RM02_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM02_HUMAN
• UniProt AC: Q5T653
• Protein Name: 39S ribosomal protein L2, mitochondrial
• Gene Name: MRPL2
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MALCALTRALRSLNLAPPTVAAPAPSLFPAAQMMNNGLLQQPSALMLLPCRPVLTSVALNANFVSWKSRTKYTITPVKMRKSGGRDHTGRIRVHGIGGGHKQRYRMIDFLRFRPEETKSGPFEEKVIQVRYDPCRSADIALVAGGSRKRWIIATENMQAGDTILNSNHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLETCVATVGRVSNVDHNKRVIGKAGRNRWLGKRPNSGRWHRKGGWAGRKIRPLPPMKSYVKLPSASAQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MALCALTRALRSLN -CHHHHHHHHHHHCC	8.72	29759185
71	Ubiquitination	VSWKSRTKYTITPVK CCCCCCCCEEEEEEE	39.01	-
72	Phosphorylation	SWKSRTKYTITPVKM CCCCCCCEEEEEEEE	11.63	-
78	Acetylation	KYTITPVKMRKSGGR CEEEEEEEEECCCCC	33.90	20167786
78	Ubiquitination	KYTITPVKMRKSGGR CEEEEEEEEECCCCC	33.90	-
106	Sulfoxidation	GHKQRYRMIDFLRFR CCHHHEEEEEEEECC	2.27	21406390
117	Phosphorylation	LRFRPEETKSGPFEE EECCCCHHCCCCCCC	28.93	21406692
118	Ubiquitination	RFRPEETKSGPFEEK ECCCCHHCCCCCCCC	57.61	2190698
119	Phosphorylation	FRPEETKSGPFEEKV CCCCHHCCCCCCCCE	60.15	21406692
146	Phosphorylation	IALVAGGSRKRWIIA EEEEECCCCCEEEEE	33.44	30108239
223	Phosphorylation	LLRKVNGTAIIQLPS EEEEECCEEEEECCC	14.96	-
230	Phosphorylation	TAIIQLPSKRQMQVL EEEEECCCHHHHHHH	49.41	24719451
239	Phosphorylation	RQMQVLETCVATVGR HHHHHHHHHHHHHCC	14.23	-
248	Phosphorylation	VATVGRVSNVDHNKR HHHHCCEECCCCCCC	29.76	27251275
254	2-Hydroxyisobutyrylation	VSNVDHNKRVIGKAG EECCCCCCCEECCCC	44.62	-
272	Phosphorylation	WLGKRPNSGRWHRKG CCCCCCCCCCCCCCC	32.20	-
293	Ubiquitination	IRPLPPMKSYVKLPS CCCCCCCCCEEECCC	44.39	-
297	Sumoylation	PPMKSYVKLPSASAQ CCCCCEEECCCCCCC	46.58	-
297	Ubiquitination	PPMKSYVKLPSASAQ CCCCCEEECCCCCCC	46.58	-
297	Sumoylation	PPMKSYVKLPSASAQ CCCCCEEECCCCCCC	46.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM02_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM02_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM02_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM11_HUMAN	MRPL11	physical	22939629
RM09_HUMAN	MRPL9	physical	22939629
RM37_HUMAN	MRPL37	physical	22939629
RM04_HUMAN	MRPL4	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM14_HUMAN	MRPL14	physical	22939629
RM24_HUMAN	MRPL24	physical	22939629
RM40_HUMAN	MRPL40	physical	22939629
RM13_HUMAN	MRPL13	physical	22939629
RM16_HUMAN	MRPL16	physical	22939629
RS18_HUMAN	RPS18	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RRF2M_HUMAN	GFM2	physical	26344197
NOG1_HUMAN	GTPBP4	physical	26344197
RM13_HUMAN	MRPL13	physical	26344197
RM17_HUMAN	MRPL17	physical	26344197
RM24_HUMAN	MRPL24	physical	26344197
RM39_HUMAN	MRPL39	physical	26344197
RM47_HUMAN	MRPL47	physical	26344197
RM09_HUMAN	MRPL9	physical	26344197
RT07_HUMAN	MRPS7	physical	26344197
PHB2_HUMAN	PHB2	physical	26344197
RPC1_HUMAN	POLR3A	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.