| UniProt ID | CUL4B_HUMAN | |
|---|---|---|
| UniProt AC | Q13620 | |
| Protein Name | Cullin-4B | |
| Gene Name | CUL4B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 913 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.. | |
| Protein Sequence | MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 (in isoform 1) | Acetylation | - | 5.42 | 20068231 | |
| 3 | Phosphorylation | -----MMSQSSGSGD -----CCCCCCCCCC | 26.13 | 24043423 | |
| 4 (in isoform 1) | Phosphorylation | - | 24.58 | 27732954 | |
| 5 | Phosphorylation | ---MMSQSSGSGDGN ---CCCCCCCCCCCC | 29.38 | 24043423 | |
| 6 | Phosphorylation | --MMSQSSGSGDGND --CCCCCCCCCCCCC | 29.37 | 24043423 | |
| 7 (in isoform 1) | Phosphorylation | - | 40.68 | 22199227 | |
| 8 | Phosphorylation | MMSQSSGSGDGNDDE CCCCCCCCCCCCCCC | 35.34 | 20068231 | |
| 8 (in isoform 1) | Phosphorylation | - | 35.34 | 25159151 | |
| 10 (in isoform 1) | Phosphorylation | - | 55.19 | 28355574 | |
| 12 (in isoform 1) | Phosphorylation | - | 59.30 | 22199227 | |
| 17 | Phosphorylation | DGNDDEATTSKDGGF CCCCCCCCCCCCCCC | 29.56 | 24043423 | |
| 18 | Phosphorylation | GNDDEATTSKDGGFS CCCCCCCCCCCCCCC | 40.61 | 24043423 | |
| 19 | Phosphorylation | NDDEATTSKDGGFSS CCCCCCCCCCCCCCC | 25.13 | 24043423 | |
| 24 | Phosphorylation | TTSKDGGFSSPSPSA CCCCCCCCCCCCHHH | 8.81 | 18669648 | |
| 25 | Phosphorylation | TSKDGGFSSPSPSAA CCCCCCCCCCCHHHH | 44.61 | 25693802 | |
| 26 | Phosphorylation | SKDGGFSSPSPSAAA CCCCCCCCCCHHHHH | 27.43 | 25693802 | |
| 28 | Phosphorylation | DGGFSSPSPSAAAAA CCCCCCCCHHHHHHH | 33.17 | 26657352 | |
| 29 | Phosphorylation | GGFSSPSPSAAAAAQ CCCCCCCHHHHHHHH | 31.22 | 18669648 | |
| 29 (in isoform 1) | Phosphorylation | - | 31.22 | 24719451 | |
| 30 | Phosphorylation | GFSSPSPSAAAAAQE CCCCCCHHHHHHHHH | 34.57 | 19664995 | |
| 31 | Phosphorylation | FSSPSPSAAAAAQEV CCCCCHHHHHHHHHH | 12.42 | 19664995 | |
| 34 | Phosphorylation | PSPSAAAAAQEVRSA CCHHHHHHHHHHHHC | 12.64 | 19413330 | |
| 35 | Phosphorylation | SPSAAAAAQEVRSAT CHHHHHHHHHHHHCC | 11.01 | 18669648 | |
| 40 | Phosphorylation | AAAQEVRSATDGNTS HHHHHHHHCCCCCCC | 40.47 | 28176443 | |
| 40 (in isoform 1) | Ubiquitination | - | 40.47 | 21890473 | |
| 42 | Phosphorylation | AQEVRSATDGNTSTT HHHHHHCCCCCCCCC | 45.76 | 28176443 | |
| 46 | Phosphorylation | RSATDGNTSTTPPTS HHCCCCCCCCCCCCH | 32.74 | 30266825 | |
| 47 | Phosphorylation | SATDGNTSTTPPTSA HCCCCCCCCCCCCHH | 33.99 | 30266825 | |
| 48 | Phosphorylation | ATDGNTSTTPPTSAK CCCCCCCCCCCCHHH | 41.08 | 29255136 | |
| 49 | Phosphorylation | TDGNTSTTPPTSAKK CCCCCCCCCCCHHHC | 27.34 | 29255136 | |
| 52 | Phosphorylation | NTSTTPPTSAKKRKL CCCCCCCCHHHCCCC | 42.38 | 23401153 | |
| 53 | Phosphorylation | TSTTPPTSAKKRKLN CCCCCCCHHHCCCCC | 43.81 | 30266825 | |
| 55 | Acetylation | TTPPTSAKKRKLNSS CCCCCHHHCCCCCCC | 53.53 | 25953088 | |
| 58 | Ubiquitination | PTSAKKRKLNSSSSS CCHHHCCCCCCCCCC | 61.98 | - | |
| 58 (in isoform 2) | Ubiquitination | - | 61.98 | 21890473 | |
| 61 | Phosphorylation | AKKRKLNSSSSSSSN HHCCCCCCCCCCCCC | 41.87 | 23401153 | |
| 62 | Phosphorylation | KKRKLNSSSSSSSNS HCCCCCCCCCCCCCC | 32.92 | 23401153 | |
| 63 | Phosphorylation | KRKLNSSSSSSSNSS CCCCCCCCCCCCCCC | 33.78 | 23401153 | |
| 64 | Phosphorylation | RKLNSSSSSSSNSSN CCCCCCCCCCCCCCC | 35.87 | 23401153 | |
| 65 | Phosphorylation | KLNSSSSSSSNSSNE CCCCCCCCCCCCCCC | 39.47 | 23401153 | |
| 66 | Phosphorylation | LNSSSSSSSNSSNER CCCCCCCCCCCCCCC | 35.17 | 23401153 | |
| 67 | Phosphorylation | NSSSSSSSNSSNERE CCCCCCCCCCCCCCC | 42.55 | 19664994 | |
| 69 | Phosphorylation | SSSSSSNSSNEREDF CCCCCCCCCCCCCCC | 36.17 | 23401153 | |
| 70 | Phosphorylation | SSSSSNSSNEREDFD CCCCCCCCCCCCCCC | 47.13 | 23401153 | |
| 78 | Phosphorylation | NEREDFDSTSSSSST CCCCCCCCCCCCCCC | 30.13 | 23927012 | |
| 79 | Phosphorylation | EREDFDSTSSSSSTP CCCCCCCCCCCCCCC | 34.18 | 23927012 | |
| 80 | Phosphorylation | REDFDSTSSSSSTPP CCCCCCCCCCCCCCC | 31.98 | 23927012 | |
| 81 | Phosphorylation | EDFDSTSSSSSTPPL CCCCCCCCCCCCCCC | 34.04 | 29255136 | |
| 82 | Phosphorylation | DFDSTSSSSSTPPLQ CCCCCCCCCCCCCCC | 28.24 | 29255136 | |
| 83 | Phosphorylation | FDSTSSSSSTPPLQP CCCCCCCCCCCCCCC | 39.93 | 29255136 | |
| 84 | Phosphorylation | DSTSSSSSTPPLQPR CCCCCCCCCCCCCCC | 47.05 | 23401153 | |
| 85 | Phosphorylation | STSSSSSTPPLQPRD CCCCCCCCCCCCCCC | 30.76 | 19664994 | |
| 93 | Phosphorylation | PPLQPRDSASPSTSS CCCCCCCCCCCCCCC | 31.74 | 23663014 | |
| 95 | Phosphorylation | LQPRDSASPSTSSFC CCCCCCCCCCCCCEE | 24.28 | 23663014 | |
| 97 | Phosphorylation | PRDSASPSTSSFCLG CCCCCCCCCCCEEEE | 38.12 | 27080861 | |
| 98 | Phosphorylation | RDSASPSTSSFCLGV CCCCCCCCCCEEEEE | 31.60 | 27080861 | |
| 99 | Phosphorylation | DSASPSTSSFCLGVS CCCCCCCCCEEEEEE | 26.25 | 27080861 | |
| 100 | Phosphorylation | SASPSTSSFCLGVSV CCCCCCCCEEEEEEH | 21.77 | 27080861 | |
| 106 | Phosphorylation | SSFCLGVSVAASSHV CCEEEEEEHHCCCCC | 12.30 | 27080861 | |
| 120 | Phosphorylation | VPIQKKLRFEDTLEF CCCCCCCCCCHHHHH | 41.61 | 19413330 | |
| 123 | Phosphorylation | QKKLRFEDTLEFVGF CCCCCCCHHHHHCEE | 54.61 | 19413330 | |
| 124 | Phosphorylation | KKLRFEDTLEFVGFD CCCCCCHHHHHCEEE | 22.46 | 19413330 | |
| 125 | Phosphorylation | KLRFEDTLEFVGFDA CCCCCHHHHHCEEEH | 8.12 | 19413330 | |
| 126 | Phosphorylation | LRFEDTLEFVGFDAK CCCCHHHHHCEEEHH | 40.14 | 19413330 | |
| 127 | Phosphorylation | RFEDTLEFVGFDAKM CCCHHHHHCEEEHHH | 7.97 | 19413330 | |
| 128 | Phosphorylation | FEDTLEFVGFDAKMA CCHHHHHCEEEHHHH | 5.65 | 19413330 | |
| 130 | Phosphorylation | DTLEFVGFDAKMAEE HHHHHCEEEHHHHCC | 7.49 | 19664995 | |
| 134 | Phosphorylation | FVGFDAKMAEESSSS HCEEEHHHHCCCCCC | 6.43 | 19413330 | |
| 138 | Phosphorylation | DAKMAEESSSSSSSS EHHHHCCCCCCCCCC | 27.33 | 23401153 | |
| 139 | Phosphorylation | AKMAEESSSSSSSSS HHHHCCCCCCCCCCC | 37.20 | 23401153 | |
| 140 | Phosphorylation | KMAEESSSSSSSSSP HHHCCCCCCCCCCCC | 43.44 | 22167270 | |
| 140 (in isoform 1) | Ubiquitination | - | 43.44 | 21890473 | |
| 141 | O-linked_Glycosylation | MAEESSSSSSSSSPT HHCCCCCCCCCCCCC | 35.87 | 30059200 | |
| 141 | Phosphorylation | MAEESSSSSSSSSPT HHCCCCCCCCCCCCC | 35.87 | 22167270 | |
| 142 | Phosphorylation | AEESSSSSSSSSPTA HCCCCCCCCCCCCCC | 35.87 | 22167270 | |
| 143 | O-linked_Glycosylation | EESSSSSSSSSPTAA CCCCCCCCCCCCCCH | 35.87 | 30059200 | |
| 143 | Phosphorylation | EESSSSSSSSSPTAA CCCCCCCCCCCCCCH | 35.87 | 22167270 | |
| 144 | Phosphorylation | ESSSSSSSSSPTAAT CCCCCCCCCCCCCHH | 36.46 | 22167270 | |
| 145 | O-linked_Glycosylation | SSSSSSSSSPTAATS CCCCCCCCCCCCHHH | 42.14 | 30059200 | |
| 145 | Phosphorylation | SSSSSSSSSPTAATS CCCCCCCCCCCCHHH | 42.14 | 22167270 | |
| 146 | Phosphorylation | SSSSSSSSPTAATSQ CCCCCCCCCCCHHHH | 28.37 | 22167270 | |
| 148 | O-linked_Glycosylation | SSSSSSPTAATSQQQ CCCCCCCCCHHHHHH | 30.76 | 30059200 | |
| 148 | Phosphorylation | SSSSSSPTAATSQQQ CCCCCCCCCHHHHHH | 30.76 | 22167270 | |
| 151 | O-linked_Glycosylation | SSSPTAATSQQQQLK CCCCCCHHHHHHHHC | 25.30 | 30059200 | |
| 151 | Phosphorylation | SSSPTAATSQQQQLK CCCCCCHHHHHHHHC | 25.30 | 25022875 | |
| 152 | O-linked_Glycosylation | SSPTAATSQQQQLKN CCCCCHHHHHHHHCC | 22.67 | 30059200 | |
| 152 | Phosphorylation | SSPTAATSQQQQLKN CCCCCHHHHHHHHCC | 22.67 | 19413330 | |
| 158 | Methylation | TSQQQQLKNKSILIS HHHHHHHCCCCEEHH | 58.97 | - | |
| 158 | Ubiquitination | TSQQQQLKNKSILIS HHHHHHHCCCCEEHH | 58.97 | - | |
| 158 (in isoform 2) | Ubiquitination | - | 58.97 | 21890473 | |
| 160 | Methylation | QQQQLKNKSILISSV HHHHHCCCCEEHHHH | 36.97 | - | |
| 161 | Phosphorylation | QQQLKNKSILISSVA HHHHCCCCEEHHHHH | 31.83 | 29214152 | |
| 165 | Phosphorylation | KNKSILISSVASVHH CCCCEEHHHHHHHHH | 18.47 | 27251275 | |
| 166 | O-linked_Glycosylation | NKSILISSVASVHHA CCCEEHHHHHHHHHH | 18.08 | 30059200 | |
| 166 | Phosphorylation | NKSILISSVASVHHA CCCEEHHHHHHHHHH | 18.08 | 28555341 | |
| 169 | Phosphorylation | ILISSVASVHHANGL EEHHHHHHHHHHCCC | 21.59 | 28555341 | |
| 175 | Phosphorylation | ASVHHANGLAKSSTT HHHHHHCCCCCCCCC | 28.00 | 18669648 | |
| 179 | Phosphorylation | HANGLAKSSTTVSSF HHCCCCCCCCCHHHH | 27.58 | 25627689 | |
| 180 | Phosphorylation | ANGLAKSSTTVSSFA HCCCCCCCCCHHHHC | 27.65 | 25262027 | |
| 181 | Phosphorylation | NGLAKSSTTVSSFAN CCCCCCCCCHHHHCC | 38.00 | 20068231 | |
| 182 | Phosphorylation | GLAKSSTTVSSFANS CCCCCCCCHHHHCCC | 21.97 | 22199227 | |
| 184 | Phosphorylation | AKSSTTVSSFANSKP CCCCCCHHHHCCCCC | 20.04 | 22199227 | |
| 185 | Phosphorylation | KSSTTVSSFANSKPG CCCCCHHHHCCCCCC | 24.84 | 22199227 | |
| 189 | Phosphorylation | TVSSFANSKPGSAKK CHHHHCCCCCCCCCE | 36.48 | 22199227 | |
| 190 | Acetylation | VSSFANSKPGSAKKL HHHHCCCCCCCCCEE | 53.88 | 25953088 | |
| 193 | Phosphorylation | FANSKPGSAKKLVIK HCCCCCCCCCEEEEC | 45.50 | 25159151 | |
| 195 | Acetylation | NSKPGSAKKLVIKNF CCCCCCCCEEEECCC | 48.62 | 25953088 | |
| 212 | Phosphorylation | KPKLPENYTDETWQK CCCCCCCCCHHHHHH | 17.57 | 29449344 | |
| 213 | Phosphorylation | PKLPENYTDETWQKL CCCCCCCCHHHHHHH | 38.65 | 29449344 | |
| 216 | Phosphorylation | PENYTDETWQKLKEA CCCCCHHHHHHHHHH | 35.69 | 29449344 | |
| 219 | Ubiquitination | YTDETWQKLKEAVEA CCHHHHHHHHHHHHH | 53.76 | - | |
| 240 | Ubiquitination | IKYNLEELYQAVENL CCCCHHHHHHHHHHH | 2.54 | 21890473 | |
| 240 (in isoform 1) | Ubiquitination | - | 2.54 | 21890473 | |
| 245 | Ubiquitination | EELYQAVENLCSYKI HHHHHHHHHHHHHCH | 47.72 | 21890473 | |
| 258 | Acetylation | KISANLYKQLRQICE CHHHHHHHHHHHHHH | 46.12 | 25953088 | |
| 258 | Methylation | KISANLYKQLRQICE CHHHHHHHHHHHHHH | 46.12 | - | |
| 258 | Ubiquitination | KISANLYKQLRQICE CHHHHHHHHHHHHHH | 46.12 | 21890473 | |
| 258 (in isoform 2) | Ubiquitination | - | 46.12 | 21890473 | |
| 287 | 2-Hydroxyisobutyrylation | LDSVLFLKKIDRCWQ CHHHHHHHHHHHHHH | 40.11 | - | |
| 305 | Phosphorylation | RQMIMIRSIFLFLDR HHHHHHHHHHHHHCC | 13.53 | 21712546 | |
| 341 | Ubiquitination | AHIISDQKVQNKTID HHHCCCHHHCCCCCC | 51.26 | - | |
| 370 | Phosphorylation | IDRSLLRSLLSMLSD CCHHHHHHHHHHHHH | 33.36 | 25003641 | |
| 373 | Phosphorylation | SLLRSLLSMLSDLQI HHHHHHHHHHHHHHH | 23.99 | 25003641 | |
| 381 | Phosphorylation | MLSDLQIYQDSFEQR HHHHHHHHHHHHHHH | 8.03 | 25003641 | |
| 385 | Ubiquitination | LQIYQDSFEQRFLEE HHHHHHHHHHHHHHH | 14.43 | 21890473 | |
| 385 (in isoform 1) | Ubiquitination | - | 14.43 | 21890473 | |
| 390 | Ubiquitination | DSFEQRFLEETNRLY HHHHHHHHHHHCHHH | 6.74 | 21890473 | |
| 403 | 2-Hydroxyisobutyrylation | LYAAEGQKLMQEREV HHHHHHHHHHHHCCH | 57.70 | - | |
| 403 | Ubiquitination | LYAAEGQKLMQEREV HHHHHHHHHHHHCCH | 57.70 | 21890473 | |
| 403 (in isoform 2) | Ubiquitination | - | 57.70 | 21890473 | |
| 413 | Phosphorylation | QEREVPEYLHHVNKR HHCCHHHHHHHHHHH | 12.79 | - | |
| 439 | Phosphorylation | LDQTTQKSLIATVEK HHHHCCHHHHHHHHH | 18.39 | - | |
| 495 | Ubiquitination | QVLLQQWIEYIKAFG HHHHHHHHHHHHHHC | 2.21 | 21890473 | |
| 495 (in isoform 1) | Ubiquitination | - | 2.21 | 21890473 | |
| 500 | Ubiquitination | QWIEYIKAFGSTIVI HHHHHHHHHCCEEEE | 12.41 | 21890473 | |
| 513 | Ubiquitination | VINPEKDKTMVQELL EECCCCCHHHHHHHH | 49.98 | 21890473 | |
| 513 (in isoform 2) | Ubiquitination | - | 49.98 | 21890473 | |
| 558 | Ubiquitination | FINKRPNKPAELIAK HHHHCCCCCHHHHHH | 48.57 | - | |
| 570 | Ubiquitination | IAKYVDSKLRAGNKE HHHHHHHHHHCCCCC | 37.21 | - | |
| 582 | Ubiquitination | NKEATDEELEKMLDK CCCCCHHHHHHHHHH | 66.11 | 21890473 | |
| 582 (in isoform 1) | Ubiquitination | - | 66.11 | 21890473 | |
| 587 | Ubiquitination | DEELEKMLDKIMIIF HHHHHHHHHHHHHHH | 10.06 | 21890473 | |
| 590 | Ubiquitination | LEKMLDKIMIIFRFI HHHHHHHHHHHHHHH | 2.09 | 21890473 | |
| 590 (in isoform 1) | Ubiquitination | - | 2.09 | 21890473 | |
| 595 | Ubiquitination | DKIMIIFRFIYGKDV HHHHHHHHHHHCHHH | 13.47 | 21890473 | |
| 598 | Phosphorylation | MIIFRFIYGKDVFEA HHHHHHHHCHHHHHH | 18.53 | 21406692 | |
| 600 | Ubiquitination | IFRFIYGKDVFEAFY HHHHHHCHHHHHHHH | 33.47 | 21890473 | |
| 600 (in isoform 2) | Ubiquitination | - | 33.47 | 21890473 | |
| 607 | Phosphorylation | KDVFEAFYKKDLAKR HHHHHHHHHHHHHHH | 24.95 | - | |
| 608 | 2-Hydroxyisobutyrylation | DVFEAFYKKDLAKRL HHHHHHHHHHHHHHH | 33.10 | - | |
| 608 | Ubiquitination | DVFEAFYKKDLAKRL HHHHHHHHHHHHHHH | 33.10 | 21890473 | |
| 608 (in isoform 2) | Ubiquitination | - | 33.10 | 21890473 | |
| 609 | Ubiquitination | VFEAFYKKDLAKRLL HHHHHHHHHHHHHHH | 46.74 | - | |
| 619 | Malonylation | AKRLLVGKSASVDAE HHHHHCCCCCCCHHH | 35.06 | 26320211 | |
| 619 | Ubiquitination | AKRLLVGKSASVDAE HHHHHCCCCCCCHHH | 35.06 | - | |
| 631 | Phosphorylation | DAEKSMLSKLKHECG HHHHHHHHHHHHHHC | 27.57 | 24260401 | |
| 632 | Ubiquitination | AEKSMLSKLKHECGA HHHHHHHHHHHHHCH | 58.56 | 21890473 | |
| 632 (in isoform 1) | Ubiquitination | - | 58.56 | 21890473 | |
| 634 | 2-Hydroxyisobutyrylation | KSMLSKLKHECGAAF HHHHHHHHHHHCHHH | 40.88 | - | |
| 634 | Ubiquitination | KSMLSKLKHECGAAF HHHHHHHHHHHCHHH | 40.88 | - | |
| 637 | Ubiquitination | LSKLKHECGAAFTSK HHHHHHHHCHHHHHH | 4.49 | 21890473 | |
| 650 | Ubiquitination | SKLEGMFKDMELSKD HHHHHHHCCCHHCHH | 47.47 | 21890473 | |
| 650 (in isoform 2) | Ubiquitination | - | 47.47 | 21890473 | |
| 691 | Ubiquitination | MGYWPTYVPMEVHLP CCCCCCCCCCEECCC | 3.91 | 21890473 | |
| 691 (in isoform 1) | Ubiquitination | - | 3.91 | 21890473 | |
| 696 | Ubiquitination | TYVPMEVHLPPEMVK CCCCCEECCCHHHHH | 21.22 | 21890473 | |
| 709 | Ubiquitination | VKLQEIFKTFYLGKH HHHHHHHHHHHCCCC | 43.30 | 21890473 | |
| 709 (in isoform 2) | Ubiquitination | - | 43.30 | 21890473 | |
| 746 | O-linked_Glycosylation | GKKELQVSLFQTLVL CCHHHHHHHHHHHHH | 15.54 | 30059200 | |
| 750 | O-linked_Glycosylation | LQVSLFQTLVLLMFN HHHHHHHHHHHHHHC | 16.11 | 30059200 | |
| 779 | Methylation | GIEDGELRRTLQSLA CCCCCHHHHHHHHHH | 25.82 | - | |
| 789 | Malonylation | LQSLACGKARVLAKN HHHHHHCCHHHHCCC | 32.67 | 26320211 | |
| 789 | Ubiquitination | LQSLACGKARVLAKN HHHHHHCCHHHHCCC | 32.67 | - | |
| 800 | Acetylation | LAKNPKGKDIEDGDK HCCCCCCCCCCCCCC | 62.75 | 23749302 | |
| 800 | Malonylation | LAKNPKGKDIEDGDK HCCCCCCCCCCCCCC | 62.75 | 26320211 | |
| 807 | Acetylation | KDIEDGDKFICNDDF CCCCCCCCEECCCCH | 42.00 | 27452117 | |
| 815 | Acetylation | FICNDDFKHKLFRIK EECCCCHHHHHHHHE | 46.99 | 27452117 | |
| 815 | Methylation | FICNDDFKHKLFRIK EECCCCHHHHHHHHE | 46.99 | - | |
| 829 | Methylation | KINQIQMKETVEEQA EECEEECCHHHHHHH | 33.58 | - | |
| 829 | Ubiquitination | KINQIQMKETVEEQA EECEEECCHHHHHHH | 33.58 | - | |
| 844 | Ubiquitination | STTERVFQDRQYQID HHHHHHHHHHHHHHH | 41.96 | 21890473 | |
| 844 (in isoform 1) | Ubiquitination | - | 41.96 | 21890473 | |
| 846 | Methylation | TERVFQDRQYQIDAA HHHHHHHHHHHHHHH | 26.73 | - | |
| 849 | Ubiquitination | VFQDRQYQIDAAIVR HHHHHHHHHHHHHHH | 20.81 | 21890473 | |
| 862 | Ubiquitination | VRIMKMRKTLSHNLL HHHHHHHHHHCCHHH | 50.77 | 21890473 | |
| 862 (in isoform 2) | Ubiquitination | - | 50.77 | 21890473 | |
| 863 | Phosphorylation | RIMKMRKTLSHNLLV HHHHHHHHHCCHHHH | 24.11 | 27251275 | |
| 864 (in isoform 1) | Ubiquitination | - | 5.71 | 21890473 | |
| 865 | Phosphorylation | MKMRKTLSHNLLVSE HHHHHHHCCHHHHHH | 18.63 | 27251275 | |
| 874 | Phosphorylation | NLLVSEVYNQLKFPV HHHHHHHHHHCCCCC | 7.98 | - | |
| 882 | Ubiquitination | NQLKFPVKPADLKKR HHCCCCCCHHHHHHH | 34.42 | - | |
| 882 (in isoform 2) | Ubiquitination | - | 34.42 | 21890473 | |
| 885 (in isoform 1) | Ubiquitination | - | 68.50 | 21890473 | |
| 887 | 2-Hydroxyisobutyrylation | PVKPADLKKRIESLI CCCHHHHHHHHHHHH | 40.32 | - | |
| 892 | Phosphorylation | DLKKRIESLIDRDYM HHHHHHHHHHCHHHH | 28.40 | 26074081 | |
| 896 | Methylation | RIESLIDRDYMERDK HHHHHHCHHHHHHHC | 29.93 | - | |
| 898 | Phosphorylation | ESLIDRDYMERDKEN HHHHCHHHHHHHCCC | 11.19 | 26074081 | |
| 903 | Ubiquitination | RDYMERDKENPNQYN HHHHHHHCCCCCCCC | 66.66 | - | |
| 903 (in isoform 2) | Ubiquitination | - | 66.66 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CUL4B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CUL4B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CUL4B_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 300354 | Mental retardation, X-linked, syndromic, 15 (MRXS15) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49 AND SER-146, AND MASSSPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49; THR-52; SER-138;SER-141; SER-142; SER-143; SER-144; SER-145; SER-146; THR-148 ANDSER-152, AND MASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-48; THR-49; SER-53;SER-146 AND SER-193, AND MASS SPECTROMETRY. | |
