KLH18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH18_HUMAN
• UniProt AC: O94889
• Protein Name: Kelch-like protein 18
• Gene Name: KLHL18
• Organism: Homo sapiens (Human).
• Sequence Length: 574
• Protein Sequence: MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCIPLLTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	EEIRRQGKLCDVTLK HHHHHCCCCCCEEEE	37.29	-
43	Ubiquitination	KLCDVTLKIGDHKFS CCCCEEEEECCCCCH	34.96	-
48	Ubiquitination	TLKIGDHKFSAHRIV EEEECCCCCHHHHHH	45.84	-
138	Ubiquitination	LRERLHPKNCLGVRQ HHHHHCCCCCCCHHH	49.93	-
156	Phosphorylation	TMMCAVLYDAANSFI HHHHHHHHHHHHHHH	9.27	-
219	Phosphorylation	DREQRGPYLPELLSN CHHHCCCCHHHHHHC	37.40	24043423
261	Ubiquitination	RDLVDEAKDYHLMPE HHHHHHHHHCCCCCC	57.69	-
263	Phosphorylation	LVDEAKDYHLMPERR HHHHHHHCCCCCCCC	8.99	28796482
368	Phosphorylation	DTWTRVGSMNSKRSA CCCEEEECCCCCCCC	16.37	28355574
386	Phosphorylation	VVLDGQIYVCGGYDG EEECCEEEEECCCCC	5.04	28985074
398	Phosphorylation	YDGNSSLSSVETYSP CCCCCCCCCEEEECC	34.00	28985074
417	Phosphorylation	WTVVTSMSSNRSAAG EEEEEECCCCCCCCC	24.99	28985074
421	Phosphorylation	TSMSSNRSAAGVTVF EECCCCCCCCCEEEE	27.07	22985185
485	Phosphorylation	KMFVCGGYDGSGFLS CEEEECCCCCCCHHH	11.47	24043423
488	Phosphorylation	VCGGYDGSGFLSIAE EECCCCCCCHHHHHH	24.39	24043423
492	Phosphorylation	YDGSGFLSIAEMYSS CCCCCHHHHHHHHHH	19.93	24043423
497	Phosphorylation	FLSIAEMYSSVADQW HHHHHHHHHHHCCCE	6.84	24043423
498	Phosphorylation	LSIAEMYSSVADQWC HHHHHHHHHHCCCEE	19.61	24043423
499	Phosphorylation	SIAEMYSSVADQWCL HHHHHHHHHCCCEEE	12.11	24043423
512	Phosphorylation	CLIVPMHTRRSRVSL EEEEECCCCCCHHHH	22.86	24043423
518	Phosphorylation	HTRRSRVSLVASCGR CCCCCHHHHHEECCC	18.93	-
522	Phosphorylation	SRVSLVASCGRLYAV CHHHHHEECCCEEEE	15.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGT1_HUMAN	SUGT1	physical	26186194
NUDC3_HUMAN	NUDCD3	physical	26186194
CUL3_HUMAN	CUL3	physical	23213400
AURKA_HUMAN	AURKA	physical	23213400
RBX1_HUMAN	RBX1	physical	23213400
CUL3_HUMAN	CUL3	physical	28514442
BAG4_HUMAN	BAG4	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
SGT1_HUMAN	SUGT1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.