VATA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATA_HUMAN
• UniProt AC: P38606
• Protein Name: V-type proton ATPase catalytic subunit A
• Gene Name: ATP6V1A
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Protein Description: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. [PubMed: 28296633]
• Protein Sequence: MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Acetylation	-	57.43	22814378
5	Ubiquitination	---MDFSKLPKILDE ---CCHHHCCCCCCC	69.66	22505724
5	Acetylation	---MDFSKLPKILDE ---CCHHHCCCCCCC	69.66	25953088
8	Ubiquitination	MDFSKLPKILDEDKE CCHHHCCCCCCCCCC	67.35	29967540
40	Phosphorylation	DMAGAAMYELVRVGH HHHCHHHHHHHHCCC	11.03	27642862
84	Ubiquitination	DPVLRTGKPLSVELG CCEECCCCCCEEEEC	42.02	29967540
99	Ubiquitination	PGIMGAIFDGIQRPL CCHHHHHHCCCCCCH	7.54	-
106	Ubiquitination	FDGIQRPLSDISSQT HCCCCCCHHHCCCCC	8.60	-
107	Phosphorylation	DGIQRPLSDISSQTQ CCCCCCHHHCCCCCC	35.26	25599653
111	Phosphorylation	RPLSDISSQTQSIYI CCHHHCCCCCCEEEE	37.27	25599653
113	Phosphorylation	LSDISSQTQSIYIPR HHHCCCCCCEEEECC	26.65	25599653
117	Phosphorylation	SSQTQSIYIPRGVNV CCCCCEEEECCCCCH	15.32	25599653
125	Phosphorylation	IPRGVNVSALSRDIK ECCCCCHHHHCCCCC	20.49	20873877
128	Phosphorylation	GVNVSALSRDIKWDF CCCHHHHCCCCCCCC	27.85	25599653
130	Ubiquitination	NVSALSRDIKWDFTP CHHHHCCCCCCCCCC	43.36	-
132	Ubiquitination	SALSRDIKWDFTPCK HHHCCCCCCCCCCCC	45.03	21906983
132	Acetylation	SALSRDIKWDFTPCK HHHCCCCCCCCCCCC	45.03	26822725
136	Phosphorylation	RDIKWDFTPCKNLRV CCCCCCCCCCCCCEE	25.88	21815630
139	Ubiquitination	KWDFTPCKNLRVGSH CCCCCCCCCCEEECE	61.29	23000965
139	Malonylation	KWDFTPCKNLRVGSH CCCCCCCCCCEEECE	61.29	26320211
139	Acetylation	KWDFTPCKNLRVGSH CCCCCCCCCCEEECE	61.29	25953088
145	Phosphorylation	CKNLRVGSHITGGDI CCCCEEECEECCCCE	14.62	20068231
148	Phosphorylation	LRVGSHITGGDIYGI CEEECEECCCCEEEE	29.68	28152594
153	Phosphorylation	HITGGDIYGIVSENS EECCCCEEEEEECCC	12.92	28152594
157	Phosphorylation	GDIYGIVSENSLIKH CCEEEEEECCCCCEE	29.19	23401153
160	Phosphorylation	YGIVSENSLIKHKIM EEEEECCCCCEEEEE	27.67	20068231
163	Ubiquitination	VSENSLIKHKIMLPP EECCCCCEEEEECCC	44.10	21906983
163	Acetylation	VSENSLIKHKIMLPP EECCCCCEEEEECCC	44.10	25953088
165	Ubiquitination	ENSLIKHKIMLPPRN CCCCCEEEEECCCCC	25.47	22817900
175	Phosphorylation	LPPRNRGTVTYIAPP CCCCCCCEEEEEECC	13.36	29978859
177	Phosphorylation	PRNRGTVTYIAPPGN CCCCCEEEEEECCCC	14.73	29978859
178	Phosphorylation	RNRGTVTYIAPPGNY CCCCEEEEEECCCCC	7.25	29978859
185	Phosphorylation	YIAPPGNYDTSDVVL EEECCCCCCCCCEEE	26.89	29978859
187	Phosphorylation	APPGNYDTSDVVLEL ECCCCCCCCCEEEEE	19.23	29978859
187	Ubiquitination	APPGNYDTSDVVLEL ECCCCCCCCCEEEEE	19.23	-
188	Phosphorylation	PPGNYDTSDVVLELE CCCCCCCCCEEEEEE	26.05	29978859
200	Ubiquitination	ELEFEGVKEKFTMVQ EEEEECHHHCEEEEE	67.07	-
220	Ubiquitination	QVRPVTEKLPANHPL CEEECCCCCCCCCCC	50.86	21906983
223	Ubiquitination	PVTEKLPANHPLLTG ECCCCCCCCCCCCCC	37.08	-
232	Ubiquitination	HPLLTGQRVLDALFP CCCCCCCHHHHHHHC	32.10	-
256	Ubiquitination	PGAFGCGKTVISQSL CCCCCCCHHHHHHHH	43.63	21963094
257	O-linked_Glycosylation	GAFGCGKTVISQSLS CCCCCCHHHHHHHHH	14.35	30059200
260	Phosphorylation	GCGKTVISQSLSKYS CCCHHHHHHHHHHCC	14.91	25627689
260	O-linked_Glycosylation	GCGKTVISQSLSKYS CCCHHHHHHHHHHCC	14.91	30059200
262	Phosphorylation	GKTVISQSLSKYSNS CHHHHHHHHHHCCCC	28.02	25627689
264	Phosphorylation	TVISQSLSKYSNSDV HHHHHHHHHCCCCCE	34.49	25627689
265	Methylation	VISQSLSKYSNSDVI HHHHHHHHCCCCCEE	58.97	-
265	Ubiquitination	VISQSLSKYSNSDVI HHHHHHHHCCCCCEE	58.97	22817900
274	Ubiquitination	SNSDVIIYVGCGERG CCCCEEEEEECCCCH	4.62	-
284	Sulfoxidation	CGERGNEMSEVLRDF CCCCHHHHHHHHHHC	4.86	30846556
296	Sulfoxidation	RDFPELTMEVDGKVE HHCCCCEEEECCCHH	8.05	21406390
307	Ubiquitination	GKVESIMKRTALVAN CCHHHHHHHHEEEEC	44.95	27667366
307	2-Hydroxyisobutyrylation	GKVESIMKRTALVAN CCHHHHHHHHEEEEC	44.95	-
309	Phosphorylation	VESIMKRTALVANTS HHHHHHHHEEEECCC	20.87	23911959
315	Phosphorylation	RTALVANTSNMPVAA HHEEEECCCCCCCHH	16.25	20068231
316	Phosphorylation	TALVANTSNMPVAAR HEEEECCCCCCCHHH	30.82	20068231
318	Sulfoxidation	LVANTSNMPVAAREA EEECCCCCCCHHHHH	2.57	30846556
342	Phosphorylation	EYFRDMGYHVSMMAD HHHHHCCCCHHEECC	7.75	22210691
350	Phosphorylation	HVSMMADSTSRWAEA CHHEECCCHHHHHHH	20.81	22210691
351	Phosphorylation	VSMMADSTSRWAEAL HHEECCCHHHHHHHH	23.90	22210691
360	Ubiquitination	RWAEALREISGRLAE HHHHHHHHHHHHHCC	42.21	-
362	Phosphorylation	AEALREISGRLAEMP HHHHHHHHHHHCCCC	17.07	22210691
364	Dimethylation	ALREISGRLAEMPAD HHHHHHHHHCCCCCC	24.76	-
364	Methylation	ALREISGRLAEMPAD HHHHHHHHHCCCCCC	24.76	-
368	Sulfoxidation	ISGRLAEMPADSGYP HHHHHCCCCCCCCCC	2.49	30846556
372	Phosphorylation	LAEMPADSGYPAYLG HCCCCCCCCCCCHHH	42.19	22210691
374	Phosphorylation	EMPADSGYPAYLGAR CCCCCCCCCCHHHHH	6.66	21082442
381	Methylation	YPAYLGARLASFYER CCCHHHHHHHHHHHH	29.05	-
384	Phosphorylation	YLGARLASFYERAGR HHHHHHHHHHHHCCC	32.71	20873877
386	Phosphorylation	GARLASFYERAGRVK HHHHHHHHHHCCCCE	11.30	22210691
393	Ubiquitination	YERAGRVKCLGNPER HHHCCCCEECCCCCC	23.52	21906983
411	Phosphorylation	VSIVGAVSPPGGDFS EEEEEEECCCCCCCC	25.50	25627689
418	Phosphorylation	SPPGGDFSDPVTSAT CCCCCCCCCHHHHHH	45.83	25627689
434	Acetylation	GIVQVFWGLDKKLAQ HHHHHHHCCCHHHHH	16.72	-
434	Ubiquitination	GIVQVFWGLDKKLAQ HHHHHHHCCCHHHHH	16.72	-
443	Acetylation	DKKLAQRKHFPSVNW CHHHHHHCCCCCHHH	37.20	26051181
447	Ubiquitination	AQRKHFPSVNWLISY HHHCCCCCHHHHHHH	27.43	-
453	Phosphorylation	PSVNWLISYSKYMRA CCHHHHHHHHHHHHH	22.60	22210691
454	Phosphorylation	SVNWLISYSKYMRAL CHHHHHHHHHHHHHH	11.37	22210691
457	Phosphorylation	WLISYSKYMRALDEY HHHHHHHHHHHHHHH	5.96	-
464	Phosphorylation	YMRALDEYYDKHFTE HHHHHHHHHHHHCHH	19.34	28152594
465	Phosphorylation	MRALDEYYDKHFTEF HHHHHHHHHHHCHHC	19.23	28152594
467	Acetylation	ALDEYYDKHFTEFVP HHHHHHHHHCHHCCC	25.21	23954790
467	Ubiquitination	ALDEYYDKHFTEFVP HHHHHHHHHCHHCCC	25.21	22817900
467	Ubiquitination	ALDEYYDKHFTEFVP HHHHHHHHHCHHCCC	25.21	21890473
470	Phosphorylation	EYYDKHFTEFVPLRT HHHHHHCHHCCCCHH	28.38	28152594
478	Ubiquitination	EFVPLRTKAKEILQE HCCCCHHHHHHHHHC	51.53	22817900
480	Ubiquitination	VPLRTKAKEILQEEE CCCHHHHHHHHHCHH	47.01	21906983
480	Ubiquitination	VPLRTKAKEILQEEE CCCHHHHHHHHHCHH	47.01	-
483	Ubiquitination	RTKAKEILQEEEDLA HHHHHHHHHCHHHHH	5.71	-
498	Ubiquitination	EIVQLVGKASLAETD HHHHHHHHHCCCCCC	27.59	32015554
500	Phosphorylation	VQLVGKASLAETDKI HHHHHHHCCCCCCCH	31.43	30622161
504	Phosphorylation	GKASLAETDKITLEV HHHCCCCCCCHHHHH	36.66	30622161
506	Ubiquitination	ASLAETDKITLEVAK HCCCCCCCHHHHHHH	45.04	29967540
506	2-Hydroxyisobutyrylation	ASLAETDKITLEVAK HCCCCCCCHHHHHHH	45.04	-
508	Phosphorylation	LAETDKITLEVAKLI CCCCCCHHHHHHHHH	23.70	23403867
513	Ubiquitination	KITLEVAKLIKDDFL CHHHHHHHHHHHHHH	56.79	21906983
513	Ubiquitination	KITLEVAKLIKDDFL CHHHHHHHHHHHHHH	56.79	21890473
516	Ubiquitination	LEVAKLIKDDFLQQN HHHHHHHHHHHHHHC	62.78	21906983
528	Phosphorylation	QQNGYTPYDRFCPFY HHCCCCCHHHCCHHH	16.38	-
530	Methylation	NGYTPYDRFCPFYKT CCCCCHHHCCHHHHH	29.26	-
531	Ubiquitination	GYTPYDRFCPFYKTV CCCCHHHCCHHHHHH	5.92	-
547	Ubiquitination	MLSNMIAFYDMARRA HHHHHHHHHHHHHHH	3.53	-
554	Ubiquitination	FYDMARRAVETTAQS HHHHHHHHHHHHHCC	9.65	-
558	Ubiquitination	ARRAVETTAQSDNKI HHHHHHHHHCCCCCC	14.81	-
561	Phosphorylation	AVETTAQSDNKITWS HHHHHHCCCCCCCHH	40.46	20068231
564	Ubiquitination	TTAQSDNKITWSIIR HHHCCCCCCCHHHHH	46.64	21906983
565	Ubiquitination	TAQSDNKITWSIIRE HHCCCCCCCHHHHHH	6.30	-
566	Phosphorylation	AQSDNKITWSIIREH HCCCCCCCHHHHHHH	18.12	27251275
568	Phosphorylation	SDNKITWSIIREHMG CCCCCCHHHHHHHHH	10.25	24719451
579	Phosphorylation	EHMGDILYKLSSMKF HHHHHHHHHHHCCCC	15.37	24927040
580	Acetylation	HMGDILYKLSSMKFK HHHHHHHHHHCCCCC	38.15	20167786
580	Ubiquitination	HMGDILYKLSSMKFK HHHHHHHHHHCCCCC	38.15	23000965
580	Ubiquitination	HMGDILYKLSSMKFK HHHHHHHHHHCCCCC	38.15	21890473
582	Phosphorylation	GDILYKLSSMKFKDP HHHHHHHHCCCCCCC	25.00	21964256
585	Ubiquitination	LYKLSSMKFKDPLKD HHHHHCCCCCCCCCC	51.73	23000965
587	Ubiquitination	KLSSMKFKDPLKDGE HHHCCCCCCCCCCCC	53.57	22817900
591	Ubiquitination	MKFKDPLKDGEAKIK CCCCCCCCCCCCCCH	69.90	21906983
591	2-Hydroxyisobutyrylation	MKFKDPLKDGEAKIK CCCCCCCCCCCCCCH	69.90	-
596	Acetylation	PLKDGEAKIKSDYAQ CCCCCCCCCHHHHHH	46.49	20167786
596	Ubiquitination	PLKDGEAKIKSDYAQ CCCCCCCCCHHHHHH	46.49	22817900
598	Ubiquitination	KDGEAKIKSDYAQLL CCCCCCCHHHHHHHH	36.25	21963094
599	Phosphorylation	DGEAKIKSDYAQLLE CCCCCCHHHHHHHHH	39.05	28857561
601	Phosphorylation	EAKIKSDYAQLLEDM CCCCHHHHHHHHHHH	11.88	28857561
614	Phosphorylation	DMQNAFRSLED---- HHHHHHHCCCC----	29.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATF_HUMAN	ATP6V1F	physical	22939629
XIAP_HUMAN	XIAP	physical	22939629
XPO2_HUMAN	CSE1L	physical	22939629
ZN593_HUMAN	ZNF593	physical	22939629
ZN706_HUMAN	ZNF706	physical	22939629
VINC_HUMAN	VCL	physical	22939629
MTPN_HUMAN	MTPN	physical	22863883
PDIA3_HUMAN	PDIA3	physical	22863883
RBBP4_HUMAN	RBBP4	physical	22863883
ATPG_HUMAN	ATP5C1	physical	26344197
VA0D1_HUMAN	ATP6V0D1	physical	26344197
COG2_HUMAN	COG2	physical	26344197
COG8_HUMAN	COG8	physical	26344197
COX41_HUMAN	COX4I1	physical	26344197
XPO2_HUMAN	CSE1L	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
MCA3_HUMAN	EEF1E1	physical	26344197
IF4A3_HUMAN	EIF4A3	physical	26344197
MCMBP_HUMAN	MCMBP	physical	26344197
PDC10_HUMAN	PDCD10	physical	26344197
RAB2A_HUMAN	RAB2A	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
GLYM_HUMAN	SHMT2	physical	26344197
STOM_HUMAN	STOM	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
VDAC1_HUMAN	VDAC1	physical	26344197
VDAC2_HUMAN	VDAC2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00630: Alendronate
• DB01077: Etidronic acid
• DB01133: Tiludronate