dbPTM

DDA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDA1_HUMAN
UniProt AC	Q9BW61
Protein Name	DET1- and DDB1-associated protein 1
Gene Name	DDA1
Organism	Homo sapiens (Human).
Sequence Length	102
Subcellular Localization
Protein Description	May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins..
Protein Sequence	MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADFLKGLP ------CCHHHCCCC	19.09	22814378
6	Ubiquitination	--MADFLKGLPVYNK --CCHHHCCCCCCCC	59.40	-
11	Phosphorylation	FLKGLPVYNKSNFSR HHCCCCCCCCCCCCH	18.22	28060719
13	Ubiquitination	KGLPVYNKSNFSRFH CCCCCCCCCCCCHHC	29.14	-
13	Acetylation	KGLPVYNKSNFSRFH CCCCCCCCCCCCHHC	29.14	26051181
23	Phosphorylation	FSRFHADSVCKASNR CCHHCHHHHHHHCCC	30.14	21712546
25	S-nitrosylation	RFHADSVCKASNRRP HHCHHHHHHHCCCCC	3.36	19483679
25	S-nitrosocysteine	RFHADSVCKASNRRP HHCHHHHHHHCCCCC	3.36	-
26	Ubiquitination	FHADSVCKASNRRPS HCHHHHHHHCCCCCC	53.33	-
28	Phosphorylation	ADSVCKASNRRPSVY HHHHHHHCCCCCCEE	19.16	26074081
33	Phosphorylation	KASNRRPSVYLPTRE HHCCCCCCEECCCCC	22.91	23401153
35	Phosphorylation	SNRRPSVYLPTREYP CCCCCCEECCCCCCC	15.99	29396449
38	Phosphorylation	RPSVYLPTREYPSEQ CCCEECCCCCCCCCC	33.27	23882029
43	Phosphorylation	LPTREYPSEQIIVTE CCCCCCCCCCEEEEE	41.03	23882029
49	Phosphorylation	PSEQIIVTEKTNILL CCCCEEEEEHHHHHH	22.73	-
52	Phosphorylation	QIIVTEKTNILLRYL CEEEEEHHHHHHHHH	22.66	-
65	Ubiquitination	YLHQQWDKKNAAKKR HHHHHHHHHHHHHHC	44.99	19608861
65	Acetylation	YLHQQWDKKNAAKKR HHHHHHHHHHHHHHC	44.99	23749302
66	Ubiquitination	LHQQWDKKNAAKKRD HHHHHHHHHHHHHCH	49.71	-
71	Ubiquitination	DKKNAAKKRDQEQVE HHHHHHHHCHHHHHH	57.38	-
83	Phosphorylation	QVELEGESSAPPRKV HHHHCCCCCCCCCCC	42.53	26074081
84	Phosphorylation	VELEGESSAPPRKVA HHHCCCCCCCCCCCC	40.26	26074081
93	Phosphorylation	PPRKVARTDSPDMHE CCCCCCCCCCCCCCC	30.96	25159151
95	Phosphorylation	RKVARTDSPDMHEDT CCCCCCCCCCCCCCC	23.37	23927012
102	Phosphorylation	SPDMHEDT------- CCCCCCCC-------	37.21	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCAF1_HUMAN	VPRBP	physical	20562859
DCA17_HUMAN	DCAF17	physical	20562859
AMRA1_HUMAN	AMBRA1	physical	20562859
DDB2_HUMAN	DDB2	physical	20562859
DDB1_HUMAN	DDB1	physical	20562859
DCA11_HUMAN	DCAF11	physical	20562859
ANFY1_HUMAN	ANKFY1	physical	20562859
LKHA4_HUMAN	LTA4H	physical	20562859
ASNS_HUMAN	ASNS	physical	20562859
FKBP4_HUMAN	FKBP4	physical	20562859
SYLC_HUMAN	LARS	physical	20562859
PGK1_HUMAN	PGK1	physical	20562859
SYTC_HUMAN	TARS	physical	20562859
ECHM_HUMAN	ECHS1	physical	20562859
PA2G4_HUMAN	PA2G4	physical	20562859
ECHA_HUMAN	HADHA	physical	20562859
GLYM_HUMAN	SHMT2	physical	20562859
ETFA_HUMAN	ETFA	physical	20562859
COPA_HUMAN	COPA	physical	20562859
PRKDC_HUMAN	PRKDC	physical	20562859
CBR1_HUMAN	CBR1	physical	20562859
SYFB_HUMAN	FARSB	physical	20562859
SPEE_HUMAN	SRM	physical	20562859
AMPL_HUMAN	LAP3	physical	20562859
DCAF5_HUMAN	DCAF5	physical	20562859
WDTC1_HUMAN	WDTC1	physical	20562859
SEPT9_HUMAN	SEPT9	physical	20562859
SIAS_HUMAN	NANS	physical	20562859
ESTD_HUMAN	ESD	physical	20562859
CAND1_HUMAN	CAND1	physical	20562859
SYWC_HUMAN	WARS	physical	20562859
AAPK1_HUMAN	PRKAA1	physical	20562859
IDH3A_HUMAN	IDH3A	physical	20562859
MCM2_HUMAN	MCM2	physical	20562859
AL7A1_HUMAN	ALDH7A1	physical	20562859
PUR8_HUMAN	ADSL	physical	20562859
AL9A1_HUMAN	ALDH9A1	physical	20562859
NAMPT_HUMAN	NAMPT	physical	20562859
GUAA_HUMAN	GMPS	physical	20562859
IF5_HUMAN	EIF5	physical	20562859
COPB2_HUMAN	COPB2	physical	20562859
ECHB_HUMAN	HADHB	physical	20562859
UB2E3_HUMAN	UBE2E3	physical	17452440
DDB1_HUMAN	DDB1	physical	17452440
CUL4A_HUMAN	CUL4A	physical	17452440
CSN3_HUMAN	COPS3	physical	17452440
DCAF1_HUMAN	VPRBP	physical	17609381
DDB1_HUMAN	DDB1	physical	17609381
RBX1_HUMAN	RBX1	physical	19295130
CUL4A_HUMAN	CUL4A	physical	19295130
CUL4B_HUMAN	CUL4B	physical	19295130
RFWD2_HUMAN	RFWD2	physical	19295130
CSN2_HUMAN	COPS2	physical	19295130
CSN3_HUMAN	COPS3	physical	19295130
CSN4_HUMAN	COPS4	physical	19295130
CSN5_HUMAN	COPS5	physical	19295130
CSN6_HUMAN	COPS6	physical	19295130
CSN7A_HUMAN	COPS7A	physical	19295130
CSN7B_HUMAN	COPS7B	physical	19295130
CSN8_HUMAN	COPS8	physical	19295130
DDB1_HUMAN	DDB1	physical	19295130
DCAF1_HUMAN	VPRBP	physical	19295130
PWP1_HUMAN	PWP1	physical	19295130
DCAF5_HUMAN	DCAF5	physical	19295130
DCA12_HUMAN	DCAF12	physical	19295130
ERCC8_HUMAN	ERCC8	physical	19295130
WDTC1_HUMAN	WDTC1	physical	19295130
DCAF6_HUMAN	DCAF6	physical	19295130
AMRA1_HUMAN	AMBRA1	physical	19295130
DCA11_HUMAN	DCAF11	physical	19295130
DCA10_HUMAN	DCAF10	physical	19295130
DTL_HUMAN	DTL	physical	19295130
DCAF8_HUMAN	DCAF8	physical	19295130
DET1_HUMAN	DET1	physical	19295130
DCA15_HUMAN	DCAF15	physical	19295130
DCA16_HUMAN	DCAF16	physical	19295130
DCA17_HUMAN	DCAF17	physical	19295130
TOIP2_HUMAN	TOR1AIP2	physical	19295130
IFG15_HUMAN	TOR1AIP2	physical	19295130
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
CUL4B_HUMAN	CUL4B	physical	16949367
CKLF5_HUMAN	CMTM5	physical	25416956
DET1_HUMAN	DET1	physical	17452440
DDB1_HUMAN	DDB1	physical	26344197
DCAF1_HUMAN	VPRBP	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-95, AND MASSSPECTROMETRY.	18669648 [Abstract]