K1C40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C40_HUMAN
• UniProt AC: Q6A162
• Protein Name: Keratin, type I cytoskeletal 40
• Gene Name: KRT40
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Protein Description: May play a role in late hair differentiation..
• Protein Sequence: MTSDCSSTHCSPESCGTASGCAPASSCSVETACLPGTCATSRCQTPSFLSRSRGLTGCLLPCYFTGSCNSPCLVGNCAWCEDGVFTSNEKETMQFLNDRLASYLEKVRSLEETNAELESRIQEQCEQDIPMVCPDYQRYFNTIEDLQQKILCTKAENSRLAVQLDNCKLATDDFKSKYESELSLRQLLEADISSLHGILEELTLCKSDLEAHVESLKEDLLCLKKNHEEEVNLLREQLGDRLSVELDTAPTLDLNRVLDEMRCQCETVLANNRREAEEWLAVQTEELNQQQLSSAEQLQGCQMEILELKRTASALEIELQAQQSLTESLECTVAETEAQYSSQLAQIQCLIDNLENQLAEIRCDLERQNQEYQVLLDVKARLEGEINTYWGLLDSEDSRLSCSPCSTTCTSSNTCEPCSAYVICTVENCCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSDCSSTH ------CCCCCCCCC	33.02	-
50	Phosphorylation	CQTPSFLSRSRGLTG CCCHHHHHCCCCCCC	26.63	24719451
52	Phosphorylation	TPSFLSRSRGLTGCL CHHHHHCCCCCCCCC	27.59	30576142
56	Phosphorylation	LSRSRGLTGCLLPCY HHCCCCCCCCCEEEE	28.77	30576142
87	Phosphorylation	CEDGVFTSNEKETMQ CCCCEECCCHHHHHH	31.37	30576142
103	Phosphorylation	LNDRLASYLEKVRSL HHHHHHHHHHHHHCH	17.17	-
183	Phosphorylation	SKYESELSLRQLLEA HHHHHHCHHHHHHHH	19.90	24719451
311	Phosphorylation	EILELKRTASALEIE HHHHHHHHHHHHHHH	24.31	-
313	Phosphorylation	LELKRTASALEIELQ HHHHHHHHHHHHHHH	32.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN792_HUMAN	ZNF792	physical	25416956
CA216_HUMAN	C1orf216	physical	25416956
K2C72_HUMAN	KRT72	physical	25416956
SHPS1_HUMAN	SIRPA	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
ZN569_HUMAN	ZNF569	physical	25416956
SYT6_HUMAN	SYT6	physical	25416956
MOB3C_HUMAN	MOB3C	physical	25416956
DCD2B_HUMAN	DCDC2B	physical	25416956
C2CD6_HUMAN	ALS2CR11	physical	25416956
ZMAT2_HUMAN	ZMAT2	physical	25416956
CC112_HUMAN	CCDC112	physical	25416956
CF206_HUMAN	C6orf165	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
CH048_HUMAN	C8orf48	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
CC185_HUMAN	CCDC185	physical	25416956
CD20B_HUMAN	CDC20B	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
FA71C_HUMAN	FAM71C	physical	25416956
CCER1_HUMAN	CCER1	physical	25416956
GGN_HUMAN	GGN	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
SPA24_HUMAN	SPATA24	physical	25416956
UCMA_HUMAN	UCMA	physical	25416956
ZBT38_HUMAN	ZBTB38	physical	25416956
TTL10_HUMAN	TTLL10	physical	25416956
T10IP_HUMAN	TSGA10IP	physical	25416956
ZN844_HUMAN	ZNF844	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
CE060_HUMAN	C5orf60	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
K2C6C_HUMAN	KRT6C	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
ARSI_HUMAN	ARSI	physical	25416956
KLH38_HUMAN	KLHL38	physical	25416956
CL18A_HUMAN	CLEC18A	physical	25416956
LCE3E_HUMAN	LCE3E	physical	25416956
CATIP_HUMAN	CATIP	physical	25416956
CK087_HUMAN	C11orf87	physical	25416956
CJ062_HUMAN	C10orf62	physical	25416956
CF226_HUMAN	C6orf226	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.