PRKN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRKN_HUMAN
• UniProt AC: O60260
• Protein Name: E3 ubiquitin-protein ligase parkin {ECO:0000305}
• Gene Name: PRKN {ECO:0000312|HGNC:HGNC:8607}
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Cytoplasm, cytosol . Nucleus. Endoplasmic reticulum. Mitochondrion . Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Mitochondrial localization gradually increases with cellula
• Protein Description: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. [PubMed: 10973942]
• Protein Sequence: MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	IVFVRFNSSHGFPVE EEEEEEECCCCCEEE		-
10	Phosphorylation	VFVRFNSSHGFPVEV EEEEEECCCCCEEEE		-
19	Phosphorylation	GFPVEVDSDTSIFQL CCEEEECCCCCEEEH		-
27 (in isoform 2)	Ubiquitination	-		-
27	Ubiquitination	DTSIFQLKEVVAKRQ CCCEEEHHHHHHHHC		-
48 (in isoform 2)	Ubiquitination	-		-
48	Ubiquitination	LRVIFAGKELRNDWT EEEEEECCCCCCCCE		-
65	Phosphorylation	NCDLDQQSIVHIVQR CCCCCHHHEEEEECC		19229105
76 (in isoform 2)	Ubiquitination	-		-
76	Ubiquitination	IVQRPWRKGQEMNAT EECCCCCCCCCCCCC		-
83	Phosphorylation	KGQEMNATGGDDPRN CCCCCCCCCCCCCCC		22468782
101	Phosphorylation	GCEREPQSLTRVDLS CCCCCCCCCEEEECC		22817900
108	Phosphorylation	SLTRVDLSSSVLPGD CCEEEECCCCCCCCC		-
116	Phosphorylation	SSVLPGDSVGLAVIL CCCCCCCCEEEEEEE		-
129 (in isoform 2)	Ubiquitination	-		-
131	Phosphorylation	HTDSRKDSPPAGSPA ECCCCCCCCCCCCCC		22817900
136	Phosphorylation	KDSPPAGSPAGRSIY CCCCCCCCCCHHHCC		22817900
143	Phosphorylation	SPAGRSIYNSFYVYC CCCHHHCCCEEEEEE		20823226
175	Phosphorylation	TCRQATLTLTQGPSC CCCCEEEEECCCCCC		18957282
193	Phosphorylation	VLIPNRMSGECQSPH EEECCCCCCCCCCCC		-
198	Phosphorylation	RMSGECQSPHCPGTS CCCCCCCCCCCCCCC		-
204	Phosphorylation	QSPHCPGTSAEFFFK CCCCCCCCCEEEEEE		-
217	Phosphorylation	FKCGAHPTSDKETSV EECCCCCCCCCHHHH		18957282
246	Phosphorylation	ITCTDVRSPVLVFQC EEECCCCCCEEEEEC		23532336
296	Phosphorylation	CVAGCPNSLIKELHH CCCCCCCHHHHHHHH		22817900
372	Phosphorylation	CRECKEAYHEGECSA EHHHHHHHHCCCCCE		-
378	Phosphorylation	AYHEGECSAVFEASG HHHCCCCCEEEEECC		22817900
380 (in isoform 2)	Ubiquitination	-		-
384 (in isoform 2)	Ubiquitination	-		-
388	Phosphorylation	FEASGTTTQAYRVDE EEECCCCCEEEECCH		-
391	Phosphorylation	SGTTTQAYRVDERAA CCCCCEEEECCHHHH		-
408	Ubiquitination	ARWEAASKETIKKTT HHHHHHCHHHHHHCC		-
412	Ubiquitination	AASKETIKKTTKPCP HHCHHHHHHCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
65	S	Phosphorylation	Kinase	PINK1	Q9BXM7	Uniprot
101	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
131	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
143	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
378	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
378	S	Phosphorylation	Kinase	PLK1	P53350	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	RNF41	Q9H4P4	PMID:15632191
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:15252205

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
65	S	Phosphorylation	Activation requires phosphorylation at Ser-65 by PINK1 and binding to PINK1 phosphorylated ubiquitin.	23754282
65	S	ubiquitylation	Activation requires phosphorylation at Ser-65 by PINK1 and binding to PINK1 phosphorylated ubiquitin.	23754282
175	T	Phosphorylation	Phosphorylation at Thr-175 by PINK1 and at Thr-217 is important for mitochondrial localization.	18957282
217	T	Phosphorylation	Phosphorylation at Thr-175 by PINK1 and at Thr-217 is important for mitochondrial localization.	18957282

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRKN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	16189514
SEPT5_HUMAN	SEPT5	physical	14559152
SYT11_HUMAN	SYT11	physical	12925569
AIMP2_HUMAN	AIMP2	physical	12783850
FBXW7_HUMAN	FBXW7	physical	12628165
CUL1_HUMAN	CUL1	physical	12628165
CCNE1_HUMAN	CCNE1	physical	12628165
CCNA1_HUMAN	CCNA1	physical	12628165
RAC1_HUMAN	RAC1	physical	16169070
RAD1_HUMAN	RAD1	physical	16169070
CSKP_HUMAN	CASK	physical	11679592
NMDE2_HUMAN	GRIN2B	physical	11679592
DLG4_HUMAN	DLG4	physical	11679592
HOME1_HUMAN	HOMER1	physical	11679592
KCC2A_HUMAN	CAMK2A	physical	11679592
GPR37_HUMAN	GPR37	physical	11439185
UB2G1_HUMAN	UBE2G1	physical	11439185
UB2J1_HUMAN	UBE2J1	physical	11439185
SYUA_HUMAN	SNCA	physical	11588587
CHIP_HUMAN	STUB1	physical	12150907
DNJA1_HUMAN	DNAJA1	physical	12150907
HSP7C_HUMAN	HSPA8	physical	12150907
DNJB1_HUMAN	DNAJB1	physical	12150907
GPR37_HUMAN	GPR37	physical	12150907
PSA1_HUMAN	PSMA1	physical	12150907
SNCAP_HUMAN	SNCAIP	physical	11590439
UB2L6_HUMAN	UBE2L6	physical	11078524
SEPT5_MOUSE	Sept5	physical	11078524
PDCD2_HUMAN	PDCD2	physical	19146857
PLCG1_HUMAN	PLCG1	physical	18671761
PRKN_HUMAN	PARK2	physical	17883392
BACH1_HUMAN	BACH1	physical	17682061
CDK5_HUMAN	CDK5	physical	17327227
LIMK1_HUMAN	LIMK1	physical	17512523
EPS15_HUMAN	EPS15	physical	16862145
HSP74_HUMAN	HSPA4	physical	16714300
TBA1A_HUMAN	TUBA1A	physical	16714300
TBG1_HUMAN	TUBG1	physical	16714300
SEPT5_HUMAN	SEPT5	physical	16714300
AIMP2_HUMAN	AIMP2	physical	16714300
PSA4_HUMAN	PSMA4	physical	16714300
SYUA_HUMAN	SNCA	physical	16714300
PRKN_HUMAN	PARK2	physical	16714300
LRRK2_HUMAN	LRRK2	physical	16352719
RBP2_HUMAN	RANBP2	physical	16332688
AIMP2_HUMAN	AIMP2	physical	16135753
SNCAP_HUMAN	SNCAIP	physical	16049031
AIMP2_HUMAN	AIMP2	physical	16049031
PSA4_HUMAN	PSMA4	physical	15987638
SIM2_HUMAN	SIM2	physical	15963499
PARK7_HUMAN	PARK7	physical	15525661
SC6A3_HUMAN	SLC6A3	physical	15492001
TBG1_HUMAN	TUBG1	physical	12928331
HSP74_HUMAN	HSPA4	physical	12676955
PRS8_HUMAN	PSMC5	physical	12676955
PARK7_HUMAN	PARK7	physical	17846173
UB2L3_HUMAN	UBE2L3	physical	11431533
SYN1_HUMAN	SYN1	physical	11431533
UB2L3_HUMAN	UBE2L3	physical	10973942
HTRA2_HUMAN	HTRA2	physical	19631192
BCL2_HUMAN	BCL2	physical	20889974
RNF41_HUMAN	RNF41	physical	15632191
A4_HUMAN	APP	physical	19610108
ZN746_HUMAN	ZNF746	physical	21376232
ABL1_HUMAN	ABL1	physical	20823226
AMRA1_HUMAN	AMBRA1	physical	21753002
PICK1_HUMAN	PICK1	physical	17553932
PRKN_HUMAN	PARK2	physical	17553932
NEMO_HUMAN	IKBKG	physical	17314283
TRAF2_HUMAN	TRAF2	physical	17314283
MFN1_HUMAN	MFN1	physical	21615408
MFN2_HUMAN	MFN2	physical	21615408
ERR1_HUMAN	ESRRA	physical	21177257
ERR2_HUMAN	ESRRB	physical	21177257
ERR3_HUMAN	ESRRG	physical	21177257
ARRB2_HUMAN	ARRB2	physical	21466165
ATX3_HUMAN	ATXN3	physical	20940148
ATX3_RAT	Atxn3	physical	20940148
PRKN_HUMAN	PARK2	physical	20940148
DNM1L_HUMAN	DNM1L	physical	21292769
PRKN_HUMAN	PARK2	physical	22008525
HSP74_HUMAN	HSPA4	physical	18784277
PSMD4_HUMAN	PSMD4	physical	19240029
ATX3_HUMAN	ATXN3	physical	22081612
PRKN_HUMAN	PARK2	physical	22200450
ABL1_HUMAN	ABL1	physical	21209200
PRKN_HUMAN	PARK2	physical	21209200
F16P1_HUMAN	FBP1	physical	21209200
GLCM_HUMAN	GBA	physical	20643691
BAG5_HUMAN	BAG5	physical	15603737
HSP74_HUMAN	HSPA4	physical	15603737
PRKN_HUMAN	PARK2	physical	15603737
SNCAP_HUMAN	SNCAIP	physical	15603737
PSMD4_HUMAN	PSMD4	physical	12634850
PSMD4_HUMAN	PSMD4	physical	20810900
PSMD2_HUMAN	PSMD2	physical	20810900
PRS8_HUMAN	PSMC5	physical	20810900
PRS6A_HUMAN	PSMC3	physical	20810900
ATX2_HUMAN	ATXN2	physical	17097639
1433F_HUMAN	YWHAH	physical	16096643
PRKN_HUMAN	PARK2	physical	16096643
SNCAP_HUMAN	SNCAIP	physical	16096643
UB2L3_HUMAN	UBE2L3	physical	16096643
ARI1_HUMAN	ARIH1	physical	21590270
PRKN_HUMAN	PARK2	physical	21694720
UB2L3_HUMAN	UBE2L3	physical	22271254
UB2L6_HUMAN	UBE2L6	physical	22271254
MK01_HUMAN	MAPK1	physical	22271254
TRAF2_HUMAN	TRAF2	physical	22271254
TFR1_HUMAN	TFRC	physical	18362144
G3P_HUMAN	GAPDH	physical	18362144
GRP75_HUMAN	HSPA9	physical	21640711
PCNA_HUMAN	PCNA	physical	19285961
PRPS1_HUMAN	PRPS1	physical	22792159
UBS3B_HUMAN	UBASH3B	physical	17599067
UBS3A_HUMAN	UBASH3A	physical	17599067
UB2J2_HUMAN	UBE2J2	physical	16720581
PSMD4_HUMAN	PSMD4	physical	22350919
CHSS2_HUMAN	CHPF	physical	22082830
PINK1_HUMAN	PINK1	physical	20798600
PINK1_HUMAN	PINK1	physical	19167501
PINK1_HUMAN	PINK1	physical	19229105
PARK7_HUMAN	PARK7	physical	19229105
PRKN_HUMAN	PARK2	physical	19229105
A4_HUMAN	APP	physical	22954671
GPR37_HUMAN	GPR37	physical	14579121
UB2L3_HUMAN	UBE2L3	physical	14559152
UBC_HUMAN	UBC	physical	22724072
PINK1_HUMAN	PINK1	physical	22724072
UB2L3_HUMAN	UBE2L3	physical	19240029
UB2G2_HUMAN	UBE2G2	physical	17553932
UBE2N_HUMAN	UBE2N	physical	17553932
UB2L3_HUMAN	UBE2L3	physical	17553932
UB2D2_HUMAN	UBE2D2	physical	17553932
UBE2N_HUMAN	UBE2N	physical	17846173
UB2L3_HUMAN	UBE2L3	physical	22008525
UB2E1_HUMAN	UBE2E1	physical	21376232
UB2L3_HUMAN	UBE2L3	physical	21376232
UB2D3_HUMAN	UBE2D3	physical	21376232
UB2J1_HUMAN	UBE2J1	physical	15603737
UB2G1_HUMAN	UBE2G1	physical	15603737
UB2J1_HUMAN	UBE2J1	physical	12150907
UB2G2_HUMAN	UBE2G2	physical	12150907
UB2D2_HUMAN	UBE2D2	physical	12150907
UB2L3_HUMAN	UBE2L3	physical	11590439
UB2J1_HUMAN	UBE2J1	physical	16862145
UB2G1_HUMAN	UBE2G1	physical	16862145
UB2L3_HUMAN	UBE2L3	physical	16714300
UB2L3_HUMAN	UBE2L3	physical	16332688
UB2L3_HUMAN	UBE2L3	physical	21694720
UB2L6_HUMAN	UBE2L6	physical	21694720
UBE2N_HUMAN	UBE2N	physical	21694720
UB2V1_HUMAN	UBE2V1	physical	21694720
UB2G2_HUMAN	UBE2G2	physical	21694720
UB2D2_HUMAN	UBE2D2	physical	21694720
UB2L3_HUMAN	UBE2L3	physical	21292769
UB2L3_HUMAN	UBE2L3	physical	21209200
PINK1_HUMAN	PINK1	physical	19880420
UBE2N_HUMAN	UBE2N	physical	19880420
NEMO_HUMAN	IKBKG	physical	19880420
PINK1_HUMAN	PINK1	genetic	19880420
SYUA_HUMAN	SNCA	genetic	12963044
VDAC1_HUMAN	VDAC1	physical	23068103
VDAC2_HUMAN	VDAC2	physical	23068103
VDAC3_HUMAN	VDAC3	physical	23068103
HXK1_HUMAN	HK1	physical	23068103
TOM70_HUMAN	TOMM70A	physical	23068103
CISD1_HUMAN	CISD1	physical	23068103
NDKB_HUMAN	NME2	physical	23068103
GPR37_HUMAN	GPR37	genetic	12670421
SYUA_HUMAN	SNCA	genetic	12670421
HSP7C_HUMAN	HSPA8	physical	14532270
HSP74_HUMAN	HSPA4	physical	14532270
TCPA_HUMAN	TCP1	physical	14532270
TCPB_HUMAN	CCT2	physical	14532270
PACRG_HUMAN	PACRG	physical	14532270
CHIP_HUMAN	STUB1	physical	14532270
DNJA1_HUMAN	DNAJA1	physical	14532270
TERA_HUMAN	VCP	physical	14532270
HS90A_HUMAN	HSP90AA1	physical	14532270
PRKN_HUMAN	PARK2	physical	15557340
VDAC1_HUMAN	VDAC1	physical	23060438
VDAC2_HUMAN	VDAC2	physical	23060438
VDAC3_HUMAN	VDAC3	physical	23060438
MIRO1_HUMAN	RHOT1	physical	23060438
MIRO2_HUMAN	RHOT2	physical	23060438
MFN1_HUMAN	MFN1	physical	23060438
MFN2_HUMAN	MFN2	physical	23060438
PINK1_HUMAN	PINK1	physical	23319602
PCH2_HUMAN	TRIP13	physical	19060904
ACSL1_HUMAN	ACSL1	physical	23503661
ACSL4_HUMAN	ACSL4	physical	23503661
MDHC_HUMAN	MDH1	physical	23503661
MDHM_HUMAN	MDH2	physical	23503661
CPT1A_HUMAN	CPT1A	physical	23503661
NB5R1_HUMAN	CYB5R1	physical	23503661
NB5R3_HUMAN	CYB5R3	physical	23503661
MARC1_HUMAN	MARC1	physical	23503661
HXK1_HUMAN	HK1	physical	23503661
HXK2_HUMAN	HK2	physical	23503661
CISD1_HUMAN	CISD1	physical	23503661
VDAC1_HUMAN	VDAC1	physical	23503661
VDAC2_HUMAN	VDAC2	physical	23503661
VDAC3_HUMAN	VDAC3	physical	23503661
TOM70_HUMAN	TOMM70A	physical	23503661
TOM22_HUMAN	TOMM22	physical	23503661
MIRO1_HUMAN	RHOT1	physical	23503661
MIRO2_HUMAN	RHOT2	physical	23503661
FIS1_HUMAN	FIS1	physical	23503661
MFN1_HUMAN	MFN1	physical	23503661
MFN2_HUMAN	MFN2	physical	23503661
MARH5_HUMAN	MARCH5	physical	23503661
TBC15_HUMAN	TBC1D15	physical	23503661
TOM1_HUMAN	TOM1	physical	23503661
MYO6_HUMAN	MYO6	physical	23503661
TAXB1_HUMAN	TAX1BP1	physical	23503661
SQSTM_HUMAN	SQSTM1	physical	23503661
CACO2_HUMAN	CALCOCO2	physical	23503661
PSA1_HUMAN	PSMA1	physical	23503661
PSA2_HUMAN	PSMA2	physical	23503661
PSA3_HUMAN	PSMA3	physical	23503661
PSA4_HUMAN	PSMA4	physical	23503661
PSA5_HUMAN	PSMA5	physical	23503661
PSA6_HUMAN	PSMA6	physical	23503661
PSA7_HUMAN	PSMA7	physical	23503661
PSB1_HUMAN	PSMB1	physical	23503661
PSB2_HUMAN	PSMB2	physical	23503661
PSB3_HUMAN	PSMB3	physical	23503661
PSB4_HUMAN	PSMB4	physical	23503661
PSB5_HUMAN	PSMB5	physical	23503661
PSB6_HUMAN	PSMB6	physical	23503661
PSB7_HUMAN	PSMB7	physical	23503661
PRS4_HUMAN	PSMC1	physical	23503661
PRS7_HUMAN	PSMC2	physical	23503661
PRS6A_HUMAN	PSMC3	physical	23503661
PRS6B_HUMAN	PSMC4	physical	23503661
PRS8_HUMAN	PSMC5	physical	23503661
PRS10_HUMAN	PSMC6	physical	23503661
RD23A_HUMAN	RAD23A	physical	23503661
RD23B_HUMAN	RAD23B	physical	23503661
ADRM1_HUMAN	ADRM1	physical	23503661
PAAF1_HUMAN	PAAF1	physical	23503661
TERA_HUMAN	VCP	physical	23503661
PSMD1_HUMAN	PSMD1	physical	23503661
PSMD2_HUMAN	PSMD2	physical	23503661
PSMD3_HUMAN	PSMD3	physical	23503661
PSMD4_HUMAN	PSMD4	physical	23503661
PSMD5_HUMAN	PSMD5	physical	23503661
PSMD6_HUMAN	PSMD6	physical	23503661
PSMD7_HUMAN	PSMD7	physical	23503661
PSMD8_HUMAN	PSMD8	physical	23503661
PSMD9_HUMAN	PSMD9	physical	23503661
PSD10_HUMAN	PSMD10	physical	23503661
PSD11_HUMAN	PSMD11	physical	23503661
PSD12_HUMAN	PSMD12	physical	23503661
PSD13_HUMAN	PSMD13	physical	23503661
PSDE_HUMAN	PSMD14	physical	23503661
PSME1_HUMAN	PSME1	physical	23503661
PSME2_HUMAN	PSME2	physical	23503661
PSME3_HUMAN	PSME3	physical	23503661
PINK1_HUMAN	PINK1	physical	23670163
UB2L3_HUMAN	UBE2L3	physical	23707686
PRKN_HUMAN	PARK2	physical	23727886
UB2L3_HUMAN	UBE2L3	physical	23727886
FBX7_HUMAN	FBXO7	physical	23933751
TOM70_HUMAN	TOMM70A	physical	24149440
TOM40_HUMAN	TOMM40	physical	24149440
LPPRC_HUMAN	LRPPRC	physical	24244333
TOM70_HUMAN	TOMM70A	physical	24244333
PRKN_HUMAN	PARK2	physical	24244333
DNJA1_HUMAN	DNAJA1	physical	24244333
HSP7C_HUMAN	HSPA8	physical	24244333
PRDX1_HUMAN	PRDX1	physical	24244333
ROA2_HUMAN	HNRNPA2B1	physical	24244333
CLPX_HUMAN	CLPX	physical	24244333
CBX1_HUMAN	CBX1	physical	24244333
CH60_HUMAN	HSPD1	physical	24244333
ACTB_HUMAN	ACTB	physical	24244333
AT2B3_HUMAN	ATP2B3	physical	24244333
AT2B1_HUMAN	ATP2B1	physical	24244333
CASPE_HUMAN	CASP14	physical	24244333
H10_HUMAN	H1F0	physical	24244333
RT29_HUMAN	DAP3	physical	24244333
GLU2B_HUMAN	PRKCSH	physical	24244333
TBA1C_HUMAN	TUBA1C	physical	24244333
AIFM1_HUMAN	AIFM1	physical	24244333
ALBU_HUMAN	ALB	physical	24244333
TBB4B_HUMAN	TUBB4B	physical	24244333
VIME_HUMAN	VIM	physical	24244333
TBA4A_HUMAN	TUBA4A	physical	24244333
HS90B_HUMAN	HSP90AB1	physical	24244333
HS90A_HUMAN	HSP90AA1	physical	24244333
GRP75_HUMAN	HSPA9	physical	24244333
NPM_HUMAN	NPM1	physical	24244333
TBB5_HUMAN	TUBB	physical	24244333
GRP78_HUMAN	HSPA5	physical	24244333
GSDMA_HUMAN	GSDMA	physical	24244333
RBM8A_HUMAN	RBM8A	physical	24244333
CALU_HUMAN	CALU	physical	24244333
RCN2_HUMAN	RCN2	physical	24244333
RT31_HUMAN	MRPS31	physical	24244333
G3P_HUMAN	GAPDH	physical	24244333
MPCP_HUMAN	SLC25A3	physical	24244333
ATPA_HUMAN	ATP5A1	physical	24244333
ECHB_HUMAN	HADHB	physical	24244333
EF1A1_HUMAN	EEF1A1	physical	24244333
NFL_HUMAN	NEFL	physical	24244333
TBB6_HUMAN	TUBB6	physical	24244333
CMC2_HUMAN	SLC25A13	physical	24244333
H2A1A_HUMAN	HIST1H2AA	physical	24244333
ATPO_HUMAN	ATP5O	physical	24244333
RT07_HUMAN	MRPS7	physical	24244333
SET_HUMAN	SET	physical	24244333
OPA1_HUMAN	OPA1	physical	24244333
NFM_HUMAN	NEFM	physical	24244333
CBX3_HUMAN	CBX3	physical	24244333
IF4B_HUMAN	EIF4B	physical	24244333
BAG2_HUMAN	BAG2	physical	24244333
SNUT1_HUMAN	SART1	physical	24244333
ATPK_HUMAN	ATP5J2	physical	24244333
ML12A_HUMAN	MYL12A	physical	24244333
ATPG_HUMAN	ATP5C1	physical	24244333
RS20_HUMAN	RPS20	physical	24244333
RL13_HUMAN	RPL13	physical	24244333
RL6_HUMAN	RPL6	physical	24244333
TCPG_HUMAN	CCT3	physical	24244333
ANXA2_HUMAN	ANXA2	physical	24244333
HNRPF_HUMAN	HNRNPF	physical	24244333
TPM4_HUMAN	TPM4	physical	24244333
NDUS4_HUMAN	NDUFS4	physical	24244333
AINX_HUMAN	INA	physical	24244333
HSP72_HUMAN	HSPA2	physical	24244333
CIRBP_HUMAN	CIRBP	physical	24244333
YBOX3_HUMAN	YBX3	physical	24244333
LMNB1_HUMAN	LMNB1	physical	24244333
ADT1_HUMAN	SLC25A4	physical	24244333
CALR_HUMAN	CALR	physical	24244333
RM12_HUMAN	MRPL12	physical	24244333
PRP19_HUMAN	PRPF19	physical	24244333
SFPQ_HUMAN	SFPQ	physical	24244333
ENPL_HUMAN	HSP90B1	physical	24244333
RFC4_HUMAN	RFC4	physical	24244333
FUS_HUMAN	FUS	physical	24244333
NDUS2_HUMAN	NDUFS2	physical	24244333
SSBP_HUMAN	SSBP1	physical	24244333
IF2B1_HUMAN	IGF2BP1	physical	24244333
HS71L_HUMAN	HSPA1L	physical	24244333
C1QBP_HUMAN	C1QBP	physical	24244333
XRCC6_HUMAN	XRCC6	physical	24244333
1433E_HUMAN	YWHAE	physical	24244333
RUVB1_HUMAN	RUVBL1	physical	24244333
LMNA_HUMAN	LMNA	physical	24244333
RUVB2_HUMAN	RUVBL2	physical	24244333
VGF_HUMAN	VGF	physical	24244333
ZC3HF_HUMAN	ZC3H15	physical	24244333
GPDM_HUMAN	GPD2	physical	24244333
HSDL2_HUMAN	HSDL2	physical	24244333
AMY2B_HUMAN	AMY2B	physical	24244333
MRP_HUMAN	MARCKSL1	physical	24244333
CMGA_HUMAN	CHGA	physical	24244333
ACTBL_HUMAN	ACTBL2	physical	24244333
NTPCR_HUMAN	NTPCR	physical	24244333
GNT2A_HUMAN	GCNT2	physical	24244333
ADAS_HUMAN	AGPS	physical	24244333
SCG1_HUMAN	CHGB	physical	24244333
CEP55_HUMAN	CEP55	physical	24244333
HDGF_HUMAN	HDGF	physical	24244333
ABCE1_HUMAN	ABCE1	physical	24244333
TGM3_HUMAN	TGM3	physical	24244333
AGK_HUMAN	AGK	physical	24244333
RT28_HUMAN	MRPS28	physical	24244333
RT18B_HUMAN	MRPS18B	physical	24244333
RL26L_HUMAN	RPL26L1	physical	24244333
STML2_HUMAN	STOML2	physical	24244333
CALL3_HUMAN	CALML3	physical	24244333
ODB2_HUMAN	DBT	physical	24244333
VAT1_HUMAN	VAT1	physical	24244333
NACAM_HUMAN	NACA	physical	24244333
NACA_HUMAN	NACA	physical	24244333
MIC19_HUMAN	CHCHD3	physical	24244333
TPM3_HUMAN	TPM3	physical	24244333
NDUAA_HUMAN	NDUFA10	physical	24244333
AMOT_HUMAN	AMOT	physical	24244333
HNRH3_HUMAN	HNRNPH3	physical	24244333
PDIA4_HUMAN	PDIA4	physical	24244333
SRSF9_HUMAN	SRSF9	physical	24244333
RT23_HUMAN	MRPS23	physical	24244333
TBB1_HUMAN	TUBB1	physical	24244333
NIPS1_HUMAN	NIPSNAP1	physical	24244333
PCCA_HUMAN	PCCA	physical	24244333
RS19_HUMAN	RPS19	physical	24244333
PCCB_HUMAN	PCCB	physical	24244333
ACTA_HUMAN	ACTA2	physical	24244333
MARCS_HUMAN	MARCKS	physical	24244333
DDX47_HUMAN	DDX47	physical	24244333
PAP1L_HUMAN	PABPC1L	physical	24244333
PRC2C_HUMAN	PRRC2C	physical	24244333
MCCB_HUMAN	MCCC2	physical	24244333
THIO_HUMAN	TXN	physical	24244333
PDIA6_HUMAN	PDIA6	physical	24244333
HNRC1_HUMAN	HNRNPCL1	physical	24244333
HNRDL_HUMAN	HNRNPDL	physical	24244333
PDIA1_HUMAN	P4HB	physical	24244333
PIP_HUMAN	PIP	physical	24244333
HNRPD_HUMAN	HNRNPD	physical	24244333
NDUS3_HUMAN	NDUFS3	physical	24244333
CKAP4_HUMAN	CKAP4	physical	24244333
ATD3B_HUMAN	ATAD3B	physical	24244333
RL22_HUMAN	RPL22	physical	24244333
PABP3_HUMAN	PABPC3	physical	24244333
ROA3_HUMAN	HNRNPA3	physical	24244333
RS27A_HUMAN	RPS27A	physical	24244333
IMDH2_HUMAN	IMPDH2	physical	24244333
MCM7_HUMAN	MCM7	physical	24244333
TPM1_HUMAN	TPM1	physical	24244333
TXTP_HUMAN	SLC25A1	physical	24244333
EF1A2_HUMAN	EEF1A2	physical	24244333
ATD3A_HUMAN	ATAD3A	physical	24244333
RL8_HUMAN	RPL8	physical	24244333
PGAM5_HUMAN	PGAM5	physical	24244333
SRSF1_HUMAN	SRSF1	physical	24244333
RALY_HUMAN	RALY	physical	24244333
ELAV1_HUMAN	ELAVL1	physical	24244333
RS2_HUMAN	RPS2	physical	24244333
H12_HUMAN	HIST1H1C	physical	24244333
RT15_HUMAN	MRPS15	physical	24244333
PTCD3_HUMAN	PTCD3	physical	24244333
HNRPR_HUMAN	HNRNPR	physical	24244333
SRSF3_HUMAN	SRSF3	physical	24244333
HNRPM_HUMAN	HNRNPM	physical	24244333
RT27_HUMAN	MRPS27	physical	24244333
PAIRB_HUMAN	SERBP1	physical	24244333
EFTU_HUMAN	TUFM	physical	24244333
SRSF2_HUMAN	SRSF2	physical	24244333
PRP6_HUMAN	PRPF6	physical	24244333
HNRPQ_HUMAN	SYNCRIP	physical	24244333
HNRPC_HUMAN	HNRNPC	physical	24244333
RL23A_HUMAN	RPL23A	physical	24244333
RS8_HUMAN	RPS8	physical	24244333
RS25_HUMAN	RPS25	physical	24244333
TCPA_HUMAN	TCP1	physical	24244333
MATR3_HUMAN	MATR3	physical	24244333
RS14_HUMAN	RPS14	physical	24244333
ADT2_HUMAN	SLC25A5	physical	24244333
DDX17_HUMAN	DDX17	physical	24244333
RL12_HUMAN	RPL12	physical	24244333
RS6_HUMAN	RPS6	physical	24244333
RL4_HUMAN	RPL4	physical	24244333
U520_HUMAN	SNRNP200	physical	24244333
HNRH1_HUMAN	HNRNPH1	physical	24244333
RT22_HUMAN	MRPS22	physical	24244333
RL7A_HUMAN	RPL7A	physical	24244333
RS16_HUMAN	RPS16	physical	24244333
RLA0_HUMAN	RPLP0	physical	24244333
RL7_HUMAN	RPL7	physical	24244333
DDX5_HUMAN	DDX5	physical	24244333
HNRPK_HUMAN	HNRNPK	physical	24244333
HNRPU_HUMAN	HNRNPU	physical	24244333
ROA1_HUMAN	HNRNPA1	physical	24244333
DDX3X_HUMAN	DDX3X	physical	24244333
SCMC1_HUMAN	SLC25A24	physical	24244333
NACC1_HUMAN	NACC1	physical	24231739
TADBP_HUMAN	TARDBP	physical	24298989
PRKN_HUMAN	PARK2	physical	24328108
UB2L3_HUMAN	UBE2L3	physical	24328108
PRKN_HUMAN	PARK2	physical	24784582
PRKN_HUMAN	PARK2	physical	24790097
UB2L3_HUMAN	UBE2L3	physical	10888878
UB2E2_HUMAN	UBE2E2	physical	10888878
UB2D2_HUMAN	UBE2D2	physical	20940148
UB2G2_HUMAN	UBE2G2	physical	20940148
UB2G1_HUMAN	UBE2G1	physical	20940148
UB2L3_HUMAN	UBE2L3	physical	20940148
UBE2N_HUMAN	UBE2N	physical	20940148
UB2V1_HUMAN	UBE2V1	physical	20940148
MFN1_HUMAN	MFN1	physical	24751536
UBC_HUMAN	UBC	physical	24751536
UBC_HUMAN	UBC	physical	24784582
BECN1_HUMAN	BECN1	physical	24879156
AMRA1_HUMAN	AMBRA1	physical	24879156
PK3C3_HUMAN	PIK3C3	physical	24879156
PRKN_HUMAN	PARK2	physical	21532592
UB2L3_HUMAN	UBE2L3	physical	21532592
UB2D3_HUMAN	UBE2D3	physical	21532592
SEPT5_HUMAN	SEPT5	physical	24722188
PCH2_HUMAN	TRIP13	physical	24722188
DLX2_HUMAN	DLX2	physical	24722188
CRX_HUMAN	CRX	physical	24722188
FA46C_HUMAN	FAM46C	physical	24722188
MEOX1_HUMAN	MEOX1	physical	24722188
MEOX2_HUMAN	MEOX2	physical	24722188
HOIL1_HUMAN	RBCK1	physical	24722188
REL_HUMAN	REL	physical	24722188
ITF2_HUMAN	TCF4	physical	24722188
DDIT4_HUMAN	DDIT4	physical	25101677
UB2L3_HUMAN	UBE2L3	physical	25101677
B2CL1_HUMAN	BCL2L1	physical	24999239
MCL1_HUMAN	MCL1	physical	24999239
BECN1_HUMAN	BECN1	physical	24386307
UCHL1_HUMAN	UCHL1	physical	25403879
PARK7_HUMAN	PARK7	physical	24242043
UBE2N_HUMAN	UBE2N	physical	25403879
UB2D2_HUMAN	UBE2D2	physical	25375667
UB2L3_HUMAN	UBE2L3	physical	25375667
PRKN_HUMAN	PARK2	physical	25375667
UB2L3_HUMAN	UBE2L3	physical	24784582
UBC_HUMAN	UBC	physical	23670163
UB2V1_HUMAN	UBE2V1	physical	19880420
AFAD_HUMAN	MLLT4	physical	23393160
SUMO1_HUMAN	SUMO1	physical	16955485
PRAME_HUMAN	PRAME	physical	26186194
PASK_HUMAN	PASK	physical	26186194
PCY2_HUMAN	PCYT2	physical	26186194
PTN5_HUMAN	PTPN5	physical	25583483
UB2L3_HUMAN	UBE2L3	physical	25583483
PRKN_HUMAN	PARK2	physical	25527291
UB2L3_HUMAN	UBE2L3	physical	25527291
ADRM1_HUMAN	ADRM1	physical	25666615
ADRM1_MOUSE	Adrm1	physical	25666615
PRS7_HUMAN	PSMC2	physical	25666615
PRS4_HUMAN	PSMC1	physical	25666615
ARRB1_HUMAN	ARRB1	physical	21466165
CTNB1_HUMAN	CTNNB1	physical	25877876
EGFR_HUMAN	EGFR	physical	25877876
UBC_HUMAN	UBC	physical	25474007
HCD2_HUMAN	HSD17B10	physical	25591737
ACTB_HUMAN	ACTB	physical	14532270
NMDE2_HUMAN	GRIN2B	physical	25241761
DLG1_HUMAN	DLG1	physical	25241761
SQSTM_HUMAN	SQSTM1	physical	26746706
UB2L3_HUMAN	UBE2L3	physical	26746706
BIRC5_HUMAN	BIRC5	physical	26148234
GRIK2_HUMAN	GRIK2	physical	25316086
GRIK2_RAT	Grik2	physical	25316086
UBC_HUMAN	UBC	physical	26254304
PRKN_HUMAN	PARK2	physical	26254304
MIRO1_HUMAN	RHOT1	physical	26254304
UB2L3_HUMAN	UBE2L3	physical	26254304
RPTOR_HUMAN	RPTOR	physical	25007995
PLK1_HUMAN	PLK1	physical	26387737
CCNB1_HUMAN	CCNB1	physical	26387737
AURKA_HUMAN	AURKA	physical	26387737
AURKB_HUMAN	AURKB	physical	26387737
NEK2_HUMAN	NEK2	physical	26387737
UB2L3_HUMAN	UBE2L3	physical	26387737
CDC20_HUMAN	CDC20	physical	26387737
FZR1_HUMAN	FZR1	physical	26387737
PTTG1_HUMAN	PTTG1	physical	26387737
UBC_HUMAN	UBC	physical	26260794
UBC_HUMAN	UBC	physical	26162776
MFN2_HUMAN	MFN2	physical	25915564
DYR1A_HUMAN	DYRK1A	physical	25963095
UB2E2_HUMAN	UBE2E2	physical	25963095
UBC_HUMAN	UBC	physical	25969509
PRKN_HUMAN	PARK2	physical	25969509
MIRO1_HUMAN	RHOT1	physical	25969509
PRKN_HUMAN	PARK2	physical	26631732
VDAC1_HUMAN	VDAC1	physical	26631732
RAB7A_HUMAN	RAB7A	physical	26911690
UB2L3_HUMAN	UBE2L3	physical	26911690
PRKN_HUMAN	PARK2	physical	26116755
MIRO1_HUMAN	RHOT1	physical	26116755
UBC_HUMAN	UBC	physical	26116755
UB2L3_HUMAN	UBE2L3	physical	26116755
CCNE1_HUMAN	CCNE1	physical	19946270
UB2L3_HUMAN	UBE2L3	physical	19946270
PINK1_HUMAN	PINK1	physical	17052189
B2CL1_HUMAN	BCL2L1	physical	28038320
PCY2_HUMAN	PCYT2	physical	28514442
BODG_HUMAN	BBOX1	physical	28514442
TERA_HUMAN	VCP	physical	28514442
PASK_HUMAN	PASK	physical	28514442
MIRO1_HUMAN	RHOT1	physical	28710279
UB2L3_HUMAN	UBE2L3	physical	28710279
PINK1_HUMAN	PINK1	physical	27528605
BNIP3_HUMAN	BNIP3	physical	27528605
DDIT3_HUMAN	DDIT3	physical	28522833
UBC_HUMAN	UBC	physical	28414322
PRKN_HUMAN	PARK2	physical	28414322
MIRO1_HUMAN	RHOT1	physical	28414322
UB2L3_HUMAN	UBE2L3	physical	28414322
UBC_HUMAN	UBC	physical	28319114
MAVS_HUMAN	MAVS	physical	27348524
PCNA_HUMAN	PCNA	physical	28430587
TADBP_HUMAN	TARDBP	physical	28430587
CHIP_HUMAN	STUB1	physical	28430587
NBN_HUMAN	NBN	physical	28430587
CAC1B_RABIT	CACNA1B	physical	28957379
MAP1B_MOUSE	Map1b	physical	28957379
P53_HUMAN	TP53	physical	28395174

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