UniProt ID | DDX28_HUMAN | |
---|---|---|
UniProt AC | Q9NUL7 | |
Protein Name | Probable ATP-dependent RNA helicase DDX28 | |
Gene Name | DDX28 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 540 | |
Subcellular Localization | Nucleus . Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . Mitochondrion matrix . Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granule | |
Protein Description | Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. [PubMed: 25683708] | |
Protein Sequence | MALTRPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPVLVRPGPLLVSARRPELNQPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVRKLSSKGSFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLISLEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRAERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
28 | Phosphorylation | RRGLTVRSPDEPLPV CCCCCCCCCCCCCCC | 32.16 | 29255136 | |
70 | Phosphorylation | RPGPLLVSARRPELN CCCCEEEECCCCCCC | 18.94 | - | |
94 | Phosphorylation | WERAPLASQGWKSRR HHCCCCHHCCHHHHH | 36.59 | 25404012 | |
98 | Ubiquitination | PLASQGWKSRRARRD CCHHCCHHHHHHHHH | 40.69 | 29967540 | |
99 | Phosphorylation | LASQGWKSRRARRDH CHHCCHHHHHHHHHC | 22.08 | 18491316 | |
127 | Phosphorylation | RKLSSKGSFADLGLE HHHCCCCCHHHCCCC | 22.46 | 29460479 | |
195 | Phosphorylation | QRLLGQPSLDSLPIP HHHHCCCCCCCCCCC | 36.60 | - | |
198 | Phosphorylation | LGQPSLDSLPIPAPR HCCCCCCCCCCCCCC | 41.14 | - | |
255 | Phosphorylation | LQLSRQPSADVLVAT EEECCCCCCCEEEEC | 28.85 | 28348404 | |
276 | Phosphorylation | ALKSRLISLEQLSFL HHHHHCCCHHHHHHH | 30.37 | - | |
281 | Phosphorylation | LISLEQLSFLVLDEA CCCHHHHHHHHHHCH | 19.07 | - | |
524 | Phosphorylation | LAARRRRSLPGLASS HHHHHHCCCCCHHHH | 36.78 | 19691289 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DDX28_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DDX28_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DDX28_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...