ABCAA_HUMAN - dbPTM
ABCAA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCAA_HUMAN
UniProt AC Q8WWZ4
Protein Name ATP-binding cassette sub-family A member 10
Gene Name ABCA10
Organism Homo sapiens (Human).
Sequence Length 1543
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Probable transporter which may play a role in macrophage lipid homeostasis..
Protein Sequence MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIKEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationRLKFNWGYRIPVIKE
EEECCCCCCCEEEEC		9.2938509
307PhosphorylationPDPSGDSYKMIATFF
CCCCCCHHHHHHHHH		14.8716094384
519PhosphorylationIMELDMQSIQDIIAK
HHHHCHHHHHHHHHH		18.6446156259
527AcetylationIQDIIAKKLSGGQKR
HHHHHHHHCCCCCCC		38.57130767
529PhosphorylationDIIAKKLSGGQKRKL
HHHHHHCCCCCCCEE		50.1624702127
533AcetylationKKLSGGQKRKLTLGI
HHCCCCCCCEEEEEE		55.57130769
568PhosphorylationFSRHRVWSLLKEHKV
CCHHHHHHHHHHCCC		22.4422817900
638PhosphorylationCDTEKITSLIKQHIP
CCHHHHHHHHHHHCC		31.4124719451
730PhosphorylationTRNTGDESEMEQVLC
ECCCCCHHHHHHHHH		47.1622180431
738PhosphorylationEMEQVLCSLPETRKA
HHHHHHHCCHHHHHH		42.6822180437
742PhosphorylationVLCSLPETRKAVSSA
HHHCCHHHHHHHHHH		35.2122180443
757PhosphorylationALWRRQIYAVATLRF
HHHHHHHHHHHHHHH		6.1546156275
761PhosphorylationRQIYAVATLRFLKLR
HHHHHHHHHHHHHHH		16.3346156267
795PhosphorylationIILEKIMYKVTRETH
HHHHHHHHHHHCCCC		13.0468740105
879PhosphorylationVSGDQKDYRFSVACN
EECCCCCCEEEEEEC		22.1610801845
887PhosphorylationRFSVACNTKKLNCFP
EEEEEECCCCCCCHH		29.4610801853
1139AcetylationVIRCLEMKYGNEIMN
HHHHHHHHHCCCCCC		40.4011789947
1140PhosphorylationIRCLEMKYGNEIMNK
HHHHHHHHCCCCCCC		24.7146156271
1154PhosphorylationKDPVFRISPRSRETH
CCCCEECCCCCCCCC		15.2546156255
1271PhosphorylationVLQGSRASVRQQHDN
EEECCCHHHHHHCCC		19.4050558317
1279PhosphorylationVRQQHDNSLKFLGYC
HHHHCCCCCEEEEEC		38.7150558325
1285PhosphorylationNSLKFLGYCPQENSL
CCCEEEEECCCCCCC		11.7850558329
1291PhosphorylationGYCPQENSLWPKLTM
EECCCCCCCCCCCCH		30.9350558333
1319PhosphorylationGKEDAALSISRLVEA
CHHHHHHHHHHHHHH		17.5024719451
1339PhosphorylationQLKAPVKTLSEGIKR
HHCCCHHHHCHHHHH		35.43-
1415PhosphorylationDRMAMMVSGTLRCIG
HHHHHHHHHHHHHHH		14.2550558321
1417PhosphorylationMAMMVSGTLRCIGSI
HHHHHHHHHHHHHHH		11.9723532336
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCAA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCAA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCAA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABCAA_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCAA_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, AND MASSSPECTROMETRY.
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-307, AND MASSSPECTROMETRY.

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