dbPTM

SEPT5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT5_HUMAN
UniProt AC	Q99719
Protein Name	Septin-5
Gene Name	5-Sep
Organism	Homo sapiens (Human).
Sequence Length	369
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton. In platelets, found in areas surrounding alpha-granules.
Protein Description	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)..
Protein Sequence	MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MSTGLRYKSKLAT --CCCCCHHHCCCCC	37.87	115916453
13	Phosphorylation	RYKSKLATPEDKQDI HHHCCCCCHHHHHCC	37.33	23312004
17 (in isoform 2)	Phosphorylation	-	48.48	28450419
24	Phosphorylation	KQDIDKQYVGFATLP HHCCCHHHCEEEECC	14.31	28060719
29	Phosphorylation	KQYVGFATLPNQVHR HHHCEEEECCCHHHH	40.25	28060719
33 (in isoform 2)	Phosphorylation	-	30.38	-
41	Ubiquitination	VHRKSVKKGFDFTLM HHHHHHHCCCCEEEE	63.76	-
77	Phosphorylation	YKDRKLLSAEERISQ HHCHHHHCHHHHHHH	44.03	21815630
83	Phosphorylation	LSAEERISQTVEILK HCHHHHHHHHHHHHH	26.48	30266825
85	Phosphorylation	AEERISQTVEILKHT HHHHHHHHHHHHHHH	17.20	30266825
168	Methylation	SPFGHGLRPVDVGFM CCCCCCCCCCCHHHH	33.51	-
218	Phosphorylation	DKFGIHVYQFPECDS HHHCEEEEECCCCCC	7.12	20873877
225	Phosphorylation	YQFPECDSDEDEDFK EECCCCCCCCCCHHH	55.34	22617229
241	Phosphorylation	QDRELKESAPFAVIG HHHHHHHHCCEEEEC	39.39	25693802
249	Phosphorylation	APFAVIGSNTVVEAK CCEEEECCCCEEEEC	20.43	25693802
251	Phosphorylation	FAVIGSNTVVEAKGQ EEEECCCCEEEECCE	27.85	25693802
318	Ubiquitination	CIQQMTSKLTQDSRM HHHHHHHHCCCCCCC	46.52	-
320	Phosphorylation	QQMTSKLTQDSRMES HHHHHHCCCCCCCCC	33.78	26074081
323	Phosphorylation	TSKLTQDSRMESPIP HHHCCCCCCCCCCCC	24.57	26074081
327	Phosphorylation	TQDSRMESPIPILPL CCCCCCCCCCCCCCC	20.84	30278072
336	Phosphorylation	IPILPLPTPDAETEK CCCCCCCCCCHHHHH	41.29	21082442
341	Phosphorylation	LPTPDAETEKLIRMK CCCCCHHHHHHHHHC	39.89	26074081
343	Ubiquitination	TPDAETEKLIRMKDE CCCHHHHHHHHHCHH	57.54	-
363	Methylation	QEMLQRMKQQMQDQ- HHHHHHHHHHHHCC-	39.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:14559152

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEPT5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEPT8_HUMAN	SEPT8	physical	12909369
KAT7_HUMAN	KAT7	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
SEPT8_HUMAN	SEPT8	physical	12023038
STX4_HUMAN	STX4	physical	11880646
PRKN_HUMAN	PARK2	physical	18845538
A4_HUMAN	APP	physical	21832049
SEPT2_HUMAN	SEPT2	physical	24722188
SEPT5_HUMAN	SEPT5	physical	24722188
MYOG_HUMAN	MYOG	physical	24722188
SEPT1_HUMAN	SEPT1	physical	24722188
SEPT6_HUMAN	SEPT6	physical	24722188
SEPT2_HUMAN	SEPT2	physical	18330356
SEPT6_HUMAN	SEPT6	physical	18330356
SEPT7_HUMAN	SEPT7	physical	18330356
SEP11_HUMAN	SEPT11	physical	18330356
SEPT5_HUMAN	SEPT5	physical	25416956
SEPT6_HUMAN	SEPT6	physical	25416956
SEP10_HUMAN	SEPT10	physical	25416956
SEP10_HUMAN	SEPT10	physical	26344197
PKHF2_HUMAN	PLEKHF2	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225 AND SER-327, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND MASSSPECTROMETRY.	18088087 [Abstract]