| UniProt ID | MTUS2_HUMAN | |
|---|---|---|
| UniProt AC | Q5JR59 | |
| Protein Name | Microtubule-associated tumor suppressor candidate 2 | |
| Gene Name | MTUS2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1369 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules. | |
| Protein Description | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.. | |
| Protein Sequence | MSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTNANQIMLEVSSSHDESKTCDLGDEIGNTNSSEPENRTHFHKEFHQLQGFGKGSQAGSASLKDFRLSSTIQRELNEEHTVERGTDSLQTTRSIQGPSLSSWRNVMSEASLDVLAKRDAEIPRHVPKDKLAKTLDNEELRRHSLERASSSVAAVGSLTPQHPQPLSLDSREARGQIPGGGEGPQKTLPDHAVPAAFPATDSTSEGKSVRHPKPSTSESKQSTPSETQTVGAHVLQVCSEHTSHSAHPEPALNLTLASKEIPSKLEAQLGQGKGEAKLDLKYVPPRRVEQEGKAAQEGYLGCHKEENLSALEGRDPCGEAHPEATDALGHLLNSDLHHLGVGRGNCEEKRGVNPGEQDSLHTTPKQGSASLGGADNQPTGKISPCAGEKLGERTSSSFSPGDSHVAFIPNNLTDSKPLDVIEEERRLGSGNKDSVMVLVFNPSVGENKTEVPEPLDPQSGRSEARESKEVTTSVAENRNLLENADKIESTSARADSVLNIPAPLHPETTVNMTYQPTTPSSSFQDVSVFGMDAGSPLVVPPPTDSARLLNTSPKVPDKNTCPSGIPKPVFTHSKDTPSSQEGMENYQVEKTEERTETKPIIMPKPKHVRPKIITYIRRNPQALGQVDASLVPVGLPYAPPTCTMPLPHEEKAAGGDLKPSANLYEKFKPDLQKPRVFSSGLMVSGIKPPGHPFSQMSEKFLQEVTDHPGKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAMSRLPSAKSRILIASQRSSASAIHPPGPITTATSLYSSDPSADLKKASSSNAAKSNLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSSVSSTQSGDSAQPEQGRPATRSTFGNEEQPVLKASLPSKDTPKGAGRVAPPASSSVTAPRRSLLPAPKSTSTPAGTKKDAQKDQDTNKPAVSSPKRVAASTTKLHSPGYPKQRTAAARNGFPPKPDPQAREAERQLVLRLKERCEQQTRQLGVAQGELKRAICGFDALAVATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSVPVAPKK ------CCCCCCCCC | 46.57 | 20068231 | |
| 12 | Phosphorylation | VAPKKSCYTQLRDNR CCCCCCHHHHHHHCH | 12.47 | 20068231 | |
| 140 | Phosphorylation | SSWRNVMSEASLDVL HHHHHHHCHHHHHHH | 26.23 | - | |
| 295 | Phosphorylation | LASKEIPSKLEAQLG ECCCCCCHHHHHHCC | 56.38 | 24719451 | |
| 309 | Ubiquitination | GQGKGEAKLDLKYVP CCCCCCEEEECEECC | 37.93 | - | |
| 435 | Phosphorylation | SSFSPGDSHVAFIPN CCCCCCCCCEEECCC | 26.27 | - | |
| 447 | Phosphorylation | IPNNLTDSKPLDVIE CCCCCCCCCCCHHHH | 30.82 | 24719451 | |
| 466 | Phosphorylation | LGSGNKDSVMVLVFN CCCCCCCCEEEEEEC | 17.45 | 27251275 | |
| 475 | Phosphorylation | MVLVFNPSVGENKTE EEEEECCCCCCCCCC | 43.81 | 27251275 | |
| 476 | Phosphorylation | VLVFNPSVGENKTEV EEEECCCCCCCCCCC | 13.55 | 27251275 | |
| 503 | Phosphorylation | ARESKEVTTSVAENR HHHCCCCHHHHHHHH | 17.91 | - | |
| 504 | Phosphorylation | RESKEVTTSVAENRN HHCCCCHHHHHHHHH | 26.78 | - | |
| 505 | Phosphorylation | ESKEVTTSVAENRNL HCCCCHHHHHHHHHH | 15.23 | - | |
| 583 | Phosphorylation | DSARLLNTSPKVPDK CHHHHHCCCCCCCCC | 46.50 | 23312004 | |
| 584 | Phosphorylation | SARLLNTSPKVPDKN HHHHHCCCCCCCCCC | 22.96 | 23312004 | |
| 592 | Phosphorylation | PKVPDKNTCPSGIPK CCCCCCCCCCCCCCC | 31.37 | 30576142 | |
| 593 | Phosphorylation | KVPDKNTCPSGIPKP CCCCCCCCCCCCCCC | 3.36 | 20068231 | |
| 595 | Phosphorylation | PDKNTCPSGIPKPVF CCCCCCCCCCCCCCE | 52.05 | 30576142 | |
| 608 | Phosphorylation | VFTHSKDTPSSQEGM CEECCCCCCCCHHHH | 28.89 | - | |
| 610 | Phosphorylation | THSKDTPSSQEGMEN ECCCCCCCCHHHHHH | 46.90 | - | |
| 611 | Phosphorylation | HSKDTPSSQEGMENY CCCCCCCCHHHHHHC | 33.19 | - | |
| 618 | Phosphorylation | SQEGMENYQVEKTEE CHHHHHHCCCEECCC | 10.71 | - | |
| 710 | Phosphorylation | LQKPRVFSSGLMVSG CCCCEEECCCCEECC | 22.19 | 25002506 | |
| 711 | Phosphorylation | QKPRVFSSGLMVSGI CCCEEECCCCEECCC | 25.20 | 25002506 | |
| 716 | Phosphorylation | FSSGLMVSGIKPPGH ECCCCEECCCCCCCC | 22.34 | 25002506 | |
| 726 | Phosphorylation | KPPGHPFSQMSEKFL CCCCCCHHHHHHHHH | 29.44 | 29978859 | |
| 729 | Phosphorylation | GHPFSQMSEKFLQEV CCCHHHHHHHHHHHH | 29.96 | 29978859 | |
| 776 | Phosphorylation | QLGLGAMSRLPSAKS CCCCCHHHCCCCCHH | 30.08 | 20068231 | |
| 780 | Phosphorylation | GAMSRLPSAKSRILI CHHHCCCCCHHHEEE | 53.58 | 20068231 | |
| 783 | Phosphorylation | SRLPSAKSRILIASQ HCCCCCHHHEEEEEC | 25.03 | 20068231 | |
| 790 | Phosphorylation | SRILIASQRSSASAI HHEEEEECCCCCCCC | 40.01 | 24719451 | |
| 793 | Phosphorylation | LIASQRSSASAIHPP EEEECCCCCCCCCCC | 28.56 | 20068231 | |
| 822 | Phosphorylation | SADLKKASSSNAAKS CCCHHHHHCCHHHHH | 43.08 | 25599653 | |
| 823 | Phosphorylation | ADLKKASSSNAAKSN CCHHHHHCCHHHHHC | 32.26 | 23532336 | |
| 824 | Phosphorylation | DLKKASSSNAAKSNL CHHHHHCCHHHHHCC | 28.17 | 25599653 | |
| 829 | Phosphorylation | SSSNAAKSNLPKSGL HCCHHHHHCCCCCCC | 38.58 | 25599653 | |
| 834 | Phosphorylation | AKSNLPKSGLRPPGY HHHCCCCCCCCCCCC | 40.91 | 24719451 | |
| 841 | Phosphorylation | SGLRPPGYSRLPAAK CCCCCCCCCCCCHHH | 9.08 | 23911959 | |
| 844 | Phosphorylation | RPPGYSRLPAAKLAA CCCCCCCCCHHHHHH | 2.52 | 24719451 | |
| 896 | Phosphorylation | EQPVLKASLPSKDTP CCCEEEEECCCCCCC | 38.94 | 28348404 | |
| 899 | Phosphorylation | VLKASLPSKDTPKGA EEEEECCCCCCCCCC | 48.75 | 24719451 | |
| 899 | O-linked_Glycosylation | VLKASLPSKDTPKGA EEEEECCCCCCCCCC | 48.75 | 30379171 | |
| 902 | Phosphorylation | ASLPSKDTPKGAGRV EECCCCCCCCCCCCC | 30.54 | 28348404 | |
| 902 | O-linked_Glycosylation | ASLPSKDTPKGAGRV EECCCCCCCCCCCCC | 30.54 | 30379171 | |
| 906 | Phosphorylation | SKDTPKGAGRVAPPA CCCCCCCCCCCCCCC | 14.56 | 27251275 | |
| 912 | Phosphorylation | GAGRVAPPASSSVTA CCCCCCCCCCCCCCC | 34.73 | 27251275 | |
| 914 | Phosphorylation | GRVAPPASSSVTAPR CCCCCCCCCCCCCCC | 28.99 | - | |
| 923 | Phosphorylation | SVTAPRRSLLPAPKS CCCCCCHHCCCCCCC | 35.22 | 20068231 | |
| 930 | Phosphorylation | SLLPAPKSTSTPAGT HCCCCCCCCCCCCCC | 26.91 | 20068231 | |
| 931 | Phosphorylation | LLPAPKSTSTPAGTK CCCCCCCCCCCCCCH | 42.62 | 20068231 | |
| 932 | Phosphorylation | LPAPKSTSTPAGTKK CCCCCCCCCCCCCHH | 39.21 | 20068231 | |
| 933 | Phosphorylation | PAPKSTSTPAGTKKD CCCCCCCCCCCCHHH | 19.76 | 20068231 | |
| 937 | Phosphorylation | STSTPAGTKKDAQKD CCCCCCCCHHHHHCC | 36.71 | 20068231 | |
| 942 | Phosphorylation | AGTKKDAQKDQDTNK CCCHHHHHCCCCCCC | 61.05 | 20068231 | |
| 947 | Phosphorylation | DAQKDQDTNKPAVSS HHHCCCCCCCCCCCC | 39.24 | 20068231 | |
| 954 | Phosphorylation | TNKPAVSSPKRVAAS CCCCCCCCHHHHEEE | 28.04 | 30576142 | |
| 1075 | Methylation | CEKLQKEKEELERRF HHHHHHHHHHHHHHH | 64.62 | 23644510 | |
| 1295 | O-linked_Glycosylation | KARIDQNTVVTRQLS HHHHCCCHHHHHHHC | 15.66 | 30379171 | |
| 1298 | O-linked_Glycosylation | IDQNTVVTRQLSEEN HCCCHHHHHHHCHHC | 14.36 | 30379171 | |
| 1302 | Phosphorylation | TVVTRQLSEENANLQ HHHHHHHCHHCCCHH | 34.23 | 26657352 | |
| 1312 | Phosphorylation | NANLQEYVEKETQEK CCCHHHHHHHHHHHH | 9.24 | 27251275 | |
| 1339 | Phosphorylation | KLQTGDPTSPIKLSP HHHHCCCCCCCEECC | 52.45 | 23186163 | |
| 1340 | Phosphorylation | LQTGDPTSPIKLSPT HHHCCCCCCCEECCC | 29.98 | 25159151 | |
| 1345 | Phosphorylation | PTSPIKLSPTSPVYR CCCCCEECCCCCCCC | 22.56 | 29083192 | |
| 1347 | Phosphorylation | SPIKLSPTSPVYRGS CCCEECCCCCCCCCC | 42.14 | - | |
| 1348 | Phosphorylation | PIKLSPTSPVYRGSS CCEECCCCCCCCCCC | 18.76 | 23186163 | |
| 1351 | Phosphorylation | LSPTSPVYRGSSSGP ECCCCCCCCCCCCCC | 16.79 | 20068231 | |
| 1360 | Phosphorylation | GSSSGPSSPARVSTT CCCCCCCCCCCCCCC | 26.22 | - | |
| 1367 | Phosphorylation | SPARVSTTPR----- CCCCCCCCCC----- | 15.01 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTUS2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTUS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
| 947 | Phosphorylation | 957 (10) | T ⇒ M | rs61999321 |
| 23251661 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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