UniProt ID | RM18_HUMAN | |
---|---|---|
UniProt AC | Q9H0U6 | |
Protein Name | 39S ribosomal protein L18, mitochondrial | |
Gene Name | MRPL18 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 180 | |
Subcellular Localization | Mitochondrion . | |
Protein Description | Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.. | |
Protein Sequence | MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
25 | Phosphorylation | GCRFAALSTSSEPAA CCCEEEEECCCCCCC | 22.86 | 26657352 | |
33 | Ubiquitination | TSSEPAAKPEVDPVE CCCCCCCCCCCCCCC | 43.76 | 22817900 | |
60 | Phosphorylation | PRNLELLSVARKERG CCCCHHHHHHHHHCC | 26.76 | - | |
155 | Phosphorylation | PTPWEAASDSMKRLQ CCHHHHHCHHHHHHH | 36.95 | 21601212 | |
163 | Phosphorylation | DSMKRLQSAMTEGGV HHHHHHHHHHHHCCE | 25.30 | - | |
179 | Phosphorylation | LREPQRIYE------ ECCCCCCCC------ | 20.13 | 29496907 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RM18_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RM18_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RM18_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ICT1_HUMAN | ICT1 | physical | 26344197 | |
RM13_HUMAN | MRPL13 | physical | 26344197 | |
RM17_HUMAN | MRPL17 | physical | 26344197 | |
RM19_HUMAN | MRPL19 | physical | 26344197 | |
RM02_HUMAN | MRPL2 | physical | 26344197 | |
RM20_HUMAN | MRPL20 | physical | 26344197 | |
RM24_HUMAN | MRPL24 | physical | 26344197 | |
RM03_HUMAN | MRPL3 | physical | 26344197 | |
RM37_HUMAN | MRPL37 | physical | 26344197 | |
RM47_HUMAN | MRPL47 | physical | 26344197 | |
RT07_HUMAN | MRPS7 | physical | 26344197 | |
EFTU_HUMAN | TUFM | physical | 26344197 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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