SPA24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPA24_HUMAN
• UniProt AC: Q86W54
• Protein Name: Spermatogenesis-associated protein 24
• Gene Name: SPATA24
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Associated with chromatin..
• Protein Description: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity)..
• Protein Sequence: MATPLGWSKAGSGSVCLALDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFRNHMSDFRIQKQQESYMAQVLDQKHKKASGTRQARSHQHPREK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	ATPLGWSKAGSGSVC CCCCCCCCCCCHHHE	50.70	-
12	Phosphorylation	LGWSKAGSGSVCLAL CCCCCCCCHHHEEHH	32.52	25693802
14	Phosphorylation	WSKAGSGSVCLALDQ CCCCCCHHHEEHHHH	16.03	25693802
28	Phosphorylation	QLRDVIESQEELIHQ HHHHHHHCHHHHHHH	31.59	-
59	Trimethylation	EFQAVEKKLVEEKAA HHHHHHHHHHHHHHH	44.23	-
59	Methylation	EFQAVEKKLVEEKAA HHHHHHHHHHHHHHH	44.23	-
70	Phosphorylation	EKAAHAKTKVLLAKE HHHHHHHHHHHHHCC	27.46	22210691
93	Ubiquitination	GEVEVLSKQLEKEKL HHHHHHHHHHHHHHH	55.53	29967540
107	Phosphorylation	LAFEKALSSVKSKVL HHHHHHHHHHHHHHH	37.63	-
108	Phosphorylation	AFEKALSSVKSKVLQ HHHHHHHHHHHHHHH	34.12	-
117	Phosphorylation	KSKVLQESSKKDQLI HHHHHHHHHHHHHHH	34.20	-
149	Ubiquitination	NGKENEIKELQQVIS CCCHHHHHHHHHHHH	46.31	29967540
159	Ubiquitination	QQVISQQKQIFRNHM HHHHHHHHHHHHHHH	37.41	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPA24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPA24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPA24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
DCA17_HUMAN	DCAF17	physical	28514442
STXB2_HUMAN	STXBP2	physical	28514442
THNS1_HUMAN	THNSL1	physical	28514442
TRIM9_HUMAN	TRIM9	physical	28514442
GRPE1_HUMAN	GRPEL1	physical	28514442
GGPPS_HUMAN	GGPS1	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
UBR1_HUMAN	UBR1	physical	28514442
DHYS_HUMAN	DHPS	physical	28514442
RBM26_HUMAN	RBM26	physical	28514442
DCAF5_HUMAN	DCAF5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.