dbPTM

SETD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SETD5_HUMAN
UniProt AC	Q9C0A6
Protein Name	SET domain-containing protein 5 {ECO:0000305}
Gene Name	SETD5 {ECO:0000312\|HGNC:HGNC:25566}
Organism	Homo sapiens (Human).
Sequence Length	1442
Subcellular Localization	Nucleus .
Protein Description	Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription..
Protein Sequence	MSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSAGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKDSDPADGEGPETLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLAPFTGTPGYFSSQPHSGNSTGSNLPRRSCPSSAASPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTGLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AIPLGVTTSDTSYSD EEECCCCCCCCCHHH	23.38	28348404
12	Phosphorylation	IPLGVTTSDTSYSDM EECCCCCCCCCHHHH	29.53	28348404
14	Phosphorylation	LGVTTSDTSYSDMAA CCCCCCCCCHHHHCC	29.36	28348404
15	Phosphorylation	GVTTSDTSYSDMAAG CCCCCCCCHHHHCCC	27.85	28348404
16	Phosphorylation	VTTSDTSYSDMAAGS CCCCCCCHHHHCCCC	15.69	28348404
17	Phosphorylation	TTSDTSYSDMAAGSD CCCCCCHHHHCCCCC	22.22	28348404
23	Phosphorylation	YSDMAAGSDPESVEA HHHHCCCCCHHHCCC	45.31	28348404
27	Phosphorylation	AAGSDPESVEASPAV CCCCCHHHCCCCCCC	30.55	28348404
65	Phosphorylation	YATIIPRSDLNGLPS EEEEEEHHHCCCCCC	40.89	30266825
72	Phosphorylation	SDLNGLPSPVEERCG HHCCCCCCCHHHHCC	46.77	23401153
136	Phosphorylation	SGGDSSATESWDEEL CCCCCCCCCCCCCCC	32.28	24275569
174	Acetylation	TKPKKRKKSPEKGRA CCCCCCCCCCCCCCC	75.24	24471291
178	Acetylation	KRKKSPEKGRAAPKT CCCCCCCCCCCCCCC	58.02	24471303
191	Phosphorylation	KTKKIKNSPSEAQNL CCCCCCCCHHHHHCC	25.46	30108239
193	Phosphorylation	KKIKNSPSEAQNLDE CCCCCCHHHHHCCCC	45.44	30108239
322	Phosphorylation	GHFFKKPYPFVLFYS CEECCCCCCEEEEEE	20.41	-
474	Phosphorylation	QEVPEKVTVSSDHEE HHCCCCEECCCCCCC	26.24	21955146
476	Phosphorylation	VPEKVTVSSDHEEVD CCCCEECCCCCCCCC	22.23	25159151
477	Phosphorylation	PEKVTVSSDHEEVDN CCCEECCCCCCCCCC	38.35	25159151
506	Phosphorylation	DQENLAHSRRTREDR CHHHHHHHHCCHHHH	20.18	20068231
539	Phosphorylation	RDQPLEQSNSDVEIT CCCCCHHCCCCCEEE	29.00	22496350
541	Phosphorylation	QPLEQSNSDVEITTT CCCHHCCCCCEEEEE	48.56	25849741
558	Phosphorylation	ETPVGEETKTEAPES CCCCCCCCCCCCCHH	38.68	24275569
560	Phosphorylation	PVGEETKTEAPESEV CCCCCCCCCCCHHHC	44.81	24275569
590	Phosphorylation	VGVNTRRSSQAGDIA CCCCCCCCCCCCCCH	24.42	23401153
591	Phosphorylation	GVNTRRSSQAGDIAA CCCCCCCCCCCCCHH	23.41	27273156
745	Phosphorylation	MLPGLIHSPLICTTP CCCCCCCCCEEECCC	17.88	24719451
751	Phosphorylation	HSPLICTTPKHYIRF CCCEEECCCCHHHCC	26.40	24719451
757	Methylation	TTPKHYIRFGSPFIP CCCCHHHCCCCCCCC	23.78	115916525
760	Phosphorylation	KHYIRFGSPFIPERR CHHHCCCCCCCCHHC	17.58	21815630
776	Phosphorylation	RPLLPDGTFSSCKKR CCCCCCCCCHHHHHH	27.94	29759185
778	Phosphorylation	LLPDGTFSSCKKRWI CCCCCCCHHHHHHHH	34.36	29759185
779	Phosphorylation	LPDGTFSSCKKRWIK CCCCCCHHHHHHHHH	26.26	29759185
797	Phosphorylation	EEGMTQTSSVPQETR HHCCCCCCCCCHHHH	21.37	24114839
803	Phosphorylation	TSSVPQETRTQHLYQ CCCCCHHHHHHHHHH	33.50	24114839
805	Phosphorylation	SVPQETRTQHLYQSN CCCHHHHHHHHHHCC	27.97	29759185
809	Phosphorylation	ETRTQHLYQSNENSS HHHHHHHHHCCCCCC	14.05	29759185
822	Ubiquitination	SSSSSICKDNADLLS CCCCCCCCCCHHHHH	52.96	-
829	Phosphorylation	KDNADLLSPLKKWKS CCCHHHHHHHHHHHH	35.17	25159151
832	Ubiquitination	ADLLSPLKKWKSRYL HHHHHHHHHHHHHHH	61.03	-
838	Phosphorylation	LKKWKSRYLMEQNVT HHHHHHHHHHHHHHH	19.93	18083107
852	Phosphorylation	TKLLRPLSPVTPPPP HHHHCCCCCCCCCCC	21.73	23401153
855	Phosphorylation	LRPLSPVTPPPPNSG HCCCCCCCCCCCCCC	33.20	23401153
861	Phosphorylation	VTPPPPNSGSKSPQL CCCCCCCCCCCCCCC	50.66	22167270
863	Phosphorylation	PPPPNSGSKSPQLAT CCCCCCCCCCCCCCC	29.76	22167270
865	Phosphorylation	PPNSGSKSPQLATPG CCCCCCCCCCCCCCC	21.41	23401153
870	Phosphorylation	SKSPQLATPGSSHPG CCCCCCCCCCCCCCC	36.45	30266825
873	Phosphorylation	PQLATPGSSHPGEEE CCCCCCCCCCCCHHH	27.03	25850435
874	Phosphorylation	QLATPGSSHPGEEEC CCCCCCCCCCCHHHH	39.35	25850435
885	Phosphorylation	EEECRNGYSLMFSPV HHHHCCCCCEEEECC	11.37	-
890	Phosphorylation	NGYSLMFSPVTSLTT CCCCEEEECCCCCCC	12.42	17001009
903	Phosphorylation	TTASRCNTPLQFELC CCCCCCCCCCCEEEC	29.06	23312004
973	Phosphorylation	HQTLVRNSDQAFRTE CCEEEECCCHHHHHH	22.12	28555341
987	Phosphorylation	EFNLMYAYSPLNAMP HEEEEEECCCCCCCC	8.04	-
988	Phosphorylation	FNLMYAYSPLNAMPR EEEEEECCCCCCCCC	18.10	24719451
1003	Phosphorylation	ADGLYRGSPLVGDRK CCCCCCCCCCCCCCC	13.18	21815630
1018	Phosphorylation	PLHLDGGYCSPAEGF CCCCCCCCCCCCCCC	8.69	29083192
1020	Phosphorylation	HLDGGYCSPAEGFSS CCCCCCCCCCCCCCH	20.75	20068231
1026	Phosphorylation	CSPAEGFSSRYEHGL CCCCCCCCHHHHCCC	25.43	19413330
1027	Phosphorylation	SPAEGFSSRYEHGLM CCCCCCCHHHHCCCC	36.30	24719451
1029	Phosphorylation	AEGFSSRYEHGLMKD CCCCCHHHHCCCCCC	17.77	24719451
1038	Phosphorylation	HGLMKDLSRGSLSPG CCCCCCCCCCCCCCC	44.74	21712546
1041	Phosphorylation	MKDLSRGSLSPGGER CCCCCCCCCCCCCCC	25.27	25159151
1043	Phosphorylation	DLSRGSLSPGGERAC CCCCCCCCCCCCCCC	24.16	29255136
1067	Phosphorylation	PPQRKKVSLLEYRKR CCCHHHCHHHHHHHH	35.80	28555341
1089	Phosphorylation	SAGGGGDSAQSKSKS CCCCCCCCCCHHCCC	31.33	28857561
1092	Phosphorylation	GGGDSAQSKSKSAGA CCCCCCCHHCCCCCC	38.32	28857561
1094	Phosphorylation	GDSAQSKSKSAGAGQ CCCCCHHCCCCCCCC	36.77	20068231
1096	Phosphorylation	SAQSKSKSAGAGQGS CCCHHCCCCCCCCCC	38.74	20068231
1103	Phosphorylation	SAGAGQGSSNSVSDT CCCCCCCCCCCCCCC	20.61	20068231
1104	Phosphorylation	AGAGQGSSNSVSDTG CCCCCCCCCCCCCCC	39.69	20068231
1106	Phosphorylation	AGQGSSNSVSDTGAH CCCCCCCCCCCCCCC	25.58	20068231
1108	Phosphorylation	QGSSNSVSDTGAHGV CCCCCCCCCCCCCCC	29.31	20068231
1110	Phosphorylation	SSNSVSDTGAHGVQG CCCCCCCCCCCCCCC	28.85	26074081
1118	Phosphorylation	GAHGVQGSSARTPSS CCCCCCCCCCCCCCC	12.06	20068231
1119	Phosphorylation	AHGVQGSSARTPSSP CCCCCCCCCCCCCCC	28.70	20068231
1122	Phosphorylation	VQGSSARTPSSPHKK CCCCCCCCCCCCCCC	27.52	26074081
1124	Phosphorylation	GSSARTPSSPHKKFS CCCCCCCCCCCCCCC	56.75	26074081
1125	Phosphorylation	SSARTPSSPHKKFSP CCCCCCCCCCCCCCC	32.02	25849741
1131	Phosphorylation	SSPHKKFSPSHSSMS CCCCCCCCCCCCCCC	34.08	23927012
1133	Phosphorylation	PHKKFSPSHSSMSHL CCCCCCCCCCCCCCC	34.50	23927012
1135	Phosphorylation	KKFSPSHSSMSHLEA CCCCCCCCCCCCCEE	31.88	23927012
1136	Phosphorylation	KFSPSHSSMSHLEAV CCCCCCCCCCCCEEC	20.91	23663014
1138	Phosphorylation	SPSHSSMSHLEAVSP CCCCCCCCCCEECCC	27.20	23663014
1144	Phosphorylation	MSHLEAVSPSDSRGT CCCCEECCCCCCCCC	26.24	23927012
1146	Phosphorylation	HLEAVSPSDSRGTSS CCEECCCCCCCCCCC	40.49	23663014
1148	Phosphorylation	EAVSPSDSRGTSSSH EECCCCCCCCCCCCC	36.63	23663014
1151	Phosphorylation	SPSDSRGTSSSHCRP CCCCCCCCCCCCCCC	25.07	29083192
1152	Phosphorylation	PSDSRGTSSSHCRPQ CCCCCCCCCCCCCCC	32.44	29083192
1153	Phosphorylation	SDSRGTSSSHCRPQE CCCCCCCCCCCCCCC	24.76	29083192
1154	Phosphorylation	DSRGTSSSHCRPQEN CCCCCCCCCCCCCCC	26.77	29083192
1163	Phosphorylation	CRPQENISSRWMVPT CCCCCCCCCCCCCCC	25.98	29083192
1164	Phosphorylation	RPQENISSRWMVPTS CCCCCCCCCCCCCCH	26.60	29083192
1170	Phosphorylation	SSRWMVPTSVERLRE CCCCCCCCHHHHHHC	33.71	28555341
1198	Phosphorylation	VAQKGEPSPTWESNI HHCCCCCCCCCCCCC	30.57	23401153
1200	Phosphorylation	QKGEPSPTWESNITE CCCCCCCCCCCCCCC	46.32	30266825
1203	Phosphorylation	EPSPTWESNITEKDS CCCCCCCCCCCCCCC	25.70	30266825
1206	Phosphorylation	PTWESNITEKDSDPA CCCCCCCCCCCCCCC	41.03	30266825
1230	Phosphorylation	SALSKGATVYSPSRY HHHHCCCEEECCCHH	28.75	30266825
1232	Phosphorylation	LSKGATVYSPSRYSY HHCCCEEECCCHHEE	15.54	30266825
1233	Phosphorylation	SKGATVYSPSRYSYQ HCCCEEECCCHHEEE	16.44	30266825
1235	Phosphorylation	GATVYSPSRYSYQLL CCEEECCCHHEEEEE	37.60	30266825
1237	Phosphorylation	TVYSPSRYSYQLLQC EEECCCHHEEEEEEC	18.96	23312004
1238	Phosphorylation	VYSPSRYSYQLLQCD EECCCHHEEEEEECC	12.80	23312004
1239	Phosphorylation	YSPSRYSYQLLQCDS ECCCHHEEEEEECCC	8.34	23312004
1246	Phosphorylation	YQLLQCDSPRTESQS EEEEECCCCCHHHHH	24.73	25849741
1258	Phosphorylation	SQSLLQQSSSPFRGH HHHHHHHCCCCCCCC	21.59	29978859
1259	Phosphorylation	QSLLQQSSSPFRGHP HHHHHHCCCCCCCCC	37.38	29978859
1260	Phosphorylation	SLLQQSSSPFRGHPT HHHHHCCCCCCCCCC	33.05	28985074
1263	Methylation	QQSSSPFRGHPTQSP HHCCCCCCCCCCCCC	45.99	115916517
1267	Phosphorylation	SPFRGHPTQSPGYSY CCCCCCCCCCCCCCE	35.68	29396449
1269	Phosphorylation	FRGHPTQSPGYSYRT CCCCCCCCCCCCEEC	23.83	24043423
1272	Phosphorylation	HPTQSPGYSYRTTAL CCCCCCCCCEECCCC	13.10	29396449
1273	Phosphorylation	PTQSPGYSYRTTALR CCCCCCCCEECCCCC	17.66	29396449
1274	Phosphorylation	TQSPGYSYRTTALRP CCCCCCCEECCCCCC	11.96	27251275
1276	Phosphorylation	SPGYSYRTTALRPGN CCCCCEECCCCCCCC	14.26	24043423
1277	Phosphorylation	PGYSYRTTALRPGNP CCCCEECCCCCCCCC	18.07	24043423
1299	Phosphorylation	SSLSSTSYSSPAHPV CCCCCCCCCCCCCCC	17.16	18452278
1301	Phosphorylation	LSSTSYSSPAHPVST CCCCCCCCCCCCCCC	20.20	18452278
1333	Phosphorylation	HSGNSTGSNLPRRSC CCCCCCCCCCCCCCC	34.97	-
1339	Phosphorylation	GSNLPRRSCPSSAAS CCCCCCCCCCCCCCC	31.49	-
1357	Phosphorylation	QGPSDSPTSDSVSQS CCCCCCCCCCCCCCC	49.47	-
1368	Phosphorylation	VSQSSTGTLSSTSFP CCCCCCCCCCCCCCC	24.45	-
1417	Methylation	NSQHYPHRGSGGVHQ CCCCCCCCCCCCCEE	36.15	115916521
1419	Phosphorylation	QHYPHRGSGGVHQYR CCCCCCCCCCCEEEE	32.12	28555341
1433	Phosphorylation	RLQPLQGSGVKTQTG EEEECCCCCCCCCCC	27.70	28674419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SETD5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SETD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SETD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPPA2_HUMAN	DPPA2	physical	16189514
LDOC1_HUMAN	LDOC1	physical	19060904
CEP70_HUMAN	CEP70	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615761	Mental retardation, autosomal dominant 23 (MRD23)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SETD5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-1020, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1125 AND SER-1198, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1269, AND MASSSPECTROMETRY.	18220336 [Abstract]