dbPTM

DCAF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCAF5_HUMAN
UniProt AC	Q96JK2
Protein Name	DDB1- and CUL4-associated factor 5
Gene Name	DCAF5
Organism	Homo sapiens (Human).
Sequence Length	942
Subcellular Localization
Protein Description	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
Protein Sequence	MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTREDPTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSEKKLKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RRAGLGGSMRSVVGF CCCCCCHHHHHHHHH	14.82	27251275
89	Phosphorylation	HMEQAIHSRVKPIQL EHHHHHHHCCCCCEE	32.43	29083192
92	Ubiquitination	QAIHSRVKPIQLKGE HHHHHCCCCCEECCC	34.98	-
209	Ubiquitination	LLATANSKEGVGLWD EEEECCCCCCCCCCC	59.29	-
219	Ubiquitination	VGLWDIRKPQSSLLR CCCCCCCCCHHHCEE	47.98	-
223	Phosphorylation	DIRKPQSSLLRYGGN CCCCCHHHCEEECCC	26.61	24719451
235	Phosphorylation	GGNLSLQSAMSVRFN CCCEEECEEEEEEEC	31.09	25002506
238	Phosphorylation	LSLQSAMSVRFNSNG EEECEEEEEEECCCC	15.17	25002506
260	Phosphorylation	RRLPPVLYDIHSRLP HCCCCCEEEHHHCCC	17.06	24719451
264	Phosphorylation	PVLYDIHSRLPVFQF CCEEEHHHCCCEEEE	35.53	24719451
363	Ubiquitination	IIKIWSPYKQPGCTG HHHHHCCCCCCCCCC	19.42	-
364	"N6,N6-dimethyllysine"	IKIWSPYKQPGCTGD HHHHCCCCCCCCCCC	54.09	-
364	Methylation	IKIWSPYKQPGCTGD HHHHCCCCCCCCCCC	54.09	-
364	Ubiquitination	IKIWSPYKQPGCTGD HHHHCCCCCCCCCCC	54.09	-
454	Phosphorylation	HAGVSERSGYTDSES HCCCCCCCCCCCCCC	31.90	27732954
456	Phosphorylation	GVSERSGYTDSESSA CCCCCCCCCCCCCCC	14.50	27732954
457	Phosphorylation	VSERSGYTDSESSAS CCCCCCCCCCCCCCC	36.25	27732954
459	Phosphorylation	ERSGYTDSESSASLP CCCCCCCCCCCCCCC	31.42	27732954
461	Phosphorylation	SGYTDSESSASLPRS CCCCCCCCCCCCCCC	34.85	27732954
462	Phosphorylation	GYTDSESSASLPRSP CCCCCCCCCCCCCCC	20.16	27732954
464	Phosphorylation	TDSESSASLPRSPPP CCCCCCCCCCCCCCC	40.63	24719451
468	Phosphorylation	SSASLPRSPPPTVDE CCCCCCCCCCCCCCC	39.56	30266825
472	Phosphorylation	LPRSPPPTVDESADN CCCCCCCCCCCCCCC	46.49	23663014
476	Phosphorylation	PPPTVDESADNAFHL CCCCCCCCCCCCEEC	36.14	30266825
489	Phosphorylation	HLGPLRVTTTNTVAS ECCCEEEEECCCCCC	22.82	22199227
490	Phosphorylation	LGPLRVTTTNTVAST CCCEEEEECCCCCCC	18.39	22199227
491	Phosphorylation	GPLRVTTTNTVASTP CCEEEEECCCCCCCC	21.37	22199227
493	Phosphorylation	LRVTTTNTVASTPPT EEEEECCCCCCCCCC	18.50	22199227
496	Phosphorylation	TTTNTVASTPPTPTC EECCCCCCCCCCCCH	36.79	26657352
497	Phosphorylation	TTNTVASTPPTPTCE ECCCCCCCCCCCCHH	24.45	21712546
500	Phosphorylation	TVASTPPTPTCEDAA CCCCCCCCCCHHHHH	32.22	21712546
502	Phosphorylation	ASTPPTPTCEDAASR CCCCCCCCHHHHHHH	30.88	22199227
508	Phosphorylation	PTCEDAASRQQRLSA CCHHHHHHHHHHHHH	32.13	29978859
528	Phosphorylation	DKRLLALSNESDSEE HHHHHHHCCCCCCCC	32.70	27732954
531	Phosphorylation	LLALSNESDSEENVC HHHHCCCCCCCCCEE	51.17	25849741
533	Phosphorylation	ALSNESDSEENVCEV HHCCCCCCCCCEEEE	56.97	27732954
552	Phosphorylation	DLFPRPRSPSPEDES CCCCCCCCCCCCCCC	32.20	-
561	Phosphorylation	SPEDESSSSSSSSSS CCCCCCCCCCCCCCC	43.44	-
562	Phosphorylation	PEDESSSSSSSSSSE CCCCCCCCCCCCCCC	35.87	-
563	Phosphorylation	EDESSSSSSSSSSED CCCCCCCCCCCCCCC	35.87	-
564	Phosphorylation	DESSSSSSSSSSEDE CCCCCCCCCCCCCCH	35.87	-
568	Phosphorylation	SSSSSSSSEDEEELN CCCCCCCCCCHHHHH	51.52	-
580	Phosphorylation	ELNERRASTWQRNAM HHHHHHHHHHHHHHH	28.50	22210691
581	Phosphorylation	LNERRASTWQRNAMR HHHHHHHHHHHHHHH	25.32	22210691
583 (in isoform 2)	Ubiquitination	-	28.92	21906983
596 (in isoform 2)	Ubiquitination	-	69.19	21906983
604	Ubiquitination	DKPSAPIKPTNTYIG CCCCCCCCCCCEEEC	44.74	-
606	Phosphorylation	PSAPIKPTNTYIGED CCCCCCCCCEEECCC	34.88	30576142
609	Phosphorylation	PIKPTNTYIGEDNYD CCCCCCEEECCCCCC	14.70	27642862
615	Phosphorylation	TYIGEDNYDYPQIKV EEECCCCCCCCCEEH	29.22	28796482
617	Phosphorylation	IGEDNYDYPQIKVDD ECCCCCCCCCEEHHH	6.15	28796482
617 (in isoform 2)	Ubiquitination	-	6.15	21906983
626	Phosphorylation	QIKVDDLSSSPTSSP CEEHHHCCCCCCCCC	35.45	23927012
627	Phosphorylation	IKVDDLSSSPTSSPE EEHHHCCCCCCCCCC	47.86	23927012
628	Phosphorylation	KVDDLSSSPTSSPER EHHHCCCCCCCCCCC	28.90	23401153
630	Phosphorylation	DDLSSSPTSSPERST HHCCCCCCCCCCCCC	43.73	23927012
631	Phosphorylation	DLSSSPTSSPERSTS HCCCCCCCCCCCCCC	47.48	23927012
632	Phosphorylation	LSSSPTSSPERSTST CCCCCCCCCCCCCCE	33.00	23927012
636	Phosphorylation	PTSSPERSTSTLEIQ CCCCCCCCCCEEEEC	25.66	23927012
637	Phosphorylation	TSSPERSTSTLEIQP CCCCCCCCCEEEECC	31.77	23927012
638	Phosphorylation	SSPERSTSTLEIQPS CCCCCCCCEEEECCC	32.04	23401153
639	Phosphorylation	SPERSTSTLEIQPSR CCCCCCCEEEECCCC	28.62	23927012
645	Phosphorylation	STLEIQPSRASPTSD CEEEECCCCCCCCCC	24.89	23401153
648	Phosphorylation	EIQPSRASPTSDIES EECCCCCCCCCCHHH	27.83	19664994
650	Phosphorylation	QPSRASPTSDIESVE CCCCCCCCCCHHHHH	36.21	29255136
651	Phosphorylation	PSRASPTSDIESVER CCCCCCCCCHHHHHH	39.72	30278072
655	Phosphorylation	SPTSDIESVERKIYK CCCCCHHHHHHHHHH	29.61	30278072
661	Phosphorylation	ESVERKIYKAYKWLR HHHHHHHHHHHHHHH	7.81	30576142
664	Ubiquitination	ERKIYKAYKWLRYSY HHHHHHHHHHHHHEE	9.88	-
664	Phosphorylation	ERKIYKAYKWLRYSY HHHHHHHHHHHHHEE	9.88	30576142
665	Ubiquitination	RKIYKAYKWLRYSYI HHHHHHHHHHHHEEE	44.61	21906983
665 (in isoform 1)	Ubiquitination	-	44.61	21906983
670	Phosphorylation	AYKWLRYSYISYSNN HHHHHHHEEEEEECC	15.00	25599653
673	Phosphorylation	WLRYSYISYSNNKDG HHHHEEEEEECCCCC	17.80	27050516
675	Phosphorylation	RYSYISYSNNKDGET HHEEEEEECCCCCCE	27.43	27050516
677	Ubiquitination	SYISYSNNKDGETSL EEEEEECCCCCCEEE	37.54	-
678	Ubiquitination	YISYSNNKDGETSLV EEEEECCCCCCEEEE	71.94	21906983
678 (in isoform 1)	Ubiquitination	-	71.94	21906983
683	Phosphorylation	NNKDGETSLVTGEAD CCCCCCEEEEEEECC	19.28	28674419
698	Ubiquitination	EGRAGTSHKDNPAPS CCCCCCCCCCCCCCC	41.13	-
699	Ubiquitination	GRAGTSHKDNPAPSS CCCCCCCCCCCCCCC	59.99	2190698
699 (in isoform 1)	Ubiquitination	-	59.99	21906983
708	Ubiquitination	NPAPSSSKEACLNIA CCCCCCCHHHHHHHH	51.80	-
740	Phosphorylation	FKEETPRTPSNGPGH CCCCCCCCCCCCCCC	32.07	27251275
742	Phosphorylation	EETPRTPSNGPGHEH CCCCCCCCCCCCCCC	54.53	27251275
750	Phosphorylation	NGPGHEHSSHAWAEV CCCCCCCCCCCEEEC	22.34	27251275
751	Phosphorylation	GPGHEHSSHAWAEVP CCCCCCCCCCEEECC	21.09	27251275
794	Phosphorylation	SRAEEPPSPPVPKAS CCCCCCCCCCCCCCC	53.18	19664994
801	Phosphorylation	SPPVPKASGSTLNSG CCCCCCCCCCCCCCC	39.13	26074081
803	Phosphorylation	PVPKASGSTLNSGSG CCCCCCCCCCCCCCC	27.50	26074081
804	Phosphorylation	VPKASGSTLNSGSGN CCCCCCCCCCCCCCC	33.22	26074081
807	Phosphorylation	ASGSTLNSGSGNCPR CCCCCCCCCCCCCCC	37.13	26074081
809	Phosphorylation	GSTLNSGSGNCPRTQ CCCCCCCCCCCCCCC	27.01	26074081
815	Phosphorylation	GSGNCPRTQSDDSEE CCCCCCCCCCCCCCH	19.98	26074081
817	Phosphorylation	GNCPRTQSDDSEERS CCCCCCCCCCCCHHH	42.65	26074081
859	Phosphorylation	GELEVVAYSSPGHSD EEEEEEEECCCCCCC	9.70	26074081
860	Phosphorylation	ELEVVAYSSPGHSDT EEEEEEECCCCCCCC	21.96	26074081
861	Phosphorylation	LEVVAYSSPGHSDTD EEEEEECCCCCCCCC	23.40	26074081
865	Phosphorylation	AYSSPGHSDTDRDNS EECCCCCCCCCCCCC	48.39	26074081
867	Phosphorylation	SSPGHSDTDRDNSSL CCCCCCCCCCCCCCC	35.63	26074081
872	Phosphorylation	SDTDRDNSSLTGTLL CCCCCCCCCCCCEEE	30.89	26074081
873	Phosphorylation	DTDRDNSSLTGTLLH CCCCCCCCCCCEEEE	35.88	26074081
875	Phosphorylation	DRDNSSLTGTLLHKD CCCCCCCCCEEEEEC	30.02	26074081
877	Phosphorylation	DNSSLTGTLLHKDCC CCCCCCCEEEEECCC	22.40	26074081
886	Phosphorylation	LHKDCCGSEMACETP EEECCCCCCEEECCC	15.41	26074081
892	Phosphorylation	GSEMACETPNAGTRE CCCEEECCCCCCCCC	23.02	21815630
904	Phosphorylation	TREDPTDTPATDSSR CCCCCCCCCCCCCCH	19.80	21815630
910	Phosphorylation	DTPATDSSRAVHGHS CCCCCCCCHHHCCCC	27.37	30576142
917	Phosphorylation	SRAVHGHSGLKRQRI CHHHCCCCCCCCCCE	50.87	24719451
920	Acetylation	VHGHSGLKRQRIELE HCCCCCCCCCCEECC	50.43	24431581
929	Phosphorylation	QRIELEDTDSENSSS CCEECCCCCCCCCCC	31.86	30576142
931	Phosphorylation	IELEDTDSENSSSEK EECCCCCCCCCCCCC	40.55	28985074
934	Phosphorylation	EDTDSENSSSEKKLK CCCCCCCCCCCCCCC	31.05	27732954
935	Phosphorylation	DTDSENSSSEKKLKT CCCCCCCCCCCCCCC	54.84	24719451
936	Phosphorylation	TDSENSSSEKKLKT- CCCCCCCCCCCCCC-	53.94	27732954
938	Acetylation	SENSSSEKKLKT--- CCCCCCCCCCCC---	66.41	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCAF5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCAF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCAF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
TCPA_HUMAN	TCP1	physical	26186194
TCPH_HUMAN	CCT7	physical	26186194
PFD4_HUMAN	PFDN4	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPZ_HUMAN	CCT6A	physical	26186194
TCPB_HUMAN	CCT2	physical	26186194
TCPG_HUMAN	CCT3	physical	26186194
PFD5_HUMAN	PFDN5	physical	26186194
CH60_HUMAN	HSPD1	physical	26186194
PDRG1_HUMAN	PDRG1	physical	26186194
PFD6_HUMAN	PFDN6	physical	26186194
PFD3_HUMAN	VBP1	physical	26186194
TCPG_HUMAN	CCT3	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
PFD6_HUMAN	PFDN6	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
PFD4_HUMAN	PFDN4	physical	28514442
PFD1_HUMAN	PFDN1	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
PFD3_HUMAN	VBP1	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCAF5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648 AND SER-651, ANDMASS SPECTROMETRY.	19690332 [Abstract]