DCA17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCA17_HUMAN
• UniProt AC: Q5H9S7
• Protein Name: DDB1- and CUL4-associated factor 17
• Gene Name: DCAF17
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Nucleus, nucleolus . According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MGPTRKPNVCSRLSRRALGCFSRDAGVVQRTNLGILRALVCQESTKFKNVWTTHSRSPIAYERGRIYFDNYRRCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDILPNSSDYKSSLIALTAHNWLLRISATTGKILEKIYLAPYCKFRYLSWDTPQEVIAVKSAQNRGSAVARQAGIQQHVLLYLAVFRVLPFSLVGILEINKKIFGNVTDATLSHGILIVMYSSGLVRLYSFQTIAEQFMQQKLDLGCACRWGGTTGTVGEAPFGIPCNIKITDMPPLLFEVSSLENAFQIGGHPWHYIVTPNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGPNQVKVLKLTEIENNSSQHQISEDFVILANRENHKNENVLTVTASGRVVKKSFNLLDDDPEQETFKIVDYEDELDLLSVVAVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQMICDTGEEEETINRSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGPTRKPNVCS ----CCCCCCCCHHH	45.67	-
31	Phosphorylation	DAGVVQRTNLGILRA CCCHHHHCCHHHHHH	20.08	25022875
52	Phosphorylation	TKFKNVWTTHSRSPI CCCCCEEECCCCCCC	15.45	21712546
53	Phosphorylation	KFKNVWTTHSRSPIA CCCCEEECCCCCCCC	11.35	21712546
76	Phosphorylation	DNYRRCVSSVASEPR CCHHHHHHHHHCCCH	23.79	30576142
77	Phosphorylation	NYRRCVSSVASEPRK CHHHHHHHHHCCCHH	10.99	28509920
80	Phosphorylation	RCVSSVASEPRKLYE HHHHHHHCCCHHHHC	46.08	28509920
92	Phosphorylation	LYEMPKCSKSEKIED HHCCCCCCCCCCHHH	45.39	-
94	Phosphorylation	EMPKCSKSEKIEDAL CCCCCCCCCCHHHHH	28.03	-
167	Ubiquitination	PQEVIAVKSAQNRGS CCEEEEEECCCCCHH	30.93	2190698
167 (in isoform 1)	Ubiquitination	-	30.93	21906983
218	Phosphorylation	FGNVTDATLSHGILI HCCCCCCCCCCCEEE	31.44	21253578
228	Phosphorylation	HGILIVMYSSGLVRL CCEEEEEECCCCHHH	6.70	21253578
404	Phosphorylation	NVLTVTASGRVVKKS CEEEEECCCCEEEEE	20.12	25627689
410	Ubiquitination	ASGRVVKKSFNLLDD CCCCEEEEEECCCCC	48.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCA17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCA17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCA17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
CUL4B_HUMAN	CUL4B	physical	16949367

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 241080: Woodhouse-Sakati syndrome (WoSaS)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.