RM18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM18_HUMAN
• UniProt AC: Q9H0U6
• Protein Name: 39S ribosomal protein L18, mitochondrial
• Gene Name: MRPL18
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Mitochondrion .
• Protein Description: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA..
• Protein Sequence: MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	GCRFAALSTSSEPAA CCCEEEEECCCCCCC	22.86	26657352
33	Ubiquitination	TSSEPAAKPEVDPVE CCCCCCCCCCCCCCC	43.76	22817900
60	Phosphorylation	PRNLELLSVARKERG CCCCHHHHHHHHHCC	26.76	-
155	Phosphorylation	PTPWEAASDSMKRLQ CCHHHHHCHHHHHHH	36.95	21601212
163	Phosphorylation	DSMKRLQSAMTEGGV HHHHHHHHHHHHCCE	25.30	-
179	Phosphorylation	LREPQRIYE------ ECCCCCCCC------	20.13	29496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ICT1_HUMAN	ICT1	physical	26344197
RM13_HUMAN	MRPL13	physical	26344197
RM17_HUMAN	MRPL17	physical	26344197
RM19_HUMAN	MRPL19	physical	26344197
RM02_HUMAN	MRPL2	physical	26344197
RM20_HUMAN	MRPL20	physical	26344197
RM24_HUMAN	MRPL24	physical	26344197
RM03_HUMAN	MRPL3	physical	26344197
RM37_HUMAN	MRPL37	physical	26344197
RM47_HUMAN	MRPL47	physical	26344197
RT07_HUMAN	MRPS7	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.