dbPTM

RM04_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RM04_HUMAN
UniProt AC	Q9BYD3
Protein Name	39S ribosomal protein L4, mitochondrial
Gene Name	MRPL4
Organism	Homo sapiens (Human).
Sequence Length	311
Subcellular Localization	Mitochondrion .
Protein Description
Protein Sequence	MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFPRPLPHATQGPAATPYHC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	ENPEQVASEGLPEPV CCHHHHHHCCCCCCC	33.08	30266825
50	Ubiquitination	LPEPVLRKVELPVPT CCCCCEEECCCCCCC	35.58	-
70	Methylation	QAWVESLRGFEQERV HHHHHHHCCCCHHHC	57.97	115483783
104	Ubiquitination	HQVAMWQKNFKRISY HHHHHHHHHHHHEEE	49.16	21890473
104 (in isoform 2)	Ubiquitination	-	49.16	21890473
104 (in isoform 1)	Ubiquitination	-	49.16	21890473
107	Ubiquitination	AMWQKNFKRISYAKT HHHHHHHHHEEECCC	59.21	-
110	Phosphorylation	QKNFKRISYAKTKTR HHHHHHEEECCCCCC	24.07	21406692
111	Phosphorylation	KNFKRISYAKTKTRA HHHHHEEECCCCCCC	15.11	21406692
114	Phosphorylation	KRISYAKTKTRAEVR HHEEECCCCCCCHHC	29.49	21406692
116	Phosphorylation	ISYAKTKTRAEVRGG EEECCCCCCCHHCCC	40.10	21406692
131 (in isoform 2)	Ubiquitination	-	55.12	21890473
131 (in isoform 1)	Ubiquitination	-	55.12	21890473
131	Ubiquitination	GRKPWPQKGTGRARH CCCCCCCCCCCCCCC	55.12	21890473
147	Methylation	SIRSPLWRGGGVAHG CCCCCCCCCCCCCCC	41.37	24129315
159	Phosphorylation	AHGPRGPTSYYYMLP CCCCCCCCCEEEEEE	31.98	20068231
160	Phosphorylation	HGPRGPTSYYYMLPM CCCCCCCCEEEEEEH	17.80	20068231
161	Phosphorylation	GPRGPTSYYYMLPMK CCCCCCCEEEEEEHH	10.90	17360941
162	Phosphorylation	PRGPTSYYYMLPMKV CCCCCCEEEEEEHHH	5.12	20068231
163	Phosphorylation	RGPTSYYYMLPMKVR CCCCCEEEEEEHHHH	5.50	20068231
238	Ubiquitination	VEATSRLKTFNLIPA HHHHHHCCCCCCCCC	50.38	-
284	Phosphorylation	DSRYRPLYPFSLPYS CCCCCCCCCCCCCCC	12.62	20860994
287	Phosphorylation	YRPLYPFSLPYSDFP CCCCCCCCCCCCCCC	24.75	20860994
290	Phosphorylation	LYPFSLPYSDFPRPL CCCCCCCCCCCCCCC	26.60	20860994
291	Phosphorylation	YPFSLPYSDFPRPLP CCCCCCCCCCCCCCC	30.73	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RM04_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RM04_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RM04_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
EI2BA_HUMAN	EIF2B1	physical	16169070
RM15_HUMAN	MRPL15	physical	22939629
RM24_HUMAN	MRPL24	physical	22939629
RM46_HUMAN	MRPL46	physical	22939629
RM14_HUMAN	MRPL14	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RS18_HUMAN	RPS18	physical	22939629
CH60_HUMAN	HSPD1	physical	26186194
SYYM_HUMAN	YARS2	physical	26186194
AMER1_HUMAN	AMER1	physical	26186194
UBR5_HUMAN	UBR5	physical	26186194
RM46_HUMAN	MRPL46	physical	26186194
MTEF3_HUMAN	MTERF3	physical	26186194
NGRN_HUMAN	NGRN	physical	26186194
WDR26_HUMAN	WDR26	physical	26186194
PTCD1_HUMAN	PTCD1	physical	26186194
ZSWM8_HUMAN	ZSWIM8	physical	26186194
FA83H_HUMAN	FAM83H	physical	26186194
TRUB2_HUMAN	TRUB2	physical	26186194
RM09_HUMAN	MRPL9	physical	26186194
ARMC8_HUMAN	ARMC8	physical	26186194
RM32_HUMAN	MRPL32	physical	26186194
RM11_HUMAN	MRPL11	physical	26186194
DDX28_HUMAN	DDX28	physical	26186194
RM48_HUMAN	MRPL48	physical	26186194
RM40_HUMAN	MRPL40	physical	26186194
RM03_HUMAN	MRPL3	physical	26186194
MAEA_HUMAN	MAEA	physical	26186194
MKLN1_HUMAN	MKLN1	physical	26186194
RM01_HUMAN	MRPL1	physical	26186194
RM39_HUMAN	MRPL39	physical	26186194
RMD5A_HUMAN	RMND5A	physical	26186194
RMD5B_HUMAN	RMND5B	physical	26186194
RM23_HUMAN	MRPL23	physical	26186194
RM41_HUMAN	MRPL41	physical	26186194
GLSK_HUMAN	GLS	physical	26186194
FAKD2_HUMAN	FASTKD2	physical	26186194
RANB9_HUMAN	RANBP9	physical	26186194
RBP10_HUMAN	RANBP10	physical	26186194
CINP_HUMAN	CINP	physical	26186194
RM22_HUMAN	MRPL22	physical	26186194
SPA5L_HUMAN	SPATA5L1	physical	26186194
RM37_HUMAN	MRPL37	physical	26186194
PDPR_HUMAN	PDPR	physical	26186194
RM10_HUMAN	MRPL10	physical	26186194
RM24_HUMAN	MRPL24	physical	26186194
RM49_HUMAN	MRPL49	physical	26186194
RM44_HUMAN	MRPL44	physical	26186194
RM50_HUMAN	MRPL50	physical	26186194
RM38_HUMAN	MRPL38	physical	26186194
RM20_HUMAN	MRPL20	physical	26186194
HTRA2_HUMAN	HTRA2	physical	26186194
RUSD4_HUMAN	RPUSD4	physical	26186194
GID4_HUMAN	GID4	physical	26186194
RM27_HUMAN	MRPL27	physical	26186194
RM55_HUMAN	MRPL55	physical	26186194
NFL_HUMAN	NEFL	physical	26186194
MASU1_HUMAN	MALSU1	physical	26186194
RM47_HUMAN	MRPL47	physical	26186194
RM16_HUMAN	MRPL16	physical	26186194
RT30_HUMAN	MRPS30	physical	26186194
GTPB6_HUMAN	GTPBP6	physical	26186194
GID8_HUMAN	GID8	physical	26186194
RT18A_HUMAN	MRPS18A	physical	26186194
RM19_HUMAN	MRPL19	physical	26186194
TCF25_HUMAN	TCF25	physical	26186194
ROA1_HUMAN	HNRNPA1	physical	26186194
ZMY19_HUMAN	ZMYND19	physical	26186194
MSI2H_HUMAN	MSI2	physical	26186194
ICT1_HUMAN	ICT1	physical	26186194
RM02_HUMAN	MRPL2	physical	26186194
TATD2_HUMAN	TATDN2	physical	26186194
RM15_HUMAN	MRPL15	physical	26186194
RM21_HUMAN	MRPL21	physical	26186194
RM13_HUMAN	MRPL13	physical	26186194
RM17_HUMAN	MRPL17	physical	26186194
YPEL5_HUMAN	YPEL5	physical	26186194
FABD_HUMAN	MCAT	physical	26186194
RM33_HUMAN	MRPL33	physical	26186194
G45IP_HUMAN	GADD45GIP1	physical	26186194
RM35_HUMAN	MRPL35	physical	26186194
DPOG1_HUMAN	POLG	physical	26186194
RM30_HUMAN	MRPL30	physical	26186194
RM42_HUMAN	MRPL42	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
RM14_HUMAN	MRPL14	physical	26186194
RM51_HUMAN	MRPL51	physical	26186194
MRM3_HUMAN	RNMTL1	physical	26186194
RM18_HUMAN	MRPL18	physical	26186194
SYAM_HUMAN	AARS2	physical	26186194
RM53_HUMAN	MRPL53	physical	26186194
RUSD3_HUMAN	RPUSD3	physical	26186194
RT63_HUMAN	MRPL57	physical	26186194
RM34_HUMAN	MRPL34	physical	26186194
SYMM_HUMAN	MARS2	physical	26186194
RM52_HUMAN	MRPL52	physical	26186194
SAV1_HUMAN	SAV1	physical	26186194
RM15_HUMAN	MRPL15	physical	26344197
RM18_HUMAN	MRPL18	physical	26344197
RM20_HUMAN	MRPL20	physical	26344197
RM03_HUMAN	MRPL3	physical	26344197
RM38_HUMAN	MRPL38	physical	26344197
RM51_HUMAN	MRPL51	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL8_HUMAN	RPL8	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
ZSWM8_HUMAN	ZSWIM8	physical	28514442
RMD5B_HUMAN	RMND5B	physical	28514442
RT30_HUMAN	MRPS30	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442
AMER1_HUMAN	AMER1	physical	28514442
RT18A_HUMAN	MRPS18A	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
RM24_HUMAN	MRPL24	physical	28514442
RM02_HUMAN	MRPL2	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
PTCD1_HUMAN	PTCD1	physical	28514442
RUSD4_HUMAN	RPUSD4	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
ICT1_HUMAN	ICT1	physical	28514442
RT63_HUMAN	MRPL57	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
MTEF3_HUMAN	MTERF3	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
RM39_HUMAN	MRPL39	physical	28514442
RM41_HUMAN	MRPL41	physical	28514442
TRUB2_HUMAN	TRUB2	physical	28514442
FAKD2_HUMAN	FASTKD2	physical	28514442
WDR26_HUMAN	WDR26	physical	28514442
RM49_HUMAN	MRPL49	physical	28514442
GID4_HUMAN	GID4	physical	28514442
RM20_HUMAN	MRPL20	physical	28514442
NGRN_HUMAN	NGRN	physical	28514442
RM33_HUMAN	MRPL33	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
RM46_HUMAN	MRPL46	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
RM53_HUMAN	MRPL53	physical	28514442
RM22_HUMAN	MRPL22	physical	28514442
RM11_HUMAN	MRPL11	physical	28514442
RMD5A_HUMAN	RMND5A	physical	28514442
RM15_HUMAN	MRPL15	physical	28514442
MAEA_HUMAN	MAEA	physical	28514442
RM44_HUMAN	MRPL44	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
RM09_HUMAN	MRPL9	physical	28514442
SPA5L_HUMAN	SPATA5L1	physical	28514442
SYMM_HUMAN	MARS2	physical	28514442
CINP_HUMAN	CINP	physical	28514442
MRM3_HUMAN	RNMTL1	physical	28514442
HTRA2_HUMAN	HTRA2	physical	28514442
RUSD3_HUMAN	RPUSD3	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
GID8_HUMAN	GID8	physical	28514442
GNA1_HUMAN	GNPNAT1	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
RBP10_HUMAN	RANBP10	physical	28514442
MSI2H_HUMAN	MSI2	physical	28514442
ROA1_HUMAN	HNRNPA1	physical	28514442
RM18_HUMAN	MRPL18	physical	28514442
RM19_HUMAN	MRPL19	physical	28514442
DDX28_HUMAN	DDX28	physical	28514442
MKLN1_HUMAN	MKLN1	physical	28514442
RM23_HUMAN	MRPL23	physical	28514442
FABD_HUMAN	MCAT	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RM04_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.	19369195 [Abstract]