RM18_HUMAN - dbPTM
RM18_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RM18_HUMAN
UniProt AC Q9H0U6
Protein Name 39S ribosomal protein L18, mitochondrial
Gene Name MRPL18
Organism Homo sapiens (Human).
Sequence Length 180
Subcellular Localization Mitochondrion .
Protein Description Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA..
Protein Sequence MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationGCRFAALSTSSEPAA
CCCEEEEECCCCCCC
22.8626657352
33UbiquitinationTSSEPAAKPEVDPVE
CCCCCCCCCCCCCCC
43.7622817900
60PhosphorylationPRNLELLSVARKERG
CCCCHHHHHHHHHCC
26.76-
155PhosphorylationPTPWEAASDSMKRLQ
CCHHHHHCHHHHHHH
36.9521601212
163PhosphorylationDSMKRLQSAMTEGGV
HHHHHHHHHHHHCCE
25.30-
179PhosphorylationLREPQRIYE------
ECCCCCCCC------
20.1329496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RM18_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RM18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RM18_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ICT1_HUMANICT1physical
26344197
RM13_HUMANMRPL13physical
26344197
RM17_HUMANMRPL17physical
26344197
RM19_HUMANMRPL19physical
26344197
RM02_HUMANMRPL2physical
26344197
RM20_HUMANMRPL20physical
26344197
RM24_HUMANMRPL24physical
26344197
RM03_HUMANMRPL3physical
26344197
RM37_HUMANMRPL37physical
26344197
RM47_HUMANMRPL47physical
26344197
RT07_HUMANMRPS7physical
26344197
EFTU_HUMANTUFMphysical
26344197

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RM18_HUMAN

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Related Literatures of Post-Translational Modification

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