DPOG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOG1_HUMAN
• UniProt AC: P54098
• Protein Name: DNA polymerase subunit gamma-1
• Gene Name: POLG
• Organism: Homo sapiens (Human).
• Sequence Length: 1239
• Subcellular Localization: Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
• Protein Description: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA..
• Protein Sequence: MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	PLDIQMLSRGLHEQI HHHHHHHHHHHHHHH	20.96	24114839
109	Ubiquitination	RSVEHLQKHGLWGQP HHHHHHHHCCCCCCC	46.10	-
296	Phosphorylation	MRFLDTMSMHMAISG HHHHHHHHHHHHHHC	13.97	-
316	Ubiquitination	RSLWIAAKQGKHKVQ HHHHHHHHCCCCCCC	51.03	-
321	Ubiquitination	AAKQGKHKVQPPTKQ HHHCCCCCCCCCCCC	46.15	-
326	Phosphorylation	KHKVQPPTKQGQKSQ CCCCCCCCCCCHHHH	42.56	22210691
327	Ubiquitination	HKVQPPTKQGQKSQR CCCCCCCCCCHHHHH	59.20	-
371	Ubiquitination	VGGPPLEKEPRELFV CCCCCCCCCCHHHHC	79.35	-
379	Ubiquitination	EPRELFVKGTMKDIR CCHHHHCCCCHHHHH	41.13	-
383	Ubiquitination	LFVKGTMKDIRENFQ HHCCCCHHHHHHHHH	50.25	-
433	Phosphorylation	GMLEMGVSYLPVNQN HHHHCCCCEEECCCC	18.41	-
475	Phosphorylation	NDACQLLSGERYKED HHHHHHHCCCCCCCC	47.39	29759185
479	Phosphorylation	QLLSGERYKEDPWLW HHHCCCCCCCCCCHH	17.90	22673903
551	Ubiquitination	MARACLQKLKGTTEL HHHHHHHHHCCCCCC	38.94	-
553	Ubiquitination	RACLQKLKGTTELLP HHHHHHHCCCCCCCC	62.34	-
561	Ubiquitination	GTTELLPKRPQHLPG CCCCCCCCCCCCCCC	76.35	-
606	Phosphorylation	TPKLMALTWDGFPLH CCCCEEEEECCCCCC	16.39	29759185
614	Phosphorylation	WDGFPLHYSERHGWG ECCCCCCCHHHCCCC	21.65	29759185
615	Phosphorylation	DGFPLHYSERHGWGY CCCCCCCHHHCCCCE	19.87	29759185
622	Phosphorylation	SERHGWGYLVPGRRD HHHCCCCEECCCCCC	9.68	22468782
633	Ubiquitination	GRRDNLAKLPTGTTL CCCCCCCCCCCCCCH	59.16	-
658	Ubiquitination	AIESLYRKHCLEQGK HHHHHHHHHHHHHHH	25.72	-
726	Ubiquitination	LTARGGPKDTQPSYH EEECCCCCCCCCCCC	76.35	-
755	Ubiquitination	WFFKLPHKDGNSCNV EEEECCCCCCCCCCC	66.45	-
768	Ubiquitination	NVGSPFAKDFLPKME CCCCCCHHHHCHHCC	49.76	-
773	Ubiquitination	FAKDFLPKMEDGTLQ CHHHHCHHCCCCCCC	58.00	-
796	Ubiquitination	PRALEINKMISFWRN CHHHHHHHHHHHHHH	43.18	-
819	Phosphorylation	MVVWLPRSALPRAVI EEEEEEHHHCCCHHH	32.02	24719451
831	Phosphorylation	AVIRHPDYDEEGLYG HHHCCCCCCCCCCHH	29.70	27642862
934	Ubiquitination	RGTDLHSKTATTVGI CCCCCCCCCCCCCCC	31.28	-
935	Phosphorylation	GTDLHSKTATTVGIS CCCCCCCCCCCCCCC	32.05	24114839
947	Ubiquitination	GISREHAKIFNYGRI CCCHHHHHHHCCCCC	50.14	-
981	Ubiquitination	TQQEAAEKAQQMYAA HHHHHHHHHHHHHHH	46.93	21906983
990	Ubiquitination	QQMYAATKGLRWYRL HHHHHHHCCCCEEEE	51.74	21906983
1014	Methylation	ELNLPVDRTEGGWIS EECCCCCCCCCCEEE	34.61	115488101
1040	Ubiquitination	ARKSQWKKWEVVAER HHHHHHHHHHHHHHH	45.70	-
1050	Ubiquitination	VVAERAWKGGTESEM HHHHHHHCCCCHHHH	46.61	-
1060	Ubiquitination	TESEMFNKLESIATS CHHHHHHHHHHHHCC	42.22	21906983
1191	Ubiquitination	DIDRCLRKEVTMDCK CHHHHHHCEECCCCC	43.52	-
1194	Phosphorylation	RCLRKEVTMDCKTPS HHHHCEECCCCCCCC	14.37	26657352
1198	Ubiquitination	KEVTMDCKTPSNPTG CEECCCCCCCCCCCH	60.24	-
1221	Phosphorylation	QGEALDIYQIIELTK CCCCCHHHHHHHHCC	8.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MKRN1	Q9UHC7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DPOG1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 157640: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 1 (PEOA1)
• 258450: Progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal recessive (PEOB)
• 607459: Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO)
• 203700: Mitochondrial DNA depletion syndrome 4A (MTDPS4A)
• 613662: Mitochondrial DNA depletion syndrome 4B (MTDPS4B)
• 256000: Leigh syndrome (LS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.