dbPTM

DCNL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCNL1_HUMAN
UniProt AC	Q96GG9
Protein Name	DCN1-like protein 1
Gene Name	DCUN1D1
Organism	Homo sapiens (Human).
Sequence Length	259
Subcellular Localization	Nucleus .
Protein Description	Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. [PubMed: 25349211]
Protein Sequence	MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNKLKSSQ -------CCCCCHHH	10.09	22814378
6	Phosphorylation	--MNKLKSSQKDKVR --CCCCCHHHHHHHH	48.73	27174698
7	Phosphorylation	-MNKLKSSQKDKVRQ -CCCCCHHHHHHHHH	39.40	27174698
19	Phosphorylation	VRQFMIFTQSSEKTA HHHEEEEECCCCHHH	19.33	28555341
21	Phosphorylation	QFMIFTQSSEKTAVS HEEEEECCCCHHHHH	37.09	28348404
22	Phosphorylation	FMIFTQSSEKTAVSC EEEEECCCCHHHHHH	33.04	28348404
24	Ubiquitination	IFTQSSEKTAVSCLS EEECCCCHHHHHHHH	43.67	-
25	Phosphorylation	FTQSSEKTAVSCLSQ EECCCCHHHHHHHHC	28.39	29083192
28	Phosphorylation	SSEKTAVSCLSQNDW CCCHHHHHHHHCCCC	13.58	29083192
31	Phosphorylation	KTAVSCLSQNDWKLD HHHHHHHHCCCCEEE	31.12	22817901
36	Ubiquitination	CLSQNDWKLDVATDN HHHCCCCEEEEECCC	37.36	-
57	Ubiquitination	LYIRESVKGSLDRKK HHHHHHHCCCCCHHH	52.65	21906983
59	Phosphorylation	IRESVKGSLDRKKLE HHHHHCCCCCHHHHH	22.75	28348404
63	Ubiquitination	VKGSLDRKKLEQLYN HCCCCCHHHHHHHHH	62.47	21906983
63	Ubiquitination	VKGSLDRKKLEQLYN HCCCCCHHHHHHHHH	62.47	21890473
64	Malonylation	KGSLDRKKLEQLYNR CCCCCHHHHHHHHHH	59.14	26320211
64	Ubiquitination	KGSLDRKKLEQLYNR CCCCCHHHHHHHHHH	59.14	21890473
64	Ubiquitination	KGSLDRKKLEQLYNR CCCCCHHHHHHHHHH	59.14	21890473
69	Phosphorylation	RKKLEQLYNRYKDPQ HHHHHHHHHHCCCCC	9.40	28152594
72	Phosphorylation	LEQLYNRYKDPQDEN HHHHHHHCCCCCCCC	18.99	-
80	Ubiquitination	KDPQDENKIGIDGIQ CCCCCCCCCCCCHHH	40.02	-
118	Phosphorylation	AATQCEFSKQEFMDG HHHCCCCCHHHHHHH	15.90	28787133
127	Phosphorylation	QEFMDGMTELGCDSI HHHHHHHHHHCCHHH	33.32	28787133
136	Ubiquitination	LGCDSIEKLKAQIPK HCCHHHHHHHHHCCH	54.33	-
138	Ubiquitination	CDSIEKLKAQIPKME CHHHHHHHHHCCHHH	49.68	-
143	Acetylation	KLKAQIPKMEQELKE HHHHHCCHHHHHHCC	57.61	25953088
143	Ubiquitination	KLKAQIPKMEQELKE HHHHHCCHHHHHHCC	57.61	21890473
143	Ubiquitination	KLKAQIPKMEQELKE HHHHHCCHHHHHHCC	57.61	21906983
144	Sulfoxidation	LKAQIPKMEQELKEP HHHHCCHHHHHHCCC	5.58	21406390
149	Acetylation	PKMEQELKEPGRFKD CHHHHHHCCCCCCCC	62.20	27452117
149	Ubiquitination	PKMEQELKEPGRFKD CHHHHHHCCCCCCCC	62.20	21890473
149	Ubiquitination	PKMEQELKEPGRFKD CHHHHHHCCCCCCCC	62.20	21906983
149	Sumoylation	PKMEQELKEPGRFKD CHHHHHHCCCCCCCC	62.20	-
155	Ubiquitination	LKEPGRFKDFYQFTF HCCCCCCCCCCHHEE	45.63	-
166	Sumoylation	QFTFNFAKNPGQKGL HHEEECCCCCCCCCC	60.58	-
171	Sumoylation	FAKNPGQKGLDLEMA CCCCCCCCCCCHHHH	68.32	-
171	Ubiquitination	FAKNPGQKGLDLEMA CCCCCCCCCCCHHHH	68.32	-
191	Ubiquitination	LVLNGRFKFLDLWNK HHHCCCCHHHHHHHH	43.59	21890473
191	Ubiquitination	LVLNGRFKFLDLWNK HHHCCCCHHHHHHHH	43.59	21906983
205	Ubiquitination	KFLLEHHKRSIPKDT HHHHHHHHHCCCHHH	50.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:21813641

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCNL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCNL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI39_HUMAN	TRIM39	physical	16189514
CUL1_HUMAN	CUL1	physical	18826954
CUL2_HUMAN	CUL2	physical	18826954
CUL3_HUMAN	CUL3	physical	18826954
CAND1_HUMAN	CAND1	physical	18826954
UBC12_HUMAN	UBE2M	physical	18826954
CUL5_HUMAN	CUL5	physical	18826954
RBX1_HUMAN	RBX1	physical	18826954
CUL1_HUMAN	CUL1	physical	21813641
ACTBL_HUMAN	ACTBL2	physical	21145461
GDE_HUMAN	AGL	physical	21145461
FBF1_HUMAN	FBF1	physical	21145461
API5_HUMAN	API5	physical	21145461
ARHG1_HUMAN	ARHGEF1	physical	21145461
ASB3_HUMAN	ASB3	physical	21145461
ASB6_HUMAN	ASB6	physical	21145461
ASNS_HUMAN	ASNS	physical	21145461
BAG4_HUMAN	BAG4	physical	21145461
BFSP1_HUMAN	BFSP1	physical	21145461
BTBD9_HUMAN	BTBD9	physical	21145461
CN166_HUMAN	C14orf166	physical	21145461
CP089_HUMAN	C16orf89	physical	21145461
C1QBP_HUMAN	C1QBP	physical	21145461
UNC80_HUMAN	UNC80	physical	21145461
CAND1_HUMAN	CAND1	physical	21145461
CBR3_HUMAN	CBR3	physical	21145461
CEP76_HUMAN	CEP76	physical	21145461
CLH1_HUMAN	CLTC	physical	21145461
CSN2_HUMAN	COPS2	physical	21145461
CSN3_HUMAN	COPS3	physical	21145461
CSN4_HUMAN	COPS4	physical	21145461
CSN5_HUMAN	COPS5	physical	21145461
CSN6_HUMAN	COPS6	physical	21145461
CSN7A_HUMAN	COPS7A	physical	21145461
CSN7B_HUMAN	COPS7B	physical	21145461
CSN8_HUMAN	COPS8	physical	21145461
YBOX3_HUMAN	YBX3	physical	21145461
CYTB_HUMAN	CSTB	physical	21145461
CUL1_HUMAN	CUL1	physical	21145461
CUL2_HUMAN	CUL2	physical	21145461
CUL3_HUMAN	CUL3	physical	21145461
CUL4A_HUMAN	CUL4A	physical	21145461
CUL4B_HUMAN	CUL4B	physical	21145461
CUL5_HUMAN	CUL5	physical	21145461
CB5D1_HUMAN	CYB5D1	physical	21145461
DCNL2_HUMAN	DCUN1D2	physical	21145461
DDB1_HUMAN	DDB1	physical	21145461
DDX1_HUMAN	DDX1	physical	21145461
DDX56_HUMAN	DDX56	physical	21145461
DDX3X_HUMAN	DDX3X	physical	21145461
DDX4_HUMAN	DDX4	physical	21145461
DDX5_HUMAN	DDX5	physical	21145461
DHX57_HUMAN	DHX57	physical	21145461
DHX9_HUMAN	DHX9	physical	21145461
DJC10_HUMAN	DNAJC10	physical	21145461
DNJC9_HUMAN	DNAJC9	physical	21145461
EF1A1_HUMAN	EEF1A1	physical	21145461
EF1A2_HUMAN	EEF1A2	physical	21145461
IF4G2_HUMAN	EIF4G2	physical	21145461
EMAL1_HUMAN	EML1	physical	21145461
EWS_HUMAN	EWSR1	physical	21145461
FAS_HUMAN	FASN	physical	21145461
FEM1B_HUMAN	FEM1B	physical	21145461
FILA2_HUMAN	FLG2	physical	21145461
FUS_HUMAN	FUS	physical	21145461
CSN1_HUMAN	GPS1	physical	21145461
GRB2_HUMAN	GRB2	physical	21145461
HMDH_HUMAN	HMGCR	physical	21145461
ROA1_HUMAN	HNRNPA1	physical	21145461
ROA2_HUMAN	HNRNPA2B1	physical	21145461
ROA3_HUMAN	HNRNPA3	physical	21145461
ROAA_HUMAN	HNRNPAB	physical	21145461
HNRPD_HUMAN	HNRNPD	physical	21145461
HNRPF_HUMAN	HNRNPF	physical	21145461
HNRH1_HUMAN	HNRNPH1	physical	21145461
HNRH3_HUMAN	HNRNPH3	physical	21145461
HNRPK_HUMAN	HNRNPK	physical	21145461
HNRPU_HUMAN	HNRNPU	physical	21145461
HNRL1_HUMAN	HNRNPUL1	physical	21145461
HNRDL_HUMAN	HNRNPDL	physical	21145461
HS90A_HUMAN	HSP90AA1	physical	21145461
HS90B_HUMAN	HSP90AB1	physical	21145461
HS71L_HUMAN	HSPA1L	physical	21145461
GRP78_HUMAN	HSPA5	physical	21145461
HSP7C_HUMAN	HSPA8	physical	21145461
GRP75_HUMAN	HSPA9	physical	21145461
ILF2_HUMAN	ILF2	physical	21145461
ILF3_HUMAN	ILF3	physical	21145461
KBTB6_HUMAN	KBTBD6	physical	21145461
BACD3_HUMAN	KCTD10	physical	21145461
KCTD3_HUMAN	KCTD3	physical	21145461
CEMIP_HUMAN	CEMIP	physical	21145461
KLD10_HUMAN	KLHDC10	physical	21145461
KLDC2_HUMAN	KLHDC2	physical	21145461
KLH42_HUMAN	KLHL42	physical	21145461
KLH12_HUMAN	KLHL12	physical	21145461
KLH13_HUMAN	KLHL13	physical	21145461
KLH15_HUMAN	KLHL15	physical	21145461
KLH18_HUMAN	KLHL18	physical	21145461
KLH22_HUMAN	KLHL22	physical	21145461
KLH23_HUMAN	KLHL23	physical	21145461
KLH26_HUMAN	KLHL26	physical	21145461
KLHL8_HUMAN	KLHL8	physical	21145461
KLHL9_HUMAN	KLHL9	physical	21145461
K2C1_HUMAN	KRT1	physical	21145461
K1C10_HUMAN	KRT10	physical	21145461
K22E_HUMAN	KRT2	physical	21145461
K1C24_HUMAN	KRT24	physical	21145461
K2C5_HUMAN	KRT5	physical	21145461
K2C75_HUMAN	KRT75	physical	21145461
K2C1B_HUMAN	KRT77	physical	21145461
K1C9_HUMAN	KRT9	physical	21145461
LATS1_HUMAN	LATS1	physical	21145461
LG3BP_HUMAN	LGALS3BP	physical	21145461
SIM17_HUMAN	SMIM17	physical	21145461
LRC41_HUMAN	LRRC41	physical	21145461
LSM12_HUMAN	LSM12	physical	21145461
MCM3_HUMAN	MCM3	physical	21145461
RT23_HUMAN	MRPS23	physical	21145461
C1TC_HUMAN	MTHFD1	physical	21145461
CSN9_HUMAN	MYEOV2	physical	21145461
NUCL_HUMAN	NCL	physical	21145461
NEDD8_HUMAN	NEDD8	physical	21145461
NFKB1_HUMAN	NFKB1	physical	21145461
NPM_HUMAN	NPM1	physical	21145461
NUDC3_HUMAN	NUDCD3	physical	21145461
8ODP_HUMAN	NUDT1	physical	21145461
PABP1_HUMAN	PABPC1	physical	21145461
PABP4_HUMAN	PABPC4	physical	21145461
PHS_HUMAN	PCBD1	physical	21145461
PHIP_HUMAN	PHIP	physical	21145461
PLOD1_HUMAN	PLOD1	physical	21145461
DPOLL_HUMAN	POLL	physical	21145461
RPB1_HUMAN	POLR2A	physical	21145461
RPB9_HUMAN	POLR2I	physical	21145461
PRDX1_HUMAN	PRDX1	physical	21145461
PRDX3_HUMAN	PRDX3	physical	21145461
KPRB_HUMAN	PRPSAP2	physical	21145461
QPCT_HUMAN	QPCT	physical	21145461
RB40C_HUMAN	RAB40C	physical	21145461
RBM3_HUMAN	RBM3	physical	21145461
RGSL_HUMAN	RGSL1	physical	21145461
MCES_HUMAN	RNMT	physical	21145461
RL15_HUMAN	RPL15	physical	21145461
RL18_HUMAN	RPL18	physical	21145461
RL23A_HUMAN	RPL23A	physical	21145461
HNRH2_HUMAN	HNRNPH2	physical	21145461
RL4_HUMAN	RPL4	physical	21145461
RL6_HUMAN	RPL6	physical	21145461
RL9_HUMAN	RPL9	physical	21145461
RLA0_HUMAN	RPLP0	physical	21145461
RLA2_HUMAN	RPLP2	physical	21145461
RS10_HUMAN	RPS10	physical	21145461
RS2_HUMAN	RPS2	physical	21145461
RS3A_HUMAN	RPS3A	physical	21145461
RS6_HUMAN	RPS6	physical	21145461
RS8_HUMAN	RPS8	physical	21145461
S10A7_HUMAN	S100A7	physical	21145461
SCRIB_HUMAN	SCRIB	physical	21145461
SDHA_HUMAN	SDHA	physical	21145461
SEP15_HUMAN	SEP15	physical	21145461
SHKB1_HUMAN	SHKBP1	physical	21145461
ADT2_HUMAN	SLC25A5	physical	21145461
U520_HUMAN	SNRNP200	physical	21145461
RU17_HUMAN	SNRNP70	physical	21145461
RSMB_HUMAN	SNRPB	physical	21145461
RU1C_HUMAN	SNRPC	physical	21145461
SMD1_HUMAN	SNRPD1	physical	21145461
SMD2_HUMAN	SNRPD2	physical	21145461
SMD3_HUMAN	SNRPD3	physical	21145461
RUXE_HUMAN	SNRPE	physical	21145461
RUXG_HUMAN	SNRPG	physical	21145461
SOCS5_HUMAN	SOCS5	physical	21145461
SOCS6_HUMAN	SOCS6	physical	21145461
SSBP_HUMAN	SSBP1	physical	21145461
STRBP_HUMAN	STRBP	physical	21145461
HNRPQ_HUMAN	SYNCRIP	physical	21145461
RBP56_HUMAN	TAF15	physical	21145461
ELOC_HUMAN	TCEB1	physical	21145461
ELOB_HUMAN	TCEB2	physical	21145461
TFG_HUMAN	TFG	physical	21145461
TIA1_HUMAN	TIA1	physical	21145461
TIAR_HUMAN	TIAL1	physical	21145461
BACD2_HUMAN	TNFAIP1	physical	21145461
TNR6B_HUMAN	TNRC6B	physical	21145461
TRRAP_HUMAN	TRRAP	physical	21145461
TBA1C_HUMAN	TUBA1C	physical	21145461
TBA4A_HUMAN	TUBA4A	physical	21145461
TBB5_HUMAN	TUBB	physical	21145461
TBB4B_HUMAN	TUBB4B	physical	21145461
THIO_HUMAN	TXN	physical	21145461
TXND5_HUMAN	TXNDC5	physical	21145461
BL1S5_HUMAN	BLOC1S5	physical	21145461
UBC_HUMAN	UBC	physical	21145461
UBC12_HUMAN	UBE2M	physical	21145461
UGGG1_HUMAN	UGGT1	physical	21145461
DCAF1_HUMAN	VPRBP	physical	21145461
WSB1_HUMAN	WSB1	physical	21145461
1433B_HUMAN	YWHAB	physical	21145461
1433E_HUMAN	YWHAE	physical	21145461
TUT4_HUMAN	ZCCHC11	physical	21145461
ZN326_HUMAN	ZNF326	physical	21145461
ZN699_HUMAN	ZNF699	physical	21145461
CUL1_HUMAN	CUL1	physical	23201271
CUL2_HUMAN	CUL2	physical	23201271
CUL3_HUMAN	CUL3	physical	23201271
CUL4A_HUMAN	CUL4A	physical	23201271
CUL4B_HUMAN	CUL4B	physical	23201271
CUL5_HUMAN	CUL5	physical	23201271
CUL2_HUMAN	CUL2	physical	23401859
VHL_HUMAN	VHL	physical	23401859
HIF1A_HUMAN	HIF1A	physical	23401859
CAND1_HUMAN	CAND1	physical	24192928
CUL1_HUMAN	CUL1	physical	24192928
CUL2_HUMAN	CUL2	physical	24192928
CUL3_HUMAN	CUL3	physical	24192928
RBX1_HUMAN	RBX1	physical	24192928
GDIA_HUMAN	GDI1	physical	22863883
GLRX3_HUMAN	GLRX3	physical	22863883
CUL1_HUMAN	CUL1	physical	19617556
CUL2_HUMAN	CUL2	physical	19617556
CUL3_HUMAN	CUL3	physical	19617556
CUL4A_HUMAN	CUL4A	physical	19617556
CUL4B_HUMAN	CUL4B	physical	19617556
CUL5_HUMAN	CUL5	physical	19617556
UBC12_HUMAN	UBE2M	physical	19617556
CUL4A_HUMAN	CUL4A	physical	18826954
CUL4B_HUMAN	CUL4B	physical	18826954
TRI39_HUMAN	TRIM39	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
ARRD3_HUMAN	ARRDC3	physical	25416956
VP37B_HUMAN	VPS37B	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
UBC_HUMAN	UBC	physical	25411243
AURKB_HUMAN	AURKB	physical	25411243
RHOA_HUMAN	RHOA	physical	25411243
UBC12_HUMAN	UBE2M	physical	25411243
CUL1_HUMAN	CUL1	physical	25411243
CAND1_HUMAN	CAND1	physical	25411243
RBX1_HUMAN	RBX1	physical	25411243
CAND1_HUMAN	CAND1	physical	25349211
CUL1_HUMAN	CUL1	physical	25349211
CUL3_HUMAN	CUL3	physical	25349211
RBX1_HUMAN	RBX1	physical	25349211
UBC12_HUMAN	UBE2M	physical	25349211
CP062_HUMAN	C16orf62	physical	26344197
DAAF5_HUMAN	DNAAF5	physical	26344197
GALE_HUMAN	GALE	physical	26344197
MK01_HUMAN	MAPK1	physical	26344197
MK03_HUMAN	MAPK3	physical	26344197
SC23A_HUMAN	SEC23A	physical	26344197
SC23B_HUMAN	SEC23B	physical	26344197
UFD1_HUMAN	UFD1L	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197
XPO6_HUMAN	XPO6	physical	26344197
CUL1_HUMAN	CUL1	physical	26906416
CUL2_HUMAN	CUL2	physical	26906416
CUL3_HUMAN	CUL3	physical	26906416
CUL4A_HUMAN	CUL4A	physical	26906416
CUL4B_HUMAN	CUL4B	physical	26906416
CUL5_HUMAN	CUL5	physical	26906416
CAND1_HUMAN	CAND1	physical	26906416
RBX1_HUMAN	RBX1	physical	26906416
DDB1_HUMAN	DDB1	physical	26906416
UBC12_HUMAN	UBE2M	physical	26906416
UBC12_HUMAN	UBE2M	physical	29074978

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCNL1_HUMAN

Related Literatures of Post-Translational Modification