COG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COG2_HUMAN
• UniProt AC: Q14746
• Protein Name: Conserved oligomeric Golgi complex subunit 2
• Gene Name: COG2
• Organism: Homo sapiens (Human).
• Sequence Length: 738
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Required for normal Golgi morphology and function..
• Protein Sequence: MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MEKSRMNLPK -----CCCCCCCCCC	41.90	19608861
4	Phosphorylation	----MEKSRMNLPKG ----CCCCCCCCCCC	24.37	26657352
5	Dimethylation	---MEKSRMNLPKGP ---CCCCCCCCCCCC	29.13	-
5	Methylation	---MEKSRMNLPKGP ---CCCCCCCCCCCC	29.13	-
19	Ubiquitination	PDTLCFDKDEFMKED CCCEEECHHHHHHHC	38.62	-
24	Ubiquitination	FDKDEFMKEDFDVDH ECHHHHHHHCCCHHH	60.49	-
52	Phosphorylation	LRDDLELYYKLLKTA HHHHHHHHHHHHHHH	6.81	18452278
54	Ubiquitination	DDLELYYKLLKTAMV HHHHHHHHHHHHHHH	33.51	21890473
54	Ubiquitination	DDLELYYKLLKTAMV HHHHHHHHHHHHHHH	33.51	21890473
57	Ubiquitination	ELYYKLLKTAMVELI HHHHHHHHHHHHHHH	44.68	21906983
104	Phosphorylation	EEVLSLRSSVSEGIR HHHHHHHHHHHHHHH	40.14	26699800
105	Phosphorylation	EVLSLRSSVSEGIRA HHHHHHHHHHHHHHH	24.19	24719451
107	Phosphorylation	LSLRSSVSEGIRAVD HHHHHHHHHHHHHHH	31.86	26699800
118	Phosphorylation	RAVDERMSKQEDIRK HHHHHHHHCCHHHHH	37.09	21060948
119	Ubiquitination	AVDERMSKQEDIRKK HHHHHHHCCHHHHHH	48.65	-
145	Ubiquitination	RSVEKIEKILNSQSS HHHHHHHHHHCCCCC	56.84	-
153	Ubiquitination	ILNSQSSKETSALEA HHCCCCCCCCCHHHH	70.97	21906983
161	Phosphorylation	ETSALEASSPLLTGQ CCCHHHHCCCHHHHH	24.10	28348404
162	Phosphorylation	TSALEASSPLLTGQI CCHHHHCCCHHHHHH	26.98	28348404
188	Ubiquitination	QFHAVQSKGMPLLDK HHHHHHCCCCCHHHH	41.98	-
195	Ubiquitination	KGMPLLDKVRPRIAG CCCCHHHHHHHHHHH	39.86	-
239	Ubiquitination	RTYATIDKTRDAEAL HHHHCCCCCCCHHHH	41.42	-
343	Ubiquitination	NPDAFHEKYTISMDF CCHHHHHHHEECHHH	38.84	-
373	Phosphorylation	RLRAHPAYHSFNKKW HHHCCCCCCCCCCCC	11.49	25690035
375	Phosphorylation	RAHPAYHSFNKKWNL HCCCCCCCCCCCCCC	20.17	20873877
378	Ubiquitination	PAYHSFNKKWNLPVY CCCCCCCCCCCCCEE	58.09	-
379	Ubiquitination	AYHSFNKKWNLPVYF CCCCCCCCCCCCEEE	42.28	-
462	Phosphorylation	SVFVNELSLRPISNE HHHHHCCCCCCCCCC	19.02	24719451
475	Ubiquitination	NESPKEIKKPLVTGS CCCHHHCCCCCCCCC	49.80	-
476	Ubiquitination	ESPKEIKKPLVTGSK CCHHHCCCCCCCCCC	49.60	-
503	Ubiquitination	GSGPSETKPVVSISR CCCCCCCCCEEEEEH	31.59	21890473
509	Phosphorylation	TKPVVSISRTQLVYV CCCEEEEEHHEEEEE	23.05	24719451
535	Ubiquitination	PELLEIIKPKLEMIG HHHHHHHHHHHHHHC	41.58	-
547 (in isoform 2)	Phosphorylation	-	35.83	22210691
567 (in isoform 2)	Phosphorylation	-	5.69	22210691
584	Ubiquitination	DSCFGFLKSALEVPR HHHHHHHHHHHHHHH	31.27	-
584	Methylation	DSCFGFLKSALEVPR HHHHHHHHHHHHHHH	31.27	-
598	Ubiquitination	RLYRRTNKEVPTTAS HHHHHCCCCCCCCHH	60.52	-
602	Phosphorylation	RTNKEVPTTASSYVD HCCCCCCCCHHHHHH	39.92	22210691
603	Phosphorylation	TNKEVPTTASSYVDS CCCCCCCCHHHHHHH	20.62	22210691
607	Phosphorylation	VPTTASSYVDSALKP CCCCHHHHHHHHHHH	13.04	22210691
613	Ubiquitination	SYVDSALKPLFQLQS HHHHHHHHHHHHCCC	39.12	-
627	Ubiquitination	SGHKDKLKQAIIQQW CCCHHHHHHHHHHHH	43.34	-
656	Phosphorylation	TVSDVLNSVKKMEES HHHHHHHHHHHHHHH	31.02	24719451
658	Ubiquitination	SDVLNSVKKMEESLK HHHHHHHHHHHHHHH	46.34	-
659	Ubiquitination	DVLNSVKKMEESLKR HHHHHHHHHHHHHHH	49.76	-
668	Acetylation	EESLKRLKQARKTTP HHHHHHHHHHHHCCC	46.04	7338877
672	Ubiquitination	KRLKQARKTTPANPV HHHHHHHHCCCCCCC	60.82	-
673	Phosphorylation	RLKQARKTTPANPVG HHHHHHHCCCCCCCC	32.24	20071362
674	Phosphorylation	LKQARKTTPANPVGP HHHHHHCCCCCCCCC	24.36	28555341
686	Phosphorylation	VGPSGGMSDDDKIRL CCCCCCCCHHHHHHH	40.96	-
690	Ubiquitination	GGMSDDDKIRLQLAL CCCCHHHHHHHHHHH	36.40	-
717	Ubiquitination	GLQASDIKSFSALAE CCCHHHHHHHHHHHH	50.90	-
730	Ubiquitination	AELVAAAKDQATAEQ HHHHHHHHHHHHCCC	45.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COG4_HUMAN	COG4	physical	15047703
COG3_HUMAN	COG3	physical	22939629
COG8_HUMAN	COG8	physical	22939629
COG5_HUMAN	COG5	physical	22939629
COG6_HUMAN	COG6	physical	22939629
COG7_HUMAN	COG7	physical	22939629
MTUS2_HUMAN	MTUS2	physical	25416956
COG1_HUMAN	COG1	physical	26344197
COG3_HUMAN	COG3	physical	26344197
COG4_HUMAN	COG4	physical	26344197
COG6_HUMAN	COG6	physical	26344197
COG7_HUMAN	COG7	physical	26344197
COG8_HUMAN	COG8	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.