ANR39_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANR39_HUMAN
• UniProt AC: Q53RE8
• Protein Name: Ankyrin repeat domain-containing protein 39
• Gene Name: ANKRD39
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Protein Sequence: MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	NGDLGRVKHLIQKAE CCCHHHHHHHHHHCC	31.19	29967540
53	Ubiquitination	RVKHLIQKAEDPSQP HHHHHHHHCCCCCCC	46.91	32015554
62	Phosphorylation	EDPSQPDSAGYTALH CCCCCCCCCCHHHHH	30.21	28152594
65	Phosphorylation	SQPDSAGYTALHYAS CCCCCCCHHHHHHHH	6.64	24927040
66	Phosphorylation	QPDSAGYTALHYASR CCCCCCHHHHHHHHH	23.09	30835493
70	Phosphorylation	AGYTALHYASRNGHY CCHHHHHHHHHCCCH	13.71	24927040
72	Phosphorylation	YTALHYASRNGHYAV HHHHHHHHHCCCHHH	21.07	28152594
105	Phosphorylation	ATALHRASYCGHTEI CHHHHCHHHCCHHHH	22.40	28857561
106	Phosphorylation	TALHRASYCGHTEIA HHHHCHHHCCHHHHH	11.06	22817900
121	Phosphorylation	RLLLSHGSNPRVVDD HHHHHCCCCCEEECC	37.93	68740257
136	Ubiquitination	DGMTSLHKAAERGHG CCCCHHHHHHHCCCH	55.36	21906983
147	Phosphorylation	RGHGDICSLLLQHSP CCCHHHHHHHHHCCH	23.53	29214152
153	Phosphorylation	CSLLLQHSPALKAIR HHHHHHCCHHHHHHH	10.02	25159151
157	Ubiquitination	LQHSPALKAIRDRKA HHCCHHHHHHHHHHH	43.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANR39_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANR39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANR39_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.
PubMed: 18669648

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65, AND MASSSPECTROMETRY.
PubMed: 15592455