DDX28_HUMAN - dbPTM
DDX28_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX28_HUMAN
UniProt AC Q9NUL7
Protein Name Probable ATP-dependent RNA helicase DDX28
Gene Name DDX28
Organism Homo sapiens (Human).
Sequence Length 540
Subcellular Localization Nucleus . Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . Mitochondrion matrix . Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granule
Protein Description Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. [PubMed: 25683708]
Protein Sequence MALTRPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPVLVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationRRGLTVRSPDEPLPV
CCCCCCCCCCCCCCC
32.1629255136
70PhosphorylationRPGPLLVSARRPELN
CCCCEEEECCCCCCC
18.94-
94PhosphorylationWERAPLASQGWKSRR
HHCCCCHHCCHHHHH
36.5925404012
98UbiquitinationPLASQGWKSRRARRD
CCHHCCHHHHHHHHH
40.6929967540
99PhosphorylationLASQGWKSRRARRDH
CHHCCHHHHHHHHHC
22.0818491316
127PhosphorylationRKLSSKGSFADLGLE
HHHCCCCCHHHCCCC
22.4629460479
195PhosphorylationQRLLGQPSLDSLPIP
HHHHCCCCCCCCCCC
36.60-
198PhosphorylationLGQPSLDSLPIPAPR
HCCCCCCCCCCCCCC
41.14-
255PhosphorylationLQLSRQPSADVLVAT
EEECCCCCCCEEEEC
28.8528348404
276PhosphorylationALKSRLISLEQLSFL
HHHHHCCCHHHHHHH
30.37-
281PhosphorylationLISLEQLSFLVLDEA
CCCHHHHHHHHHHCH
19.07-
524PhosphorylationLAARRRRSLPGLASS
HHHHHHCCCCCHHHH
36.7819691289

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX28_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX28_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ICT1_HUMANICT1physical
22939629
LTOR3_HUMANLAMTOR3physical
22939629
PCDH7_HUMANPCDH7physical
22939629
VATH_HUMANATP6V1Hphysical
22939629
RB11B_HUMANRAB11Bphysical
22939629
RT63_HUMANMRPL57physical
22939629
VATD_HUMANATP6V1Dphysical
22939629
VATA_HUMANATP6V1Aphysical
22939629
RM42_HUMANMRPL42physical
22939629
RM52_HUMANMRPL52physical
22939629
RM09_HUMANMRPL9physical
22939629
RM32_HUMANMRPL32physical
22939629
RM02_HUMANMRPL2physical
22939629
TMM43_HUMANTMEM43physical
22939629
RBMS2_HUMANRBMS2physical
22939629
VPP3_HUMANTCIRG1physical
22939629
RM17_HUMANMRPL17physical
22939629
ILF2_HUMANILF2physical
22939629
MFF_HUMANMFFphysical
22939629
RM11_HUMANMRPL11physical
22939629
RUSD4_HUMANRPUSD4physical
28514442
MAP2_HUMANMETAP2physical
28514442
TRUB2_HUMANTRUB2physical
28514442
PTCD1_HUMANPTCD1physical
28514442
MTEF3_HUMANMTERF3physical
28514442
MASU1_HUMANMALSU1physical
28514442
SYYM_HUMANYARS2physical
28514442
FABD_HUMANMCATphysical
28514442
UBR5_HUMANUBR5physical
28514442
NGRN_HUMANNGRNphysical
28514442
FAKD2_HUMANFASTKD2physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX28_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP