNDSFTTCIELGKS CCCCCCHHHHHHHHH	14.96	24076635
1970	Glutathionylation	RNDSFTTCIELGKSL CCCCCHHHHHHHHHH	1.75	22555962
1975	Acetylation	TTCIELGKSLLARKH HHHHHHHHHHHHHCC	51.02	26051181
1976	Acetylation	TCIELGKSLLARKHY HHHHHHHHHHHHCCC	27.15	19608861
1983	Phosphorylation	SLLARKHYASEEIKE HHHHHCCCCCHHHHH	18.17	-
1985	Phosphorylation	LARKHYASEEIKEKL HHHCCCCCHHHHHHH	28.70	-
1989	Acetylation	HYASEEIKEKLLQLT CCCCHHHHHHHHHHH	52.67	19608861
1991	Acetylation	ASEEIKEKLLQLTEK CCHHHHHHHHHHHHH	49.88	25953088
1991	Ubiquitination	ASEEIKEKLLQLTEK CCHHHHHHHHHHHHH	49.88	-
1996	Phosphorylation	KEKLLQLTEKRKEMI HHHHHHHHHHHHHHH	26.88	-
2039	Phosphorylation	WLLGQEPYLSSREIG HHHCCCCCCCHHHHC	20.61	27422710
2041	Phosphorylation	LGQEPYLSSREIGQS HCCCCCCCHHHHCCC	22.85	25106551
2042	Phosphorylation	GQEPYLSSREIGQSV CCCCCCCHHHHCCCH	31.19	25106551
2048	Phosphorylation	SSREIGQSVDEVEKL CHHHHCCCHHHHHHH	26.73	28857561
2054	Acetylation	QSVDEVEKLIKRHEA CCHHHHHHHHHHHHH	61.77	26051181
2064	Acetylation	KRHEAFEKSAATWDE HHHHHHHHHHCCHHH	38.65	26051181
2064	Ubiquitination	KRHEAFEKSAATWDE HHHHHHHHHHCCHHH	38.65	-
2068	O-linked_Glycosylation	AFEKSAATWDERFSA HHHHHHCCHHHHHHH	32.92	20068230
2072	Methylation	SAATWDERFSALERL HHCCHHHHHHHHHHH	28.48	115917665
2074	Phosphorylation	ATWDERFSALERLTT CCHHHHHHHHHHHHH	37.86	28857561
2080	Phosphorylation	FSALERLTTLELLEV HHHHHHHHHHHHHHH	35.24	-
2081	Phosphorylation	SALERLTTLELLEVR HHHHHHHHHHHHHHH	23.87	-
2102	O-linked_Glycosylation	ERKRRPPSPEPSTKV HHHHCCCCCCCCCCC	44.57	20068230
2102	Phosphorylation	ERKRRPPSPEPSTKV HHHHCCCCCCCCCCC	44.57	29255136
2106	Phosphorylation	RPPSPEPSTKVSEEA CCCCCCCCCCCCHHH	38.92	26846344
2107	Phosphorylation	PPSPEPSTKVSEEAE CCCCCCCCCCCHHHH	46.29	26846344
2110	Phosphorylation	PEPSTKVSEEAESQQ CCCCCCCCHHHHHHH	31.13	23927012
2110 (in isoform 3)	Ubiquitination	-	31.13	21890473
2115	Phosphorylation	KVSEEAESQQQWDTS CCCHHHHHHHCCCCC	40.09	23927012
2115 (in isoform 3)	Phosphorylation	-	40.09	18510355
2121	Phosphorylation	ESQQQWDTSKGEQVS HHHHCCCCCCCCCCH	29.40	23927012
2122	Phosphorylation	SQQQWDTSKGEQVSQ HHHCCCCCCCCCCHH	35.87	23927012
2123	Acetylation	QQQWDTSKGEQVSQN HHCCCCCCCCCCHHC	69.43	26051181
2123	Ubiquitination	QQQWDTSKGEQVSQN HHCCCCCCCCCCHHC	69.43	21906983
2123 (in isoform 1)	Ubiquitination	-	69.43	21890473
2123 (in isoform 2)	Ubiquitination	-	69.43	21890473
2125 (in isoform 3)	Phosphorylation	-	52.09	19664994
2128	Phosphorylation	TSKGEQVSQNGLPAE CCCCCCCHHCCCCCC	20.02	29255136
2128 (in isoform 2)	Phosphorylation	-	20.02	18510355
2132 (in isoform 3)	Phosphorylation	-	4.81	30622161
2134 (in isoform 3)	Phosphorylation	-	27.13	30622161
2135 (in isoform 3)	Phosphorylation	-	54.24	28796482
2138	Phosphorylation	GLPAEQGSPRMAETV CCCCCCCCCCCCCCC	14.72	19664994
2138 (in isoform 2)	Phosphorylation	-	14.72	19664994
2138 (in isoform 3)	Phosphorylation	-	14.72	30622161
2144	Phosphorylation	GSPRMAETVDTSEMV CCCCCCCCCCHHHHH	17.72	22777824
2145 (in isoform 2)	Phosphorylation	-	5.94	30622161
2147	Phosphorylation	RMAETVDTSEMVNGA CCCCCCCHHHHHCCC	23.42	28102081
2147 (in isoform 2)	Phosphorylation	-	23.42	30622161
2148	Phosphorylation	MAETVDTSEMVNGAT CCCCCCHHHHHCCCC	21.16	22115753
2148 (in isoform 2)	Phosphorylation	-	21.16	28796482
2148 (in isoform 3)	Phosphorylation	-	21.16	29507054
2151 (in isoform 2)	Phosphorylation	-	5.40	30622161
2155	Phosphorylation	SEMVNGATEQRTSSK HHHHCCCCCCCCCCC	33.77	25159151
2159	Phosphorylation	NGATEQRTSSKESSP CCCCCCCCCCCCCCC	36.73	26846344
2160	Phosphorylation	GATEQRTSSKESSPI CCCCCCCCCCCCCCC	41.42	26846344
2161	Phosphorylation	ATEQRTSSKESSPIP CCCCCCCCCCCCCCC	39.57	26846344
2161 (in isoform 2)	Phosphorylation	-	39.57	29507054
2164	O-linked_Glycosylation	QRTSSKESSPIPSPT CCCCCCCCCCCCCCC	45.19	20068230
2164	Phosphorylation	QRTSSKESSPIPSPT CCCCCCCCCCCCCCC	45.19	29255136
2165	Phosphorylation	RTSSKESSPIPSPTS CCCCCCCCCCCCCCC	28.13	29255136
2169	Phosphorylation	KESSPIPSPTSDRKA CCCCCCCCCCCCCCC	41.34	19664994
2171	Phosphorylation	SSPIPSPTSDRKAKT CCCCCCCCCCCCCHH	47.82	29255136
2172	Phosphorylation	SPIPSPTSDRKAKTA CCCCCCCCCCCCHHC	38.51	29255136
2177	Malonylation	PTSDRKAKTALPAQS CCCCCCCHHCCCCCC	37.05	26320211
2177	Ubiquitination	PTSDRKAKTALPAQS CCCCCCCHHCCCCCC	37.05	21890473
2177 (in isoform 1)	Ubiquitination	-	37.05	21890473
2178	Phosphorylation	TSDRKAKTALPAQSA CCCCCCHHCCCCCCC	37.98	23403867
2184	Phosphorylation	KTALPAQSAATLPAR HHCCCCCCCCCCCCC	23.21	30266825
2187	Phosphorylation	LPAQSAATLPARTQE CCCCCCCCCCCCCCC	32.75	19664994
2192	Phosphorylation	AATLPARTQETPSAQ CCCCCCCCCCCCCHH	32.63	30266825
2195	Phosphorylation	LPARTQETPSAQMEG CCCCCCCCCCHHHHH	16.84	30266825
2197	Phosphorylation	ARTQETPSAQMEGFL CCCCCCCCHHHHHHH	38.25	26657352
2200	Sulfoxidation	QETPSAQMEGFLNRK CCCCCHHHHHHHCCH	5.63	21406390
2207	Ubiquitination	MEGFLNRKHEWEAHN HHHHHCCHHHHHHHC	44.81	-
2221	Phosphorylation	NKKASSRSWHNVYCV CCCCCCCCCCCEEEE	34.34	-
2238	Acetylation	NQEMGFYKDAKTAAS CCCCEEECCCCCCCC	49.28	25953088
2238	Malonylation	NQEMGFYKDAKTAAS CCCCEEECCCCCCCC	49.28	26320211
2241	Malonylation	MGFYKDAKTAASGIP CEEECCCCCCCCCCC	49.16	26320211
2241	Ubiquitination	MGFYKDAKTAASGIP CEEECCCCCCCCCCC	49.16	-
2249	Phosphorylation	TAASGIPYHSEVPVS CCCCCCCCCCCCCCC	18.96	24927040
2251	Phosphorylation	ASGIPYHSEVPVSLK CCCCCCCCCCCCCHH	34.15	28152594
2256	Phosphorylation	YHSEVPVSLKEAVCE CCCCCCCCHHHHHHH	27.88	28152594
2258	Acetylation	SEVPVSLKEAVCEVA CCCCCCHHHHHHHHH	35.80	26051181
2268	Phosphorylation	VCEVALDYKKKKHVF HHHHHCCCCCCCCEE	26.09	24927040
2269	Acetylation	CEVALDYKKKKHVFK HHHHCCCCCCCCEEE	58.76	25953088
2269	Malonylation	CEVALDYKKKKHVFK HHHHCCCCCCCCEEE	58.76	26320211
2270	Acetylation	EVALDYKKKKHVFKL HHHCCCCCCCCEEEE	61.91	24889771
2276	Ubiquitination	KKKKHVFKLRLNDGN CCCCCEEEEECCCCC	31.44	-
2285	Phosphorylation	RLNDGNEYLFQAKDD ECCCCCCEEEECCCH	19.47	-
2297	O-linked_Glycosylation	KDDEEMNTWIQAISS CCHHHHHHHHHHHHH	23.72	20068230
2297	Phosphorylation	KDDEEMNTWIQAISS CCHHHHHHHHHHHHH	23.72	24144214
2303	O-linked_Glycosylation	NTWIQAISSAISSDK HHHHHHHHHHHHCCC	19.41	20068230
2303	Phosphorylation	NTWIQAISSAISSDK HHHHHHHHHHHHCCC	19.41	26657352
2304	O-linked_Glycosylation	TWIQAISSAISSDKH HHHHHHHHHHHCCCC	24.41	20068230
2304	Phosphorylation	TWIQAISSAISSDKH HHHHHHHHHHHCCCC	24.41	26657352
2307	O-linked_Glycosylation	QAISSAISSDKHEVS HHHHHHHHCCCCCCC	32.00	20068230
2307	Phosphorylation	QAISSAISSDKHEVS HHHHHHHHCCCCCCC	32.00	26657352
2308	Phosphorylation	AISSAISSDKHEVSA HHHHHHHCCCCCCCC	44.56	26657352
2310	Ubiquitination	SSAISSDKHEVSAST HHHHHCCCCCCCCCC	43.54	-
2314	O-linked_Glycosylation	SSDKHEVSASTQSTP HCCCCCCCCCCCCCC	17.33	20068230
2314	Phosphorylation	SSDKHEVSASTQSTP HCCCCCCCCCCCCCC	17.33	25159151
2316	O-linked_Glycosylation	DKHEVSASTQSTPAS CCCCCCCCCCCCCCH	21.34	20068230
2316	Phosphorylation	DKHEVSASTQSTPAS CCCCCCCCCCCCCCH	21.34	29255136
2317	O-linked_Glycosylation	KHEVSASTQSTPASS CCCCCCCCCCCCCHH	26.67	20068230
2317	Phosphorylation	KHEVSASTQSTPASS CCCCCCCCCCCCCHH	26.67	29255136
2319	O-linked_Glycosylation	EVSASTQSTPASSRA CCCCCCCCCCCHHHC	36.12	20068230
2319	Phosphorylation	EVSASTQSTPASSRA CCCCCCCCCCCHHHC	36.12	29255136
2320	O-linked_Glycosylation	VSASTQSTPASSRAQ CCCCCCCCCCHHHCC	17.04	20068230
2320	Phosphorylation	VSASTQSTPASSRAQ CCCCCCCCCCHHHCC	17.04	29255136
2323	O-linked_Glycosylation	STQSTPASSRAQTLP CCCCCCCHHHCCCCC	22.89	20068230
2323	Phosphorylation	STQSTPASSRAQTLP CCCCCCCHHHCCCCC	22.89	29255136
2324	O-linked_Glycosylation	TQSTPASSRAQTLPT CCCCCCHHHCCCCCC	33.47	32574038
2324	O-linked_Glycosylation	TQSTPASSRAQTLPT CCCCCCHHHCCCCCC	33.47	20068230
2324	Phosphorylation	TQSTPASSRAQTLPT CCCCCCHHHCCCCCC	33.47	29255136
2328	O-linked_Glycosylation	PASSRAQTLPTSVVT CCHHHCCCCCCEEEE	33.45	20068230
2328	Phosphorylation	PASSRAQTLPTSVVT CCHHHCCCCCCEEEE	33.45	29255136
2331	O-linked_Glycosylation	SRAQTLPTSVVTITS HHCCCCCCEEEEEEC	36.95	20068230
2331	Phosphorylation	SRAQTLPTSVVTITS HHCCCCCCEEEEEEC	36.95	26846344
2332	O-linked_Glycosylation	RAQTLPTSVVTITSE HCCCCCCEEEEEECC	16.79	20068230
2332	Phosphorylation	RAQTLPTSVVTITSE HCCCCCCEEEEEECC	16.79	26846344
2335	Phosphorylation	TLPTSVVTITSESSP CCCCEEEEEECCCCC	19.17	26846344
2337	O-linked_Glycosylation	PTSVVTITSESSPGK CCEEEEEECCCCCCC	19.64	20068230
2337	Phosphorylation	PTSVVTITSESSPGK CCEEEEEECCCCCCC	19.64	26846344
2338	O-linked_Glycosylation	TSVVTITSESSPGKR CEEEEEECCCCCCCC	31.46	20068230
2338	Phosphorylation	TSVVTITSESSPGKR CEEEEEECCCCCCCC	31.46	29255136
2340	Phosphorylation	VVTITSESSPGKREK EEEEECCCCCCCCCC	41.42	29255136
2341	O-linked_Glycosylation	VTITSESSPGKREKD EEEECCCCCCCCCCC	33.35	20068230
2341	Phosphorylation	VTITSESSPGKREKD EEEECCCCCCCCCCC	33.35	19664994
2344	Acetylation	TSESSPGKREKDKEK ECCCCCCCCCCCCHH	61.85	25953088
2344	Malonylation	TSESSPGKREKDKEK ECCCCCCCCCCCCHH	61.85	26320211
2344	Ubiquitination	TSESSPGKREKDKEK ECCCCCCCCCCCCHH	61.85	-
2344 (in isoform 1)	Ubiquitination	-	61.85	21890473
2358	Phosphorylation	KDKEKRFSLFGKKK- HHHHHHHHHCCCCC-	27.16	23401153
2362	Acetylation	KRFSLFGKKK----- HHHHHCCCCC-----	50.48	19608861
2362	Malonylation	KRFSLFGKKK----- HHHHHCCCCC-----	50.48	26320211
2363	Acetylation	RFSLFGKKK------ HHHHCCCCC------	65.18	11921257
2364	Ubiquitination	FSLFGKKK------- HHHCCCCC-------	69.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2110	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
2110	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
2159	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
2159	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
2159	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
2159	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E41L3_HUMAN	EPB41L3	physical	15116094
DCTN1_HUMAN	DCTN1	physical	8991093
GRIA2_HUMAN	GRIA2	physical	10576550
PJA1_HUMAN	PJA1	physical	16247473
THIOM_HUMAN	TXN2	physical	22939629
SMAD3_HUMAN	SMAD3	physical	12543979
ANK1_HUMAN	ANK1	physical	12543979
TPM1_HUMAN	TPM1	physical	12543979
TGFR1_HUMAN	TGFBR1	physical	12543979
SMAD2_HUMAN	SMAD2	physical	12543979
SMAD4_HUMAN	SMAD4	physical	12543979
TB182_HUMAN	TNKS1BP1	physical	22863883
CNDD3_HUMAN	NCAPD3	physical	26344197
THAP3_HUMAN	THAP3	physical	21866423
SPTB2_HUMAN	SPTBN1	physical	21866423
NOP53_HUMAN	GLTSCR2	physical	21866423
SEPT8_HUMAN	SEPT8	physical	21866423
COPB_HUMAN	COPB1	physical	21866423
ZN251_HUMAN	ZNF251	physical	21866423
STXB1_HUMAN	STXBP1	physical	21866423
GG6LA_HUMAN	GOLGA6L10	physical	21866423
EIF3H_HUMAN	EIF3H	physical	21866423

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-90; LYS-1815; LYS-1913 ANDLYS-1989, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1447; SER-2138;SER-2169; THR-2187 AND SER-2341, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2138; SER-2164; SER-2165AND SER-2169, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102; SER-2138;THR-2159; SER-2160; SER-2164; SER-2165; SER-2169; THR-2187; THR-2328AND SER-2341, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 ANDSER-14 (ISOFORM 3), AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102 AND SER-2138, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102; SER-2164 ANDSER-2169, AND MASS SPECTROMETRY.
PubMed: 18088087

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2169, AND MASSSPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102, AND MASSSPECTROMETRY.
PubMed: 19007248

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102, AND MASSSPECTROMETRY.
PubMed: 17924679

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102; SER-2128 ANDSER-2138, AND MASS SPECTROMETRY.
PubMed: 17081983

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2102 AND SER-2169, ANDMASS SPECTROMETRY.
PubMed: 16083285

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2128; SER-2138; SER-2165AND SER-2169, AND MASS SPECTROMETRY.
PubMed: 15302935