dbPTM

CUL4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CUL4A_HUMAN
UniProt AC	Q13619
Protein Name	Cullin-4A
Gene Name	CUL4A
Organism	Homo sapiens (Human).
Sequence Length	759
Subcellular Localization
Protein Description	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL..
Protein Sequence	MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MADEAPRKGSFSALV CCCCCCCCCCHHHHH	58.82	26051181
8	Sumoylation	MADEAPRKGSFSALV CCCCCCCCCCHHHHH	58.82	28112733
8	Ubiquitination	MADEAPRKGSFSALV CCCCCCCCCCHHHHH	58.82	-
10	Phosphorylation	DEAPRKGSFSALVGR CCCCCCCCHHHHHCC	21.04	29255136
12	Phosphorylation	APRKGSFSALVGRTN CCCCCCHHHHHCCCC	23.53	30266825
22	Phosphorylation	VGRTNGLTKPAALAA HCCCCCCCCHHHHHC	36.06	22817900
23	Acetylation	GRTNGLTKPAALAAA CCCCCCCCHHHHHCC	37.39	26051181
33	Acetylation	ALAAAPAKPGGAGGS HHHCCCCCCCCCCCC	43.04	26051181
33	Ubiquitination	ALAAAPAKPGGAGGS HHHCCCCCCCCCCCC	43.04	18781797
40	Phosphorylation	KPGGAGGSKKLVIKN CCCCCCCCCEEEEEC	26.21	29514088
41	Acetylation	PGGAGGSKKLVIKNF CCCCCCCCEEEEECC	54.09	12435295
42	Acetylation	GGAGGSKKLVIKNFR CCCCCCCEEEEECCC	50.08	12436343
58	Phosphorylation	RPRLPDNYTQDTWRK CCCCCCCCCHHHHHH	17.10	27642862
75	Phosphorylation	EAVRAVQSSTSIRYN HHHHHHHCCCCCCCC	29.05	20860994
76	Phosphorylation	AVRAVQSSTSIRYNL HHHHHHCCCCCCCCH	14.75	21406692
77	Phosphorylation	VRAVQSSTSIRYNLE HHHHHCCCCCCCCHH	33.16	21406692
78	Phosphorylation	RAVQSSTSIRYNLEE HHHHCCCCCCCCHHH	13.66	21406692
99	Phosphorylation	NLCSHKVSPMLYKQL HHHHCCCCHHHHHHH	14.92	19413330
104	Acetylation	KVSPMLYKQLRQACE CCCHHHHHHHHHHHH	38.60	25953088
104	Malonylation	KVSPMLYKQLRQACE CCCHHHHHHHHHHHH	38.60	26320211
104	Ubiquitination	KVSPMLYKQLRQACE CCCHHHHHHHHHHHH	38.60	-
104 (in isoform 1)	Ubiquitination	-	38.60	21890473
133	Acetylation	LDSVLFLKKINTCWQ CHHHHHHHHHHHHCH	44.25	27452117
133	Ubiquitination	LDSVLFLKKINTCWQ CHHHHHHHHHHHHCH	44.25	-
151	Phosphorylation	RQMIMIRSIFLFLDR HHHHHHHHHHHHCCC	13.53	21712546
159	Phosphorylation	IFLFLDRTYVLQNST HHHHCCCCHHHCCCC	20.04	23898821
160	Phosphorylation	FLFLDRTYVLQNSTL HHHCCCCHHHCCCCC	10.48	23898821
165	Phosphorylation	RTYVLQNSTLPSIWD CCHHHCCCCCCCHHH	20.54	23898821
166	Phosphorylation	TYVLQNSTLPSIWDM CHHHCCCCCCCHHHH	50.68	23898821
169	Phosphorylation	LQNSTLPSIWDMGLE HCCCCCCCHHHHHHH	39.15	23898821
180	Phosphorylation	MGLELFRTHIISDKM HHHHHHHHHHCCCHH	15.30	23898821
184	Phosphorylation	LFRTHIISDKMVQSK HHHHHHCCCHHHCCC	30.49	23898821
186	Ubiquitination	RTHIISDKMVQSKTI HHHHCCCHHHCCCCC	33.89	-
216	Phosphorylation	VDRSLLRSLLGMLSD HCHHHHHHHHHHHCC	28.10	20068231
227	Phosphorylation	MLSDLQVYKDSFELK HHCCHHHHHCCEEEE	8.98	22817900
234	Ubiquitination	YKDSFELKFLEETNC HHCCEEEEEHHHHCC	40.48	-
259	Phosphorylation	QEREVPEYLNHVSKR HHHCHHHHHHHHHHH	13.51	-
265	Ubiquitination	EYLNHVSKRLEEEGD HHHHHHHHHHHHCCC	60.97	-
276	O-linked_Glycosylation	EEGDRVITYLDHSTQ HCCCCEEEEEECCCC	18.38	28510447
284	Acetylation	YLDHSTQKPLIACVE EEECCCCCCHHHHHH	41.71	26051181
284	Malonylation	YLDHSTQKPLIACVE EEECCCCCCHHHHHH	41.71	26320211
284	Ubiquitination	YLDHSTQKPLIACVE EEECCCCCCHHHHHH	41.71	-
292	Acetylation	PLIACVEKQLLGEHL CHHHHHHHHHHHHHH	26.33	26051181
322 (in isoform 2)	Ubiquitination	-	1.59	21890473
330	Methylation	YQLFSRVRGGQQALL HHHHHHHHHHHHHHH	42.27	-
354 (in isoform 2)	Ubiquitination	-	27.99	21890473
357	Ubiquitination	AIVINPEKDKDMVQD EEEECCCCCHHHHHH	71.92	-
359	Ubiquitination	VINPEKDKDMVQDLL EECCCCCHHHHHHHH	59.81	-
369	Ubiquitination	VQDLLDFKDKVDHVI HHHHHHHHHHHCHHH	57.20	-
391	Ubiquitination	ERFVNLMKESFETFI HHHHHHHHHHHHHHH	54.06	-
396 (in isoform 2)	Ubiquitination	-	28.01	21890473
404	Ubiquitination	FINKRPNKPAELIAK HHHCCCCCCHHHHHH	48.57	-
411	Ubiquitination	KPAELIAKHVDSKLR CCHHHHHHHHHHHHH	36.85	-
416	Ubiquitination	IAKHVDSKLRAGNKE HHHHHHHHHHCCCCC	37.21	-
422	Acetylation	SKLRAGNKEATDEEL HHHHCCCCCCCHHHH	48.05	26051181
422	Ubiquitination	SKLRAGNKEATDEEL HHHHCCCCCCCHHHH	48.05	21906983
422 (in isoform 1)	Ubiquitination	-	48.05	21890473
425	Phosphorylation	RAGNKEATDEELERT HCCCCCCCHHHHHHH	45.06	20860994
453	Phosphorylation	KDVFEAFYKKDLAKR HHHHHHHHCHHHHHH	24.95	-
454	Ubiquitination	DVFEAFYKKDLAKRL HHHHHHHCHHHHHHH	33.10	2190698
454 (in isoform 1)	Ubiquitination	-	33.10	21890473
465	Acetylation	AKRLLVGKSASVDAE HHHHHCCCCCCCHHH	35.06	25953088
465	Malonylation	AKRLLVGKSASVDAE HHHHHCCCCCCCHHH	35.06	26320211
465	Ubiquitination	AKRLLVGKSASVDAE HHHHHCCCCCCCHHH	35.06	-
473	Acetylation	SASVDAEKSMLSKLK CCCCHHHHHHHHHHH	42.77	25953088
477	Phosphorylation	DAEKSMLSKLKHECG HHHHHHHHHHHHHHC	27.57	24260401
480	Acetylation	KSMLSKLKHECGAAF HHHHHHHHHHHCHHH	40.88	26051181
480	Ubiquitination	KSMLSKLKHECGAAF HHHHHHHHHHHCHHH	40.88	-
490	Ubiquitination	CGAAFTSKLEGMFKD HCHHHHHHHHHHHCC	47.72	-
496	Acetylation	SKLEGMFKDMELSKD HHHHHHHCCCCCCHH	47.47	26051181
496	Ubiquitination	SKLEGMFKDMELSKD HHHHHHHCCCCCCHH	47.47	-
496 (in isoform 1)	Ubiquitination	-	47.47	21890473
502	Ubiquitination	FKDMELSKDIMVHFK HCCCCCCHHHHHHHH	64.99	-
541	Acetylation	PTYTPMEVHLTPEMI CCCCCCEEECCHHHH	3.49	19608861
541 (in isoform 2)	Acetylation	-	3.49	-
555	Acetylation	IKLQEVFKAFYLGKH HHHHHHHHHHHCCCC	42.64	129845
561	Acetylation	FKAFYLGKHSGRKLQ HHHHHCCCCCCCCEE	31.81	25953088
561	Ubiquitination	FKAFYLGKHSGRKLQ HHHHHCCCCCCCCEE	31.81	-
615	Sulfoxidation	FSFEEIKMATGIEDS CCHHHHHHHHCCCHH	5.05	21406390
633	S-nitrosylation	RTLQSLACGKARVLI HHHHHHHCCCEEEEE	7.53	22126794
635	Acetylation	LQSLACGKARVLIKS HHHHHCCCEEEEEEC	32.67	25953088
635	Malonylation	LQSLACGKARVLIKS HHHHHCCCEEEEEEC	32.67	26320211
635	Ubiquitination	LQSLACGKARVLIKS HHHHHCCCEEEEEEC	32.67	-
641	Acetylation	GKARVLIKSPKGKEV CCEEEEEECCCCCCC	57.45	19608861
642	Phosphorylation	KARVLIKSPKGKEVE CEEEEEECCCCCCCC	25.50	23911959
646	Acetylation	LIKSPKGKEVEDGDK EEECCCCCCCCCCCE	65.79	26051181
646	Ubiquitination	LIKSPKGKEVEDGDK EEECCCCCCCCCCCE	65.79	-
661	Ubiquitination	FIFNGEFKHKLFRIK EEECCCCCCEEEEEE	35.21	-
683	Phosphorylation	ETVEEQVSTTERVFQ HHHHHHHHHHHHHHH	29.34	24719451
684	Phosphorylation	TVEEQVSTTERVFQD HHHHHHHHHHHHHHH	33.54	25627689
692	Methylation	TERVFQDRQYQIDAA HHHHHHHHHHHHHHH	26.73	-
702	Dimethylation	QIDAAIVRIMKMRKT HHHHHHHHHHHHHHH	19.71	-
705	Ubiquitination	AAIVRIMKMRKTLGH HHHHHHHHHHHHHCC	32.93	-
708	Ubiquitination	VRIMKMRKTLGHNLL HHHHHHHHHHCCCHH	44.60	-
724	Ubiquitination	SELYNQLKFPVKPGD HHHHHHCCCCCCCCC	37.55	-
728	Acetylation	NQLKFPVKPGDLKKR HHCCCCCCCCCHHHH	43.45	25953088
728	Ubiquitination	NQLKFPVKPGDLKKR HHCCCCCCCCCHHHH	43.45	-
733	Malonylation	PVKPGDLKKRIESLI CCCCCCHHHHHHHHH	44.75	26320211
733	Ubiquitination	PVKPGDLKKRIESLI CCCCCCHHHHHHHHH	44.75	-
738	Phosphorylation	DLKKRIESLIDRDYM CHHHHHHHHHCHHHH	28.40	26074081
742	Methylation	RIESLIDRDYMERDK HHHHHHCHHHHHHCC	29.93	-
744	Phosphorylation	ESLIDRDYMERDKDN HHHHCHHHHHHCCCC	11.19	26074081
749	Ubiquitination	RDYMERDKDNPNQYH HHHHHHCCCCCCCCC	66.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CUL4A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CUL4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CUL4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAND1_HUMAN	CAND1	physical	12609982
HS90A_HUMAN	HSP90AA1	physical	12481031
NEDD8_HUMAN	NEDD8	physical	12481031
TBA1B_HUMAN	TUBA1B	physical	12481031
CDN1A_HUMAN	CDKN1A	physical	18794347
DDB1_HUMAN	DDB1	physical	18593899
DDB2_HUMAN	DDB2	physical	18593899
RBX1_HUMAN	RBX1	physical	18593899
CUL4B_HUMAN	CUL4B	physical	18593899
MERL_HUMAN	NF2	physical	18332868
UBC_HUMAN	UBC	physical	16964240
PCNA_HUMAN	PCNA	physical	16964240
CUL4B_HUMAN	CUL4B	physical	16964240
TP4AP_HUMAN	TRPC4AP	physical	16964240
DET1_HUMAN	DET1	physical	16964240
DDA1_HUMAN	DDA1	physical	16964240
NEDD8_HUMAN	NEDD8	physical	16964240
CRBN_HUMAN	CRBN	physical	16964240
CSN3_HUMAN	COPS3	physical	16964240
CSN4_HUMAN	COPS4	physical	16964240
CSN5_HUMAN	COPS5	physical	16964240
CSN2_HUMAN	COPS2	physical	16964240
CSN8_HUMAN	COPS8	physical	16964240
CSN7B_HUMAN	COPS7B	physical	16964240
CSN7A_HUMAN	COPS7A	physical	16964240
CSN6_HUMAN	COPS6	physical	16964240
DDB1_HUMAN	DDB1	physical	16964240
DDB2_HUMAN	DDB2	physical	16964240
DCA11_HUMAN	DCAF11	physical	16964240
DCAF5_HUMAN	DCAF5	physical	16964240
BRWD1_HUMAN	BRWD1	physical	16964240
PHIP_HUMAN	PHIP	physical	16964240
DCAF6_HUMAN	DCAF6	physical	16964240
DCA12_HUMAN	DCAF12	physical	16964240
DCA10_HUMAN	DCAF10	physical	16964240
DCAF4_HUMAN	DCAF4	physical	16964240
WDTC1_HUMAN	WDTC1	physical	16964240
CAND1_HUMAN	CAND1	physical	16964240
SKP2_HUMAN	SKP2	physical	16537899
CDN1B_HUMAN	CDKN1B	physical	16537899
TOIP2_HUMAN	TOR1AIP2	physical	16964240
IFG15_HUMAN	TOR1AIP2	physical	16964240
BAF_HUMAN	BANF1	physical	19759913
EMD_HUMAN	EMD	physical	19759913
DDB1_HUMAN	DDB1	physical	15811626
DDB2_HUMAN	DDB2	physical	17041588
DTL_HUMAN	DTL	physical	17041588
WDR26_HUMAN	WDR26	physical	17041588
GRWD1_HUMAN	GRWD1	physical	17041588
RBBP5_HUMAN	RBBP5	physical	17041588
RFWD2_HUMAN	RFWD2	physical	17041588
WDR5B_HUMAN	WDR5B	physical	17041588
POC1B_HUMAN	POC1B	physical	17041588
SNR40_HUMAN	SNRNP40	physical	17041588
WDR61_HUMAN	WDR61	physical	17041588
WDR76_HUMAN	WDR76	physical	17041588
WDR82_HUMAN	WDR82	physical	17041588
WDR5_HUMAN	WDR5	physical	17041588
TLE2_HUMAN	TLE2	physical	17041588
EED_HUMAN	EED	physical	17041588
DDB1_HUMAN	DDB1	physical	15448697
CAND1_HUMAN	CAND1	physical	15448697
RBX1_HUMAN	RBX1	physical	15448697
CDT1_HUMAN	CDT1	physical	15448697
RBX1_HUMAN	RBX1	physical	11861641
DDB2_HUMAN	DDB2	physical	11564859
COMD1_HUMAN	COMMD1	physical	21778237
RBX1_HUMAN	RBX1	physical	19287380
RASF1_HUMAN	RASSF1	physical	21205828
CAND1_HUMAN	CAND1	physical	21249194
DCAF1_HUMAN	VPRBP	physical	17630831
GLMN_HUMAN	GLMN	physical	22405651
RBX1_HUMAN	RBX1	physical	22405651
CAND1_HUMAN	CAND1	physical	22405651
CTNB1_HUMAN	CTNNB1	physical	17954973
CDN1B_HUMAN	CDKN1B	physical	16467204
CDT1_HUMAN	CDT1	physical	14578910
CAND1_HUMAN	CAND1	physical	12504026
P53_HUMAN	TP53	physical	16861890
MDM2_HUMAN	MDM2	physical	16861890
PCNA_HUMAN	PCNA	physical	16861890
DDB1_HUMAN	DDB1	physical	17079684
RBX1_HUMAN	RBX1	physical	17079684
DDB2_HUMAN	DDB2	physical	17079684
CDT1_HUMAN	CDT1	physical	17079684
CUL1_HUMAN	CUL1	physical	17079684
CAND1_HUMAN	CAND1	physical	17079684
DCAF1_HUMAN	VPRBP	physical	17079684
DCA11_HUMAN	DCAF11	physical	17079684
CSN1_HUMAN	GPS1	physical	17079684
CSN3_HUMAN	COPS3	physical	17079684
CSN4_HUMAN	COPS4	physical	17079684
CSN5_HUMAN	COPS5	physical	17079684
CSN6_HUMAN	COPS6	physical	17079684
CSN7A_HUMAN	COPS7A	physical	17079684
CSN7B_HUMAN	COPS7B	physical	17079684
CSN8_HUMAN	COPS8	physical	17079684
RBBP7_HUMAN	RBBP7	physical	17079684
FBXW5_HUMAN	FBXW5	physical	17079684
FBXW8_HUMAN	FBXW8	physical	17079684
RFWD2_HUMAN	RFWD2	physical	17079684
WSB1_HUMAN	WSB1	physical	17079684
WSB2_HUMAN	WSB2	physical	17079684
NUP43_HUMAN	NUP43	physical	17079684
FBW1A_HUMAN	BTRC	physical	17079684
PWP1_HUMAN	PWP1	physical	17079684
RBBP4_HUMAN	RBBP4	physical	17079684
GRWD1_HUMAN	GRWD1	physical	17079684
CHK1_HUMAN	CHEK1	physical	19808933
DCAF1_HUMAN	VPRBP	physical	18606781
CAND1_HUMAN	CAND1	physical	18606781
DDB1_HUMAN	DDB1	physical	18606781
CSN1_HUMAN	GPS1	physical	18606781
CSN2_HUMAN	COPS2	physical	18606781
CSN3_HUMAN	COPS3	physical	18606781
CSN4_HUMAN	COPS4	physical	18606781
CSN5_HUMAN	COPS5	physical	18606781
CSN6_HUMAN	COPS6	physical	18606781
CSN7A_HUMAN	COPS7A	physical	18606781
CSN7B_HUMAN	COPS7B	physical	18606781
CSN8_HUMAN	COPS8	physical	18606781
UBXN7_HUMAN	UBXN7	physical	22466964
DCAF6_HUMAN	DCAF6	physical	21145461
CUL4A_HUMAN	CUL4A	physical	21145461
DCNL1_HUMAN	DCUN1D1	physical	21145461
KAD9_HUMAN	AK9	physical	21145461
DCST1_HUMAN	DCST1	physical	21145461
WDTC1_HUMAN	WDTC1	physical	21145461
TP4AP_HUMAN	TRPC4AP	physical	21145461
DCA12_HUMAN	DCAF12	physical	21145461
CSN4_HUMAN	COPS4	physical	21145461
PHIP_HUMAN	PHIP	physical	21145461
DCAF8_HUMAN	DCAF8	physical	21145461
AMRA1_HUMAN	AMBRA1	physical	21145461
DCAF1_HUMAN	VPRBP	physical	21145461
DDB2_HUMAN	DDB2	physical	21145461
DCAF4_HUMAN	DCAF4	physical	21145461
CSN3_HUMAN	COPS3	physical	21145461
CSN1_HUMAN	GPS1	physical	21145461
DCA11_HUMAN	DCAF11	physical	21145461
DDB1_HUMAN	DDB1	physical	21145461
CSN5_HUMAN	COPS5	physical	21145461
DC122_HUMAN	DCAF12L2	physical	21145461
CSN2_HUMAN	COPS2	physical	21145461
CRBN_HUMAN	CRBN	physical	21145461
CSN7A_HUMAN	COPS7A	physical	21145461
DCA16_HUMAN	DCAF16	physical	21145461
ERCC8_HUMAN	ERCC8	physical	21145461
BRWD1_HUMAN	BRWD1	physical	21145461
DTL_HUMAN	DTL	physical	21145461
CUL4B_HUMAN	CUL4B	physical	21145461
CSN6_HUMAN	COPS6	physical	21145461
CUL5_HUMAN	CUL5	physical	21145461
DC4L1_HUMAN	DCAF4L1	physical	21145461
CAND1_HUMAN	CAND1	physical	21145461
CSN7B_HUMAN	COPS7B	physical	21145461
DDA1_HUMAN	DDA1	physical	21145461
TOIP2_HUMAN	TOR1AIP2	physical	21145461
IFG15_HUMAN	TOR1AIP2	physical	21145461
CSN8_HUMAN	COPS8	physical	21145461
IF2B1_HUMAN	IGF2BP1	physical	21145461
CSN9_HUMAN	MYEOV2	physical	21145461
DCAF5_HUMAN	DCAF5	physical	21145461
NEDD8_HUMAN	NEDD8	physical	21145461
APC5_HUMAN	ANAPC5	physical	21145461
CDY2_HUMAN	CDY2A	physical	21145461
OTUL_HUMAN	OTULIN	physical	21145461
NXPH3_HUMAN	NXPH3	physical	21145461
RFWD2_HUMAN	RFWD2	physical	21145461
RGS12_HUMAN	RGS12	physical	21145461
SCAFB_HUMAN	SCAF11	physical	21145461
SH3R2_HUMAN	SH3RF2	physical	21145461
SLAP1_HUMAN	SLA	physical	21145461
TCHP_HUMAN	TCHP	physical	21145461
DCA10_HUMAN	DCAF10	physical	21145461
UBP7_HUMAN	USP7	physical	21145461
MAP4_HUMAN	MAP4	physical	21145461
ABCAA_HUMAN	ABCA10	physical	21145461
XXLT1_HUMAN	XXYLT1	physical	21145461
SYNEM_HUMAN	SYNM	physical	21145461
ZN407_HUMAN	ZNF407	physical	21145461
CSR2B_HUMAN	CSRP2BP	physical	21145461
RL26_HUMAN	RPL26	physical	21145461
GHC1_HUMAN	SLC25A22	physical	21145461
SFXN1_HUMAN	SFXN1	physical	21145461
HSP7C_HUMAN	HSPA8	physical	21145461
TFG_HUMAN	TFG	physical	21145461
CUL3_HUMAN	CUL3	physical	21145461
K1C10_HUMAN	KRT10	physical	21145461
DCAF7_HUMAN	DCAF7	physical	21145461
CAH2_HUMAN	CA2	physical	21145461
KLHL9_HUMAN	KLHL9	physical	21145461
K2C1_HUMAN	KRT1	physical	21145461
FUS_HUMAN	FUS	physical	21145461
K1C9_HUMAN	KRT9	physical	21145461
TBB4B_HUMAN	TUBB4B	physical	21145461
ENPL_HUMAN	HSP90B1	physical	21145461
PRS10_HUMAN	PSMC6	physical	21145461
SKP1_HUMAN	SKP1	physical	21145461
TBA4A_HUMAN	TUBA4A	physical	21145461
UBC_HUMAN	UBC	physical	21145461
EWS_HUMAN	EWSR1	physical	21145461
H2AV_HUMAN	H2AFV	physical	21145461
HAX1_HUMAN	HAX1	physical	21145461
ROA2_HUMAN	HNRNPA2B1	physical	21145461
HNRL1_HUMAN	HNRNPUL1	physical	21145461
HS71L_HUMAN	HSPA1L	physical	21145461
SYIC_HUMAN	IARS	physical	21145461
K22E_HUMAN	KRT2	physical	21145461
K1C24_HUMAN	KRT24	physical	21145461
PHS_HUMAN	PCBD1	physical	21145461
PWP1_HUMAN	PWP1	physical	21145461
SMD1_HUMAN	SNRPD1	physical	21145461
TBA1C_HUMAN	TUBA1C	physical	21145461
TBB1_HUMAN	TUBB1	physical	21145461
HNRH1_HUMAN	HNRNPH1	physical	21145461
HNRH3_HUMAN	HNRNPH3	physical	21145461
GRP78_HUMAN	HSPA5	physical	21145461
LG3BP_HUMAN	LGALS3BP	physical	21145461
NUCL_HUMAN	NCL	physical	21145461
PABP1_HUMAN	PABPC1	physical	21145461
2AAA_HUMAN	PPP2R1A	physical	21145461
SNRPA_HUMAN	SNRPA	physical	21145461
RSMB_HUMAN	SNRPB	physical	21145461
TCPE_HUMAN	CCT5	physical	21145461
DJC10_HUMAN	DNAJC10	physical	21145461
EF1A1_HUMAN	EEF1A1	physical	21145461
EF1A2_HUMAN	EEF1A2	physical	21145461
ENOA_HUMAN	ENO1	physical	21145461
ROAA_HUMAN	HNRNPAB	physical	21145461
HNRPF_HUMAN	HNRNPF	physical	21145461
HNRDL_HUMAN	HNRNPDL	physical	21145461
GRP75_HUMAN	HSPA9	physical	21145461
K22O_HUMAN	KRT76	physical	21145461
PRDX1_HUMAN	PRDX1	physical	21145461
QPCT_HUMAN	QPCT	physical	21145461
RL15_HUMAN	RPL15	physical	21145461
RL7A_HUMAN	RPL7A	physical	21145461
RLA2_HUMAN	RPLP2	physical	21145461
RS2_HUMAN	RPS2	physical	21145461
SRSF3_HUMAN	SRSF3	physical	21145461
ADT2_HUMAN	SLC25A5	physical	21145461
ADT3_HUMAN	SLC25A6	physical	21145461
SSBP_HUMAN	SSBP1	physical	21145461
RBP56_HUMAN	TAF15	physical	21145461
TBB5_HUMAN	TUBB	physical	21145461
BAG4_HUMAN	BAG4	physical	21145461
C1QBP_HUMAN	C1QBP	physical	21145461
DDX21_HUMAN	DDX21	physical	21145461
DDX5_HUMAN	DDX5	physical	21145461
DHX15_HUMAN	DHX15	physical	21145461
DHX9_HUMAN	DHX9	physical	21145461
H2A1B_HUMAN	HIST1H2AE	physical	21145461
H2A1J_HUMAN	HIST1H2AJ	physical	21145461
H2A1_HUMAN	HIST1H2AI	physical	21145461
HNRPD_HUMAN	HNRNPD	physical	21145461
HS90A_HUMAN	HSP90AA1	physical	21145461
HS90B_HUMAN	HSP90AB1	physical	21145461
CH60_HUMAN	HSPD1	physical	21145461
K2C75_HUMAN	KRT75	physical	21145461
NFKB1_HUMAN	NFKB1	physical	21145461
NPM_HUMAN	NPM1	physical	21145461
PABP4_HUMAN	PABPC4	physical	21145461
RL10A_HUMAN	RPL10A	physical	21145461
RL11_HUMAN	RPL11	physical	21145461
RL19_HUMAN	RPL19	physical	21145461
RL22_HUMAN	RPL22	physical	21145461
RL23A_HUMAN	RPL23A	physical	21145461
RL38_HUMAN	RPL38	physical	21145461
RL4_HUMAN	RPL4	physical	21145461
RLA1_HUMAN	RPLP1	physical	21145461
RS14_HUMAN	RPS14	physical	21145461
RS15A_HUMAN	RPS15A	physical	21145461
RS18_HUMAN	RPS18	physical	21145461
RS20_HUMAN	RPS20	physical	21145461
RS3_HUMAN	RPS3	physical	21145461
SDHA_HUMAN	SDHA	physical	21145461
RU17_HUMAN	SNRNP70	physical	21145461
SMD3_HUMAN	SNRPD3	physical	21145461
RUXE_HUMAN	SNRPE	physical	21145461
TIA1_HUMAN	TIA1	physical	21145461
TIAR_HUMAN	TIAL1	physical	21145461
NEDD8_HUMAN	NEDD8	physical	22474075
SKP1_HUMAN	SKP1	physical	22474075
DDB1_HUMAN	DDB1	physical	22474075
RBX1_HUMAN	RBX1	physical	22474075
CASA1_HUMAN	CSN1S1	physical	22474075
CSN6_HUMAN	COPS6	physical	22474075
CSN5_HUMAN	COPS5	physical	22474075
CAND1_HUMAN	CAND1	physical	22474075
FBXW5_HUMAN	FBXW5	physical	22910413
LRWD1_HUMAN	LRWD1	physical	22935713
DDB1_HUMAN	DDB1	physical	22342275
DDB1_HUMAN	DDB1	physical	16260596
DDB2_HUMAN	DDB2	physical	16260596
DDB1_HUMAN	DDB1	physical	22952844
GRK5_HUMAN	GRK5	physical	22952844
LTP_EBVB9	BPLF1	physical	20190741
SENP8_HUMAN	SENP8	physical	20190741
RFWD2_HUMAN	RFWD2	physical	19295130
CSN2_HUMAN	COPS2	physical	19295130
CSN3_HUMAN	COPS3	physical	19295130
CSN4_HUMAN	COPS4	physical	19295130
CSN5_HUMAN	COPS5	physical	19295130
CSN6_HUMAN	COPS6	physical	19295130
CSN7A_HUMAN	COPS7A	physical	19295130
CSN7B_HUMAN	COPS7B	physical	19295130
CSN8_HUMAN	COPS8	physical	19295130
UBC_HUMAN	UBC	physical	19295130
NEDD8_HUMAN	NEDD8	physical	19295130
RBX1_HUMAN	RBX1	physical	19295130
DDB1_HUMAN	DDB1	physical	19295130
DDB2_HUMAN	DDB2	physical	19295130
DCAF6_HUMAN	DCAF6	physical	19295130
DCAF1_HUMAN	VPRBP	physical	19295130
AMRA1_HUMAN	AMBRA1	physical	19295130
DCA11_HUMAN	DCAF11	physical	19295130
DCAF8_HUMAN	DCAF8	physical	19295130
PWP1_HUMAN	PWP1	physical	19295130
PHIP_HUMAN	PHIP	physical	19295130
DDA1_HUMAN	DDA1	physical	19295130
DCA15_HUMAN	DCAF15	physical	19295130
DCA16_HUMAN	DCAF16	physical	19295130
CAND1_HUMAN	CAND1	physical	19295130
DDB1_HUMAN	DDB1	physical	22939629
SGT1_HUMAN	SUGT1	physical	22939629
CUL4B_HUMAN	CUL4B	physical	23555860
SF3B3_HUMAN	SF3B3	physical	23951410
DICER_HUMAN	DICER1	physical	23849790
RHG07_HUMAN	DLC1	physical	24082123
ICAL_HUMAN	CAST	physical	22863883
ANM5_HUMAN	PRMT5	physical	22863883
RBX1_HUMAN	RBX1	physical	22863883
CSN2_HUMAN	COPS2	physical	25349427
CSN5_HUMAN	COPS5	physical	25349427
DDB1_HUMAN	DDB1	physical	25349427
RBX1_HUMAN	RBX1	physical	17452440
LTP_EBVB9	BPLF1	physical	22474075
LTP_HHV8P	ORF64	physical	22474075
TERA_HUMAN	VCP	physical	22466964
CLCN1_HUMAN	CLCN1	physical	26021757
TBG1_HUMAN	TUBG1	physical	25542213
AMRA1_HUMAN	AMBRA1	physical	25499913
DDB1_HUMAN	DDB1	physical	26344197
CENPA_HUMAN	CENPA	physical	25727006
CRBN_HUMAN	CRBN	physical	26231201
DDB1_HUMAN	DDB1	physical	26231201
GBB2_HUMAN	GNB2	physical	25982117
DDB1_HUMAN	DDB1	physical	25982117
GBB1_HUMAN	GNB1	physical	25982117
GBB3_HUMAN	GNB3	physical	25982117
GBB4_HUMAN	GNB4	physical	25982117
GNB5_HUMAN	GNB5	physical	25982117
DDB1_HUMAN	DDB1	physical	25795299
RBBP7_HUMAN	RBBP7	physical	25795299
DDB1_HUMAN	DDB1	physical	26613412
CDN1A_HUMAN	CDKN1A	physical	26613412
CDN1B_HUMAN	CDKN1B	physical	26613412
UBC_HUMAN	UBC	physical	27001857
CUL4A_HUMAN	CUL4A	physical	17254749
CUL4A_HUMAN	CUL4A	physical	16751180
DDB1_HUMAN	DDB1	physical	27203177
CAND1_HUMAN	CAND1	physical	27203177
UVRAG_HUMAN	UVRAG	physical	27203177
CSN2_HUMAN	COPS2	physical	26976604
CSN5_HUMAN	COPS5	physical	26976604
DDB1_HUMAN	DDB1	physical	26976604
RBX1_HUMAN	RBX1	physical	26976604
CSN1_HUMAN	GPS1	physical	26976604
RBX1_HUMAN	RBX1	physical	26990986
SLBP_HUMAN	SLBP	physical	27254819
FKBP8_HUMAN	FKBP8	physical	27580824
CRBN_HUMAN	CRBN	physical	27294876
IKZF3_HUMAN	IKZF3	physical	27294876
DDB1_HUMAN	DDB1	physical	27294876
LATS1_HUMAN	LATS1	physical	28420424
DDB1_HUMAN	DDB1	physical	28886238

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CUL4A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-22, UBIQUITINATION[LARGE SCALE ANALYSIS] AT LYS-33, AND MASS SPECTROMETRY.	18781797 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-227, AND MASSSPECTROMETRY.	18187866 [Abstract]
Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-22, UBIQUITINATION[LARGE SCALE ANALYSIS] AT LYS-33, AND MASS SPECTROMETRY.	18781797 [Abstract]