KLH23_HUMAN - dbPTM
KLH23_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLH23_HUMAN
UniProt AC Q8NBE8
Protein Name Kelch-like protein 23
Gene Name KLHL23
Organism Homo sapiens (Human).
Sequence Length 558
Subcellular Localization
Protein Description
Protein Sequence MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Ubiquitination----MALKGQEDYIY
----CCCCCCCCEEE		49.35-
164PhosphorylationESRRILCSKFKEVWQ
HHHHHHHHHHHHHHH		37.3727251275
165UbiquitinationSRRILCSKFKEVWQQ
HHHHHHHHHHHHHHH		60.5029967540
196UbiquitinationRKNLSVWKEEAIIEP
CCCCCHHCHHHHHHH		43.4529967540
234PhosphorylationNIDIDPVYLKTALGL
CCCCCHHHHHHHHHC		14.1026074081
244PhosphorylationTALGLQRSCLLTENK
HHHHCCHHHCCCHHH		8.9921712546
251UbiquitinationSCLLTENKIRSLIYN
HHCCCHHHHHHHHHH		33.0122505724
254PhosphorylationLTENKIRSLIYNALN
CCHHHHHHHHHHHHC		23.6921712546
257PhosphorylationNKIRSLIYNALNPMH
HHHHHHHHHHHCHHH		10.3221712546
265UbiquitinationNALNPMHKEISQRST
HHHCHHHHHHHHHCC		50.9521890473
313PhosphorylationPDYTRESYGVTCLGP
CCCCHHHCCCEEECC		15.7430278072
379UbiquitinationYALGGYRKGAPAEEA
EECCCCCCCCCHHHH		51.44-
393UbiquitinationAEFYDPLKEKWIPIA
HHHCCCHHHCCEEHH		63.7429967540
395UbiquitinationFYDPLKEKWIPIANM
HCCCHHHCCEEHHHH		49.16-
489DimethylationDPEQNEWREIAPMME
CHHCCCHHHHHHHHH		21.18-
489MethylationDPEQNEWREIAPMME
CHHCCCHHHHHHHHH		21.1830762501
529UbiquitinationTYLQSIEKYDPDLNK
EEECCHHHHCCCCCC		53.9729967540
536UbiquitinationKYDPDLNKWEIVGNL
HHCCCCCCCEEEECC		54.20-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLH23_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLH23_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLH23_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KLH23_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLH23_HUMAN

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Related Literatures of Post-Translational Modification

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