| UniProt ID | ZWILC_HUMAN | |
|---|---|---|
| UniProt AC | Q9H900 | |
| Protein Name | Protein zwilch homolog | |
| Gene Name | ZWILCH | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 591 | |
| Subcellular Localization | Chromosome, centromere, kinetochore . | |
| Protein Description | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. [PubMed: 15824131] | |
| Protein Sequence | MWERLNCAAEDFYSRLLQKFNEEKKGIRKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIALDISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLADGLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERIFFTNMVTCSQVHFK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | DVQVQLISKGQPNPL EEEEEEEECCCCCCH | 39.05 | 24719451 | |
| 74 | Phosphorylation | VPLEKEETSHIEELQ CCCCHHHCCCHHHHH | 27.05 | 27251275 | |
| 75 | Phosphorylation | PLEKEETSHIEELQS CCCHHHCCCHHHHHC | 26.25 | 27251275 | |
| 82 | Phosphorylation | SHIEELQSEETAISD CCHHHHHCCCCCCCC | 50.45 | 18669648 | |
| 85 | Phosphorylation | EELQSEETAISDFST HHHHCCCCCCCCCCC | 25.82 | 17192257 | |
| 88 | Phosphorylation | QSEETAISDFSTGEN HCCCCCCCCCCCCCC | 30.09 | 17192257 | |
| 91 | Phosphorylation | ETAISDFSTGENVGP CCCCCCCCCCCCCCC | 40.26 | 18691976 | |
| 92 | Phosphorylation | TAISDFSTGENVGPL CCCCCCCCCCCCCCC | 48.81 | 20068231 | |
| 186 | Ubiquitination | SVNLENLKNLHKKRH CCCHHHHHHHHHHCC | 69.88 | - | |
| 191 | Ubiquitination | NLKNLHKKRHHLSTV HHHHHHHHCCCHHHH | 46.33 | - | |
| 206 | Phosphorylation | TSKGFAQYELFKSSA CCCCCHHHHHHHHCC | 15.92 | 27642862 | |
| 212 (in isoform 2) | Ubiquitination | - | 33.18 | 21906983 | |
| 315 | Phosphorylation | KLDGFGDSTKKDTEV HCCCCCCCCCCCCCC | 42.37 | 28674419 | |
| 316 | Phosphorylation | LDGFGDSTKKDTEVE CCCCCCCCCCCCCCC | 47.02 | 21815630 | |
| 320 | Phosphorylation | GDSTKKDTEVETLKH CCCCCCCCCCCCCCC | 51.30 | - | |
| 324 | Phosphorylation | KKDTEVETLKHDTAA CCCCCCCCCCCCHHH | 46.40 | - | |
| 326 | Ubiquitination | DTEVETLKHDTAAVD CCCCCCCCCCHHHHH | 47.02 | 2190698 | |
| 326 (in isoform 1) | Ubiquitination | - | 47.02 | 21906983 | |
| 344 | Phosphorylation | KRLFKVRSDLDFAEQ HHHHHHCCCCHHHHH | 45.58 | 21406692 | |
| 357 | Phosphorylation | EQLWCKMSSSVISYQ HHHHHHHCCCCCCHH | 12.64 | 25072903 | |
| 358 | Phosphorylation | QLWCKMSSSVISYQD HHHHHHCCCCCCHHH | 25.73 | 25072903 | |
| 359 | Phosphorylation | LWCKMSSSVISYQDL HHHHHCCCCCCHHHH | 19.03 | 25072903 | |
| 362 | Phosphorylation | KMSSSVISYQDLVKC HHCCCCCCHHHHHHH | 18.00 | 25072903 | |
| 363 | Phosphorylation | MSSSVISYQDLVKCF HCCCCCCHHHHHHHH | 8.57 | 25072903 | |
| 392 | Phosphorylation | WLHSGSNSLLSKLIH HCCCCCHHHHHHHHH | 32.17 | 24719451 | |
| 523 | Phosphorylation | PTAVKNLYQSEKPQK HHHHHHHHHCCCCCC | 21.27 | 27642862 | |
| 527 | Ubiquitination | KNLYQSEKPQKWRVE HHHHHCCCCCCEEEE | 58.98 | - | |
| 565 | Phosphorylation | NFHKPDFSELTLNGS CCCCCCHHHEECCCC | 38.79 | 22067460 | |
| 568 | Phosphorylation | KPDFSELTLNGSLEE CCCHHHEECCCCHHH | 17.71 | 28450419 | |
| 572 | Phosphorylation | SELTLNGSLEERIFF HHEECCCCHHHCEEE | 31.38 | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZWILC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZWILC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZWILC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ZWILC_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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