ATX3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATX3_RAT
• UniProt AC: O35815
• Protein Name: Ataxin-3
• Gene Name: Atxn3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 355
• Subcellular Localization: Nucleus .
• Protein Description: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. [PubMed: 17696782 Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity]
• Protein Sequence: MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERLRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIKVQQMHRPKLIGEELAHLKEQSALKADLERVLEAADGPGMFDDDEDDLQRALAMSRQEIDMEDEEADLRRAIQLSMQGSSRGMCEDSPQTSSTDLSSEELRKRREAYFEKQQHQQQEADRPGYLSYPCERPTTSSGGLRSNQAGNAMSEEDVLRATVTVSLETAKDSLKAERKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
260	Phosphorylation	IQLSMQGSSRGMCED HHHHHHCCCCCCCCC	10.44	22673903
261	Phosphorylation	QLSMQGSSRGMCEDS HHHHHCCCCCCCCCC	39.41	22673903
268	Phosphorylation	SRGMCEDSPQTSSTD CCCCCCCCCCCCCCC	9.16	29779826
271	Phosphorylation	MCEDSPQTSSTDLSS CCCCCCCCCCCCCCH	28.20	28432305
272	Phosphorylation	CEDSPQTSSTDLSSE CCCCCCCCCCCCCHH	26.45	28432305
273	Phosphorylation	EDSPQTSSTDLSSEE CCCCCCCCCCCCHHH	29.36	22673903
274	Phosphorylation	DSPQTSSTDLSSEEL CCCCCCCCCCCHHHH	40.50	22673903
277	Phosphorylation	QTSSTDLSSEELRKR CCCCCCCCHHHHHHH	38.21	25575281
278	Phosphorylation	TSSTDLSSEELRKRR CCCCCCCHHHHHHHH	42.24	25575281
321	Phosphorylation	TSSGGLRSNQAGNAM CCCCCCCCCCCCCCC	38.03	-
329	Phosphorylation	NQAGNAMSEEDVLRA CCCCCCCCHHHHHHH	35.11	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATX3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATX3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATX3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA1A_RAT	Tuba1a	physical	19666135

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.