dbPTM

RL13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL13_HUMAN
UniProt AC	P26373
Protein Name	60S ribosomal protein L13
Gene Name	RPL13
Organism	Homo sapiens (Human).
Sequence Length	211
Subcellular Localization
Protein Description
Protein Sequence	MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	SRNGMVLKPHFHKDW CCCCEEECCCCCHHH	25.65	25953088
11	Ubiquitination	SRNGMVLKPHFHKDW CCCCEEECCCCCHHH	25.65	-
16	Ubiquitination	VLKPHFHKDWQRRVA EECCCCCHHHHHHHH	60.77	19608861
16	Acetylation	VLKPHFHKDWQRRVA EECCCCCHHHHHHHH	60.77	19608861
52	Phosphorylation	RIAPRPASGPIRPIV HHCCCCCCCCCCCCE	48.02	23403867
74	Methylation	HTKVRAGRGFSLEEL ECCCCCCCCCCHHHH	41.83	54558869
77	Phosphorylation	VRAGRGFSLEELRVA CCCCCCCCHHHHHHC	37.38	23927012
82	Methylation	GFSLEELRVAGIHKK CCCHHHHHHCCHHHH	21.37	115491663
88	2-Hydroxyisobutyrylation	LRVAGIHKKVARTIG HHHCCHHHHHHHHHC	47.20	-
88	Ubiquitination	LRVAGIHKKVARTIG HHHCCHHHHHHHHHC	47.20	-
93	Phosphorylation	IHKKVARTIGISVDP HHHHHHHHHCCCCCC	17.51	20068231
93 (in isoform 2)	Phosphorylation	-	17.51	29743597
97	Phosphorylation	VARTIGISVDPRRRN HHHHHCCCCCCCCCC	18.43	24670416
101	Methylation	IGISVDPRRRNKSTE HCCCCCCCCCCCCHH	45.81	115491671
105	2-Hydroxyisobutyrylation	VDPRRRNKSTESLQA CCCCCCCCCHHHHHH	57.87	-
105	Ubiquitination	VDPRRRNKSTESLQA CCCCCCCCCHHHHHH	57.87	21890473
105	Ubiquitination	VDPRRRNKSTESLQA CCCCCCCCCHHHHHH	57.87	21890473
105	Acetylation	VDPRRRNKSTESLQA CCCCCCCCCHHHHHH	57.87	26051181
106	Phosphorylation	DPRRRNKSTESLQAN CCCCCCCCHHHHHHH	40.74	22167270
107	Phosphorylation	PRRRNKSTESLQANV CCCCCCCHHHHHHHH	31.07	30266825
109	Phosphorylation	RRNKSTESLQANVQR CCCCCHHHHHHHHHH	26.35	30266825
122	Phosphorylation	QRLKEYRSKLILFPR HHHHHHHHHEEEECC	30.80	-
123	Ubiquitination	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	21890473
123	2-Hydroxyisobutyrylation	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	-
123	Sumoylation	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	28112733
123	Sumoylation	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	-
123	Ubiquitination	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	21890473
123	Acetylation	RLKEYRSKLILFPRK HHHHHHHHEEEECCC	30.46	25953088
130	Acetylation	KLILFPRKPSAPKKG HEEEECCCCCCCCCC	43.49	19608861
130	Ubiquitination	KLILFPRKPSAPKKG HEEEECCCCCCCCCC	43.49	19608861
132	Phosphorylation	ILFPRKPSAPKKGDS EEECCCCCCCCCCCC	61.31	20860994
136	Acetylation	RKPSAPKKGDSSAEE CCCCCCCCCCCCHHH	67.88	25953088
136	Ubiquitination	RKPSAPKKGDSSAEE CCCCCCCCCCCCHHH	67.88	21890473
139	Phosphorylation	SAPKKGDSSAEELKL CCCCCCCCCHHHHHH	39.87	29255136
140	Phosphorylation	APKKGDSSAEELKLA CCCCCCCCHHHHHHH	44.43	29255136
145	Sumoylation	DSSAEELKLATQLTG CCCHHHHHHHHHCCC	39.08	28112733
145	Acetylation	DSSAEELKLATQLTG CCCHHHHHHHHHCCC	39.08	25953088
145	Ubiquitination	DSSAEELKLATQLTG CCCHHHHHHHHHCCC	39.08	21890473
148	Phosphorylation	AEELKLATQLTGPVM HHHHHHHHHCCCCCC	34.25	30108239
151	Phosphorylation	LKLATQLTGPVMPVR HHHHHHCCCCCCCCC	29.62	30108239
155	Sulfoxidation	TQLTGPVMPVRNVYK HHCCCCCCCCCCCCH	2.60	28465586
158	Acetylation	TGPVMPVRNVYKKEK CCCCCCCCCCCHHHH	22.49	19608861
158	Ubiquitination	TGPVMPVRNVYKKEK CCCCCCCCCCCHHHH	22.49	19608861
162	Sumoylation	MPVRNVYKKEKARVI CCCCCCCHHHHCEEE	50.61	-
170	Phosphorylation	KEKARVITEEEKNFK HHHCEEECHHHHHHH	34.19	-
174	Ubiquitination	RVITEEEKNFKAFAS EEECHHHHHHHHHHH	71.60	21890473
174	Sumoylation	RVITEEEKNFKAFAS EEECHHHHHHHHHHH	71.60	25114211
174	Acetylation	RVITEEEKNFKAFAS EEECHHHHHHHHHHH	71.60	23749302
174	Ubiquitination	RVITEEEKNFKAFAS EEECHHHHHHHHHHH	71.60	21890473
177	Ubiquitination	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	21890473
177	Ubiquitination	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	21890473
177	Methylation	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	19608861
177	Acetylation	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	19608861
177	Sumoylation	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	-
177	Sumoylation	TEEEKNFKAFASLRM CHHHHHHHHHHHHHH	52.57	28112733
181	Phosphorylation	KNFKAFASLRMARAN HHHHHHHHHHHHHHH	15.28	22199227
200	Acetylation	GIRAKRAKEAAEQDV CHHHHHHHHHHHHHH	52.50	26051181
200	Ubiquitination	GIRAKRAKEAAEQDV CHHHHHHHHHHHHHH	52.50	21890473
200	Methylation	GIRAKRAKEAAEQDV CHHHHHHHHHHHHHH	52.50	21679131
210	Acetylation	AEQDVEKKK------ HHHHHHHCC------	50.65	23749302
211	Acetylation	EQDVEKKK------- HHHHHHCC-------	76.32	12435169

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
106	S	Phosphorylation	Kinase	AKT1	P31749	PSP
170	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS16_HUMAN	RPS16	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RL15_HUMAN	RPL15	physical	22939629
RL18_HUMAN	RPL18	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL21_HUMAN	RPL21	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL27A_HUMAN	RPL27A	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL22_HUMAN	RPL22	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RL36_HUMAN	RPL36	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RL17_HUMAN	RPL17	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
UBIM_HUMAN	FAU	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
AIMP1_HUMAN	AIMP1	physical	22863883
SYDC_HUMAN	DARS	physical	22863883
SYMC_HUMAN	MARS	physical	22863883
SYQ_HUMAN	QARS	physical	22863883
RL19_HUMAN	RPL19	physical	22863883
RL21_HUMAN	RPL21	physical	22863883
RL23A_HUMAN	RPL23A	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
RL26_HUMAN	RPL26	physical	22863883
RL36_HUMAN	RPL36	physical	22863883
CEP70_HUMAN	CEP70	physical	25416956
TF3C2_HUMAN	GTF3C2	physical	26186194
RT09_HUMAN	MRPS9	physical	26186194
PTCD3_HUMAN	PTCD3	physical	26186194
TF3C3_HUMAN	GTF3C3	physical	26186194
RNBP6_HUMAN	RANBP6	physical	26186194
IPO5_HUMAN	IPO5	physical	26186194
RT27_HUMAN	MRPS27	physical	26186194
RM09_HUMAN	MRPL9	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
TROP_HUMAN	TRO	physical	26186194
RM32_HUMAN	MRPL32	physical	26186194
RM48_HUMAN	MRPL48	physical	26186194
RM40_HUMAN	MRPL40	physical	26186194
RM01_HUMAN	MRPL1	physical	26186194
TF3C1_HUMAN	GTF3C1	physical	26186194
RT05_HUMAN	MRPS5	physical	26186194
RM28_HUMAN	MRPL28	physical	26186194
SENP3_HUMAN	SENP3	physical	26186194
TEX10_HUMAN	TEX10	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
DCAF1_HUMAN	VPRBP	physical	26186194
RM50_HUMAN	MRPL50	physical	26186194
RM27_HUMAN	MRPL27	physical	26186194
RM55_HUMAN	MRPL55	physical	26186194
RL15_HUMAN	RPL15	physical	26186194
RM47_HUMAN	MRPL47	physical	26186194
RM16_HUMAN	MRPL16	physical	26186194
RT24_HUMAN	MRPS24	physical	26186194
RM38_HUMAN	MRPL38	physical	26186194
NSUN4_HUMAN	NSUN4	physical	26186194
ICT1_HUMAN	ICT1	physical	26186194
RM13_HUMAN	MRPL13	physical	26186194
PELP1_HUMAN	PELP1	physical	26186194
RM17_HUMAN	MRPL17	physical	26186194
RT33_HUMAN	MRPS33	physical	26186194
G45IP_HUMAN	GADD45GIP1	physical	26186194
RM30_HUMAN	MRPL30	physical	26186194
NSA2_HUMAN	NSA2	physical	26186194
RM20_HUMAN	MRPL20	physical	26186194
RT18A_HUMAN	MRPS18A	physical	26186194
RM42_HUMAN	MRPL42	physical	26186194
RM18_HUMAN	MRPL18	physical	26186194
RT30_HUMAN	MRPS30	physical	26186194
RM34_HUMAN	MRPL34	physical	26186194
NSA2_HUMAN	NSA2	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL24_HUMAN	RPL24	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL26L_HUMAN	RPL26L1	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL28_HUMAN	RPL28	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL4_HUMAN	RPL4	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
NSUN4_HUMAN	NSUN4	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
RM28_HUMAN	MRPL28	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
TEX10_HUMAN	TEX10	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
IPO5_HUMAN	IPO5	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RNBP6_HUMAN	RANBP6	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
NUFP1_HUMAN	NUFIP1	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL13_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-16 AND LYS-177, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-106, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.	19007248 [Abstract]