SEPT8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEPT8_HUMAN
• UniProt AC: Q92599
• Protein Name: Septin-8
• Gene Name: 8-Sep
• Organism: Homo sapiens (Human).
• Sequence Length: 483
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. In platelets, found in areas surrounding alpha-granules.
• Protein Description: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion..
• Protein Sequence: MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELEEETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKNRSDIGAHQPGMSLSSSKVMMTKASVEPLNCSSWWPAIQCCSCLVRDATWREGFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATDLERF ------CCCCHHHHH	21.04	22814378
4	Phosphorylation	----MAATDLERFSN ----CCCCHHHHHHC	31.42	28857561
10	Phosphorylation	ATDLERFSNAEPEPR CCHHHHHHCCCCCCC	41.15	28355574
17	Methylation	SNAEPEPRSLSLGGH HCCCCCCCCCCCCCC	48.87	115916457
18	Phosphorylation	NAEPEPRSLSLGGHV CCCCCCCCCCCCCCC	32.78	22617229
20	Phosphorylation	EPEPRSLSLGGHVGF CCCCCCCCCCCCCCC	26.64	22617229
29	Phosphorylation	GGHVGFDSLPDQLVS CCCCCCCCCCHHHCC	39.27	20068231
36	Phosphorylation	SLPDQLVSKSVTQGF CCCHHHCCCCCCCCC	28.01	27362937
53	Phosphorylation	NILCVGETGIGKSTL EEEEECCCCCCHHHH	28.33	-
100	Phosphorylation	SNVQLKLTIVDAVGF CCCEEEEEEEEHHCC	19.84	-
141	Phosphorylation	EELKIRRSLFDYHDT HHHHHCHHHHHHHCC	24.44	30108239
163	Phosphorylation	FITPTGHSLKSLDLV EECCCCCCCCCCCEE	38.55	-
166	Phosphorylation	PTGHSLKSLDLVTMK CCCCCCCCCCEEEHH	32.20	21964256
171	Phosphorylation	LKSLDLVTMKKLDSK CCCCCEEEHHHCCCC	30.48	20068231
173	Ubiquitination	SLDLVTMKKLDSKVN CCCEEEHHHCCCCCC	40.60	-
178	Ubiquitination	TMKKLDSKVNIIPII EHHHCCCCCCEEEEE	38.68	-
192	Phosphorylation	IAKADTISKSELHKF EEECCCCCHHHHHHH	32.02	-
193	Acetylation	AKADTISKSELHKFK EECCCCCHHHHHHHE	44.06	12430123
193	Ubiquitination	AKADTISKSELHKFK EECCCCCHHHHHHHE	44.06	-
194	Phosphorylation	KADTISKSELHKFKI ECCCCCHHHHHHHEE	38.30	28348404
198	Acetylation	ISKSELHKFKIKIMG CCHHHHHHHEEEEEH	62.06	12430135
198	Ubiquitination	ISKSELHKFKIKIMG CCHHHHHHHEEEEEH	62.06	-
200	Acetylation	KSELHKFKIKIMGEL HHHHHHHEEEEEHHH	48.14	12430147
202	Ubiquitination	ELHKFKIKIMGELVS HHHHHEEEEEHHHHH	27.51	-
251	Ubiquitination	EEVKVGNKLVRARQY CEEEECCEEEECCCC	42.29	-
275	Acetylation	ENHCDFVKLREMLIR CCCCCHHHHHHHHHH	41.65	26051181
297	Phosphorylation	EQTHSRHYELYRRCK HHHHHHHHHHHHHHC	13.40	-
300	Phosphorylation	HSRHYELYRRCKLEE HHHHHHHHHHHCHHH	5.53	-
304	Ubiquitination	YELYRRCKLEEMGFQ HHHHHHHCHHHCCCC	58.06	-
313	Phosphorylation	EEMGFQDSDGDSQPF HHCCCCCCCCCCCCC	32.48	29802988
317	Phosphorylation	FQDSDGDSQPFSLQE CCCCCCCCCCCCHHH	45.33	26471730
321	Phosphorylation	DGDSQPFSLQETYEA CCCCCCCCHHHHHHH	35.51	28555341
326	Phosphorylation	PFSLQETYEAKRKEF CCCHHHHHHHHHHHH	17.09	-
329	Ubiquitination	LQETYEAKRKEFLSE HHHHHHHHHHHHHHH	52.65	-
331	Ubiquitination	ETYEAKRKEFLSELQ HHHHHHHHHHHHHHH	52.70	-
340	Ubiquitination	FLSELQRKEEEMRQM HHHHHHHHHHHHHHH	57.42	-
351	Ubiquitination	MRQMFVNKVKETELE HHHHHHHHHHHHHHH	49.75	-
353	Ubiquitination	QMFVNKVKETELELK HHHHHHHHHHHHHHH	61.60	-
360	Ubiquitination	KETELELKEKERELH HHHHHHHHHHHHHHH	58.32	-
369	2-Hydroxyisobutyrylation	KERELHEKFEHLKRV HHHHHHHHHHHHHHH	45.35	-
369	Ubiquitination	KERELHEKFEHLKRV HHHHHHHHHHHHHHH	45.35	-
381	Acetylation	KRVHQEEKRKVEEKR HHHHHHHHHHHHHHH	57.68	7708507
387	Acetylation	EKRKVEEKRRELEEE HHHHHHHHHHHHHHH	43.16	20167786
402	Ubiquitination	TNAFNRRKAAVEALQ HHHHHHHHHHHHHHH	37.14	-
410	Phosphorylation	AAVEALQSQALHATS HHHHHHHHHHHHHHC	20.47	24719451
416	Phosphorylation	QSQALHATSQQPLRK HHHHHHHHCCCCCCC	19.13	29514088
417	Phosphorylation	SQALHATSQQPLRKD HHHHHHHCCCCCCCC	27.83	29514088
435 (in isoform 4)	Phosphorylation	-	9.85	-
438 (in isoform 4)	Phosphorylation	-	30.50	-
440 (in isoform 4)	Phosphorylation	-	4.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
163	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	PSP
192	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEPT8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEPT8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEPT5_HUMAN	SEPT5	physical	12023038
PPHLN_HUMAN	PPHLN1	physical	21900206
KMT2B_HUMAN	KMT2B	physical	21900206
JADE1_HUMAN	JADE1	physical	21900206
SH3G3_HUMAN	SH3GL3	physical	21900206
A2MG_HUMAN	A2M	physical	21900206
SH3G1_HUMAN	SH3GL1	physical	21900206
RNF8_HUMAN	RNF8	physical	23442799
SEP10_HUMAN	SEPT10	physical	26344197
SEP11_HUMAN	SEPT11	physical	26344197
SEPT5_HUMAN	SEPT5	physical	26344197
ZWILC_HUMAN	ZWILCH	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.